AU4907293A - Antiretroviral acyl compounds - Google Patents

Antiretroviral acyl compounds

Info

Publication number
AU4907293A
AU4907293A AU49072/93A AU4907293A AU4907293A AU 4907293 A AU4907293 A AU 4907293A AU 49072/93 A AU49072/93 A AU 49072/93A AU 4907293 A AU4907293 A AU 4907293A AU 4907293 A AU4907293 A AU 4907293A
Authority
AU
Australia
Prior art keywords
antiretroviral
acyl compounds
acyl
compounds
salts
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
AU49072/93A
Other versions
AU670121B2 (en
Inventor
Guido Dr. Bold
Alexander Dr. Fassler
Marc Dr. Lang
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis AG
Original Assignee
Novartis AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis AG filed Critical Novartis AG
Publication of AU4907293A publication Critical patent/AU4907293A/en
Application granted granted Critical
Publication of AU670121B2 publication Critical patent/AU670121B2/en
Assigned to NOVARTIS AG reassignment NOVARTIS AG Request to Amend Deed and Register Assignors: CIBA-GEIGY AG
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/021—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-(X)n-C(=0)-, n being 5 or 6; for n > 6, classification in C07K5/06 - C07K5/10, according to the moiety having normal peptide bonds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Abstract

The invention relates to compounds of the formula I <IMAGE> in which R1 is acyl, and salts thereof, which have antiretroviral activity, in particular against AIDS.
AU49072/93A 1992-10-23 1993-10-18 Antiretroviral acyl compounds Ceased AU670121B2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH3312/92 1992-10-23
CH331292 1992-10-23

Publications (2)

Publication Number Publication Date
AU4907293A true AU4907293A (en) 1994-05-05
AU670121B2 AU670121B2 (en) 1996-07-04

Family

ID=4253267

Family Applications (1)

Application Number Title Priority Date Filing Date
AU49072/93A Ceased AU670121B2 (en) 1992-10-23 1993-10-18 Antiretroviral acyl compounds

Country Status (19)

Country Link
EP (1) EP0594540B1 (en)
JP (1) JPH06228132A (en)
KR (1) KR940009177A (en)
CN (1) CN1089606A (en)
AT (1) ATE164592T1 (en)
AU (1) AU670121B2 (en)
CA (1) CA2108934A1 (en)
CZ (1) CZ223893A3 (en)
DE (1) DE59308336D1 (en)
FI (1) FI934634A (en)
HU (1) HU214330B (en)
IL (1) IL107356A (en)
MX (1) MX9306588A (en)
NO (1) NO933816L (en)
NZ (1) NZ250017A (en)
PL (1) PL173529B1 (en)
SK (1) SK115193A3 (en)
TW (1) TW372972B (en)
ZA (1) ZA937859B (en)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995007269A1 (en) * 1993-09-10 1995-03-16 Narhex Limited Polar-substituted hydrocarbons
US5679688A (en) 1992-03-11 1997-10-21 Narhex Limited Quinaldoyl-amine derivatives of oxo-and hydroxy-substituted hydrocarbons
US5888992A (en) 1992-03-11 1999-03-30 Narhex Limited Polar substituted hydrocarbons
US6071895A (en) 1992-03-11 2000-06-06 Narhex Limited Polar-substituted hydrocarbons
US6258806B1 (en) 1992-03-11 2001-07-10 Narhex Limited Amine derivatives of oxo- and hydroxy- substituted hydrocarbons

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6878728B1 (en) 1999-06-11 2005-04-12 Vertex Pharmaceutical Incorporated Inhibitors of aspartyl protease
US20040122000A1 (en) 1981-01-07 2004-06-24 Vertex Pharmaceuticals Incorporated. Inhibitors of aspartyl protease
SK1296A3 (en) 1995-01-04 1996-08-07 Bayer Ag Acyled pseudopeptides with trifluoromethyl-substituted 2-azabicyklooctane, manufacturing process thereof and medicaments containing these substances
DE19500122A1 (en) * 1995-01-04 1996-07-11 Bayer Ag New pseudopeptides with trifluoromethyl-substituted 2-azabicyclooctane
US6008228A (en) * 1995-06-06 1999-12-28 Hoffman-La Roche Inc. Pharmaceutical compositions containing proteinase inhibitors
US6436989B1 (en) 1997-12-24 2002-08-20 Vertex Pharmaceuticals, Incorporated Prodrugs of aspartyl protease inhibitors
AU767728B2 (en) 1998-06-19 2003-11-20 Vertex Pharmaceuticals Incorporated Sulfonamide inhibitors of aspartyl protease
TWI260322B (en) 1999-02-12 2006-08-21 Vertex Pharma Inhibitors of aspartyl protease

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4668685A (en) * 1984-07-05 1987-05-26 E.I. Du Pont De Nemours And Company Substituted benzoate ester prodrug derivatives of 3-hydroxymorphinans, which are analgesics or narcotic antagonists
US5024968A (en) * 1988-07-08 1991-06-18 Engelsberg Audrey C Removal of surface contaminants by irradiation from a high-energy source
GB8927915D0 (en) * 1989-12-11 1990-02-14 Hoffmann La Roche Novel alcohols
GB8927913D0 (en) * 1989-12-11 1990-02-14 Hoffmann La Roche Amino acid derivatives

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5679688A (en) 1992-03-11 1997-10-21 Narhex Limited Quinaldoyl-amine derivatives of oxo-and hydroxy-substituted hydrocarbons
US5888992A (en) 1992-03-11 1999-03-30 Narhex Limited Polar substituted hydrocarbons
US5942504A (en) 1992-03-11 1999-08-24 Narhex Limited Amine derivatives of oxo- and hydroxy- substituted hydrocarbons
US6071895A (en) 1992-03-11 2000-06-06 Narhex Limited Polar-substituted hydrocarbons
US6258806B1 (en) 1992-03-11 2001-07-10 Narhex Limited Amine derivatives of oxo- and hydroxy- substituted hydrocarbons
WO1995007269A1 (en) * 1993-09-10 1995-03-16 Narhex Limited Polar-substituted hydrocarbons

Also Published As

Publication number Publication date
KR940009177A (en) 1994-05-20
ZA937859B (en) 1994-04-25
JPH06228132A (en) 1994-08-16
ATE164592T1 (en) 1998-04-15
FI934634A0 (en) 1993-10-20
AU670121B2 (en) 1996-07-04
MX9306588A (en) 1994-05-31
HU9303011D0 (en) 1994-01-28
NZ250017A (en) 1996-04-26
HU214330B (en) 1998-03-02
SK115193A3 (en) 1994-11-09
IL107356A (en) 1998-01-04
CZ223893A3 (en) 1994-05-18
NO933816D0 (en) 1993-10-22
PL173529B1 (en) 1998-03-31
CN1089606A (en) 1994-07-20
EP0594540A1 (en) 1994-04-27
TW372972B (en) 1999-11-01
EP0594540B1 (en) 1998-04-01
HUT65876A (en) 1994-07-28
DE59308336D1 (en) 1998-05-07
FI934634A (en) 1994-04-24
NO933816L (en) 1994-04-25
IL107356A0 (en) 1994-01-25
CA2108934A1 (en) 1994-04-24

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