DK77090D0 - Immunmodulerende azaspiraner - Google Patents

Immunmodulerende azaspiraner

Info

Publication number
DK77090D0
DK77090D0 DK077090A DK77090A DK77090D0 DK 77090 D0 DK77090 D0 DK 77090D0 DK 077090 A DK077090 A DK 077090A DK 77090 A DK77090 A DK 77090A DK 77090 D0 DK77090 D0 DK 77090D0
Authority
DK
Denmark
Prior art keywords
immunomodulatory
azaspirans
azaspiranes
formulae
chem
Prior art date
Application number
DK077090A
Other languages
English (en)
Other versions
DK77090A (da
DK170042B1 (da
Inventor
Alison Mary Badger
David Aaron Schwartz
Elaine Nicholas Cheeseman
Michael John Dimartino
James Woodrow Dorman
Christopher Kevin Mirabelli
Donald Harold Picker
Original Assignee
Smithkline Beckman Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smithkline Beckman Corp filed Critical Smithkline Beckman Corp
Publication of DK77090D0 publication Critical patent/DK77090D0/da
Publication of DK77090A publication Critical patent/DK77090A/da
Application granted granted Critical
Publication of DK170042B1 publication Critical patent/DK170042B1/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/20—Spiro-condensed ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • C—CHEMISTRY; METALLURGY
    • C04—CEMENTS; CONCRETE; ARTIFICIAL STONE; CERAMICS; REFRACTORIES
    • C04B—LIME, MAGNESIA; SLAG; CEMENTS; COMPOSITIONS THEREOF, e.g. MORTARS, CONCRETE OR LIKE BUILDING MATERIALS; ARTIFICIAL STONE; CERAMICS; REFRACTORIES; TREATMENT OF NATURAL STONE
    • C04B35/00—Shaped ceramic products characterised by their composition; Ceramics compositions; Processing powders of inorganic compounds preparatory to the manufacturing of ceramic products
    • C04B35/01—Shaped ceramic products characterised by their composition; Ceramics compositions; Processing powders of inorganic compounds preparatory to the manufacturing of ceramic products based on oxide ceramics
    • C04B35/45—Shaped ceramic products characterised by their composition; Ceramics compositions; Processing powders of inorganic compounds preparatory to the manufacturing of ceramic products based on oxide ceramics based on copper oxide or solid solutions thereof with other oxides
    • C04B35/4504—Shaped ceramic products characterised by their composition; Ceramics compositions; Processing powders of inorganic compounds preparatory to the manufacturing of ceramic products based on oxide ceramics based on copper oxide or solid solutions thereof with other oxides containing rare earth oxides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/54—Spiro-condensed
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/96—Spiro-condensed ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/22—Bridged ring systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Ceramic Engineering (AREA)
  • Manufacturing & Machinery (AREA)
  • Materials Engineering (AREA)
  • Structural Engineering (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Transplantation (AREA)
  • Biomedical Technology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Saccharide Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DK077090A 1987-09-28 1990-03-23 Immunmodulerende azaspiraner, farmaceutiske midler, der indeholder dem, samt anvendelse af azaspiranerne til fremstilling af et immunmodulerende middel DK170042B1 (da)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US10170487A 1987-09-28 1987-09-28
US10170487 1987-09-28
US07/244,229 US4963557A (en) 1987-09-28 1988-09-13 Immunomodulatory azaspiranes
US24422988 1988-09-13
US8803323 1988-09-27
PCT/US1988/003323 WO1989002889A1 (en) 1987-09-28 1988-09-27 Immunomodulatory azaspiranes

Publications (3)

Publication Number Publication Date
DK77090D0 true DK77090D0 (da) 1990-03-23
DK77090A DK77090A (da) 1990-03-23
DK170042B1 DK170042B1 (da) 1995-05-08

Family

ID=26798539

Family Applications (1)

Application Number Title Priority Date Filing Date
DK077090A DK170042B1 (da) 1987-09-28 1990-03-23 Immunmodulerende azaspiraner, farmaceutiske midler, der indeholder dem, samt anvendelse af azaspiranerne til fremstilling af et immunmodulerende middel

