ATE153022T1 - 3',5'-ditertbutyl-4'-hydroxyflavone, verfahren zu ihrer herstellung und pharmazeutische zusammensetzung mit antioxidations- und antivasokonstriktionsaktivität - Google Patents
3',5'-ditertbutyl-4'-hydroxyflavone, verfahren zu ihrer herstellung und pharmazeutische zusammensetzung mit antioxidations- und antivasokonstriktionsaktivitätInfo
- Publication number
- ATE153022T1 ATE153022T1 AT93400811T AT93400811T ATE153022T1 AT E153022 T1 ATE153022 T1 AT E153022T1 AT 93400811 T AT93400811 T AT 93400811T AT 93400811 T AT93400811 T AT 93400811T AT E153022 T1 ATE153022 T1 AT E153022T1
- Authority
- AT
- Austria
- Prior art keywords
- antivasoconstriction
- hydroxyflavones
- ditertbutyl
- antioxidation
- activity
- Prior art date
Links
- 230000003064 anti-oxidating effect Effects 0.000 title 1
- 230000000694 effects Effects 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
- C07D311/26—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3
- C07D311/28—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3 with aromatic rings attached in position 2 only
- C07D311/30—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3 with aromatic rings attached in position 2 only not hydrogenated in the hetero ring, e.g. flavones
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Cardiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Heart & Thoracic Surgery (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyrane Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR9203861A FR2689127B1 (fr) | 1992-03-31 | 1992-03-31 | Nouvelles 3', 5' -ditertbutyl-4'-hydroxy flavones, leur procede de preparation et les compositions pharmaceutiques les renfermant. |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE153022T1 true ATE153022T1 (de) | 1997-05-15 |
Family
ID=9428265
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT93400811T ATE153022T1 (de) | 1992-03-31 | 1993-03-30 | 3',5'-ditertbutyl-4'-hydroxyflavone, verfahren zu ihrer herstellung und pharmazeutische zusammensetzung mit antioxidations- und antivasokonstriktionsaktivität |
Country Status (13)
| Country | Link |
|---|---|
| US (2) | US5280024A (de) |
| EP (1) | EP0564350B1 (de) |
| JP (1) | JPH07119221B2 (de) |
| AT (1) | ATE153022T1 (de) |
| AU (1) | AU655106B2 (de) |
| CA (1) | CA2092961A1 (de) |
| DE (1) | DE69310602T2 (de) |
| DK (1) | DK0564350T3 (de) |
| ES (1) | ES2104090T3 (de) |
| FR (1) | FR2689127B1 (de) |
| GR (1) | GR3023938T3 (de) |
| NZ (1) | NZ247287A (de) |
| ZA (1) | ZA932312B (de) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2689127B1 (fr) * | 1992-03-31 | 1994-05-06 | Adir Cie | Nouvelles 3', 5' -ditertbutyl-4'-hydroxy flavones, leur procede de preparation et les compositions pharmaceutiques les renfermant. |
| WO1996031206A2 (en) * | 1995-04-07 | 1996-10-10 | Warner-Lambert Company | Flavones and coumarins as agents for the treatment of atherosclerosis |
| DE19638515B4 (de) * | 1996-09-20 | 2004-01-15 | Grundig Car Intermedia System Gmbh | Verfahren und Vorrichtung zur Zuordnung von Nachrichten, insbesondere Verkehrsnachrichten |
