NO921908L - AMINOSYRAZETIDINYL SUBSTITUTED PYRIDON DERIVATIVES, THEIR PREPARATION AND USE AS MEDICINES - Google Patents
AMINOSYRAZETIDINYL SUBSTITUTED PYRIDON DERIVATIVES, THEIR PREPARATION AND USE AS MEDICINESInfo
- Publication number
- NO921908L NO921908L NO92921908A NO921908A NO921908L NO 921908 L NO921908 L NO 921908L NO 92921908 A NO92921908 A NO 92921908A NO 921908 A NO921908 A NO 921908A NO 921908 L NO921908 L NO 921908L
- Authority
- NO
- Norway
- Prior art keywords
- radical
- hydrogen atom
- lower alkyl
- group
- atom
- Prior art date
Links
- 239000003814 drug Substances 0.000 title 1
- UBQKCCHYAOITMY-UHFFFAOYSA-N pyridin-2-ol Chemical class OC1=CC=CC=N1 UBQKCCHYAOITMY-UHFFFAOYSA-N 0.000 title 1
- -1 alkoxy radical Chemical class 0.000 abstract 15
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 6
- MDFFNEOEWAXZRQ-UHFFFAOYSA-N aminyl Chemical compound [NH2] MDFFNEOEWAXZRQ-UHFFFAOYSA-N 0.000 abstract 2
- 150000005840 aryl radicals Chemical class 0.000 abstract 2
- 125000001153 fluoro group Chemical group F* 0.000 abstract 2
- 125000003282 alkyl amino group Chemical group 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000000539 amino acid group Chemical group 0.000 abstract 1
- 150000001413 amino acids Chemical group 0.000 abstract 1
- 229910052799 carbon Chemical group 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 229910052731 fluorine Inorganic materials 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- BLNWTAHYTCHDJH-UHFFFAOYSA-O hydroxy(oxo)azanium Chemical compound O[NH+]=O BLNWTAHYTCHDJH-UHFFFAOYSA-O 0.000 abstract 1
- TUJKJAMUKRIRHC-UHFFFAOYSA-N hydroxyl Chemical compound [OH] TUJKJAMUKRIRHC-UHFFFAOYSA-N 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 229920001184 polypeptide Chemical group 0.000 abstract 1
- 108090000765 processed proteins & peptides Chemical group 0.000 abstract 1
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 230000003381 solubilizing effect Effects 0.000 abstract 1
- ORGHESHFQPYLAO-UHFFFAOYSA-N vinyl radical Chemical compound C=[CH] ORGHESHFQPYLAO-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
- C07D215/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3 with oxygen atoms in position 4
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
- C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D205/04—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Communicable Diseases (AREA)
- Animal Behavior & Ethology (AREA)
- Oncology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pyridine Compounds (AREA)
- Peptides Or Proteins (AREA)
Abstract
Den foreliggende oppfinnelse angår forbindelsene som tilsvarer den generelle formel I og deres farmasøytiske akseptable salter, i hvilken X betegner et nitrogenatom eller et karbonatom bundet til et hydrogenatom, bundet til et halogenatom, et hydroksyl eller alkoksyradikal, et alkylradikal, et halogenert alkylradikal eller et alkylaminoradikal; Rj^ betegner et lavere alkyl eller cykloalkylradikal, et lavere haloalkyl- radikal, et hydroksyalkylradikal, et vinylradikal, et arylradikal eller et arylradikal substituert med en eller flere fluoratomer, eller