ATE250034T1 - Pyridylverbindungen und diese enthaltende pharmazeutische zubereitungen - Google Patents
Pyridylverbindungen und diese enthaltende pharmazeutische zubereitungenInfo
- Publication number
- ATE250034T1 ATE250034T1 AT98945453T AT98945453T ATE250034T1 AT E250034 T1 ATE250034 T1 AT E250034T1 AT 98945453 T AT98945453 T AT 98945453T AT 98945453 T AT98945453 T AT 98945453T AT E250034 T1 ATE250034 T1 AT E250034T1
- Authority
- AT
- Austria
- Prior art keywords
- pharmaceutical preparations
- preparations containing
- containing same
- pyridyl compounds
- compounds
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 2
- 239000000825 pharmaceutical preparation Substances 0.000 title 1
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 abstract 2
- YNGDWRXWKFWCJY-UHFFFAOYSA-N 1,4-Dihydropyridine Chemical class C1C=CNC=C1 YNGDWRXWKFWCJY-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 150000007513 acids Chemical class 0.000 abstract 1
- 229940045200 cardioprotective agent Drugs 0.000 abstract 1
- 239000012659 cardioprotective agent Substances 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 238000007254 oxidation reaction Methods 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/79—Acids; Esters
- C07D213/80—Acids; Esters in position 3
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4418—Non condensed pyridines; Hydrogenated derivatives thereof having a carbocyclic group directly attached to the heterocyclic ring, e.g. cyproheptadine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/443—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with oxygen as a ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Cardiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Heart & Thoracic Surgery (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Plural Heterocyclic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH02364/97A CH692199A8 (fr) | 1997-10-09 | 1997-10-09 | Composes pyridiques et compositions pharmaceutique |
| PCT/IB1998/001555 WO1999019302A1 (en) | 1997-10-09 | 1998-10-07 | Pyridyl compounds and pharmaceutical compositions containing them |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE250034T1 true ATE250034T1 (de) | 2003-10-15 |
Family
ID=4232069
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT98945453T ATE250034T1 (de) | 1997-10-09 | 1998-10-07 | Pyridylverbindungen und diese enthaltende pharmazeutische zubereitungen |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US6482841B1 (de) |
| EP (1) | EP1023267B1 (de) |
| JP (1) | JP2001519415A (de) |
| AT (1) | ATE250034T1 (de) |
| AU (1) | AU747150B2 (de) |
| CA (1) | CA2306789A1 (de) |
| CH (1) | CH692199A8 (de) |
| DE (1) | DE69818286T2 (de) |
| ES (1) | ES2206989T3 (de) |
| PT (1) | PT1023267E (de) |
| WO (1) | WO1999019302A1 (de) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1162197B1 (de) * | 2000-06-08 | 2004-05-26 | Bayer Chemicals AG | Verfahren zur Herstellung von Pyridinen durch Oxidation von Dihydropyridinen mittels Methylnitrit |
| DE10115945A1 (de) * | 2001-03-30 | 2002-10-02 | Bayer Ag | Substituierte 2-Carba-3,5-dicyano-4-aryl-6-aminopyridine und ihre Verwendung |
| US7183410B2 (en) * | 2001-08-02 | 2007-02-27 | Bidachem S.P.A. | Stable polymorph of flibanserin |
| US20030060475A1 (en) * | 2001-08-10 | 2003-03-27 | Boehringer Ingelheim Pharma Kg | Method of using flibanserin for neuroprotection |
| UA78974C2 (en) * | 2001-10-20 | 2007-05-10 | Boehringer Ingelheim Pharma | Use of flibanserin for treating disorders of sexual desire |
| US10675280B2 (en) | 2001-10-20 | 2020-06-09 | Sprout Pharmaceuticals, Inc. | Treating sexual desire disorders with flibanserin |
| US20040048877A1 (en) * | 2002-05-22 | 2004-03-11 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Pharmaceutical compositions containing flibanserin |
| AU2002368531A1 (en) * | 2002-12-30 | 2004-07-22 | Eos Eczacibasi Ozgun Kimyasal Urunler Sanayi Ve Ticaret A.S. | Isolation of dihydropyridine derivative and preparation salts thereof |
| EP1863457A2 (de) * | 2005-03-15 | 2007-12-12 | Lupin Ltd. | Pharmazeutische zusammensetzungen von amlodipin und benazepril |
