NO20012832L - Heterocyclic carboxamide-containing thiourea inhibitors of herpesvirus containing phenylenediamine group - Google Patents
Heterocyclic carboxamide-containing thiourea inhibitors of herpesvirus containing phenylenediamine groupInfo
- Publication number
- NO20012832L NO20012832L NO20012832A NO20012832A NO20012832L NO 20012832 L NO20012832 L NO 20012832L NO 20012832 A NO20012832 A NO 20012832A NO 20012832 A NO20012832 A NO 20012832A NO 20012832 L NO20012832 L NO 20012832L
- Authority
- NO
- Norway
- Prior art keywords
- carbon atoms
- alkyl
- hydrogen
- heteroaryl
- perhaloalkyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/30—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D263/34—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
- A61P31/22—Antivirals for DNA viruses for herpes viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
- C07D285/01—Five-membered rings
- C07D285/02—Thiadiazoles; Hydrogenated thiadiazoles
- C07D285/04—Thiadiazoles; Hydrogenated thiadiazoles not condensed with other rings
- C07D285/06—1,2,3-Thiadiazoles; Hydrogenated 1,2,3-thiadiazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D307/68—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Virology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Diabetes (AREA)
- Pulmonology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Hematology (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Ophthalmology & Optometry (AREA)
- AIDS & HIV (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Hydrogenated Pyridines (AREA)
- Furan Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Det er beskrevet en forbindelse med formel (I) hvor Ri-R5 er uavhengig valgt fra hydrogen, alkyl med 1 til 6 karbonatomer, alkenyl med 2 til 6 karbonatomer, alkynyl med 2 til 6 karbonatomer, perhalogenalkyl med 1 til 6 karnbonatomer, sykloalkyl med 3 til 10 karbonatomer, heterosykloalkyl med 3 til 10 karbonledd, aryl, heteroaryl, halogen, CN, NO2, CO2R6, OR6, SR6, SOR6l SO2R6, CONR7RB, NR6N(R7R8), N(R7R8) eller W-Y-(CH2)n-Z forutsatt at minst en av RrR5 ikke er hydrogen; eller R2 og R3 eller R3 og R4, danner sammen en 3 til 7-leddet heterosykloalkyl eller 3 til 7 leddet heteroaryl; Re og R7 er uavhengig hydrogen, alkyl med 1 til 6 karbonatomer, perhalogenalkyl med 1 til 6 karbonatomer, eller aryl; R8 er hydrogen, alkyl med 1 til 6 karbonatomer, perhalogenalkyl med 1 til 6 karbonatomer, sykloalkyl med 3 tiMO karbonatomer, heterosykloalkyl med 3 til 10 ledd, aryl eller heteroaryl, eller R7 eller RB, kan sammen danne en 3 til 7 leddet heterosykloalkyl; W er O, NR6 eller er fraværende; Y er (CO)- eller (CO2)- eller er fraværende; Z er alkyl med 1 til 4 karbonatomer, CN, CO2R6, COR6, CONR7R8, OCOR6, NR6COR7, OCONR6, OR6l SR6, SOR6, SO2R6, SReNfR.Ra), N(R7R8) eller fenyl; G er monosyklisk heteroaryl; X er en binding; NH, alkyl med 1 til 6 karbonatomer, alkenyl med 1 til 6 karbonatomer, alkoksy med 1 til 6 karbonatomer, eller tioalkyl med 1 til 6 karbonatomer, alkylamino med 1 til 6 karbonatomer, eller (CH)J; J er alkyl med 1 til 6 karbonatomer, sykloalkyl med 3 til 7 karbonatomer, fenyl eller benzyl; og n er et tall fra 1 til 6, nyttig for behandling av sykdommer assosiert