AR001838A1 - Derivados de azacicloal canos utiles para el tratamiento de la obesidad diabetes e hiperglucemia procedimiento para prepararlos composiciones farmacéuticas que los contienen y aplicación de dichos derivados en la preparación de dichas composiciones - Google Patents

Derivados de azacicloal canos utiles para el tratamiento de la obesidad diabetes e hiperglucemia procedimiento para prepararlos composiciones farmacéuticas que los contienen y aplicación de dichos derivados en la preparación de dichas composiciones

Info

Publication number
AR001838A1
AR001838A1 AR33637996A AR33637996A AR001838A1 AR 001838 A1 AR001838 A1 AR 001838A1 AR 33637996 A AR33637996 A AR 33637996A AR 33637996 A AR33637996 A AR 33637996A AR 001838 A1 AR001838 A1 AR 001838A1
Authority
AR
Argentina
Prior art keywords
derivatives
group
application
azacicloal
canos
Prior art date
Application number
AR33637996A
Other languages
English (en)
Original Assignee
Synthelabo
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Synthelabo filed Critical Synthelabo
Publication of AR001838A1 publication Critical patent/AR001838A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
    • C07D217/06—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines with the ring nitrogen atom acylated by carboxylic or carbonic acids, or with sulfur or nitrogen analogues thereof, e.g. carbamates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

Se trata de derivados de azacicloalcanos de fórmula (I), en la cual R1 y R2 representan hidrógeno, alquilo o fenilo, o R1 y R2 juntos forman un grupo oxo;R3 representa hidrógeno o alquilo, o bien R3 forma un grupo metileno, R4 es un grupo aromático,o, si R3 forma un grupo metileno, R4 es un grupo fenilenoenlazado a Y, y R4 representa un grupo fenilo uno de cuyos átomos de carbono está vinculado a Y, y otro de cuyos átomos de carbono, adyacente al precedente,está vinculado a dicho grupo metileno, R5 es un grupo OR7 siendo R7 hidrógeno o bencilo, o un grupo N4-metil-piperazinilo, un grupo NHR8 siendo R8 un grupohidroxilo, piridinilmetilo o fenilmetilo; A es un ciclo aromático, eventualmente sustituido; n es 1 ó 2; X es CH,O o N, e Y es CH2, O o S.También se propone la síntesis de dichos derivados y composiciones formuladas con dichos derivados como agente activo y la aplicación de los mismos en lasformulaciones mencionadas.
AR33637996A 1995-05-03 1996-05-02 Derivados de azacicloal canos utiles para el tratamiento de la obesidad diabetes e hiperglucemia procedimiento para prepararlos composiciones farmacéuticas que los contienen y aplicación de dichos derivados en la preparación de dichas composiciones AR001838A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9505260A FR2733750B1 (fr) 1995-05-03 1995-05-03 Derives de l'acide gamma-oxo-alpha-(phenylmethyl)-5,6- dihydro-4h-thieno(3,4-c)pyrrole-5-butanoique, leur preparation et leur application en therapeutique

Publications (1)

Publication Number Publication Date
AR001838A1 true AR001838A1 (es) 1997-12-10

Family

ID=9478644

Family Applications (1)

Application Number Title Priority Date Filing Date
AR33637996A AR001838A1 (es) 1995-05-03 1996-05-02 Derivados de azacicloal canos utiles para el tratamiento de la obesidad diabetes e hiperglucemia procedimiento para prepararlos composiciones farmacéuticas que los contienen y aplicación de dichos derivados en la preparación de dichas composiciones

Country Status (22)

