NO921908L - Aminosyreazetidinylsubstituerte pyridonderivater, deres fremstilling og anvendelse som medikamenter - Google Patents

Aminosyreazetidinylsubstituerte pyridonderivater, deres fremstilling og anvendelse som medikamenter

Info

Publication number
NO921908L
NO921908L NO92921908A NO921908A NO921908L NO 921908 L NO921908 L NO 921908L NO 92921908 A NO92921908 A NO 92921908A NO 921908 A NO921908 A NO 921908A NO 921908 L NO921908 L NO 921908L
Authority
NO
Norway
Prior art keywords
radical
hydrogen atom
lower alkyl
group
atom
Prior art date
Application number
NO92921908A
Other languages
English (en)
Other versions
NO921908D0 (no
Inventor
Jordi Corbera-Arjona
Jordi Frigola Constansa
Juan Pares Corominas
Original Assignee
Esteve Labor Dr
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Esteve Labor Dr filed Critical Esteve Labor Dr
Publication of NO921908D0 publication Critical patent/NO921908D0/no
Publication of NO921908L publication Critical patent/NO921908L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
    • C07D215/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3 with oxygen atoms in position 4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/04—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Communicable Diseases (AREA)
  • Animal Behavior & Ethology (AREA)
  • Oncology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pyridine Compounds (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Den foreliggende oppfinnelse angår forbindelsene som tilsvarer den generelle formel I og deres farmasøytiske akseptable salter, i hvilken X betegner et nitrogenatom eller et karbonatom bundet til et hydrogenatom, bundet til et halogenatom, et hydroksyl eller alkoksyradikal, et alkylradikal, et halogenert alkylradikal eller et alkylaminoradikal; Rj^ betegner et lavere alkyl eller cykloalkylradikal, et lavere haloalkyl- radikal, et hydroksyalkylradikal, et vinylradikal, et arylradikal eller et arylradikal substituert med en eller flere fluoratomer, eller et alkylamino- radikal; R2 betegner et hydrogenatom eller et lavere alkylradikal; R3 betegner et hydroksylradikal eller et C1-C4 lavere alkoksy- radikal; R4 betegner et hydrogenatom, et fluor- atom, et lavere alkylradikal, et nitroradlkal, et aminoradikal eller et substituert aminoradikal; RS, Rg og R7 betegner et hydrogenatom eller et lavere alkyl- radikal; n er et tall som kan være O eller 1; X og R! kan sammen danne en binding representert av en gruppe C-CH2-CH2-CH-Rg eller C-O-CH-CH2-CH-R9 eller C-S-CH2-CH- R9/ i hvilken R9 betegner et hydrogen- atom-, et lavere alkylradikal eller et lavere haloalkylradikal; R! og R2 kan sammen danne en binding representert av en gruppe -CHR^Q-S- i hvilken R^g betegner et hydrogenatom eller et lavere .alkylradikal eller et lavere haloalkylradikal; R2 og R3 kan sammen danne en binding representert av en gruppe -S-NH-; A er en oppløsende gruppe som er representert av en residual aminosyre eller en polypeptidkjede som består av to til fire eller mer aminosyrerester, som er bundet kovalent til hverandre ved peptidbindinger, og en fremgangsmåte for deres fremstilling.
NO92921908A 1991-05-16 1992-05-14 Aminosyreazetidinylsubstituerte pyridonderivater, deres fremstilling og anvendelse som medikamenter NO921908L (no)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9105937A FR2676445B1 (fr) 1991-05-16 1991-05-16 Derives de pyridone amino acide azetidinyl substitues, leur preparation et leur application en tant que medicaments.

Publications (2)

Publication Number Publication Date
NO921908D0 NO921908D0 (no) 1992-05-14
NO921908L true NO921908L (no) 1992-11-17

Family

ID=9412841

Family Applications (1)

Application Number Title Priority Date Filing Date
NO92921908A NO921908L (no) 1991-05-16 1992-05-14 Aminosyreazetidinylsubstituerte pyridonderivater, deres fremstilling og anvendelse som medikamenter

Country Status (20)

