DK0564350T3 - 3, 5-di-tert-butyl-4-hydroxyflavoner, fremgangsmåde til deres fremstilling og farmaceutiske sammensætninger med antioxidant- og anti-vasokonstriktorisk virkning - Google Patents

3, 5-di-tert-butyl-4-hydroxyflavoner, fremgangsmåde til deres fremstilling og farmaceutiske sammensætninger med antioxidant- og anti-vasokonstriktorisk virkning

Info

Publication number
DK0564350T3
DK0564350T3 DK93400811.1T DK93400811T DK0564350T3 DK 0564350 T3 DK0564350 T3 DK 0564350T3 DK 93400811 T DK93400811 T DK 93400811T DK 0564350 T3 DK0564350 T3 DK 0564350T3
Authority
DK
Denmark
Prior art keywords
antioxidant
tert
butyl
preparation
pharmaceutical compositions
Prior art date
Application number
DK93400811.1T
Other languages
English (en)
Inventor
Jean-Paul Vilaine
Albert Lenaers
Catherine Thollon
Yves Rolland
Guy Lewin
Original Assignee
Adir
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Adir filed Critical Adir
Application granted granted Critical
Publication of DK0564350T3 publication Critical patent/DK0564350T3/da

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
    • C07D311/26—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3
    • C07D311/28—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3 with aromatic rings attached in position 2 only
    • C07D311/30—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3 with aromatic rings attached in position 2 only not hydrogenated in the hetero ring, e.g. flavones
DK93400811.1T 1992-03-31 1993-03-30 3, 5-di-tert-butyl-4-hydroxyflavoner, fremgangsmåde til deres fremstilling og farmaceutiske sammensætninger med antioxidant- og anti-vasokonstriktorisk virkning DK0564350T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9203861A FR2689127B1 (fr) 1992-03-31 1992-03-31 Nouvelles 3', 5' -ditertbutyl-4'-hydroxy flavones, leur procede de preparation et les compositions pharmaceutiques les renfermant.

Publications (1)

Publication Number Publication Date
DK0564350T3 true DK0564350T3 (da) 1997-12-15

Family

ID=9428265

Family Applications (1)

Application Number Title Priority Date Filing Date
DK93400811.1T DK0564350T3 (da) 1992-03-31 1993-03-30 3, 5-di-tert-butyl-4-hydroxyflavoner, fremgangsmåde til deres fremstilling og farmaceutiske sammensætninger med antioxidant- og anti-vasokonstriktorisk virkning

Country Status (13)

Country Link
US (2) US5280024A (da)
EP (1) EP0564350B1 (da)
JP (1) JPH07119221B2 (da)
AT (1) ATE153022T1 (da)
AU (1) AU655106B2 (da)
CA (1) CA2092961A1 (da)
DE (1) DE69310602T2 (da)
DK (1) DK0564350T3 (da)
ES (1) ES2104090T3 (da)
FR (1) FR2689127B1 (da)
GR (1) GR3023938T3 (da)
NZ (1) NZ247287A (da)
ZA (1) ZA932312B (da)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2689127B1 (fr) * 1992-03-31 1994-05-06 Adir Cie Nouvelles 3', 5' -ditertbutyl-4'-hydroxy flavones, leur procede de preparation et les compositions pharmaceutiques les renfermant.
AU5259296A (en) * 1995-04-07 1996-10-23 Warner-Lambert Company Flavones and coumarins as agents for the treatment of athero sclerosis
DE19638515B4 (de) * 1996-09-20 2004-01-15 Grundig Car Intermedia System Gmbh Verfahren und Vorrichtung zur Zuordnung von Nachrichten, insbesondere Verkehrsnachrichten
FR2753969B1 (fr) * 1996-09-27 1998-10-30 Adir Nouveaux derives de flavones, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
US6207665B1 (en) 1997-06-12 2001-03-27 Schering Aktiengesellschaft Piperazine derivatives and their use as anti-inflammatory agents
US6028088A (en) * 1998-10-30 2000-02-22 The University Of Mississippi Flavonoid derivatives
EP1127572A3 (en) * 2000-02-25 2003-05-02 Basf Aktiengesellschaft Use of flavones for treating cycloxygenase-2 mediated diseases
FR2815033B1 (fr) 2000-10-06 2003-09-05 Negma Lab Derives de 7-carboxy-flavones, porcede pour leur preparation et leur application en therapeutique
US6818668B2 (en) 2002-04-12 2004-11-16 Biotest Laboratories, Llc 5-alkyl-7-alkylcarbonate-isoflavone ester and related method
GB0216371D0 (en) * 2002-07-13 2002-08-21 Rowett Res Inst The Compounds
DE10232595A1 (de) * 2002-07-18 2004-02-05 Merck Patent Gmbh Lichtschutzmittel
US8093273B2 (en) 2004-10-20 2012-01-10 Resverlogix Corp. Flavanoids and isoflavanoids for the prevention and treatment of cardiovascular diseases
KR100729731B1 (ko) * 2005-07-19 2007-06-20 건국대학교 산학협력단 사람 피부 세포의 세포사멸을 억제하는 활성을 갖는플라보노이드
EP2314295B1 (en) * 2005-07-29 2015-01-28 Resverlogix, Inc Pharmaceutical compositions for the prevention and treatment of complex diseases and their delivery by insertable medical devices
DK2118074T3 (da) 2007-02-01 2014-03-10 Resverlogix Corp Forbindelser til forebyggelse og behandling af hjertekarsygdomme
JP5602728B2 (ja) 2008-06-26 2014-10-08 レスバーロジックス コーポレイション キナゾリノン誘導体の製造方法
US8952021B2 (en) 2009-01-08 2015-02-10 Resverlogix Corp. Compounds for the prevention and treatment of cardiovascular disease
KR101709492B1 (ko) 2009-03-18 2017-02-23 리스버로직스 코퍼레이션 신규한 소염제
SI2421533T1 (sl) 2009-04-22 2019-01-31 Resverlogix Corp. Nova protivnetna sredstva
GB201017315D0 (en) 2010-10-13 2010-11-24 Antoxis Ltd Compound
JP5992049B2 (ja) 2011-11-01 2016-09-14 レスバーロジックス コーポレイション 置換されたキナゾリノンのための経口速放性製剤
US9073878B2 (en) 2012-11-21 2015-07-07 Zenith Epigenetics Corp. Cyclic amines as bromodomain inhibitors
WO2014080291A2 (en) 2012-11-21 2014-05-30 Rvx Therapeutics Inc. Biaryl derivatives as bromodomain inhibitors
US9271978B2 (en) 2012-12-21 2016-03-01 Zenith Epigenetics Corp. Heterocyclic compounds as bromodomain inhibitors
CN107530356A (zh) 2015-03-13 2018-01-02 雷斯韦洛吉克斯公司 用于治疗补体相关疾病之组合物及治疗方法