Country Link
US (1) US5869518A (es)
EP (1) EP0823912A1 (es)
JP (1) JPH11504913A (es)
KR (1) KR19990008276A (es)
AR (1) AR001838A1 (es)
AU (1) AU699120B2 (es)
BG (1) BG102015A (es)
BR (1) BR9608309A (es)
CA (1) CA2220015A1 (es)
CO (1) CO4750652A1 (es)
CZ (1) CZ346697A3 (es)
EE (1) EE9700288A (es)
FR (1) FR2733750B1 (es)
HU (1) HUP9903886A3 (es)
IL (1) IL118119A0 (es)
NO (1) NO975020L (es)
NZ (1) NZ307230A (es)
PL (1) PL323177A1 (es)
SK (1) SK147897A3 (es)
TR (1) TR199701287T1 (es)
WO (1) WO1996034870A1 (es)
ZA (1) ZA963485B (es)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6177443B1 (en) 1997-03-07 2001-01-23 Novo Nordisk A/S 4,5,6,7-tetrahydro-thieno[3, 2-C]pyridine derivatives, their preparation and use
JP2001514631A (ja) * 1997-03-07 2001-09-11 ノボ ノルディスク アクティーゼルスカブ ４，５，６，７−テトラヒドロ−チエノ［３，２−ｃ］ピリジン誘導体類、それらの製造方法及び使用
WO1999045013A1 (en) * 1998-03-06 1999-09-10 Novo Nordisk A/S 4,5,6,7-TETRAHYDRO-THIENO[3,2-c]PYRIDINE DERIVATIVES
FR2777566B1 (fr) 1998-04-15 2003-02-21 Synthelabo Derives d'azacycloalcanes, leur preparation et leur application en therapeutique
FR2779428B1 (fr) * 1998-06-03 2001-05-18 Synthelabo Derives d'oxo-azacycloalcanes, leurs preparations et leurs applications en therapeutique
AU5154699A (en) * 1998-09-02 2000-03-27 Novo Nordisk A/S 4,5,6,7-tetrahydro-thieno(2,3-c)pyridine derivatives
US6090797A (en) * 1998-09-02 2000-07-18 Novo Nordisk A/S 4,5,6,7-tetrahydro-thieno(2,3-C)pyridine derivatives
FR2793411B1 (fr) * 1999-05-11 2001-06-29 Synthelabo Utilisation de derives de l'acide succinique pour obtenir un medicament destine au traitement de l'inflammation
EP1088824B1 (en) * 1999-09-30 2004-01-07 Pfizer Products Inc. Bicyclic pyrrolyl amides as glycogen phosphorylase inhibitors
US6797820B2 (en) 1999-12-17 2004-09-28 Vicuron Pharmaceuticals Inc. Succinate compounds, compositions and methods of use and preparation
US6987104B2 (en) * 2001-06-15 2006-01-17 Vicuron Pharmaceuticals Inc. Pyrrolidine bicyclic compounds and its derivatives, compositions and methods of use
AR036053A1 (es) 2001-06-15 2004-08-04 Versicor Inc Compuestos de n-formil-hidroxilamina, un proceso para su preparacion y composiciones farmaceuticas
US20090312470A1 (en) * 2008-06-11 2009-12-17 Ferro Corporation Asymmetric Cyclic Diester Compounds
US20100113664A1 (en) * 2008-06-11 2010-05-06 Ferro Corporation Asymmetric Cyclic Diester Compounds
PT2350093E (pt) * 2008-10-24 2012-11-02 Gruenenthal Gmbh 4,5,6,7-tetra-hidrotienopiridinas substituídas como moduladores de kcnq2/3 para tratamento da dor, epilepsia e incontinência urinária
KR20140009251A (ko) 2010-11-15 2014-01-22 애브비 인코포레이티드 Ｎａｍｐｔ 및 ｒｏｃｋ 억제제

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3190950A (en) * 1961-03-13 1965-06-22 Acf Ind Inc Pictorial position display
US3706810A (en) * 1970-09-15 1972-12-19 American Cyanamid Co N-morpholinoalkyl-thieno(3,2-b)pyrrole-5-carboxamides
ZA821020B (en) * 1981-02-18 1983-10-26 Thomae Gmbh Dr K Azepine derivatives, process for their preparation and pharmaceutical compositions thereof
FR2537974A1 (fr) * 1982-12-16 1984-06-22 Adir Nouveaux derives de thieno (2,3-b) pyrrole, leur procede de preparation et les compositions pharmaceutiques les renfermant
FR2571723B1 (fr) * 1984-10-12 1988-08-26 Lipha Derives de thieno et furo-(2,3-c) pyrroles, procedes de preparation et medicaments les contenant
FR2652579B1 (fr) * 1989-10-02 1992-01-24 Sanofi Sa Derives d'hydroxy-2 thiophene et furanne condenses avec un cycle azote, sur procede de preparation et leur application en therapeutique.
FR2676446B1 (fr) * 1991-05-17 1993-08-06 Rhone Poulenc Rorer Sa Nouveaux derives du thiopyranopyrrole, leur preparation et les compositions pharmaceutiques qui les contiennent.
EP0599697A1 (fr) * 1992-11-24 1994-06-01 Synthelabo Dérivés de pyrrole, leur préparation et leur application en thérapeutique
FR2719844B1 (fr) * 1994-05-10 1996-06-07 Synthelabo Dérivés de 5,6-dihydro-4h-thiéno[3,4-c]pyrrole, leur préparation et leur application en thérapeutique.

Also Published As

Publication number Publication date
NZ307230A (en) 1998-11-25
JPH11504913A (ja) 1999-05-11
SK147897A3 (en) 1998-05-06
KR19990008276A (ko) 1999-01-25
IL118119A0 (en) 1996-09-12
PL323177A1 (en) 1998-03-16
WO1996034870A1 (fr) 1996-11-07
BR9608309A (pt) 1999-01-26
BG102015A (en) 1998-08-31
CZ346697A3 (cs) 1998-02-18
AU5652096A (en) 1996-11-21
NO975020D0 (no) 1997-10-31
ZA963485B (en) 1996-11-25
CO4750652A1 (es) 1999-03-31
NO975020L (no) 1998-01-05
AU699120B2 (en) 1998-11-19
HUP9903886A3 (en) 2000-04-28
FR2733750A1 (fr) 1996-11-08
MX9708322A (es) 1998-06-28
EP0823912A1 (fr) 1998-02-18
US5869518A (en) 1999-02-09
FR2733750B1 (fr) 1997-06-13
HUP9903886A2 (hu) 2000-03-28
TR199701287T1 (xx) 1998-03-21
EE9700288A (et) 1998-04-15
CA2220015A1 (fr) 1996-11-07

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