et alkylamino- radikal; R2 betegner et hydrogenatom eller et lavere alkylradikal; R3 betegner et hydroksylradikal eller et C1-C4 lavere alkoksy- radikal; R4 betegner et hydrogenatom, et fluor- atom, et lavere alkylradikal, et nitroradlkal, et aminoradikal eller et substituert aminoradikal; RS, Rg og R7 betegner et hydrogenatom eller et lavere alkyl- radikal; n er et tall som kan være O eller 1; X og R! kan sammen danne en binding representert av en gruppe C-CH2-CH2-CH-Rg eller C-O-CH-CH2-CH-R9 eller C-S-CH2-CH- R9/ i hvilken R9 betegner et hydrogen- atom-, et lavere alkylradikal eller et lavere haloalkylradikal; R! og R2 kan sammen danne en binding representert av en gruppe -CHR^Q-S- i hvilken R^g betegner et hydrogenatom eller et lavere .alkylradikal eller et lavere haloalkylradikal; R2 og R3 kan sammen danne en binding representert av en gruppe -S-NH-; A er en oppløsende gruppe som er representert av en residual aminosyre eller en polypeptidkjede som består av to til fire eller mer aminosyrerester, som er bundet kovalent til hverandre ved peptidbindinger, og en fremgangsmåte for deres fremstilling.The present invention relates to the compounds corresponding to the general formula I and their pharmaceutically acceptable salts, wherein X represents a nitrogen atom or a carbon atom bonded to a hydrogen atom bonded to a halogen atom, a hydroxyl or alkoxy radical, an alkyl radical, a halogenated alkyl radical or an alkyl amino radical ; R 1 represents a lower alkyl or cycloalkyl radical, a lower haloalkyl radical, a hydroxyalkyl radical, a vinyl radical, an aryl radical or an aryl radical substituted by one or more fluorine atoms, or an alkylamino radical; R 2 represents a hydrogen atom or a lower alkyl radical; R 3 represents a hydroxyl radical or a C 1 -C 4 lower alkoxy radical; R4 represents a hydrogen atom, a fluorine atom, a lower alkyl radical, a nitro radical, an amino radical or a substituted amino radical; R5, R8 and R7 represent a hydrogen atom or a lower alkyl radical; n is a number which may be 0 or 1; X and R! may together form a bond represented by a group C-CH2-CH2-CH-Rg or CO-CH-CH2-CH-R9 or CS-CH2-CH-R9 / wherein R9 represents a hydrogen atom, a lower alkyl radical or a lower haloalkyl radical; R! and R 2 may together form a bond represented by a group -CHR 2 Q-S- in which R 2 g represents a hydrogen atom or a lower alkyl radical or a lower haloalkyl radical; R 2 and R 3 may together form a bond represented by a group -S-NH-; A is a solubilizing group represented by a residual amino acid or a polypeptide chain consisting of two to four or more amino acid residues covalently linked to each other by peptide bonds and a process for their preparation.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR9105937A FR2676445B1 (en) | 1991-05-16 | 1991-05-16 | SUBSTITUTED PYRIDONE AMINO ACID AZETIDINYL DERIVATIVES, THEIR PREPARATION AND THEIR APPLICATION AS MEDICAMENTS. |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| NO921908D0 NO921908D0 (en) | 1992-05-14 |
| NO921908L true NO921908L (en) | 1992-11-17 |
Family
ID=9412841