Country Link
EP (1) EP0514268A1 (no)
JP (1) JPH05132479A (no)
KR (1) KR920021528A (no)
CN (1) CN1066656A (no)
AU (1) AU660311B2 (no)
CA (1) CA2068853A1 (no)
CZ (1) CZ147992A3 (no)
ES (1) ES2039192B1 (no)
FI (1) FI922225A7 (no)
FR (1) FR2676445B1 (no)
HU (1) HUT61304A (no)
IL (1) IL101886A0 (no)
IS (1) IS3862A (no)
MA (1) MA22526A1 (no)
MX (1) MX9202273A (no)
NO (1) NO921908L (no)
NZ (1) NZ242733A (no)
OA (1) OA09794A (no)
PL (1) PL294561A1 (no)
ZA (1) ZA923538B (no)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU3459797A (en) 1996-07-12 1998-02-09 Daiichi Pharmaceutical Co., Ltd. Cis-substituted aminocyclopropane derivatives
KR100613690B1 (ko) * 2004-07-30 2006-08-21 한국화학연구원 4-퀴놀린온 유도체 및 이를 포함하는 농원예용 살균제조성물
KR100613688B1 (ko) * 2004-08-30 2006-08-21 한국화학연구원 2-아미노-4-퀴놀린온 유도체 및 이를 포함하는 농원예용살균제 조성물
CA2587985C (en) 2004-11-24 2016-05-10 Neopro Labs, Llc Peptides for use in treatment in fever or pain
US7557088B2 (en) 2006-03-28 2009-07-07 Neopro Labs, Llc Methods and compositions for treating conditions
CA2683288A1 (en) 2007-05-17 2008-11-27 Neopro Labs, Llc Crystalline and amorphous forms of peptide
CN101898990B (zh) * 2009-06-01 2012-12-19 中国科学院化学研究所 微生物体系催化合成手性氮杂环丁烷酰胺和羧酸类化合物的方法
US12036286B2 (en) 2021-03-18 2024-07-16 Seagen Inc. Selective drug release from internalized conjugates of biologically active compounds

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5746986A (en) * 1980-09-02 1982-03-17 Dai Ichi Seiyaku Co Ltd Pyrido(1,2,3-de)(1,4)benzoxazine derivative
IE55898B1 (en) * 1982-09-09 1991-02-14 Warner Lambert Co Antibacterial agents
DE3306771A1 (de) * 1983-02-25 1984-08-30 Bayer Ag, 5090 Leverkusen Chinoloncarbonsaeuren, verfahren zu ihrer herstellung sowie diese enthaltende antibakterielle mittel
CA1267413A (en) * 1984-04-26 1990-04-03 Abbott Laboratories Quino-benoxazine antibacterial compounds
US4617308A (en) * 1985-01-25 1986-10-14 Warner-Lambert Company 7-substituted amino-1-aryl-6,8-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acids and derivatives thereof as antibacterial agents
US4851418A (en) * 1987-08-21 1989-07-25 Warner-Lambert Company Naphthyridine antibacterial agents containing an α-amino acid in the side chain of the 7-substituent
FR2634483B2 (fr) * 1987-12-29 1994-03-04 Esteve Labor Dr Derives des acides 7-(1-azetidinyl)-1,4-dihydro-4-oxoquinoleine-3-carboxyliques, leur preparation et leur application en tant que medicaments
IL91648A (en) * 1988-09-22 1997-03-18 Abbott Lab Amino acid quinoline and naphthyridine derivatives, their preparation and pharmaceutical compositions containing them
AU5123690A (en) * 1989-03-13 1990-09-13 Bristol-Myers Squibb Company 5-substituted-1,4-dihydro-4-oxo-nephthyridine-3-carboxylate antibacterial agents
NO177302C (no) * 1989-03-16 1995-08-23 Esteve Labor Dr Analogifremgangsmåte til fremstilling av terapeutisk aktive substituerte azetidinylkinolon(naftyridon)karboksylsyrederivater
FR2645862B1 (fr) * 1989-04-18 1991-07-12 Esteve Labor Dr Derives d'isothiazolo-pyrydone azetidinyl substitues, leur preparation et leur application en tant que medicaments
FR2649100B1 (fr) * 1989-06-29 1994-03-04 Laboratorios Dr Esteve Sa Nouvelles azetidines, leur preparation et leur application comme intermediaires pour la preparation de composes avec activite antimicrobienne

Also Published As

Publication number Publication date
ES2039192A1 (es) 1993-09-01
FR2676445A1 (fr) 1992-11-20
AU660311B2 (en) 1995-06-22
OA09794A (fr) 1994-04-15
CN1066656A (zh) 1992-12-02
KR920021528A (ko) 1992-12-18
FI922225A0 (fi) 1992-05-15
ZA923538B (en) 1993-01-27
PL294561A1 (en) 1993-05-04
HUT61304A (en) 1992-12-28
CA2068853A1 (fr) 1992-11-17
ES2039192B1 (es) 1994-04-01
EP0514268A1 (fr) 1992-11-19
CZ147992A3 (en) 1993-09-15
MX9202273A (es) 1993-05-01
FI922225A7 (fi) 1992-11-17
IL101886A0 (en) 1992-12-30
NZ242733A (en) 1994-06-27
JPH05132479A (ja) 1993-05-28
AU1624992A (en) 1992-11-19
MA22526A1 (fr) 1992-12-31
NO921908D0 (no) 1992-05-14
HU9201621D0 (en) 1992-08-28
IS3862A (is) 1992-11-17
FR2676445B1 (fr) 1995-02-03

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