Country Status (24)

Country Link
US (1) US4963557A (da)
EP (1) EP0310321B1 (da)
JP (1) JP2582888B2 (da)
KR (1) KR0166336B1 (da)
CN (1) CN1031618C (da)
AT (1) ATE114463T1 (da)
AU (1) AU619780B2 (da)
CA (1) CA1313189C (da)
CY (1) CY1955A (da)
DE (1) DE3852266T2 (da)
DK (1) DK170042B1 (da)
ES (1) ES2064356T3 (da)
FI (1) FI93006C (da)
GR (1) GR3014931T3 (da)
HK (1) HK1006274A1 (da)
HU (1) HU208809B (da)
IE (1) IE67891B1 (da)
IL (1) IL87908A (da)
MX (1) MX9203765A (da)
NO (1) NO173824C (da)
NZ (1) NZ226354A (da)
PT (1) PT88603B (da)
WO (1) WO1989002889A1 (da)
ZW (1) ZW12388A1 (da)

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JP2675194B2 (ja) * 1990-08-10 1997-11-12 スミスクライン・ビーチャム・コーポレイション 免疫抑制組成物
US6051596A (en) * 1990-08-10 2000-04-18 Anormed, Inc. Immunosuppressive compositions
JPH06501468A (ja) * 1990-09-24 1994-02-17 スミスクライン・ビーチャム・コーポレイション 方法
ZA921120B (en) * 1991-02-19 1993-01-27 Smithkline Beecham Corp Cytokine inhibitors
US5591748A (en) * 1991-06-07 1997-01-07 Smithkline Beecham Corporation Immunomodulatory azaspiranes
PT100566B (pt) * 1991-06-07 1999-06-30 Smithkline Beecham Corp Azaspiranos imunomoduladores, composicoes farmaceuticas que os contem, sua preparacao e seu uso
GB9122721D0 (en) * 1991-10-25 1991-12-11 Smithkline Beecham Corp Methods
GB9122735D0 (en) * 1991-10-25 1991-12-11 Smithkline Beecham Corp Methods
US5455247A (en) * 1991-10-25 1995-10-03 Smithkline Beecham Corporation Methods for the treatment of hyperlipidemia using azaspiranes
AU675633B2 (en) * 1991-12-18 1997-02-13 Minnesota Mining And Manufacturing Company Suspension aerosol formulations
US7105152B1 (en) 1991-12-18 2006-09-12 3M Innovative Properties Company Suspension aerosol formulations
US7101534B1 (en) 1991-12-18 2006-09-05 3M Innovative Properties Company Suspension aerosol formulations
US5482959A (en) * 1992-01-28 1996-01-09 Smithkline Beecham Corporation Method for delaying aids in an HIV infected individual by administration of substituted azaspirane compounds
GB9201804D0 (en) * 1992-01-28 1992-03-11 Smithkline Beecham Corp Methods
GB9201803D0 (en) * 1992-01-28 1992-03-11 Smithkline Beecham Corp Methods
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GB9217121D0 (en) * 1992-08-13 1992-09-23 Smithkline Beecham Corp Methods
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US5484788A (en) * 1993-03-26 1996-01-16 Beth Israel Hospital Association Buspirone as a systemic immunosuppressant
US5631017A (en) * 1993-03-26 1997-05-20 Beth Israel Deaconess Medical Center, Inc. Topical application of buspirone for treatment of pathological conditions associated with immune responses
PT690715E (pt) * 1993-03-26 2003-10-31 Beth Israel Hospital Aplicacao topica e sistemica de buspirona ou seus derivados para tratamento de condicoes patologicas associadas a respostas imunitarias
GB9308780D0 (en) * 1993-04-28 1993-06-09 Smithkline Beecham Corp Methods
US5708019A (en) * 1993-04-28 1998-01-13 Smithkline Beecham Corporation Methods of treating hyperlipidemia using azaspirane derivatives
US5505948A (en) * 1993-06-01 1996-04-09 Dermatology Home Products, Inc. Home skin peel composition for producing healthy and attractive skin
GB9315298D0 (en) * 1993-07-23 1993-09-08 Smithkline Beecham Corp Methods
GB9315306D0 (en) * 1993-07-23 1993-09-08 Smithkline Beecham Corp Methods
