NO173824C - Analogifremgangsmaate ved fremstilling av immunomodulerende azaspiraner - Google Patents

Analogifremgangsmaate ved fremstilling av immunomodulerende azaspiraner

Info

Publication number
NO173824C
NO173824C NO901392A NO901392A NO173824C NO 173824 C NO173824 C NO 173824C NO 901392 A NO901392 A NO 901392A NO 901392 A NO901392 A NO 901392A NO 173824 C NO173824 C NO 173824C
Authority
NO
Norway
Prior art keywords
preparation
immunomodulatory
azaspirans
analogous procedure
azaspiranes
Prior art date
Application number
NO901392A
Other languages
English (en)
Norwegian (no)
Other versions
NO901392L (no
NO901392D0 (no
NO173824B (no
Inventor
Alison Mary Badger
Elaine Nicholas Cheeseman
Michael John Dimartino
James Woodrow Dorman
Christopher Kevin Mirabelli
Donald Harold Picker
David Aaron Schwartz
Original Assignee
Smithkline Beckman Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smithkline Beckman Corp filed Critical Smithkline Beckman Corp
Publication of NO901392L publication Critical patent/NO901392L/no
Publication of NO901392D0 publication Critical patent/NO901392D0/no
Publication of NO173824B publication Critical patent/NO173824B/no
Publication of NO173824C publication Critical patent/NO173824C/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/20—Spiro-condensed ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • C—CHEMISTRY; METALLURGY
    • C04—CEMENTS; CONCRETE; ARTIFICIAL STONE; CERAMICS; REFRACTORIES
    • C04B—LIME, MAGNESIA; SLAG; CEMENTS; COMPOSITIONS THEREOF, e.g. MORTARS, CONCRETE OR LIKE BUILDING MATERIALS; ARTIFICIAL STONE; CERAMICS; REFRACTORIES; TREATMENT OF NATURAL STONE
    • C04B35/00—Shaped ceramic products characterised by their composition; Ceramics compositions; Processing powders of inorganic compounds preparatory to the manufacturing of ceramic products
    • C04B35/01—Shaped ceramic products characterised by their composition; Ceramics compositions; Processing powders of inorganic compounds preparatory to the manufacturing of ceramic products based on oxide ceramics
    • C04B35/45—Shaped ceramic products characterised by their composition; Ceramics compositions; Processing powders of inorganic compounds preparatory to the manufacturing of ceramic products based on oxide ceramics based on copper oxide or solid solutions thereof with other oxides
    • C04B35/4504—Shaped ceramic products characterised by their composition; Ceramics compositions; Processing powders of inorganic compounds preparatory to the manufacturing of ceramic products based on oxide ceramics based on copper oxide or solid solutions thereof with other oxides containing rare earth oxides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/54—Spiro-condensed
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/96—Spiro-condensed ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/22—Bridged ring systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Ceramic Engineering (AREA)
  • Manufacturing & Machinery (AREA)
  • Structural Engineering (AREA)
  • Materials Engineering (AREA)
  • Pain & Pain Management (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Rheumatology (AREA)
  • Transplantation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
NO901392A 1987-09-28 1990-03-27 Analogifremgangsmaate ved fremstilling av immunomodulerende azaspiraner NO173824C (no)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US10170487A 1987-09-28 1987-09-28
US07/244,229 US4963557A (en) 1987-09-28 1988-09-13 Immunomodulatory azaspiranes
PCT/US1988/003323 WO1989002889A1 (en) 1987-09-28 1988-09-27 Immunomodulatory azaspiranes

Publications (4)

Publication Number Publication Date
NO901392L NO901392L (no) 1990-03-27
NO901392D0 NO901392D0 (no) 1990-03-27
NO173824B NO173824B (no) 1993-11-01
NO173824C true NO173824C (no) 1994-02-09

Family

ID=26798539

Family Applications (1)

Application Number Title Priority Date Filing Date
NO901392A NO173824C (no) 1987-09-28 1990-03-27 Analogifremgangsmaate ved fremstilling av immunomodulerende azaspiraner

Country Status (24)