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO92921908A NO921908L (en) | 1991-05-16 | 1992-05-14 | AMINOSYRAZETIDINYL SUBSTITUTED PYRIDON DERIVATIVES, THEIR PREPARATION AND USE AS MEDICINES |
Country Status (20)
| Country | Link |
|---|---|
| EP (1) | EP0514268A1 (en) |
| JP (1) | JPH05132479A (en) |
| KR (1) | KR920021528A (en) |
| CN (1) | CN1066656A (en) |
| AU (1) | AU660311B2 (en) |
| CA (1) | CA2068853A1 (en) |
| CZ (1) | CZ147992A3 (en) |
| ES (1) | ES2039192B1 (en) |
| FI (1) | FI922225A7 (en) |
| FR (1) | FR2676445B1 (en) |
| HU (1) | HUT61304A (en) |
| IL (1) | IL101886A0 (en) |
| IS (1) | IS3862A (en) |
| MA (1) | MA22526A1 (en) |
| MX (1) | MX9202273A (en) |
| NO (1) | NO921908L (en) |
| NZ (1) | NZ242733A (en) |
| OA (1) | OA09794A (en) |
| PL (1) | PL294561A1 (en) |
| ZA (1) | ZA923538B (en) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU3459797A (en) | 1996-07-12 | 1998-02-09 | Daiichi Pharmaceutical Co., Ltd. | Cis-substituted aminocyclopropane derivatives |
| KR100613690B1 (en) * | 2004-07-30 | 2006-08-21 | 한국화학연구원 | 4-quinolinone derivatives and agricultural and horticultural germicide compositions comprising the same |
| KR100613688B1 (en) * | 2004-08-30 | 2006-08-21 | 한국화학연구원 | 2-amino-4-quinolinone derivatives and agrohorticultural fungicide compositions comprising the same |
| CA2587985C (en) | 2004-11-24 | 2016-05-10 | Neopro Labs, Llc | Peptides for use in treatment in fever or pain |
| US7557088B2 (en) | 2006-03-28 | 2009-07-07 | Neopro Labs, Llc | Methods and compositions for treating conditions |
| CA2683288A1 (en) | 2007-05-17 | 2008-11-27 | Neopro Labs, Llc | Crystalline and amorphous forms of peptide |
| CN101898990B (en) * | 2009-06-01 | 2012-12-19 | 中国科学院化学研究所 | Method for catalyzing and synthesizing chirality azetidine amide and carboxylic acid compound by microorganism system |
| US12036286B2 (en) | 2021-03-18 | 2024-07-16 | Seagen Inc. | Selective drug release from internalized conjugates of biologically active compounds |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5746986A (en) * | 1980-09-02 | 1982-03-17 | Dai Ichi Seiyaku Co Ltd | Pyrido(1,2,3-de)(1,4)benzoxazine derivative |
| IE55898B1 (en) * | 1982-09-09 | 1991-02-14 | Warner Lambert Co | Antibacterial agents |
| DE3306771A1 (en) * | 1983-02-25 | 1984-08-30 | Bayer Ag, 5090 Leverkusen | CHINOLONIC CARBONIC ACIDS, METHOD FOR THE PRODUCTION THEREOF AND THE ANTIBACTERIAL AGENTS CONTAINING THEM |
| CA1267413A (en) * | 1984-04-26 | 1990-04-03 | Abbott Laboratories | Quino-benoxazine antibacterial compounds |
| US4617308A (en) * | 1985-01-25 | 1986-10-14 | Warner-Lambert Company | 7-substituted amino-1-aryl-6,8-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acids and derivatives thereof as antibacterial agents |
| US4851418A (en) * | 1987-08-21 | 1989-07-25 | Warner-Lambert Company | Naphthyridine antibacterial agents containing an α-amino acid in the side chain of the 7-substituent |
| FR2634483B2 (en) * | 1987-12-29 | 1994-03-04 | Esteve Labor Dr | DERIVATIVES OF ACIDS 7- (1-AZETIDINYL) -1,4-DIHYDRO-4-OXOQUINOLEINE-3-CARBOXYLIQUES, THEIR PREPARATION AND THEIR APPLICATION AS MEDICAMENTS |
