ATE44748T1 - 4-substituierte 6-alkylidene-androsten-3,17-dion- derivate und verfahren zu ihrer herstellung. - Google Patents
4-substituierte 6-alkylidene-androsten-3,17-dion- derivate und verfahren zu ihrer herstellung.Info
- Publication number
- ATE44748T1 ATE44748T1 AT87308252T AT87308252T ATE44748T1 AT E44748 T1 ATE44748 T1 AT E44748T1 AT 87308252 T AT87308252 T AT 87308252T AT 87308252 T AT87308252 T AT 87308252T AT E44748 T1 ATE44748 T1 AT E44748T1
- Authority
- AT
- Austria
- Prior art keywords
- substituted
- dione derivatives
- androstene
- alkylidene
- preparation
- Prior art date
Links
- OSVMTWJCGUFAOD-KZQROQTASA-N formestane Chemical class O=C1CC[C@]2(C)[C@H]3CC[C@](C)(C(CC4)=O)[C@@H]4[C@@H]3CCC2=C1O OSVMTWJCGUFAOD-KZQROQTASA-N 0.000 title abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 1
- 102000014654 Aromatase Human genes 0.000 abstract 1
- 108010078554 Aromatase Proteins 0.000 abstract 1
- 206010004446 Benign prostatic hyperplasia Diseases 0.000 abstract 1
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical group FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 208000004403 Prostatic Hyperplasia Diseases 0.000 abstract 1
- 125000003277 amino group Chemical group 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 230000001419 dependent effect Effects 0.000 abstract 1
- 229910052731 fluorine Chemical group 0.000 abstract 1
- 239000011737 fluorine Chemical group 0.000 abstract 1
- 229940088597 hormone Drugs 0.000 abstract 1
- 239000005556 hormone Substances 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- PXQLVRUNWNTZOS-UHFFFAOYSA-N sulfanyl Chemical class [SH] PXQLVRUNWNTZOS-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0005—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring the nitrogen atom being directly linked to the cyclopenta(a)hydro phenanthrene skeleton
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
- C07J1/0003—Androstane derivatives
- C07J1/0011—Androstane derivatives substituted in position 17 by a keto group
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
- C07J31/003—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring the S atom directly linked to a ring carbon atom of the cyclopenta(a)hydrophenanthrene skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
- C07J71/0005—Oxygen-containing hetero ring
- C07J71/001—Oxiranes
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB868622330A GB8622330D0 (en) | 1986-09-17 | 1986-09-17 | 4-substituted 6-alkylidenandrostene-3,17-dione derivatives |
| EP87308252A EP0260975B1 (de) | 1986-09-17 | 1987-09-17 | 4-Substituierte 6-Alkylidene-androsten-3,17-dion-Derivate und Verfahren zu ihrer Herstellung |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE44748T1 true ATE44748T1 (de) | 1989-08-15 |
Family
ID=10604292
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT87308252T ATE44748T1 (de) | 1986-09-17 | 1987-09-17 | 4-substituierte 6-alkylidene-androsten-3,17-dion- derivate und verfahren zu ihrer herstellung. |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US4822528A (de) |
| EP (1) | EP0260975B1 (de) |
| JP (1) | JPS6383095A (de) |
| AT (1) | ATE44748T1 (de) |
| DE (1) | DE3760335D1 (de) |
| ES (1) | ES2010514B3 (de) |
| GB (1) | GB8622330D0 (de) |
| GR (1) | GR3000104T3 (de) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5364847A (en) * | 1989-03-10 | 1994-11-15 | Endorecherche | Inhibitors of sex steroid biosynthesis and methods for their production and use |
| US5372996A (en) * | 1989-03-10 | 1994-12-13 | Endorecherche, Inc. | Method of treatment of androgen-related diseases |
| JP3350048B2 (ja) * | 1989-07-07 | 2002-11-25 | アンドルシェルシュ・インコーポレイテッド | アンドロゲン関連疾患の治療方法 |