| FR2753969B1 (fr) * | 1996-09-27 | 1998-10-30 | Adir | Nouveaux derives de flavones, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| US6207665B1 (en) * | 1997-06-12 | 2001-03-27 | Schering Aktiengesellschaft | Piperazine derivatives and their use as anti-inflammatory agents |
| US6028088A (en) * | 1998-10-30 | 2000-02-22 | The University Of Mississippi | Flavonoid derivatives |
| EP1127572A3 (de) * | 2000-02-25 | 2003-05-02 | Basf Aktiengesellschaft | Verwendung von Flavonen zur Behandlung von Cyclooxygenase-2 ermittelten Krankheiten |
| FR2815033B1 (fr) | 2000-10-06 | 2003-09-05 | Negma Lab | Derives de 7-carboxy-flavones, porcede pour leur preparation et leur application en therapeutique |
| US6818668B2 (en) | 2002-04-12 | 2004-11-16 | Biotest Laboratories, Llc | 5-alkyl-7-alkylcarbonate-isoflavone ester and related method |
| GB0216371D0 (en) * | 2002-07-13 | 2002-08-21 | Rowett Res Inst The | Compounds |
| DE10232595A1 (de) * | 2002-07-18 | 2004-02-05 | Merck Patent Gmbh | Lichtschutzmittel |
| US7846915B2 (en) | 2004-10-20 | 2010-12-07 | Resverlogix Corporation | Stilbenes and chalcones for the prevention and treatment of cardiovascular diseases |
| KR100729731B1 (ko) * | 2005-07-19 | 2007-06-20 | 건국대학교 산학협력단 | 사람 피부 세포의 세포사멸을 억제하는 활성을 갖는플라보노이드 |
| US8410109B2 (en) * | 2005-07-29 | 2013-04-02 | Resverlogix Corp. | Pharmaceutical compositions for the prevention and treatment of complex diseases and their delivery by insertable medical devices |
| MX2009008099A (es) | 2007-02-01 | 2009-12-14 | Resverlogix Corp | Compuestos para la prevencion y tratamiento de enfermedades cardiovasculares. |
| KR101629356B1 (ko) | 2008-06-26 | 2016-06-13 | 리스버로직스 코퍼레이션 | 퀴나졸리논 유도체의 제조방법 |
| CA2747417C (en) | 2009-01-08 | 2017-01-03 | Resverlogix Corp. | Compounds for the prevention and treatment of cardiovascular disease |
| KR101913109B1 (ko) | 2009-03-18 | 2018-10-31 | 리스버로직스 코퍼레이션 | 신규한 소염제 |
| DK2421533T3 (en) | 2009-04-22 | 2019-01-07 | Resverlogix Corp | Hitherto unknown anti-inflammatory agents |
| GB201017315D0 (en) | 2010-10-13 | 2010-11-24 | Antoxis Ltd | Compound |
| LT2773354T (lt) | 2011-11-01 | 2019-08-12 | Resverlogix Corp. | Geriamosios greitai atsipalaiduojančios pakeistų chinozolinų vaisto formos |
| WO2014080291A2 (en) | 2012-11-21 | 2014-05-30 | Rvx Therapeutics Inc. | Biaryl derivatives as bromodomain inhibitors |
| US9073878B2 (en) | 2012-11-21 | 2015-07-07 | Zenith Epigenetics Corp. | Cyclic amines as bromodomain inhibitors |
| WO2014096965A2 (en) | 2012-12-21 | 2014-06-26 | Rvx Therapeutics Inc. | Novel heterocyclic compounds as bromodomain inhibitors |
| JP6903585B2 (ja) | 2015-03-13 | 2021-07-14 | レスバーロジックス コーポレイション | 補体関連疾患の治療のための組成物および治療方法 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR1247909A (fr) * | 1955-11-02 | 1960-12-09 | Recordati Lab Farmacologico Dr | Procédé de préparation des dérivés d'hydroxychromones |
| DE1054091B (de) * | 1958-05-30 | 1959-04-02 | Chemiewerk Homburg Ag | Verfahren zur Herstellung von N-substituierten 2-Phenyl-7-aminoalkoxy-chromonen |
