NO20012836L - Thiourea inhibitors of herpes virus - Google Patents

Thiourea inhibitors of herpes virus

Info

Publication number
NO20012836L
NO20012836L NO20012836A NO20012836A NO20012836L NO 20012836 L NO20012836 L NO 20012836L NO 20012836 A NO20012836 A NO 20012836A NO 20012836 A NO20012836 A NO 20012836A NO 20012836 L NO20012836 L NO 20012836L
Authority
NO
Norway
Prior art keywords
carbon atoms
alkyl
aryl
hydrogen
heteroaryl
Prior art date
Application number
NO20012836A
Other languages
Norwegian (no)
Other versions
NO20012836D0 (en
Inventor
Jonathan David Bloom
Martin Joseph Digrandi
Russel George Dushin
Stanley Albert Lang
Bryan Mark O'hara
Original Assignee
American Home Prod
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/US1999/028892 external-priority patent/WO2000034269A1/en
Application filed by American Home Prod filed Critical American Home Prod
Publication of NO20012836D0 publication Critical patent/NO20012836D0/en
Publication of NO20012836L publication Critical patent/NO20012836L/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/82—Benzo [b] furans; Hydrogenated benzo [b] furans with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • C07D307/84—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D307/85—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C335/00—Thioureas, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C335/04—Derivatives of thiourea
    • C07C335/16—Derivatives of thiourea having nitrogen atoms of thiourea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C335/20—Derivatives of thiourea having nitrogen atoms of thiourea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C335/00—Thioureas, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C335/04—Derivatives of thiourea
    • C07C335/16—Derivatives of thiourea having nitrogen atoms of thiourea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C335/22—Derivatives of thiourea having nitrogen atoms of thiourea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/81—Amides; Imides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
    • C07D217/26—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D307/81—Radicals substituted by nitrogen atoms not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pyridine Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Det er beskrevet forbindelser med formel (I) hvor R1-R5 er uavhengig valgt fra hydrogen, alkyl med 1 til 6 karbonatomer, alkenyl med 2 til 6 karbonatomer, alkynyl med 2 til 6 karbonatomer, perhalogen- alkyl med 1 til 6 kambonatomer, sykloalkyl med 3 til 10 karbonatomer, heterosykloalkyl med 3 til 10 karbonledd, aryl, heteroaryl, halogen, -CN, -NO2, -CO2R6, -CORe, -ORe, -SRs, -SORe, -SC^Rs, -CONR7R8. -NReNfR/Ra), -N(R7R8) eller W-Y-(CH2)n-Z forutsatt at minst en av RrRs ikke er hydrogen; eller R2 og R3, eller R3 og R* sammen danner en 3 til 7-leddet heterosykloalkyl eller 3 til 7 leddet heteroaryl; Re og R7 er uavhengig hydrogen, alkyl med 1 til 6 karbonatomer, perhalogenalkyl med 1 til 6 karbonatomer, eller aryl; Ra er hydrogen, alkyl med 1 til 6 karbonatomer, perhalogenalkyl med 1 til 6 karbon- atomer, sykloalkyl med 3 til 10 karbonatomer, heterosykloalkyl med 3 til 10 ledd, aryl eller heteroaryl, eller R7 eller Ra, sammen kan danne en 3 til 7 leddet heterosykloalkyl; W er O, NRe eller er fraværende; Y er -(CO)- eller -(CO2)- eller er fraværende; Z er alkyl med 1 til 4 karbonatomer, -CN, -CO2R6, -COR6, -CONR7R8, -OCOR6l -NR6COR7, -OCONR6, -OR6, -SR6, -SOR6, -SO2R6, SR6N(R7R8), -N(R7R8) eller fenyl; G er aryl eller kondensert bisyklisk hetero- aryl; X er en binding, -NH, alkyl med 1 til 6 karbonatomer, alkenyl med 1 til 6 karbonatomer, alkoksy med 1 til 6 karbonatomer, tioalkyl med 1 til 6 karbon- atomer, alkylamino med 1 til 6 karbonatomer, eller (CH)J; J er alkyl med 1 til 6 karbonatomer, sykloalkyl med 3 til 7 karbonatomer, fenyl eller benzyl; og n er et tall fra 1 til 6, nyttig for behandling av sykdommer assosiert med herpesvirus inkludert human cytomegalovirus, herpes simplex virus, Epstein-Barr virus, varicella-zoster virus, humane herpesviruser -6 og -7 og Kaposi herpesvirus.Compounds of formula (I) are described wherein R 1 -R 5 is independently selected from hydrogen, alkyl of 1 to 6 carbon atoms, alkenyl of 2 to 6 carbon atoms, alkynyl of 2 to 6 carbon atoms, perhaloalkyl of 1 to 6 carbon atoms, cycloalkyl having 3 to 10 carbon atoms, heterocycloalkyl having 3 to 10 carbon joints, aryl, heteroaryl, halogen, -CN, -NO2, -CO2R6, -CORe, -ORe, -SRs, -SORe, -SC2R5, -CONR7R8. -NReNfR / Ra), -N (R7R8) or W-Y- (CH2) n-Z provided that at least one of the RrRs is not hydrogen; or R2 and R3, or R3 and R * together form a 3 to 7 membered heterocycloalkyl or 3 to 7 membered heteroaryl; Re and R7 are independently hydrogen, alkyl of 1 to 6 carbon atoms, perhaloalkyl of 1 to 6 carbon atoms, or aryl; R a is hydrogen, alkyl of 1 to 6 carbon atoms, perhaloalkyl of 1 to 6 carbon atoms, cycloalkyl of 3 to 10 carbon atoms, 3 to 10 membered heterocycloalkyl, aryl or heteroaryl, or R 7 or Ra may together form a 3 to 7 linked heterocycloalkyl; W is O, NRe or is absent; Y is - (CO) - or - (CO2) - or is absent; Z is alkyl of 1 to 4 carbon atoms, -CN, -CO2R6, -COR6, -CONR7R8, -OCOR6l -NR6COR7, -OCONR6, -OR6, -SR6, -SOR6, -SO2R6, SR6N (R7R8), -N (R7R8) ) or phenyl; G is aryl or condensed bicyclic heteroaryl; X is a bond, -NH, alkyl of 1 to 6 carbon atoms, alkenyl of 1 to 6 carbon atoms, alkoxy of 1 to 6 carbon atoms, thioalkyl of 1 to 6 carbon atoms, alkylamino of 1 to 6 carbon atoms, or (CH) J ; J is alkyl of 1 to 6 carbon atoms, cycloalkyl of 3 to 7 carbon atoms, phenyl or benzyl; and n is a number from 1 to 6, useful for the treatment of diseases associated with herpes virus including human cytomegalovirus, herpes simplex virus, Epstein-Barr virus, varicella-zoster virus, human herpes viruses -6 and -7 and Kaposi herpes virus.

