NO975020L - Azacykloalkanderivater, fremstilling derav og deres anvendelse i terapi - Google Patents

Azacykloalkanderivater, fremstilling derav og deres anvendelse i terapi

Info

Publication number
NO975020L
NO975020L NO975020A NO975020A NO975020L NO 975020 L NO975020 L NO 975020L NO 975020 A NO975020 A NO 975020A NO 975020 A NO975020 A NO 975020A NO 975020 L NO975020 L NO 975020L
Authority
NO
Norway
Prior art keywords
group
therapy
preparation
hydrogen atom
carbon atom
Prior art date
Application number
NO975020A
Other languages
English (en)
Other versions
NO975020D0 (no
Inventor
Manuel Bedoya Zurita
Juan Antonio Diaz Martin
Gregorio Del Sol Moreno
Ulpiano Martin-Escudero Perez
Maria Dolores Jimenez Bargueno
Magali Romanach Ferrer
Original Assignee
Synthelabo
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Synthelabo filed Critical Synthelabo
Publication of NO975020D0 publication Critical patent/NO975020D0/no
Publication of NO975020L publication Critical patent/NO975020L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
    • C07D217/06—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines with the ring nitrogen atom acylated by carboxylic or carbonic acids, or with sulfur or nitrogen analogues thereof, e.g. carbamates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

Azacykloalkanderivater med generell formel (I) hvor Rx og R, representerer et hydrogenatom, en alkylgruppe eller en fenylgruppe, eller Rx og R2 danner sammen en oksogruppe, R3 er et hydrogenatom eller en alkylgruppe, eller R3 danner en metylengruppe, R4 er en aromatisk gruppe eller, når R3 danner en metylengruppe, er R4 en fenylengruppe hvor et karbonatom er bundet til Y og det andre karbonatom i nabostilling til det førstnevnte karbonatom er bundet til den nevnte metylengruppe, R5 er enten en gruppe OR7 hvor R7 er et hydrogenatom eller en benzylgruppe, eller er en gruppe N4- metyl-piperazinyl eller en gruppe NHR8 hvor R8 er en hydroksyl-, pyridinylmetyl- eller fenylmetylgruppe, A er en eventuelt substituert aromatisk ring, n er l eller 2, X er CH, O eller N, og Y er CH2, O eller S; en fremgangsmåte for deres fremstilling og deres anvendelse i terapi.
NO975020A 1995-05-03 1997-10-31 Azacykloalkanderivater, fremstilling derav og deres anvendelse i terapi NO975020L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9505260A FR2733750B1 (fr) 1995-05-03 1995-05-03 Derives de l'acide gamma-oxo-alpha-(phenylmethyl)-5,6- dihydro-4h-thieno(3,4-c)pyrrole-5-butanoique, leur preparation et leur application en therapeutique
PCT/FR1996/000555 WO1996034870A1 (fr) 1995-05-03 1996-04-12 Derives d'azacycloalcanes, leur preparation et leurs applications en therapeutique

Publications (2)

Publication Number Publication Date
NO975020D0 NO975020D0 (no) 1997-10-31
NO975020L true NO975020L (no) 1998-01-05

Family

ID=9478644

Family Applications (1)

Application Number Title Priority Date Filing Date
NO975020A NO975020L (no) 1995-05-03 1997-10-31 Azacykloalkanderivater, fremstilling derav og deres anvendelse i terapi

Country Status (22)

