ZA937859B - Antiretroviral acyl compounds - Google Patents

Antiretroviral acyl compounds

Info

Publication number
ZA937859B
ZA937859B ZA937859A ZA937859A ZA937859B ZA 937859 B ZA937859 B ZA 937859B ZA 937859 A ZA937859 A ZA 937859A ZA 937859 A ZA937859 A ZA 937859A ZA 937859 B ZA937859 B ZA 937859B
Authority
ZA
South Africa
Prior art keywords
antiretroviral
acyl compounds
acyl
compounds
salts
Prior art date
Application number
ZA937859A
Inventor
Guido Bold
Alexander Faessler
Marc Lang
Original Assignee
Ciba Geigy
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ciba Geigy filed Critical Ciba Geigy
Publication of ZA937859B publication Critical patent/ZA937859B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/021—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-(X)n-C(=0)-, n being 5 or 6; for n > 6, classification in C07K5/06 - C07K5/10, according to the moiety having normal peptide bonds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Abstract

The invention relates to compounds of the formula I <IMAGE> in which R1 is acyl, and salts thereof, which have antiretroviral activity, in particular against AIDS.
ZA937859A 1992-10-23 1993-10-22 Antiretroviral acyl compounds ZA937859B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH331292 1992-10-23

Publications (1)

Publication Number Publication Date
ZA937859B true ZA937859B (en) 1994-04-25

Family

ID=4253267

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA937859A ZA937859B (en) 1992-10-23 1993-10-22 Antiretroviral acyl compounds

Country Status (19)

Country Link
EP (1) EP0594540B1 (en)
JP (1) JPH06228132A (en)
KR (1) KR940009177A (en)
CN (1) CN1089606A (en)
AT (1) ATE164592T1 (en)
AU (1) AU670121B2 (en)
CA (1) CA2108934A1 (en)
CZ (1) CZ223893A3 (en)
DE (1) DE59308336D1 (en)
FI (1) FI934634A (en)
HU (1) HU214330B (en)
IL (1) IL107356A (en)
MX (1) MX9306588A (en)
NO (1) NO933816L (en)
NZ (1) NZ250017A (en)
PL (1) PL173529B1 (en)
SK (1) SK115193A3 (en)
TW (1) TW372972B (en)
ZA (1) ZA937859B (en)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6878728B1 (en) 1999-06-11 2005-04-12 Vertex Pharmaceutical Incorporated Inhibitors of aspartyl protease
US20040122000A1 (en) 1981-01-07 2004-06-24 Vertex Pharmaceuticals Incorporated. Inhibitors of aspartyl protease
US5888992A (en) 1992-03-11 1999-03-30 Narhex Limited Polar substituted hydrocarbons
DE69333270T2 (en) 1992-03-11 2004-08-05 Narhex Ltd. AMINE DERIVATIVES OF OXO AND HYDROXY SUBSTITUTED CARBON HYDROGEN
BR9306058A (en) 1992-03-11 1997-11-18 Narhex Ltd Amine derivatives of oxo- and hydroxy-substituted hydrocarbons
US6071895A (en) 1992-03-11 2000-06-06 Narhex Limited Polar-substituted hydrocarbons
IL110898A0 (en) * 1993-09-10 1994-11-28 Narhex Australia Pty Ltd Polar-substituted hydrocarbons
DE19500122A1 (en) * 1995-01-04 1996-07-11 Bayer Ag New pseudopeptides with trifluoromethyl-substituted 2-azabicyclooctane
DE19500120A1 (en) 1995-01-04 1996-07-11 Bayer Ag New acylated pseudopeptides with trifluoromethyl-substituted 2-azabicyclooctane
US6008228A (en) * 1995-06-06 1999-12-28 Hoffman-La Roche Inc. Pharmaceutical compositions containing proteinase inhibitors
US6436989B1 (en) 1997-12-24 2002-08-20 Vertex Pharmaceuticals, Incorporated Prodrugs of aspartyl protease inhibitors
EP1086076B1 (en) 1998-06-19 2004-12-22 Vertex Pharmaceuticals Incorporated Sulfonamide inhibitors of aspartyl protease
CO5261510A1 (en) 1999-02-12 2003-03-31 Vertex Pharma ASPARTIL PROTEASA INHIBITORS

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4668685A (en) * 1984-07-05 1987-05-26 E.I. Du Pont De Nemours And Company Substituted benzoate ester prodrug derivatives of 3-hydroxymorphinans, which are analgesics or narcotic antagonists
US5024968A (en) * 1988-07-08 1991-06-18 Engelsberg Audrey C Removal of surface contaminants by irradiation from a high-energy source
GB8927913D0 (en) * 1989-12-11 1990-02-14 Hoffmann La Roche Amino acid derivatives
GB8927915D0 (en) * 1989-12-11 1990-02-14 Hoffmann La Roche Novel alcohols

Also Published As

Publication number Publication date
MX9306588A (en) 1994-05-31
CN1089606A (en) 1994-07-20
FI934634A0 (en) 1993-10-20
NO933816D0 (en) 1993-10-22
EP0594540B1 (en) 1998-04-01
NO933816L (en) 1994-04-25
FI934634A (en) 1994-04-24
HU9303011D0 (en) 1994-01-28
HUT65876A (en) 1994-07-28
PL173529B1 (en) 1998-03-31
AU4907293A (en) 1994-05-05
IL107356A (en) 1998-01-04
ATE164592T1 (en) 1998-04-15
CZ223893A3 (en) 1994-05-18
KR940009177A (en) 1994-05-20
HU214330B (en) 1998-03-02
NZ250017A (en) 1996-04-26
SK115193A3 (en) 1994-11-09
TW372972B (en) 1999-11-01
JPH06228132A (en) 1994-08-16
DE59308336D1 (en) 1998-05-07
IL107356A0 (en) 1994-01-25
EP0594540A1 (en) 1994-04-27
CA2108934A1 (en) 1994-04-24
AU670121B2 (en) 1996-07-04

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