ATE47398T1 - 10-beta-alkynyl-estrenderivate und verfahren zu ihrer herstellung. - Google Patents

10-beta-alkynyl-estrenderivate und verfahren zu ihrer herstellung.

Info

Publication number
ATE47398T1
ATE47398T1 AT86310077T AT86310077T ATE47398T1 AT E47398 T1 ATE47398 T1 AT E47398T1 AT 86310077 T AT86310077 T AT 86310077T AT 86310077 T AT86310077 T AT 86310077T AT E47398 T1 ATE47398 T1 AT E47398T1
Authority
AT
Austria
Prior art keywords
halogen
beta
derivatives
hydrogen
group
Prior art date
Application number
AT86310077T
Other languages
English (en)
Inventor
Franco Faustini
Salle Enrico Di
Vittoria Villa
Paolo Lombardi
Original Assignee
Erba Carlo Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Erba Carlo Spa filed Critical Erba Carlo Spa
Application granted granted Critical
Publication of ATE47398T1 publication Critical patent/ATE47398T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0003—Androstane derivatives
    • C07J1/0011—Androstane derivatives substituted in position 17 by a keto group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0003—Androstane derivatives
    • C07J1/0018—Androstane derivatives substituted in position 17 beta, not substituted in position 17 alfa
    • C07J1/0022—Androstane derivatives substituted in position 17 beta, not substituted in position 17 alfa the substituent being an OH group free esterified or etherified
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J21/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having an oxygen-containing hetero ring spiro-condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J21/005—Ketals
    • C07J21/006—Ketals at position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0005—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring the nitrogen atom being directly linked to the cyclopenta(a)hydro phenanthrene skeleton
    • C07J41/0011—Unsubstituted amino radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0005—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring the nitrogen atom being directly linked to the cyclopenta(a)hydro phenanthrene skeleton
    • C07J41/0027—Azides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0005—Oxygen-containing hetero ring
    • C07J71/001—Oxiranes

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
AT86310077T 1985-12-24 1986-12-23 10-beta-alkynyl-estrenderivate und verfahren zu ihrer herstellung. ATE47398T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB858531747A GB8531747D0 (en) 1985-12-24 1985-12-24 10beta-alkynylestrene derivatives
EP86310077A EP0227472B1 (de) 1985-12-24 1986-12-23 10-Beta-alkynyl-estrenderivate und Verfahren zu ihrer Herstellung

Publications (1)

Publication Number Publication Date
ATE47398T1 true ATE47398T1 (de) 1989-11-15

Family

ID=10590250

Family Applications (1)

Application Number Title Priority Date Filing Date
AT86310077T ATE47398T1 (de) 1985-12-24 1986-12-23 10-beta-alkynyl-estrenderivate und verfahren zu ihrer herstellung.

Country Status (19)