| IL91648A (en) * | 1988-09-22 | 1997-03-18 | Abbott Lab | Amino acid quinoline and naphthyridine derivatives, their preparation and pharmaceutical compositions containing them |
| AU5123690A (en) * | 1989-03-13 | 1990-09-13 | Bristol-Myers Squibb Company | 5-substituted-1,4-dihydro-4-oxo-nephthyridine-3-carboxylate antibacterial agents |
| NO177302C (en) * | 1989-03-16 | 1995-08-23 | Esteve Labor Dr | Analogous Process for Preparing Therapeutically Active Substituted Azetidinyl Quinolone (Naphthyridone) Carboxylic Acid Derivatives |
| FR2645862B1 (en) * | 1989-04-18 | 1991-07-12 | Esteve Labor Dr | SUBSTITUTED ISOTHIAZOLO-PYRYDONE AZETIDINYL DERIVATIVES, THEIR PREPARATION AND THEIR APPLICATION AS MEDICAMENTS |
| FR2649100B1 (en) * | 1989-06-29 | 1994-03-04 | Laboratorios Dr Esteve Sa | NOVEL AZETIDINES, THEIR PREPARATION AND THEIR APPLICATION AS INTERMEDIATES FOR THE PREPARATION OF COMPOUNDS WITH ANTIMICROBIAL ACTIVITY |
-
1991
- 1991-05-16 FR FR9105937A patent/FR2676445B1/en not_active Expired - Lifetime
-
1992
- 1992-05-14 ES ES9200994A patent/ES2039192B1/en not_active Expired - Fee Related
- 1992-05-14 NO NO92921908A patent/NO921908L/en unknown
- 1992-05-14 NZ NZ242733A patent/NZ242733A/en unknown
- 1992-05-14 IS IS3862A patent/IS3862A/en unknown
- 1992-05-14 EP EP92401318A patent/EP0514268A1/en not_active Withdrawn
- 1992-05-14 MA MA22811A patent/MA22526A1/en unknown
- 1992-05-14 AU AU16249/92A patent/AU660311B2/en not_active Ceased
- 1992-05-15 CA CA002068853A patent/CA2068853A1/en not_active Abandoned
- 1992-05-15 MX MX9202273A patent/MX9202273A/en unknown
- 1992-05-15 OA OA60208A patent/OA09794A/en unknown
- 1992-05-15 FI FI922225A patent/FI922225A7/en not_active Application Discontinuation
- 1992-05-15 IL IL101886A patent/IL101886A0/en unknown
- 1992-05-15 ZA ZA923538A patent/ZA923538B/en unknown
- 1992-05-15 CZ CS921479A patent/CZ147992A3/en unknown
- 1992-05-15 JP JP4123901A patent/JPH05132479A/en active Pending
- 1992-05-15 HU HU9201621A patent/HUT61304A/en unknown
- 1992-05-15 PL PL29456192A patent/PL294561A1/en unknown
- 1992-05-16 KR KR1019920008309A patent/KR920021528A/en not_active Ceased
- 1992-05-16 CN CN92103602A patent/CN1066656A/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| ES2039192A1 (en) | 1993-09-01 |
| FR2676445A1 (en) | 1992-11-20 |
| AU660311B2 (en) | 1995-06-22 |
| OA09794A (en) | 1994-04-15 |
| CN1066656A (en) | 1992-12-02 |
| KR920021528A (en) | 1992-12-18 |
| FI922225A0 (en) | 1992-05-15 |
| ZA923538B (en) | 1993-01-27 |
| PL294561A1 (en) | 1993-05-04 |
| HUT61304A (en) | 1992-12-28 |
| CA2068853A1 (en) | 1992-11-17 |
| ES2039192B1 (en) | 1994-04-01 |
| EP0514268A1 (en) | 1992-11-19 |
| CZ147992A3 (en) | 1993-09-15 |
| MX9202273A (en) | 1993-05-01 |
| FI922225A7 (en) | 1992-11-17 |
| IL101886A0 (en) | 1992-12-30 |
| NZ242733A (en) | 1994-06-27 |
| JPH05132479A (en) | 1993-05-28 |
| AU1624992A (en) | 1992-11-19 |
| MA22526A1 (en) | 1992-12-31 |
| NO921908D0 (en) | 1992-05-14 |
| HU9201621D0 (en) | 1992-08-28 |
| IS3862A (en) | 1992-11-17 |
| FR2676445B1 (en) | 1995-02-03 |
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