NO20012836A 1998-12-09 2001-06-08 Thiourea inhibitors of herpes virus NO20012836L (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US20854098A 1998-12-09 1998-12-09
PCT/US1999/028892 WO2000034269A1 (en) 1998-12-09 1999-12-06 Thiourea inhibitors of herpes viruses

Publications (2)

Publication Number Publication Date
NO20012836D0 NO20012836D0 (en) 2001-06-08
NO20012836L true NO20012836L (en) 2001-08-08

Family

ID=22774965

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20012836A NO20012836L (en) 1998-12-09 2001-06-08 Thiourea inhibitors of herpes virus

Country Status (18)

Country Link
EP (1) EP1140913A1 (en)
JP (1) JP2002531558A (en)
KR (1) KR20010086082A (en)
CN (1) CN1335843A (en)
AU (1) AU756043B2 (en)
BG (1) BG105580A (en)
BR (1) BR9916042A (en)
CA (1) CA2351390A1 (en)
CZ (1) CZ20011958A3 (en)
EA (1) EA200100637A1 (en)
HU (1) HUP0104758A3 (en)
ID (1) ID29064A (en)
IL (1) IL143203A0 (en)
NO (1) NO20012836L (en)
PL (1) PL348177A1 (en)
SK (1) SK7692001A3 (en)
TR (1) TR200101598T2 (en)
ZA (1) ZA200104373B (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000055152A1 (en) * 1999-03-12 2000-09-21 Boehringer Ingelheim Pharmaceuticals, Inc. Aromatic heterocyclic compounds as anti-inflammatory agents
JP3938651B2 (en) * 2000-04-13 2007-06-27 セントラル硝子株式会社 Process for producing optically active α-methyl-bis-3,5- (trifluoromethyl) benzylamine
WO2005000795A2 (en) * 2003-06-10 2005-01-06 Smithkline Beecham Corporation Aniline derivatived androgen-, glucocorticoid-, mineralcorticoid- and progesterone- receptor modulators
EP1928847A4 (en) * 2005-08-29 2011-08-10 Gerard M Housey Theramutein modulators
CN108642926B (en) * 2018-04-26 2023-11-14 浙江汉邦新材料股份有限公司 Thiourea derivative for dyeing and cleaning terylene and preparation method thereof
WO2021100730A1 (en) * 2019-11-19 2021-05-27 武田薬品工業株式会社 Method for producing pyrrolidine compound

Also Published As

Publication number Publication date
AU756043B2 (en) 2003-01-02
ID29064A (en) 2001-07-26
EA200100637A1 (en) 2001-12-24
CN1335843A (en) 2002-02-13
HUP0104758A2 (en) 2002-04-29
AU3112200A (en) 2000-06-26
IL143203A0 (en) 2002-04-21
BR9916042A (en) 2001-12-04
SK7692001A3 (en) 2002-09-10
PL348177A1 (en) 2002-05-06
CA2351390A1 (en) 2000-06-15
EP1140913A1 (en) 2001-10-10
KR20010086082A (en) 2001-09-07
BG105580A (en) 2002-01-31
NO20012836D0 (en) 2001-06-08
JP2002531558A (en) 2002-09-24
HUP0104758A3 (en) 2002-05-28
CZ20011958A3 (en) 2001-10-17
TR200101598T2 (en) 2001-10-22
ZA200104373B (en) 2002-09-18

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