Family Cites Families (12)

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Publication number Priority date Publication date Assignee Title
FR1247909A (fr) * 1955-11-02 1960-12-09 Recordati Lab Farmacologico Dr Procédé de préparation des dérivés d'hydroxychromones
DE1054091B (de) * 1958-05-30 1959-04-02 Chemiewerk Homburg Ag Verfahren zur Herstellung von N-substituierten 2-Phenyl-7-aminoalkoxy-chromonen
DE1418516A1 (de) * 1959-07-28 1968-12-05 Klosa Dipl Chem Dr Josef Verfahren zur Herstellung von Flavon-7-oxyessigsaeureamiden
GB1250388A (da) 1968-11-27 1971-10-20
DE2029658A1 (de) * 1970-06-16 1971-12-23 Boehnnger Mannheim GmbH, 6800 Mann heim Waldhof 2 (4 Oxo-4H 1 benzopyran 7 yl) oxy isobutter saure Derivate und Verfahren zur Herstellung derselben
US3816466A (en) * 1971-12-22 1974-06-11 Warner Lambert Co Flavanoid ring systems
JPH02214780A (ja) * 1989-02-14 1990-08-27 San Ei Chem Ind Ltd アントシアン色素の安定化法
JPH035423A (ja) * 1989-06-01 1991-01-11 Ichimaru Pharcos Co Ltd フラボノイド含有過酸化脂質生成抑制剤
DE4011187A1 (de) * 1990-04-06 1991-10-10 Hoechst Ag Substituierte 3-thia- bzw. 3-oxa-alkyl-flavone, verfahren zu ihrer herstellung, verwendung derselben, arzneimittel auf basis dieser verbindungen sowie zwischenprodukte
DE69006502T2 (de) * 1990-04-06 1994-05-19 Chinoin Gyogyszer Es Vegyeszet Verbessertes verfahren zur darstellung substituierter isoflavonderivate.
SG65570A1 (en) * 1992-02-25 1999-06-22 Recordati Chem Pharm Heterobicyclic compounds
FR2689127B1 (fr) * 1992-03-31 1994-05-06 Adir Cie Nouvelles 3', 5' -ditertbutyl-4'-hydroxy flavones, leur procede de preparation et les compositions pharmaceutiques les renfermant.

Also Published As

Publication number Publication date
FR2689127A1 (fr) 1993-10-01
ES2104090T3 (es) 1997-10-01
US5457103A (en) 1995-10-10
CA2092961A1 (fr) 1993-10-01
ZA932312B (en) 1993-10-18
DE69310602D1 (de) 1997-06-19
EP0564350B1 (fr) 1997-05-14
JPH0625212A (ja) 1994-02-01
ATE153022T1 (de) 1997-05-15
JPH07119221B2 (ja) 1995-12-20
AU655106B2 (en) 1994-12-01
US5280024A (en) 1994-01-18
NZ247287A (en) 1994-08-26
GR3023938T3 (en) 1997-09-30
AU3559193A (en) 1993-10-07
EP0564350A1 (fr) 1993-10-06
FR2689127B1 (fr) 1994-05-06
DE69310602T2 (de) 1997-12-18

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