NO20012832L - Heterocyclic carboxamide-containing thiourea inhibitors of herpesvirus containing phenylenediamine group - Google Patents

Heterocyclic carboxamide-containing thiourea inhibitors of herpesvirus containing phenylenediamine group

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Publication number
NO20012832L
NO20012832L NO20012832A NO20012832A NO20012832L NO 20012832 L NO20012832 L NO 20012832L NO 20012832 A NO20012832 A NO 20012832A NO 20012832 A NO20012832 A NO 20012832A NO 20012832 L NO20012832 L NO 20012832L
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Norway
Prior art keywords
carbon atoms
alkyl
hydrogen
heteroaryl
perhaloalkyl
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Application number
NO20012832A
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Norwegian (no)
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NO20012832D0 (en
Inventor
Jonathan David Bloom
Kevin Joseph
Martin Joseph Digrandi
Russel George Dushin
Thomas Richard Jones
Stanley Albert Lang
Adma Antonia Ross
Eugene Anthony Terefenko
Bryan Mark O'hara
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American Home Prod
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Publication date
Application filed by American Home Prod filed Critical American Home Prod
Publication of NO20012832D0 publication Critical patent/NO20012832D0/en
Publication of NO20012832L publication Critical patent/NO20012832L/en

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D263/00Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/30Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D263/34Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/14Antivirals for RNA viruses
    • A61P31/18Antivirals for RNA viruses for HIV
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/20Antivirals for DNA viruses
    • A61P31/22Antivirals for DNA viruses for herpes viruses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D233/00Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/90Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D277/00Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/56Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D285/00Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
    • C07D285/01Five-membered rings
    • C07D285/02Thiadiazoles; Hydrogenated thiadiazoles
    • C07D285/04Thiadiazoles; Hydrogenated thiadiazoles not condensed with other rings
    • C07D285/061,2,3-Thiadiazoles; Hydrogenated 1,2,3-thiadiazoles
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D307/00Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/56Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/68Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Molecular Biology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Dermatology (AREA)
  • AIDS & HIV (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Furan Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Det er beskrevet en forbindelse med formel (I) hvor Ri-R5 er uavhengig valgt fra hydrogen, alkyl med 1 til 6 karbonatomer, alkenyl med 2 til 6 karbonatomer, alkynyl med 2 til 6 karbonatomer, perhalogenalkyl med 1 til 6 karnbonatomer, sykloalkyl med 3 til 10 karbonatomer, heterosykloalkyl med 3 til 10 karbonledd, aryl, heteroaryl, halogen, CN, NO2, CO2R6, OR6, SR6, SOR6l SO2R6, CONR7RB, NR6N(R7R8), N(R7R8) eller W-Y-(CH2)n-Z forutsatt at minst en av RrR5 ikke er hydrogen; eller R2 og R3 eller R3 og R4, danner sammen en 3 til 7-leddet heterosykloalkyl eller 3 til 7 leddet heteroaryl; Re og R7 er uavhengig hydrogen, alkyl med 1 til 6 karbonatomer, perhalogenalkyl med 1 til 6 karbonatomer, eller aryl; R8 er hydrogen, alkyl med 1 til 6 karbonatomer, perhalogenalkyl med 1 til 6 karbonatomer, sykloalkyl med 3 tiMO karbonatomer, heterosykloalkyl med 3 til 10 ledd, aryl eller heteroaryl, eller R7 eller RB, kan sammen danne en 3 til 7 leddet heterosykloalkyl; W er O, NR6 eller er fraværende; Y er (CO)- eller (CO2)- eller er fraværende; Z er alkyl med 1 til 4 karbonatomer, CN, CO2R6, COR6, CONR7R8, OCOR6, NR6COR7, OCONR6, OR6l SR6, SOR6, SO2R6, SReNfR.Ra), N(R7R8) eller fenyl; G er monosyklisk heteroaryl; X er en binding; NH, alkyl med 1 til 6 karbonatomer, alkenyl med 1 til 6 karbonatomer, alkoksy med 1 til 6 karbonatomer, eller tioalkyl med 1 til 6 karbonatomer, alkylamino med 1 til 6 karbonatomer, eller (CH)J; J er alkyl med 1 til 6 karbonatomer, sykloalkyl med 3 til 7 karbonatomer, fenyl eller benzyl; og n er et tall fra 1 til 6, nyttig for behandling av sykdommer assosiert med herpesviruser inkludert human cytomegalovirus, herpes simplex viruser, Epstein-Barr virus, varicella-zoster virus, humane herpesviruser-6 og -7 og Kaposi herpesvirus.A compound of formula (I) is disclosed wherein R 1 -R 5 is independently selected from hydrogen, alkyl of 1 to 6 carbon atoms, alkenyl of 2 to 6 carbon atoms, alkynyl of 2 to 6 carbon atoms, perhaloalkyl of 1 to 6 carbon atoms, cycloalkyl of 3 to 10 carbon atoms, heterocycloalkyl of 3 to 10 carbon members, aryl, heteroaryl, halogen, CN, NO2, CO2R6, OR6, SR6, SOR6l SO2R6, CONR7RB, NR6N (R7R8), N (R7R8) or WY- (CH2) nZ provided at least one of RrR5 is not hydrogen; or R2 and R3 or R3 and R4 together form a 3 to 7 membered heterocycloalkyl or 3 to 7 membered heteroaryl; Re and R7 are independently hydrogen, alkyl of 1 to 6 carbon atoms, perhaloalkyl of 1 to 6 carbon atoms, or aryl; R8 is hydrogen, alkyl of 1 to 6 carbon atoms, perhaloalkyl of 1 to 6 carbon atoms, cycloalkyl of 3 to 10 carbon atoms, 3 to 10 membered heterocycloalkyl, aryl or heteroaryl, or R7 or RB may together form a 3 to 7 membered heterocycloalkyl; W is O, NR 6 or is absent; Y is (CO) or (CO2) - or is absent; Z is alkyl of 1 to 4 carbon atoms, CN, CO2R6, COR6, CONR7R8, OCOR6, NR6COR7, OCONR6, OR6l SR6, SOR6, SO2R6, SReNfR.Ra), N (R7R8) or phenyl; G is monocyclic heteroaryl; X is a bond; NH, alkyl of 1 to 6 carbon atoms, alkenyl of 1 to 6 carbon atoms, alkoxy of 1 to 6 carbon atoms, or thioalkyl of 1 to 6 carbon atoms, alkylamino of 1 to 6 carbon atoms, or (CH) J; J is alkyl of 1 to 6 carbon atoms, cycloalkyl of 3 to 7 carbon atoms, phenyl or benzyl; and n is a number from 1 to 6, useful for treating diseases associated with herpes viruses including human cytomegalovirus, herpes simplex virus, Epstein-Barr virus, varicella-zoster virus, human herpesviruses-6 and -7, and Kaposi herpes virus.