| ES2646326T3 (es) | 2005-08-03 | 2017-12-13 | Sprout Pharmaceuticals, Inc. | Uso de flibanserina en el tratamiento de la obesidad |
| WO2007048803A1 (en) | 2005-10-29 | 2007-05-03 | Boehringer Ingelheim International Gmbh | Benzimidazolone derivatives for the treatment of premenstrual and other female sexual disorders |
| EP1991228A1 (de) * | 2006-02-28 | 2008-11-19 | Boehringer Ingelheim International GmbH | Präventionsbehandlung für herzklappenfehler mit flibanserin |
| BRPI0712039A2 (pt) * | 2006-05-09 | 2011-12-20 | Boehringer Ingelheim Int | uso de flibanserina para o tratamento de distúrbios de desejo sexual pós-menopausa |
| WO2008000760A1 (en) | 2006-06-30 | 2008-01-03 | Boehringer Ingelheim International Gmbh | Flibanserin for the treatment of urinary incontinence and related diseases |
| EP2043648A1 (de) * | 2006-07-14 | 2009-04-08 | Boehringer Ingelheim International GmbH | Verwendung von flibanserin zur behandlung von sexualstörungen bei frauen |
| BRPI0716439B8 (pt) | 2006-08-14 | 2021-05-25 | Boehringer Ingelheim Int | sistemas de liberação farmacêutico compreendendo flibanserina, processo para preparação e uso dos mesmos |
| CL2007002214A1 (es) | 2006-08-14 | 2008-03-07 | Boehringer Ingelheim Int | Composicion farmaceutica en la forma de comprimido, donde al menos la longitud del comprimido en el estado anterior de la aplicacion es al menos 7/12 del diametro pilorico del paciente y despues de ingerirlo en estado alimentado, la longitud del comp |
| BRPI0716436B8 (pt) * | 2006-08-25 | 2021-05-25 | Boehringer Ingelheim Int | sistema de liberação controlada e método para fabricação do mesmo |
| JP5087011B2 (ja) * | 2007-01-23 | 2012-11-28 | 馨 井上 | 眼疾患モデル用非ヒト動物 |
| CL2008002693A1 (es) | 2007-09-12 | 2009-10-16 | Boehringer Ingelheim Int | Uso de flibanserina para el tratamiento de sintomas vasomotores seleccionados de sofocos, sudores nocturnos, cambios de estado de animo e irritabilidad |
| WO2017131601A1 (en) * | 2016-01-26 | 2017-08-03 | Ataturk Universitesi Bilimsel Arastirma Projeleri Birimi | N3,n6-bis(2-(5-methoxy-1h-indole-3-yl)ethyl)-2,6-dimethyl-4-(2-nitrophenyl)pyridine-3,5-dicarboxamide and use thereof in the field of neurotoxicity |
| CN109020875B (zh) * | 2018-08-27 | 2020-05-22 | 北京市药品检验所 | 二氢吡啶类化合物脱氢芳构化方法及在药品检测中的用途 |
| EP3976177A4 (de) * | 2019-05-31 | 2023-05-31 | RDiscovery, LLC | Drp1-filamin-komplexbildungsinhibitoren |
| CN112457242B (zh) * | 2020-12-03 | 2021-11-23 | 广州隽沐生物科技股份有限公司 | 一种拉西地平杂质b的制备方法 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3209276A1 (de) * | 1982-03-13 | 1983-09-15 | Bayer Ag, 5090 Leverkusen | Arzneimittel mit antihypoxischer und ischaemie-protektiver wirkung |
| EP0179239A3 (de) * | 1984-09-17 | 1986-08-13 | Sterling Drug Inc. | 7-(Pyridinyl)-/-alkyl-1,4-dihydro-4-oxo-3-chinolincarbonsäure mit antibakterieller Aktivität und deren Herstellung |
| US4698350A (en) * | 1984-09-17 | 1987-10-06 | Sterling Drug Inc. | 1-ethyl-6-fluoro-1,4-dihydro-7-(2,6-dimethyl-4-pyridinyl)-4-oxo-3-quinolinecarboxylic acid and antibacterial use thereof |
| US4843085A (en) * | 1987-07-01 | 1989-06-27 | Yamanouchi Pharmaceutical Co., Ltd. | Pyridine derivatives, process for production thereof and pharmaceutical compositions useful as anti-arhytmics |
| GB8905526D0 (en) * | 1989-03-10 | 1989-04-19 | Fujisawa Pharmaceutical Co | N-containing heterocyclic compounds,processes for the preparation thereof and composition comprising the same |
| DE4200714A1 (de) * | 1992-01-14 | 1993-07-15 | Bayer Ag | Spezieller 1,4-dihydropyridin-3,5-dicarbonsaeureester, verfahren zu seiner herstellung und seine pharmazeutische verwendung |
| JP3286645B2 (ja) * | 1993-03-26 | 2002-05-27 | メルシャン株式会社 | 光学活性１，４−ジヒドロピリジン誘導体およびその製造方法 |
| DE4430639A1 (de) * | 1994-08-29 | 1996-03-07 | Bayer Ag | Verwendung von 5-substituierten Pyridin- und Hexahydrochinolin-3-carbonsäurederivaten |
| WO1997027177A2 (en) * | 1996-01-29 | 1997-07-31 | The United States Of America, Represented By The Secretary, Department Of Health And Human Services | Dihydropyridine-, pyridine-, benzopyran-4-one- and triazoloquinazoline derivatives, their preparation and their use as adenosine receptor antagonists |
-
1997