Country Link
US (1) US5869518A (no)
EP (1) EP0823912A1 (no)
JP (1) JPH11504913A (no)
KR (1) KR19990008276A (no)
AR (1) AR001838A1 (no)
AU (1) AU699120B2 (no)
BG (1) BG102015A (no)
BR (1) BR9608309A (no)
CA (1) CA2220015A1 (no)
CO (1) CO4750652A1 (no)
CZ (1) CZ346697A3 (no)
EE (1) EE9700288A (no)
FR (1) FR2733750B1 (no)
HU (1) HUP9903886A3 (no)
IL (1) IL118119A0 (no)
NO (1) NO975020L (no)
NZ (1) NZ307230A (no)
PL (1) PL323177A1 (no)
SK (1) SK147897A3 (no)
TR (1) TR199701287T1 (no)
WO (1) WO1996034870A1 (no)
ZA (1) ZA963485B (no)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998040385A1 (en) * 1997-03-07 1998-09-17 Novo Nordisk A/S 4,5,6,7-TETRAHYDRO-THIENO[3,2-c]PYRIDINE DERIVATIVES, THEIR PREPARATION AND USE
US6177443B1 (en) 1997-03-07 2001-01-23 Novo Nordisk A/S 4,5,6,7-tetrahydro-thieno[3, 2-C]pyridine derivatives, their preparation and use
WO1999045013A1 (en) * 1998-03-06 1999-09-10 Novo Nordisk A/S 4,5,6,7-TETRAHYDRO-THIENO[3,2-c]PYRIDINE DERIVATIVES
FR2777566B1 (fr) 1998-04-15 2003-02-21 Synthelabo Derives d'azacycloalcanes, leur preparation et leur application en therapeutique
FR2779428B1 (fr) * 1998-06-03 2001-05-18 Synthelabo Derives d'oxo-azacycloalcanes, leurs preparations et leurs applications en therapeutique
AU5154699A (en) * 1998-09-02 2000-03-27 Novo Nordisk A/S 4,5,6,7-tetrahydro-thieno(2,3-c)pyridine derivatives
US6090797A (en) * 1998-09-02 2000-07-18 Novo Nordisk A/S 4,5,6,7-tetrahydro-thieno(2,3-C)pyridine derivatives
FR2793411B1 (fr) * 1999-05-11 2001-06-29 Synthelabo Utilisation de derives de l'acide succinique pour obtenir un medicament destine au traitement de l'inflammation
PT1088824E (pt) * 1999-09-30 2004-04-30 Pfizer Prod Inc Pirrolil-amidas biciclicas como inibidores de glicogenio-fosforilase
US6797820B2 (en) 1999-12-17 2004-09-28 Vicuron Pharmaceuticals Inc. Succinate compounds, compositions and methods of use and preparation
AR036053A1 (es) 2001-06-15 2004-08-04 Versicor Inc Compuestos de n-formil-hidroxilamina, un proceso para su preparacion y composiciones farmaceuticas
WO2002102791A1 (en) * 2001-06-15 2002-12-27 Vicuron Pharmaceuticals Inc. Pyrrolidine bicyclic compounds
US20090312470A1 (en) * 2008-06-11 2009-12-17 Ferro Corporation Asymmetric Cyclic Diester Compounds
US20100113664A1 (en) * 2008-06-11 2010-05-06 Ferro Corporation Asymmetric Cyclic Diester Compounds
DK2350093T3 (da) * 2008-10-24 2012-11-12 Gruenenthal Gmbh Substituerede 4,5,6,7-tetrahydrothienopyridiner som KCNQ2/3-modulatorer til behandling af smerte, epilepsi og urininkontinens.
US9302989B2 (en) 2010-11-15 2016-04-05 Abbvie Inc. NAMPT and rock inhibitors

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3190950A (en) * 1961-03-13 1965-06-22 Acf Ind Inc Pictorial position display
US3706810A (en) * 1970-09-15 1972-12-19 American Cyanamid Co N-morpholinoalkyl-thieno(3,2-b)pyrrole-5-carboxamides
ZA821020B (en) * 1981-02-18 1983-10-26 Thomae Gmbh Dr K Azepine derivatives, process for their preparation and pharmaceutical compositions thereof
FR2537974A1 (fr) * 1982-12-16 1984-06-22 Adir Nouveaux derives de thieno (2,3-b) pyrrole, leur procede de preparation et les compositions pharmaceutiques les renfermant
FR2571723B1 (fr) * 1984-10-12 1988-08-26 Lipha Derives de thieno et furo-(2,3-c) pyrroles, procedes de preparation et medicaments les contenant
FR2652579B1 (fr) * 1989-10-02 1992-01-24 Sanofi Sa Derives d'hydroxy-2 thiophene et furanne condenses avec un cycle azote, sur procede de preparation et leur application en therapeutique.
FR2676446B1 (fr) * 1991-05-17 1993-08-06 Rhone Poulenc Rorer Sa Nouveaux derives du thiopyranopyrrole, leur preparation et les compositions pharmaceutiques qui les contiennent.
EP0599697A1 (fr) * 1992-11-24 1994-06-01 Synthelabo Dérivés de pyrrole, leur préparation et leur application en thérapeutique
FR2719844B1 (fr) * 1994-05-10 1996-06-07 Synthelabo Dérivés de 5,6-dihydro-4h-thiéno[3,4-c]pyrrole, leur préparation et leur application en thérapeutique.

Also Published As

Publication number Publication date
US5869518A (en) 1999-02-09
FR2733750A1 (fr) 1996-11-08
AU699120B2 (en) 1998-11-19
TR199701287T1 (xx) 1998-03-21
IL118119A0 (en) 1996-09-12
CO4750652A1 (es) 1999-03-31
PL323177A1 (en) 1998-03-16
HUP9903886A2 (hu) 2000-03-28
FR2733750B1 (fr) 1997-06-13
EE9700288A (et) 1998-04-15
JPH11504913A (ja) 1999-05-11
NZ307230A (en) 1998-11-25
KR19990008276A (ko) 1999-01-25
BR9608309A (pt) 1999-01-26
WO1996034870A1 (fr) 1996-11-07
ZA963485B (en) 1996-11-25
HUP9903886A3 (en) 2000-04-28
AU5652096A (en) 1996-11-21
NO975020D0 (no) 1997-10-31
MX9708322A (es) 1998-06-28
CA2220015A1 (fr) 1996-11-07
EP0823912A1 (fr) 1998-02-18
CZ346697A3 (cs) 1998-02-18
AR001838A1 (es) 1997-12-10
SK147897A3 (en) 1998-05-06
BG102015A (en) 1998-08-31

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