Country Link
US (1) US4963557A (da)
EP (1) EP0310321B1 (da)
JP (1) JP2582888B2 (da)
KR (1) KR0166336B1 (da)
CN (1) CN1031618C (da)
AT (1) ATE114463T1 (da)
AU (1) AU619780B2 (da)
CA (1) CA1313189C (da)
CY (1) CY1955A (da)
DE (1) DE3852266T2 (da)
DK (1) DK170042B1 (da)
ES (1) ES2064356T3 (da)
FI (1) FI93006C (da)
GR (1) GR3014931T3 (da)
HK (1) HK1006274A1 (da)
HU (1) HU208809B (da)
IE (1) IE67891B1 (da)
IL (1) IL87908A (da)
MX (1) MX9203765A (da)
NO (1) NO173824C (da)
NZ (1) NZ226354A (da)
PT (1) PT88603B (da)
WO (1) WO1989002889A1 (da)
ZW (1) ZW12388A1 (da)

Families Citing this family (55)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6051596A (en) * 1990-08-10 2000-04-18 Anormed, Inc. Immunosuppressive compositions
KR100215167B1 (ko) * 1990-08-10 1999-08-16 위샤르트 아이 시 면역 억제 조성물
JPH06501468A (ja) * 1990-09-24 1994-02-17 スミスクライン・ビーチャム・コーポレイション 方法
ZA921120B (en) * 1991-02-19 1993-01-27 Smithkline Beecham Corp Cytokine inhibitors
US5591748A (en) * 1991-06-07 1997-01-07 Smithkline Beecham Corporation Immunomodulatory azaspiranes
PT100566B (pt) * 1991-06-07 1999-06-30 Smithkline Beecham Corp Azaspiranos imunomoduladores, composicoes farmaceuticas que os contem, sua preparacao e seu uso
GB9122721D0 (en) * 1991-10-25 1991-12-11 Smithkline Beecham Corp Methods
US5455247A (en) * 1991-10-25 1995-10-03 Smithkline Beecham Corporation Methods for the treatment of hyperlipidemia using azaspiranes
GB9122735D0 (en) * 1991-10-25 1991-12-11 Smithkline Beecham Corp Methods
US7105152B1 (en) 1991-12-18 2006-09-12 3M Innovative Properties Company Suspension aerosol formulations
US7101534B1 (en) 1991-12-18 2006-09-05 3M Innovative Properties Company Suspension aerosol formulations
DE69218455T2 (de) * 1991-12-18 1997-10-23 Minnesota Mining And Mfg. Co., Saint Paul, Minn. Aerosolzusammensetzungen für arzneimittelsuspensionen
GB9201803D0 (en) * 1992-01-28 1992-03-11 Smithkline Beecham Corp Methods
GB9201804D0 (en) * 1992-01-28 1992-03-11 Smithkline Beecham Corp Methods
US5482959A (en) * 1992-01-28 1996-01-09 Smithkline Beecham Corporation Method for delaying aids in an HIV infected individual by administration of substituted azaspirane compounds
DE4222459C2 (de) * 1992-07-08 1995-09-14 Sigma Tau Ind Farmaceuti 3,9-disubstituierte-Spiro[5.5]undecane, ein Verfahren zu deren Herstellung und pharmazeutische Zusammensetzungen, die diese enthalten
GB9217116D0 (en) * 1992-08-13 1992-09-23 Smithkline Beecham Corp Methods
GB9217121D0 (en) * 1992-08-13 1992-09-23 Smithkline Beecham Corp Methods
US5484788A (en) * 1993-03-26 1996-01-16 Beth Israel Hospital Association Buspirone as a systemic immunosuppressant
US5631017A (en) * 1993-03-26 1997-05-20 Beth Israel Deaconess Medical Center, Inc. Topical application of buspirone for treatment of pathological conditions associated with immune responses
ES2201074T3 (es) * 1993-03-26 2004-03-16 Beth Israel Hospital Association Utilizacion topica o sistemica de buspirona o de derivados de esta para el tratamiento de trastornos patologicos asociados con reacciones inmunitarias.
US5708019A (en) * 1993-04-28 1998-01-13 Smithkline Beecham Corporation Methods of treating hyperlipidemia using azaspirane derivatives
GB9308780D0 (en) * 1993-04-28 1993-06-09 Smithkline Beecham Corp Methods