med herpesviruser inkludert human cytomegalovirus, herpes simplex viruser, Epstein-Barr virus, varicella-zoster virus, humane herpesviruser-6 og -7 og Kaposi herpesvirus.A compound of formula (I) is disclosed wherein R 1 -R 5 is independently selected from hydrogen, alkyl of 1 to 6 carbon atoms, alkenyl of 2 to 6 carbon atoms, alkynyl of 2 to 6 carbon atoms, perhaloalkyl of 1 to 6 carbon atoms, cycloalkyl of 3 to 10 carbon atoms, heterocycloalkyl of 3 to 10 carbon members, aryl, heteroaryl, halogen, CN, NO2, CO2R6, OR6, SR6, SOR6l SO2R6, CONR7RB, NR6N (R7R8), N (R7R8) or WY- (CH2) nZ provided at least one of RrR5 is not hydrogen; or R2 and R3 or R3 and R4 together form a 3 to 7 membered heterocycloalkyl or 3 to 7 membered heteroaryl; Re and R7 are independently hydrogen, alkyl of 1 to 6 carbon atoms, perhaloalkyl of 1 to 6 carbon atoms, or aryl; R8 is hydrogen, alkyl of 1 to 6 carbon atoms, perhaloalkyl of 1 to 6 carbon atoms, cycloalkyl of 3 to 10 carbon atoms, 3 to 10 membered heterocycloalkyl, aryl or heteroaryl, or R7 or RB may together form a 3 to 7 membered heterocycloalkyl; W is O, NR 6 or is absent; Y is (CO) or (CO2) - or is absent; Z is alkyl of 1 to 4 carbon atoms, CN, CO2R6, COR6, CONR7R8, OCOR6, NR6COR7, OCONR6, OR6l SR6, SOR6, SO2R6, SReNfR.Ra), N (R7R8) or phenyl; G is monocyclic heteroaryl; X is a bond; NH, alkyl of 1 to 6 carbon atoms, alkenyl of 1 to 6 carbon atoms, alkoxy of 1 to 6 carbon atoms, or thioalkyl of 1 to 6 carbon atoms, alkylamino of 1 to 6 carbon atoms, or (CH) J; J is alkyl of 1 to 6 carbon atoms, cycloalkyl of 3 to 7 carbon atoms, phenyl or benzyl; and n is a number from 1 to 6, useful for treating diseases associated with herpes viruses including human cytomegalovirus, herpes simplex virus, Epstein-Barr virus, varicella-zoster virus, human herpesviruses-6 and -7, and Kaposi herpes virus.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US20855998A | 1998-12-09 | 1998-12-09 | |
| PCT/US1999/028842 WO2000034258A2 (en) | 1998-12-09 | 1999-12-06 | Heterocyclic carboxamide-containing thiourea inhibitors of herpes viruses containing phenylenediamine group |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| NO20012832D0 NO20012832D0 (en) | 2001-06-08 |
| NO20012832L true NO20012832L (en) | 2001-08-07 |
Family
ID=22775044
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20012832A NO20012832L (en) | 1998-12-09 | 2001-06-08 | Heterocyclic carboxamide-containing thiourea inhibitors of herpesvirus containing phenylenediamine group |
Country Status (18)
| Country | Link |
|---|---|
| EP (1) | EP1144397A3 (en) |
| JP (1) | JP2002531554A (en) |
| CN (1) | CN1348446A (en) |
| AU (1) | AU1934700A (en) |
| BG (1) | BG105581A (en) |
| BR (1) | BR9916046A (en) |
| CA (1) | CA2350767A1 (en) |
| CZ (1) | CZ20011956A3 (en) |
| EA (1) | EA200100631A1 (en) |
| HU (1) | HUP0200232A2 (en) |
| ID (1) | ID30158A (en) |
| IL (1) | IL143182A0 (en) |
| NO (1) | NO20012832L (en) |
| PL (1) | PL349217A1 (en) |
| SK (1) | SK7682001A3 (en) |
| TR (1) | TR200101664T2 (en) |
| WO (1) | WO2000034258A2 (en) |
| ZA (1) | ZA200104377B (en) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6166028A (en) * | 1998-12-09 | 2000-12-26 | American Home Products Corporation | Diaminopuridine-containing thiourea inhibitors of herpes viruses |