Country Link
US (1) US4808578A (de)
EP (1) EP0227472B1 (de)
JP (1) JPS62158300A (de)
KR (1) KR870006082A (de)
AT (1) ATE47398T1 (de)
AU (1) AU599942B2 (de)
CA (1) CA1310957C (de)
DE (1) DE3666438D1 (de)
DK (1) DK624586A (de)
ES (1) ES2011618B3 (de)
FI (1) FI83522C (de)
GB (1) GB8531747D0 (de)
GR (1) GR3000222T3 (de)
HU (1) HU197919B (de)
IL (1) IL81008A (de)
NZ (1) NZ218714A (de)
PT (1) PT84013B (de)
SU (1) SU1577701A3 (de)
ZA (1) ZA869459B (de)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4534722A (en) * 1984-04-16 1985-08-13 Gold Bond Ice Cream, Inc. Forming and conveying of baked confection shells
US4882322A (en) * 1988-10-27 1989-11-21 Merrell Dow Pharmaceuticals Inc. 3β,17β-hydroxy-substituted steroids and related steroidal compounds
NZ237559A (en) * 1990-04-02 1993-04-28 Merrell Dow Pharma Halogenoethyl steroid derivatives and pharmaceutical compositions
CH683151A5 (de) * 1991-04-24 1994-01-31 Ciba Geigy Ag Antikonzeption bei weiblichen Primaten ohne Beeinflussung des menstruellen Zyklus.
US6407082B1 (en) * 1996-09-13 2002-06-18 New Life Pharmaceuticals Inc. Prevention of ovarian cancer by administration of a vitamin D compound
US6765002B2 (en) 2000-03-21 2004-07-20 Gustavo Rodriguez Prevention of ovarian cancer by administration of products that induce transforming growth factor-β and/or apoptosis in the ovarian epithelium
US6511970B1 (en) 1996-09-13 2003-01-28 New Life Pharmaceuticals Inc. Prevention of ovarian cancer by administration of products that induce transforming growth factor-beta and/or apoptosis in the ovarian epithelium
US6028064A (en) 1996-09-13 2000-02-22 New Life Pharmaceuticals Inc. Prevention of ovarian cancer by administration of progestin products
US6034074A (en) 1996-09-13 2000-03-07 New Life Pharmaceuticals Inc. Prevention of ovarian cancer by administration of a Vitamin D compound
US20010044431A1 (en) * 2000-03-21 2001-11-22 Rodriguez Gustavo C. Prevention of ovarian cancer by administration of products that induce biologic effects in the ovarian epithelium
US8969327B2 (en) 2010-04-08 2015-03-03 Emory University Substituted androst-4-ene diones

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2744120A (en) * 1953-01-14 1956-05-01 Olin Mathieson 1-dehydrotestololactone
GB1042291A (en) * 1961-11-08 1966-09-14 Organon Labor Ltd í¸-6ª‡-amino steroids and the preparation thereof
US4289762A (en) * 1980-06-27 1981-09-15 Merrell Dow Pharmaceuticals Inc. 10-(1,2-Propadienyl) steroids as irreversible aromatase inhibitors
US4322416A (en) * 1980-06-27 1982-03-30 Merrell Dow Pharmaceuticals Inc. 10-Alkynyl steroids
DE3121153A1 (de) * 1981-05-22 1982-12-09 Schering Ag, 1000 Berlin Und 4619 Bergkamen "verwendung von aromatase-hemmern zur prophylaxe und therapie der prostatahyperplasie"
US4446071A (en) * 1982-09-09 1984-05-01 E. R. Squibb & Sons, Inc. Intermediates useful in the preparation of 17,17-bis(substituted thio) androstenes
US4546098A (en) * 1984-04-13 1985-10-08 The Rockefeller University Estrogen synthesis inhibitors

Also Published As

Publication number Publication date
AU599942B2 (en) 1990-08-02
FI83522C (fi) 1991-07-25
PT84013A (en) 1987-01-01
NZ218714A (en) 1990-02-26
FI865259A7 (fi) 1987-06-25
EP0227472B1 (de) 1989-10-18
DK624586D0 (da) 1986-12-22
US4808578A (en) 1989-02-28
GB8531747D0 (en) 1986-02-05
DK624586A (da) 1987-06-25
IL81008A0 (en) 1987-03-31
AU6666186A (en) 1987-06-25
GR3000222T3 (en) 1991-03-15
FI865259A0 (fi) 1986-12-22
JPS62158300A (ja) 1987-07-14
ES2011618B3 (es) 1990-02-01
HU197919B (en) 1989-06-28
IL81008A (en) 1991-06-10
PT84013B (pt) 1989-07-31
CA1310957C (en) 1992-12-01
HUT44574A (en) 1988-03-28
KR870006082A (ko) 1987-07-09
ZA869459B (en) 1987-08-26
EP0227472A1 (de) 1987-07-01
DE3666438D1 (en) 1989-11-23
SU1577701A3 (ru) 1990-07-07
FI83522B (fi) 1991-04-15

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Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee