CH692199A8 - Composes pyridiques et compositions pharmaceutique - Google Patents
Composes pyridiques et compositions pharmaceutique Download PDFInfo
- Publication number
- CH692199A8 CH692199A8 CH02364/97A CH236497A CH692199A8 CH 692199 A8 CH692199 A8 CH 692199A8 CH 02364/97 A CH02364/97 A CH 02364/97A CH 236497 A CH236497 A CH 236497A CH 692199 A8 CH692199 A8 CH 692199A8
- Authority
- CH
- Switzerland
- Prior art keywords
- compounds
- pharmaceutical compositions
- pyridic
- oxydation
- dihydropyridines
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/79—Acids; Esters
- C07D213/80—Acids; Esters in position 3
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4418—Non condensed pyridines; Hydrogenated derivatives thereof having a carbocyclic group directly attached to the heterocyclic ring, e.g. cyproheptadine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/443—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with oxygen as a ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Priority Applications (11)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CH02364/97A CH692199A8 (fr) | 1997-10-09 | 1997-10-09 | Composes pyridiques et compositions pharmaceutique |
DE69818286T DE69818286T2 (de) | 1997-10-09 | 1998-10-07 | Pyridylverbindungen und diese enthaltende pharmazeutische zubereitungen |
PCT/IB1998/001555 WO1999019302A1 (fr) | 1997-10-09 | 1998-10-07 | Composes de pyridyle et compositions pharmaceutiques contenant ces composes |
AT98945453T ATE250034T1 (de) | 1997-10-09 | 1998-10-07 | Pyridylverbindungen und diese enthaltende pharmazeutische zubereitungen |
EP98945453A EP1023267B1 (fr) | 1997-10-09 | 1998-10-07 | Composes de pyridyle et compositions pharmaceutiques contenant ces composes |
PT98945453T PT1023267E (pt) | 1997-10-09 | 1998-10-07 | Compostos de piridilo e composicoes farmaceuticas que os contem |
US09/529,112 US6482841B1 (en) | 1997-10-09 | 1998-10-07 | Pyridyl compounds and pharmaceutical compositions containing them |
CA002306789A CA2306789A1 (fr) | 1997-10-09 | 1998-10-07 | Composes de pyridyle et compositions pharmaceutiques contenant ces composes |
AU92771/98A AU747150B2 (en) | 1997-10-09 | 1998-10-07 | Pyridyl compounds and pharmaceutical compositions containing them |
ES98945453T ES2206989T3 (es) | 1997-10-09 | 1998-10-07 | Compuestos de piridilo y composiciones farmaceuticas que los contienen. |
JP2000515875A JP2001519415A (ja) | 1997-10-09 | 1998-10-07 | ピリジル化合物およびこれを含有した薬剤組成物 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CH02364/97A CH692199A8 (fr) | 1997-10-09 | 1997-10-09 | Composes pyridiques et compositions pharmaceutique |
Publications (2)
Publication Number | Publication Date |
---|---|
CH692199A5 CH692199A5 (fr) | 2002-03-15 |
CH692199A8 true CH692199A8 (fr) | 2002-06-14 |
Family
ID=4232069
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CH02364/97A CH692199A8 (fr) | 1997-10-09 | 1997-10-09 | Composes pyridiques et compositions pharmaceutique |
Country Status (11)
Country | Link |
---|---|
US (1) | US6482841B1 (fr) |
EP (1) | EP1023267B1 (fr) |
JP (1) | JP2001519415A (fr) |
AT (1) | ATE250034T1 (fr) |
AU (1) | AU747150B2 (fr) |
CA (1) | CA2306789A1 (fr) |
CH (1) | CH692199A8 (fr) |
DE (1) | DE69818286T2 (fr) |
ES (1) | ES2206989T3 (fr) |
PT (1) | PT1023267E (fr) |
WO (1) | WO1999019302A1 (fr) |
Families Citing this family (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1162197B1 (fr) * | 2000-06-08 | 2004-05-26 | Bayer Chemicals AG | Procédé pour la préparation des pyridines par oxidation des dihydropyridines en utilisant methyl nitrite |