GB9315351D0 (en) * 1993-07-23 1993-09-08 Smithkline Beecham Corp Methods
GB9315271D0 (en) * 1993-07-23 1993-09-08 Smithkline Beecham Corp Methods
GB9315340D0 (en) * 1993-07-23 1993-09-08 Smithkline Beecham Corp Methods
GB9315341D0 (en) * 1993-07-23 1993-09-08 Smithkline Beecham Corp Methods
US5461054A (en) * 1993-12-09 1995-10-24 Bayer Aktiengesellschaft Anthracene-spiro-pyrrolindines
GB9325854D0 (en) * 1993-12-17 1994-02-23 Smithkline Beecham Corp Porcess
US5786376A (en) * 1994-07-23 1998-07-28 Smithkline Beecham Corporation Methods of treating opportunistic infections with azaspiranes
GB9414902D0 (en) * 1994-07-23 1994-09-14 Smithkline Beecham Corp Methods
GB9414901D0 (en) * 1994-07-23 1994-09-14 Smithkline Beecham Corp Methods
US5734061A (en) * 1994-12-07 1998-03-31 Smithkline Beecham Corporation Process for preparing spirocyclic lactams
US5637314A (en) * 1995-06-07 1997-06-10 Beth Israel Deaconess Medical Center, Inc. Topical and systemic application of buspirone or derivatives thereof for treating atopic dermatitis
BG62359B1 (bg) * 1995-07-13 1999-09-30 Anormed N,n-диетил-8,8-дипропил-2-азаспиро[4,5]декан-2-пропанаминдималеат
EP0837678A1 (en) * 1995-07-13 1998-04-29 Smithkline Beecham Corporation N,n-dimethyl-8,8-dipropyl-2-azaspiro 4,5]decane-2-propanamine dimaleate
WO1997002819A1 (en) * 1995-07-13 1997-01-30 Anormed Inc, 2-[2-(dimethylamino)ethyl]-8,8-dipropyl-2-azaspiro[4.5]decane dimaleate
BR9601909A (pt) * 1995-07-13 1999-10-13 Smithkline Beecham Corp N,n-dietil-8,8-dipropil-2-azaspiro(4,5)decano-2-propan amina dimaleato
IL127040A0 (en) * 1996-05-17 1999-09-22 Anormed Inc Use of substituted azaspirane in the treatment of asthma
US5843936A (en) * 1996-06-28 1998-12-01 Bernstein; Lawrence R. Topical administration of azaspiranes to prevent or treat skin conditions associated with hyperproliferation of keratinocytes
GB0208742D0 (en) 2002-04-17 2002-05-29 Bradford Particle Design Ltd Particulate materials
US7582284B2 (en) 2002-04-17 2009-09-01 Nektar Therapeutics Particulate materials
JP4458514B2 (ja) * 2002-07-18 2010-04-28 第一三共株式会社 高純度のエナミン類の製造方法
TW200505438A (en) * 2003-03-10 2005-02-16 Callisto Pharmaceuticals Inc Method of treating cancer with azaspirane compositions
US20110104186A1 (en) 2004-06-24 2011-05-05 Nicholas Valiante Small molecule immunopotentiators and assays for their detection
WO2006010379A1 (en) 2004-07-29 2006-02-02 Actelion Pharmaceuticals Ltd. Novel thiophene derivatives as immunosuppressive agents
CN101948462A (zh) * 2004-09-20 2011-01-19 塔加西普特公司 具有烟碱性胆碱能受体活性的氮杂螺烯和氮杂螺烷化合物
WO2006100631A1 (en) 2005-03-23 2006-09-28 Actelion Pharmaceuticals Ltd Hydrogenated benzo (c) thiophene derivatives as immunomodulators
AR057894A1 (es) 2005-11-23 2007-12-26 Actelion Pharmaceuticals Ltd Derivados de tiofeno
ES2335242T3 (es) 2006-01-24 2010-03-23 Actelion Pharmaceuticals Ltd. Derivados novedosos de piridina.
AU2007215140B2 (en) * 2006-02-13 2013-01-10 The Board Of Trustees Of The Leland Stanford Junior University Blockade of gamma-secretase activity to promote myelination by oligodendrocytes
EP2120875B1 (en) 2007-02-11 2018-07-11 Map Pharmaceuticals Inc. Method of therapeutic administration of dhe to enable rapid relief of migraine while minimizing side effect profile