| US6844367B1 (en) | 1999-09-17 | 2005-01-18 | Millennium Pharmaceuticals, Inc. | Benzamides and related inhibitors of factor Xa |
| EP1259485B1 (en) | 2000-02-29 | 2005-11-30 | Millennium Pharmaceuticals, Inc. | BENZAMIDES AND RELATED INHIBITORS OF FACTOR Xa |
| US7220768B2 (en) * | 2003-02-11 | 2007-05-22 | Wyeth Holdings Corp. | Isoxazole-containing thiourea inhibitors useful for treatment of varicella zoster virus |
| ES2382055T3 (en) | 2006-11-02 | 2012-06-04 | Millennium Pharmaceuticals, Inc. | Methods for synthesizing pharmaceutical salts of a factor Xa inhibitor |
| JP6372666B2 (en) * | 2012-11-03 | 2018-08-15 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | Inhibitor of cytomegalovirus |
| EP2914591B1 (en) * | 2012-11-03 | 2017-10-11 | Boehringer Ingelheim International GmbH | Inhibitors of cytomegalovirus |
| CN110565100B (en) * | 2019-07-12 | 2021-05-07 | 西北工业大学 | Cobaltocene cation-based corrosion inhibitor and preparation method and use method thereof |
| EP4382527A1 (en) | 2021-08-05 | 2024-06-12 | Zhejiang Hisun Pharmaceutical Co., Ltd. | Aromatic acetylene derivative, and preparation method therefor and use thereof |
| WO2023088718A1 (en) | 2021-11-19 | 2023-05-25 | Basf Se | Bicyclic compounds for the control of invertebrate pests |
| CN115433093A (en) * | 2022-09-26 | 2022-12-06 | 无锡双启科技有限公司 | Preparation method of 3-chloro-4-trifluoromethylaniline |
| CN115710190A (en) * | 2022-11-16 | 2023-02-24 | 常州佳德医药科技有限公司 | 4-methoxy-2-amino-N, N-dimethylaniline, preparation method and application |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE69830751T2 (en) * | 1997-04-10 | 2006-05-18 | Pharmacia & Upjohn Co. Llc, Kalamazoo | Polyaromatic compounds for the treatment of herpes infections |
-
1999
- 1999-12-06 EP EP99963023A patent/EP1144397A3/en not_active Withdrawn
- 1999-12-06 CA CA002350767A patent/CA2350767A1/en not_active Abandoned
- 1999-12-06 IL IL14318299A patent/IL143182A0/en unknown
- 1999-12-06 PL PL99349217A patent/PL349217A1/en not_active Application Discontinuation
- 1999-12-06 EA EA200100631A patent/EA200100631A1/en unknown
- 1999-12-06 WO PCT/US1999/028842 patent/WO2000034258A2/en not_active Application Discontinuation
- 1999-12-06 JP JP2000586705A patent/JP2002531554A/en active Pending
- 1999-12-06 BR BR9916046-3A patent/BR9916046A/en not_active Application Discontinuation
- 1999-12-06 CZ CZ20011956A patent/CZ20011956A3/en unknown
- 1999-12-06 AU AU19347/00A patent/AU1934700A/en not_active Abandoned
- 1999-12-06 TR TR2001/01664T patent/TR200101664T2/en unknown
- 1999-12-06 HU HU0200232A patent/HUP0200232A2/en unknown
- 1999-12-06 CN CN99815997A patent/CN1348446A/en active Pending
- 1999-12-06 SK SK768-2001A patent/SK7682001A3/en unknown
- 1999-12-06 ID IDW00200101231A patent/ID30158A/en unknown
-
2001
- 2001-05-28 ZA ZA200104377A patent/ZA200104377B/en unknown
- 2001-06-08 BG BG105581A patent/BG105581A/en unknown
- 2001-06-08 NO NO20012832A patent/NO20012832L/en not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| IL143182A0 (en) | 2002-04-21 |
| EP1144397A3 (en) | 2002-09-11 |
| WO2000034258A2 (en) | 2000-06-15 |