DE10115945A1 (de) | 2001-03-30 | 2002-10-02 | Bayer Ag | Substituierte 2-Carba-3,5-dicyano-4-aryl-6-aminopyridine und ihre Verwendung |
US7183410B2 (en) | 2001-08-02 | 2007-02-27 | Bidachem S.P.A. | Stable polymorph of flibanserin |
US20030060475A1 (en) * | 2001-08-10 | 2003-03-27 | Boehringer Ingelheim Pharma Kg | Method of using flibanserin for neuroprotection |
US10675280B2 (en) | 2001-10-20 | 2020-06-09 | Sprout Pharmaceuticals, Inc. | Treating sexual desire disorders with flibanserin |
UA78974C2 (en) | 2001-10-20 | 2007-05-10 | Boehringer Ingelheim Pharma | Use of flibanserin for treating disorders of sexual desire |
US20040048877A1 (en) * | 2002-05-22 | 2004-03-11 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Pharmaceutical compositions containing flibanserin |
AU2002368531A1 (en) * | 2002-12-30 | 2004-07-22 | Eos Eczacibasi Ozgun Kimyasal Urunler Sanayi Ve Ticaret A.S. | Isolation of dihydropyridine derivative and preparation salts thereof |
WO2006097943A2 (fr) * | 2005-03-15 | 2006-09-21 | Lupin Limited | Compositions pharmaceutiques d'amlodipine et de benazepril. |
CA2617546C (fr) | 2005-08-03 | 2014-07-15 | Boehringer Ingelheim International Gmbh | Utilisation de la flibanserine dans le traitement de l'obesite |
CA2626134C (fr) | 2005-10-29 | 2013-12-24 | Boehringer Ingelheim International Gmbh | Derives de benzimidazolone utiles pour le traitement des troubles premenstruels et d'autres troubles sexuels chez la femme |
WO2007099070A1 (fr) * | 2006-02-28 | 2007-09-07 | Boehringer Ingelheim International Gmbh | Traitement ou prevention de la cardiopathie valvulaire par la flibanserine |
WO2007128802A2 (fr) * | 2006-05-09 | 2007-11-15 | Boehringer Ingelheim International Gmbh | Utilisation de flibansérine pour le traitement des troubles de la libido post-ménopausiques |
JP2009541443A (ja) | 2006-06-30 | 2009-11-26 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 尿失禁及び関連疾患の治療のためのフリバンセリン |
US20090318469A1 (en) * | 2006-07-14 | 2009-12-24 | Boehringer Ingelheim International Gmbh | Use of Flibanserin for the Treatment of Sexual Disorders in Females |
KR20090042967A (ko) | 2006-08-14 | 2009-05-04 | 베링거 인겔하임 인터내셔날 게엠베하 | 플리반세린 제형 및 이의 제조방법 |
CL2007002214A1 (es) | 2006-08-14 | 2008-03-07 | Boehringer Ingelheim Int | Composicion farmaceutica en la forma de comprimido, donde al menos la longitud del comprimido en el estado anterior de la aplicacion es al menos 7/12 del diametro pilorico del paciente y despues de ingerirlo en estado alimentado, la longitud del comp |
MX2009002031A (es) * | 2006-08-25 | 2009-03-06 | Boehringer Ingelheim Int | Sistema de liberacion controlada y metodo para fabricarlo. |
WO2008090742A1 (fr) * | 2007-01-23 | 2008-07-31 | National University Corporation Hokkaido University | Animal non humain pour un modèle de maladie des yeux |
PE20091188A1 (es) | 2007-09-12 | 2009-08-31 | Boehringer Ingelheim Int | Compuesto 1-[2-(4-(3-trifluorometil-fenil)piperazin-1-il)etil]-2,3-dihidro-1h-benzimidazol-2-ona (flibanserina), sus sales de adicion y composiciones farmaceuticas que los contienen |
JP6555702B2 (ja) * | 2016-01-26 | 2019-08-07 | アタトゥルク ユニヴァーシテシ ビリムセル アラスティルマ プロジェレリ ビリミ | N3,n5‐ビス(2‐(5‐メトキシ‐1h‐インドール‐3‐イル)エチル)‐2,6‐ジメチル‐4‐(2‐ニトロフェニル)ピリジン‐3,5‐ジカルボキシアミドおよび神経毒分野におけるその使用 |
CN109020875B (zh) * | 2018-08-27 | 2020-05-22 | 北京市药品检验所 | 二氢吡啶类化合物脱氢芳构化方法及在药品检测中的用途 |