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GB823338A (en) * 1956-11-07 1959-11-11 Thomae Gmbh Dr K Diquaternary salts of aminoalkyl piperidines
US3106552A (en) * 1960-07-19 1963-10-08 Geschickter Fund Med Res Nu-substituted azaspiranes and azaspirane-diones and processes for their preparation
US3418324A (en) * 1961-03-13 1968-12-24 Geschickter Fund Med Res Heterocyclic secondary amines
US3282947A (en) * 1962-05-17 1966-11-01 Geschickter Fund Med Res Unsymmetrically substituted 3, 9-diazaspiro(5, 5)undecane compounds
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US3424755A (en) * 1964-03-09 1969-01-28 Rolf Denss 4-piperidine-p-fluorobutyrophenones and related compounds
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DE1770697C3 (de) * 1967-07-06 1981-04-23 Dupher International Research B.V., Weesp 2,2-(N-Methyl-2-azatetramethylen)- -adamantan, dessen Salze, Verfahren zu deren Herstellung und Arzneimittel
BE759371A (fr) * 1969-11-24 1971-05-24 Bristol Myers Co Azaspirodecanediones heterocycliques et procedes pour leur preparation
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US4468393A (en) * 1982-12-06 1984-08-28 Unimed, Inc. Treatment of arthritis
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Also Published As

Publication number Publication date
JPH03500290A (ja) 1991-01-24
FI93006C (fi) 1995-02-10
HU885889D0 (en) 1991-11-28
FI93006B (fi) 1994-10-31
NO901392L (no) 1990-03-27
PT88603B (pt) 1992-12-31
AU2533388A (en) 1989-04-18
DE3852266D1 (de) 1995-01-12
MX9203765A (es) 1992-07-01
GR3014931T3 (en) 1995-05-31
AU619780B2 (en) 1992-02-06
HUT57722A (en) 1991-12-30
DK77090A (da) 1990-03-23
ZW12388A1 (en) 1989-01-04
CA1313189C (en) 1993-01-26
IE67891B1 (en) 1996-05-01
US4963557A (en) 1990-10-16
PT88603A (pt) 1988-10-01
CY1955A (en) 1997-05-16
NZ226354A (en) 1991-02-26
EP0310321A2 (en) 1989-04-05
DK170042B1 (da) 1995-05-08
ATE114463T1 (de) 1994-12-15
FI901530A0 (fi) 1990-03-27
CN1032437A (zh) 1989-04-19
IE882929L (en) 1989-03-28
NO173824B (no) 1993-11-01
HK1006274A1 (en) 1999-02-19
HU208809B (en) 1995-06-28
KR0166336B1 (ko) 1999-01-15
CN1031618C (zh) 1996-04-24
IL87908A (en) 1993-02-21
EP0310321B1 (en) 1994-11-30
NO901392D0 (no) 1990-03-27
WO1989002889A1 (en) 1989-04-06
EP0310321A3 (en) 1991-02-06
ES2064356T3 (es) 1995-02-01
DE3852266T2 (de) 1995-05-18
JP2582888B2 (ja) 1997-02-19
IL87908A0 (en) 1989-03-31
KR890701562A (ko) 1989-12-20
NO173824C (no) 1994-02-09

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Legal Events

Date Code Title Description
B1 Patent granted (law 1993)
PUP Patent expired