- 1997-10-09 CH CH02364/97A patent/CH692199A8/xx not_active IP Right Cessation
-
1998
- 1998-10-07 ES ES98945453T patent/ES2206989T3/es not_active Expired - Lifetime
- 1998-10-07 CA CA002306789A patent/CA2306789A1/en not_active Abandoned
- 1998-10-07 PT PT98945453T patent/PT1023267E/pt unknown
- 1998-10-07 JP JP2000515875A patent/JP2001519415A/ja active Pending
- 1998-10-07 US US09/529,112 patent/US6482841B1/en not_active Expired - Fee Related
- 1998-10-07 DE DE69818286T patent/DE69818286T2/de not_active Expired - Fee Related
- 1998-10-07 WO PCT/IB1998/001555 patent/WO1999019302A1/en not_active Ceased
- 1998-10-07 AT AT98945453T patent/ATE250034T1/de not_active IP Right Cessation
- 1998-10-07 EP EP98945453A patent/EP1023267B1/de not_active Expired - Lifetime
- 1998-10-07 AU AU92771/98A patent/AU747150B2/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| DE69818286D1 (de) | 2003-10-23 |
| ES2206989T3 (es) | 2004-05-16 |
| CA2306789A1 (en) | 1999-04-22 |
| EP1023267B1 (de) | 2003-09-17 |
| DE69818286T2 (de) | 2004-07-01 |
| AU747150B2 (en) | 2002-05-09 |
| PT1023267E (pt) | 2004-01-30 |
| JP2001519415A (ja) | 2001-10-23 |
| AU9277198A (en) | 1999-05-03 |
| US6482841B1 (en) | 2002-11-19 |
| EP1023267A1 (de) | 2000-08-02 |
| WO1999019302A1 (en) | 1999-04-22 |
| CH692199A8 (fr) | 2002-06-14 |
| CH692199A5 (fr) | 2002-03-15 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DE69818286D1 (de) | Pyridylverbindungen und diese enthaltende pharmazeutische zubereitungen | |
| IL109526A0 (en) | Benzofuranyl- and thiophenyl-alkanecarboxylic acid derivatives, their preparation and pharmaceutical compositions containing them | |
| NO971889D0 (no) | Forbindelser og sammensetninger for levering av aktive midler | |
| DE69516540D1 (de) | AMINO-IMIDAZO [4,5-c] CHINOLINE | |
| CA2244785A1 (en) | Pentafluorobenzenesulfonamides and analogs | |
| RU94038064A (ru) | Производные пиперазина и пиперидина, их применение в качестве противопсихотических средств, способ их получения фармацевтическая композиция | |
| DK0425650T3 (da) | Antiinflammatoriske 4-aminophenolderivater | |
| FI940696A0 (fi) | Uudet pyratsiinijohdannaiset, niiden valmistus ja käyttö | |
| ES2107284T3 (es) | Nuevas n-piridil-carboxamidas, su procedimiento de preparacion y composiciones farmaceuticas que las contienen. | |
| PT992509E (pt) | Novos derivados macrolidos | |
| DK0825197T3 (da) | Nye 6-hydroxy- og 6-oxo-androstanderivater, der er aktive i forhold til det cardiovaskulære system, og farmaceutiske præpar | |
| IT1224405B (it) | Composti attivi sul sistema cardiovascolare | |
| UA48958C2 (uk) | 9-o-оксимові похідні еритроміцину а та фармацевтична композиція на їх основі | |
| RU94038042A (ru) | Производные гексагидроазепинов, фармацевтическая композиция на их основе и антипсихотропный агент | |
| MD502G2 (ro) | Derivaţi noi ai adenozinei, procedee de preparare a lor, compoziţii farmaceutice ce le conţin | |
| BG60101B2 (bg) | Метод за получаване на 4-флуор-2-(((4-метокси-2- пиридинил)метил)тионил)-1н-бензимидазол | |
| RU94000064A (ru) | Новые 2-циано-3-гидроксипропенамиды, метод их получения и содержащие их фармацевтические композиции | |
| IT1216104B (it) | Peptidi ad attivita' farmaceutica. | |
| GEP20032975B (en) | Echinocandin Derivatives, Preparation Method and Pharmaceutical Composition | |
| DE69307071D1 (de) | Kardioaktive 17B-aryl und 17B-heterozyklyl-5-beta,14-beta-Androstan-Derivate,ein Verfahren zu ihrer Herstellung und pharmazeutische Phäparate davon | |
| TR200003451T2 (tr) | Pirimidin-Aminometil-Piridin Türevleri, Hazırlanmaları ve helikobakter bakterinin kontrolünde kullanımları | |
| ATE229028T1 (de) | 9-n-ethenylderivate von 9(s)-erythromycylamin | |
| FI892685A0 (fi) | Menetelmä uusien, sytostaattisesti vaikuttavien antrasykliinijohdannaisten valmistamiseksi | |
| EP2266566A3 (de) | Nicotinamid Derivate und ihrer Verwendung als Therapeutika | |
| DE69812059D1 (de) | Beta,beta-disubstituierte Derivate von 9-Deoxo-9a-N-ethenyl-9a-aza-9a-homoerythromycin A |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
Ref document number: 1023267 Country of ref document: EP |
|
| REN | Ceased due to non-payment of the annual fee |