NO20012832A 1998-12-09 2001-06-08 Heterocyclic carboxamide-containing thiourea inhibitors of herpesvirus containing phenylenediamine group NO20012832L (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US20855998A 1998-12-09 1998-12-09
PCT/US1999/028842 WO2000034258A2 (en) 1998-12-09 1999-12-06 Heterocyclic carboxamide-containing thiourea inhibitors of herpes viruses containing phenylenediamine group

Publications (2)

Publication Number Publication Date
NO20012832D0 NO20012832D0 (en) 2001-06-08
NO20012832L true NO20012832L (en) 2001-08-07

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
NO20012832A NO20012832L (en) 1998-12-09 2001-06-08 Heterocyclic carboxamide-containing thiourea inhibitors of herpesvirus containing phenylenediamine group

Country Status (18)

Country Link
EP (1) EP1144397A3 (en)
JP (1) JP2002531554A (en)
CN (1) CN1348446A (en)
AU (1) AU1934700A (en)
BG (1) BG105581A (en)
BR (1) BR9916046A (en)
CA (1) CA2350767A1 (en)
CZ (1) CZ20011956A3 (en)
EA (1) EA200100631A1 (en)
HU (1) HUP0200232A2 (en)
ID (1) ID30158A (en)
IL (1) IL143182A0 (en)
NO (1) NO20012832L (en)
PL (1) PL349217A1 (en)
SK (1) SK7682001A3 (en)
TR (1) TR200101664T2 (en)
WO (1) WO2000034258A2 (en)
ZA (1) ZA200104377B (en)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6166028A (en) * 1998-12-09 2000-12-26 American Home Products Corporation Diaminopuridine-containing thiourea inhibitors of herpes viruses
US6844367B1 (en) 1999-09-17 2005-01-18 Millennium Pharmaceuticals, Inc. Benzamides and related inhibitors of factor Xa
EP1259485B1 (en) 2000-02-29 2005-11-30 Millennium Pharmaceuticals, Inc. BENZAMIDES AND RELATED INHIBITORS OF FACTOR Xa
US7220768B2 (en) * 2003-02-11 2007-05-22 Wyeth Holdings Corp. Isoxazole-containing thiourea inhibitors useful for treatment of varicella zoster virus
CN101595092B (en) 2006-11-02 2012-02-01 米伦纽姆医药公司 Methods of synthesizing pharmaceutical salts of a factor XA inhibitor
EP2914592B1 (en) * 2012-11-03 2017-10-11 Boehringer Ingelheim International GmbH Inhibitors of cytomegalovirus
EP2914591B1 (en) * 2012-11-03 2017-10-11 Boehringer Ingelheim International GmbH Inhibitors of cytomegalovirus
CN110565100B (en) * 2019-07-12 2021-05-07 西北工业大学 Cobaltocene cation-based corrosion inhibitor and preparation method and use method thereof
EP4382527A1 (en) 2021-08-05 2024-06-12 Zhejiang Hisun Pharmaceutical Co., Ltd. Aromatic acetylene derivative, and preparation method therefor and use thereof
WO2023088718A1 (en) 2021-11-19 2023-05-25 Basf Se Bicyclic compounds for the control of invertebrate pests
CN115433093A (en) * 2022-09-26 2022-12-06 无锡双启科技有限公司 Preparation method of 3-chloro-4-trifluoromethylaniline
CN115710190A (en) * 2022-11-16 2023-02-24 常州佳德医药科技有限公司 4-methoxy-2-amino-N, N-dimethylaniline, preparation method and application

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US5958983A (en) * 1997-04-10 1999-09-28 Pharmacia & Upjohn Company Polyaromatic antiviral compositions

Also Published As

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ID30158A (en) 2001-11-08
HUP0200232A2 (en) 2002-05-29
EP1144397A3 (en) 2002-09-11
EP1144397A2 (en) 2001-10-17
BR9916046A (en) 2001-10-02
CN1348446A (en) 2002-05-08
AU1934700A (en) 2000-06-26
EA200100631A1 (en) 2002-02-28
TR200101664T2 (en) 2002-03-21
IL143182A0 (en) 2002-04-21
WO2000034258A2 (en) 2000-06-15
NO20012832D0 (en) 2001-06-08
WO2000034258A3 (en) 2001-11-29
PL349217A1 (en) 2002-07-01
CZ20011956A3 (en) 2001-10-17
ZA200104377B (en) 2002-12-20
JP2002531554A (en) 2002-09-24
BG105581A (en) 2001-12-31
CA2350767A1 (en) 2000-06-15
SK7682001A3 (en) 2002-07-02

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