| US5227375A (en) * | 1990-02-08 | 1993-07-13 | Endorecherche, Inc. | Aromatase inhibitors |
| NZ239142A (en) * | 1990-08-01 | 1994-05-26 | Merrell Dow Pharma | 4-amino-delta-4-steroids; preparatory processes and pharmaceutical compositions |
| US5130424A (en) * | 1990-08-01 | 1992-07-14 | Merrell Dow Pharmaceuticals Inc. | 4-amino-delta-4,6-steroids and their use as 5 alpha-reductase inhibitors |
| US5143909A (en) * | 1991-03-19 | 1992-09-01 | Merrell Dow Pharmaceuticals Inc. | Aminosteroids in a method for inhibiting c17-20 lyase |
| US5318961A (en) * | 1990-08-01 | 1994-06-07 | Merrell Dow Pharmaceuticals Inc. | 4-amino-Δ4-steroids and their use as 5α-reductase inhibitors |
| US5120840A (en) * | 1990-08-01 | 1992-06-09 | Merrell Dow Pharmaceuticals Inc. | 4-amino-4-ene-steroids and their use as 5α-reductase inhibitors |
| US5218110A (en) * | 1990-08-01 | 1993-06-08 | Merrell Dow Pharmaceuticals | 4-amino-Δ4 -steroids and their use as 5α-reductase inhibitors |
| US5189032A (en) * | 1991-03-19 | 1993-02-23 | Merrell Dow Pharmaceuticals Inc. | 4-amino-Δ4,6 -steroids and their use as 5α-reductase inhibitors |
| GB9201224D0 (en) * | 1992-01-21 | 1992-03-11 | Erba Carlo Spa | Difluoromethylenandrostenone derivatives and process for their preparation |
| CZ286894A3 (en) * | 1992-05-21 | 1995-09-13 | Endorecherche Inc | Pharmaceutical preparation |
| GB9217035D0 (en) * | 1992-08-11 | 1992-09-23 | Erba Carlo Spa | Androst-4-eno(4,5-b)pyrrole derivatives and process for their preparation |
| CA2118317A1 (en) * | 1993-02-18 | 1994-09-01 | Pharmacia S.P.A. | Fluorinated 4-aminoandrostadienone derivatives and process for their preparation |
| US20040082557A1 (en) * | 2001-01-26 | 2004-04-29 | Wajszczuk Charles Paul | Methods for treating estrogen-dependent disorders |
| ES2382609T3 (es) * | 2004-01-16 | 2012-06-11 | Cedarburg Pharmaceuticals, Inc. | Exemestano y sus productos intermedios y métodos de preparación de los mismos |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB929985A (de) * | ||||
| US2744120A (en) * | 1953-01-14 | 1956-05-01 | Olin Mathieson | 1-dehydrotestololactone |
| US3341560A (en) * | 1961-10-09 | 1967-09-12 | Upjohn Co | 6-monofluoromethyl-17alpha-hydroxyprogesterones and 17-acylates thereof |
| JPS5614675B2 (de) * | 1973-06-16 | 1981-04-06 | ||
| US4235893A (en) * | 1978-05-08 | 1980-11-25 | Brodie Angela M | Ester derivatives of 4-hydroxy-4-androstene-3,17-dione and a method for inhibiting estrogen biosynthesis |
| GB8503940D0 (en) * | 1985-02-15 | 1985-03-20 | Erba Farmitalia | 4-substituted androstendione derivatives |
| GB8517360D0 (en) * | 1985-07-09 | 1985-08-14 | Erba Farmitalia | Substituted androsta-1,4-diene-3,17-diones |
-
1986
- 1986-09-17 GB GB868622330A patent/GB8622330D0/en active Pending
-
1987
- 1987-08-18 US US07/086,608 patent/US4822528A/en not_active Expired - Fee Related
- 1987-09-16 JP JP62231941A patent/JPS6383095A/ja active Pending
- 1987-09-17 ES ES87308252T patent/ES2010514B3/es not_active Expired
- 1987-09-17 AT AT87308252T patent/ATE44748T1/de not_active IP Right Cessation
- 1987-09-17 DE DE8787308252T patent/DE3760335D1/de not_active Expired
- 1987-09-17 EP EP87308252A patent/EP0260975B1/de not_active Expired
-
1989
- 1989-07-20 GR GR89400107T patent/GR3000104T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ES2010514B3 (es) | 1989-11-16 |
| EP0260975A1 (de) | 1988-03-23 |
| DE3760335D1 (en) | 1989-08-24 |
| GR3000104T3 (en) | 1990-11-29 |
| US4822528A (en) | 1989-04-18 |
| GB8622330D0 (en) | 1986-10-22 |
| EP0260975B1 (de) | 1989-07-19 |
| JPS6383095A (ja) | 1988-04-13 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification | ||
| REN | Ceased due to non-payment of the annual fee |