WO2020241638A1 (fr) * | 2019-05-31 | 2020-12-03 | Kyushu University, National University Corporation | Inhibiteurs de formation de complexe drp1-filamine |
CN112457242B (zh) * | 2020-12-03 | 2021-11-23 | 广州隽沐生物科技股份有限公司 | 一种拉西地平杂质b的制备方法 |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3209276A1 (de) * | 1982-03-13 | 1983-09-15 | Bayer Ag, 5090 Leverkusen | Arzneimittel mit antihypoxischer und ischaemie-protektiver wirkung |
EP0179239A3 (fr) * | 1984-09-17 | 1986-08-13 | Sterling Drug Inc. | Acide 7-(pyridinyl)-/-alkyl-1,4-dihydro-4-oxo-3-quinoléine carboxylique ayant une activité antibactérienne et sa préparation |
US4698350A (en) * | 1984-09-17 | 1987-10-06 | Sterling Drug Inc. | 1-ethyl-6-fluoro-1,4-dihydro-7-(2,6-dimethyl-4-pyridinyl)-4-oxo-3-quinolinecarboxylic acid and antibacterial use thereof |
CA1312611C (fr) * | 1987-07-01 | 1993-01-12 | Yamanouchi Pharmaceutical Co., Ltd. | Derives pyridine, procede pour leur production et composition pharmaceutique en contenant |
GB8905526D0 (en) * | 1989-03-10 | 1989-04-19 | Fujisawa Pharmaceutical Co | N-containing heterocyclic compounds,processes for the preparation thereof and composition comprising the same |
DE4200714A1 (de) * | 1992-01-14 | 1993-07-15 | Bayer Ag | Spezieller 1,4-dihydropyridin-3,5-dicarbonsaeureester, verfahren zu seiner herstellung und seine pharmazeutische verwendung |
JP3286645B2 (ja) * | 1993-03-26 | 2002-05-27 | メルシャン株式会社 | 光学活性1,4−ジヒドロピリジン誘導体およびその製造方法 |
DE4430639A1 (de) * | 1994-08-29 | 1996-03-07 | Bayer Ag | Verwendung von 5-substituierten Pyridin- und Hexahydrochinolin-3-carbonsäurederivaten |
WO1997027177A2 (fr) * | 1996-01-29 | 1997-07-31 | The United States Of America, Represented By The Secretary, Department Of Health And Human Services | Derives de dihydropyridine-, pyridine-, benzopyrane- mono- et triazoloquinazoline, leur preparation, et utilsation comme antagonistes des recepteurs de l'adenosine |
-
1997
- 1997-10-09 CH CH02364/97A patent/CH692199A8/fr not_active IP Right Cessation
-
1998
- 1998-10-07 US US09/529,112 patent/US6482841B1/en not_active Expired - Fee Related
- 1998-10-07 CA CA002306789A patent/CA2306789A1/fr not_active Abandoned
- 1998-10-07 ES ES98945453T patent/ES2206989T3/es not_active Expired - Lifetime
- 1998-10-07 AT AT98945453T patent/ATE250034T1/de not_active IP Right Cessation
- 1998-10-07 JP JP2000515875A patent/JP2001519415A/ja active Pending
- 1998-10-07 PT PT98945453T patent/PT1023267E/pt unknown
- 1998-10-07 AU AU92771/98A patent/AU747150B2/en not_active Ceased
- 1998-10-07 WO PCT/IB1998/001555 patent/WO1999019302A1/fr active IP Right Grant
- 1998-10-07 EP EP98945453A patent/EP1023267B1/fr not_active Expired - Lifetime
- 1998-10-07 DE DE69818286T patent/DE69818286T2/de not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
CA2306789A1 (fr) | 1999-04-22 |
EP1023267A1 (fr) | 2000-08-02 |
WO1999019302A1 (fr) | 1999-04-22 |
EP1023267B1 (fr) | 2003-09-17 |
AU9277198A (en) | 1999-05-03 |
DE69818286T2 (de) | 2004-07-01 |
US6482841B1 (en) | 2002-11-19 |
AU747150B2 (en) | 2002-05-09 |
DE69818286D1 (de) | 2003-10-23 |
PT1023267E (pt) | 2004-01-30 |
CH692199A5 (fr) | 2002-03-15 |
ES2206989T3 (es) | 2004-05-16 |
ATE250034T1 (de) | 2003-10-15 |
JP2001519415A (ja) | 2001-10-23 |
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Legal Events
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PK | Correction |
Free format text: RECTIFICATION DU FASCICULE DU BREVET |
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PL | Patent ceased |