| ZA200104377B (en) | 2002-12-20 |
| PL349217A1 (en) | 2002-07-01 |
| SK7682001A3 (en) | 2002-07-02 |
| NO20012832D0 (en) | 2001-06-08 |
| ID30158A (en) | 2001-11-08 |
| BR9916046A (en) | 2001-10-02 |
| CZ20011956A3 (en) | 2001-10-17 |
| WO2000034258A3 (en) | 2001-11-29 |
| JP2002531554A (en) | 2002-09-24 |
| CA2350767A1 (en) | 2000-06-15 |
| EA200100631A1 (en) | 2002-02-28 |
| HUP0200232A2 (en) | 2002-05-29 |
| TR200101664T2 (en) | 2002-03-21 |
| EP1144397A2 (en) | 2001-10-17 |
| CN1348446A (en) | 2002-05-08 |
| BG105581A (en) | 2001-12-31 |
| AU1934700A (en) | 2000-06-26 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| NO20012832L (en) | Heterocyclic carboxamide-containing thiourea inhibitors of herpesvirus containing phenylenediamine group | |
| ES8500911A1 (en) | Guanidin derivatives. | |
| EA200000993A1 (en) | TRIPLE-SUBSTITUTE DERIVATIVES 1,3,5-TRIAZINE FOR THE TREATMENT OF HIV INFECTIOUS DISEASES | |
| EP0254327A3 (en) | N-n-disubstituted-omega-(2-amino-3-(carbonylmethyl)-3,4-dihydroquinazolinyl) oxyalkylamides and related compounds | |
| DE69434720D1 (en) | Use of 2,6-dialkyl-4-silyl-phenol derivatives for the treatment of xanthoma | |
| NO20012834L (en) | Acetamide- and substituted acetamide-containing thiourea inhibitors for herpes virus | |
| NO20012835L (en) | Heterocyclic carboxamide-containing thiourea inhibitors of herpes virus containing a substituted phenylenediamine group | |
| ATE57930T1 (en) | DIHYDROPYRIDINE. | |
| JPS5681578A (en) | Novel thioalkyl amide derivative | |
| NO940019L (en) | Process for the preparation of sulfur-containing imidazole derivatives | |
| DE69810800D1 (en) | AZETIDINE DERIVATIVES FOR TREATING HCMV INFLAMMATION | |
| NO940018L (en) | Process for the preparation of sulfur-containing imidazole derivatives | |
| NO20012836L (en) | Thiourea inhibitors of herpes virus | |
| DE3167155D1 (en) | Aminopropanol derivatives, process for their preparation and their use as fungicides | |
| WO2000034260A3 (en) | Alpha-methylbenzyl-containing thiourea inhibitors of herpes viruses containing a phenylenediamine group | |
| EA200100635A1 (en) | DERIVATIVES OF THIOMOCHEVIA AS HERPES VIRUS INHIBITORS | |
| NO961537L (en) | Nitric acid esters from derivatives of 2- (2,6-dihalophenylamino) -phenylacetoxyacetic acid, and their preparation procedures | |
| DK0579059T3 (en) | Pyridazinone derivatives and processes for preparing the same | |
| BR0013409B1 (en) | fungicidal compounds having a fluorovinyl or fluorpropenyl oxyphenyloxime moiety and process for preparing them. | |
| CA2142463A1 (en) | Herbicidal pyrazolyloxy-picolinamides | |
| DK74185A (en) | 3-PHENYL-2-PROPEN-AMINE DERIVATIVES, PROCEDURES FOR THEIR PREPARATION AND MEDICINES CONTAINING THESE COMPOUNDS | |
| ES8603414A1 (en) | Vasodilating trinitratoalkyl esters of 2-cyano-1,4-dihydropyridines | |
| BG106613A (en) | Phenyl-and pyridyl-tetrahydro-pyridines having tnf inhibiting activity | |
| EP0146271A3 (en) | Aralykyl (arylethynyl) aralkyl amines for use as vasodilators and antihypertensives | |
| ES471895A1 (en) | Benzamidine derivatives |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FC2A | Withdrawal, rejection or dismissal of laid open patent application |