| DE1418516A1 (de) * | 1959-07-28 | 1968-12-05 | Klosa Dipl Chem Dr Josef | Verfahren zur Herstellung von Flavon-7-oxyessigsaeureamiden |
| GB1250388A (de) * | 1968-11-27 | 1971-10-20 | ||
| DE2029658A1 (de) * | 1970-06-16 | 1971-12-23 | Boehnnger Mannheim GmbH, 6800 Mann heim Waldhof | 2 (4 Oxo-4H 1 benzopyran 7 yl) oxy isobutter saure Derivate und Verfahren zur Herstellung derselben |
| US3816466A (en) * | 1971-12-22 | 1974-06-11 | Warner Lambert Co | Flavanoid ring systems |
| JPH02214780A (ja) * | 1989-02-14 | 1990-08-27 | San Ei Chem Ind Ltd | アントシアン色素の安定化法 |
| JPH035423A (ja) * | 1989-06-01 | 1991-01-11 | Ichimaru Pharcos Co Ltd | フラボノイド含有過酸化脂質生成抑制剤 |
| DE4011187A1 (de) * | 1990-04-06 | 1991-10-10 | Hoechst Ag | Substituierte 3-thia- bzw. 3-oxa-alkyl-flavone, verfahren zu ihrer herstellung, verwendung derselben, arzneimittel auf basis dieser verbindungen sowie zwischenprodukte |
| JPH089610B2 (ja) * | 1990-04-06 | 1996-01-31 | キノイン・ジョージセル・エーシュ・ヴェジェーセティ・テルメーケク・ジャーラ・エルテー | 置換イソフラボン誘導体の改良された製造方法 |
| SG65570A1 (en) * | 1992-02-25 | 1999-06-22 | Recordati Chem Pharm | Heterobicyclic compounds |
| FR2689127B1 (fr) * | 1992-03-31 | 1994-05-06 | Adir Cie | Nouvelles 3', 5' -ditertbutyl-4'-hydroxy flavones, leur procede de preparation et les compositions pharmaceutiques les renfermant. |
-
1992
- 1992-03-31 FR FR9203861A patent/FR2689127B1/fr not_active Expired - Fee Related
-
1993
- 1993-03-25 US US08/036,814 patent/US5280024A/en not_active Expired - Fee Related
- 1993-03-30 EP EP93400811A patent/EP0564350B1/de not_active Expired - Lifetime
- 1993-03-30 AU AU35591/93A patent/AU655106B2/en not_active Ceased
- 1993-03-30 DK DK93400811.1T patent/DK0564350T3/da active
- 1993-03-30 DE DE69310602T patent/DE69310602T2/de not_active Expired - Fee Related
- 1993-03-30 AT AT93400811T patent/ATE153022T1/de not_active IP Right Cessation
- 1993-03-30 NZ NZ247287A patent/NZ247287A/en unknown
- 1993-03-30 CA CA002092961A patent/CA2092961A1/fr not_active Abandoned
- 1993-03-30 ES ES93400811T patent/ES2104090T3/es not_active Expired - Lifetime
- 1993-03-30 JP JP5072457A patent/JPH07119221B2/ja not_active Expired - Lifetime
- 1993-03-31 ZA ZA932312A patent/ZA932312B/xx unknown
- 1993-08-18 US US08/108,333 patent/US5457103A/en not_active Expired - Fee Related
-
1997
- 1997-06-30 GR GR970401586T patent/GR3023938T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP0564350B1 (de) | 1997-05-14 |
| US5457103A (en) | 1995-10-10 |
| GR3023938T3 (en) | 1997-09-30 |
| AU655106B2 (en) | 1994-12-01 |
| FR2689127B1 (fr) | 1994-05-06 |
| NZ247287A (en) | 1994-08-26 |
| ES2104090T3 (es) | 1997-10-01 |
| DK0564350T3 (da) | 1997-12-15 |
| JPH0625212A (ja) | 1994-02-01 |
| JPH07119221B2 (ja) | 1995-12-20 |
| AU3559193A (en) | 1993-10-07 |
| ZA932312B (en) | 1993-10-18 |
| CA2092961A1 (fr) | 1993-10-01 |
| EP0564350A1 (de) | 1993-10-06 |
| FR2689127A1 (fr) | 1993-10-01 |
| US5280024A (en) | 1994-01-18 |
| DE69310602D1 (de) | 1997-06-19 |
| DE69310602T2 (de) | 1997-12-18 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification | ||
| REN | Ceased due to non-payment of the annual fee |