US5505948A (en) * 1993-06-01 1996-04-09 Dermatology Home Products, Inc. Home skin peel composition for producing healthy and attractive skin
GB9315271D0 (en) * 1993-07-23 1993-09-08 Smithkline Beecham Corp Methods
GB9315341D0 (en) * 1993-07-23 1993-09-08 Smithkline Beecham Corp Methods
GB9315351D0 (en) * 1993-07-23 1993-09-08 Smithkline Beecham Corp Methods
GB9315340D0 (en) * 1993-07-23 1993-09-08 Smithkline Beecham Corp Methods
GB9315306D0 (en) * 1993-07-23 1993-09-08 Smithkline Beecham Corp Methods
GB9315298D0 (en) * 1993-07-23 1993-09-08 Smithkline Beecham Corp Methods
US5461054A (en) * 1993-12-09 1995-10-24 Bayer Aktiengesellschaft Anthracene-spiro-pyrrolindines
GB9325854D0 (en) * 1993-12-17 1994-02-23 Smithkline Beecham Corp Porcess
GB9414901D0 (en) * 1994-07-23 1994-09-14 Smithkline Beecham Corp Methods
US5786376A (en) * 1994-07-23 1998-07-28 Smithkline Beecham Corporation Methods of treating opportunistic infections with azaspiranes
GB9414902D0 (en) * 1994-07-23 1994-09-14 Smithkline Beecham Corp Methods
US5734061A (en) * 1994-12-07 1998-03-31 Smithkline Beecham Corporation Process for preparing spirocyclic lactams
US5637314A (en) * 1995-06-07 1997-06-10 Beth Israel Deaconess Medical Center, Inc. Topical and systemic application of buspirone or derivatives thereof for treating atopic dermatitis
AU6636996A (en) * 1995-07-13 1997-02-10 Anormed Inc. 2-{2-(dimethylamino)ethyl}-8,8-dipropyl-2-azaspiro{4.5}decan edimaleate
BR9601909A (pt) * 1995-07-13 1999-10-13 Smithkline Beecham Corp N,n-dietil-8,8-dipropil-2-azaspiro(4,5)decano-2-propan amina dimaleato
US5939450A (en) * 1995-07-13 1999-08-17 Anormed Inc. N,N-dimethyl-8,8-dipropyl-2-azaspiro 4.5!decane-2-propanamine dimaleate
BG62359B1 (bg) * 1995-07-13 1999-09-30 Anormed N,n-диетил-8,8-дипропил-2-азаспиро[4,5]декан-2-пропанаминдималеат
WO1997044030A1 (en) * 1996-05-17 1997-11-27 Anormed Inc. Use of substituted azaspirane in the treatment of asthma
US5843936A (en) * 1996-06-28 1998-12-01 Bernstein; Lawrence R. Topical administration of azaspiranes to prevent or treat skin conditions associated with hyperproliferation of keratinocytes
GB0208742D0 (en) 2002-04-17 2002-05-29 Bradford Particle Design Ltd Particulate materials
US7582284B2 (en) 2002-04-17 2009-09-01 Nektar Therapeutics Particulate materials
JP4458514B2 (ja) * 2002-07-18 2010-04-28 第一三共株式会社 高純度のエナミン類の製造方法
US20070015780A1 (en) * 2003-03-10 2007-01-18 Picker Donald H Method of treating cancer with azaspirane compositions
US20110104186A1 (en) 2004-06-24 2011-05-05 Nicholas Valiante Small molecule immunopotentiators and assays for their detection
WO2006010379A1 (en) 2004-07-29 2006-02-02 Actelion Pharmaceuticals Ltd. Novel thiophene derivatives as immunosuppressive agents
CN101948462A (zh) * 2004-09-20 2011-01-19 塔加西普特公司 具有烟碱性胆碱能受体活性的氮杂螺烯和氮杂螺烷化合物
SI1863787T1 (sl) 2005-03-23 2011-10-28 Actelion Pharmaceuticals Ltd Hidrogenirani benzo(c)tiofenski derivati kot imunomodulatorji
AR057894A1 (es) 2005-11-23 2007-12-26 Actelion Pharmaceuticals Ltd Derivados de tiofeno
US8178562B2 (en) 2006-01-24 2012-05-15 Actelion Pharmaceuticals, Ltd. Pyridine derivatives
CA2646140C (en) * 2006-02-13 2015-04-28 The Board Of Trustees Of The Leland Stanford Junior University Blockade of gamma-secretase activity to promote myelination by oligodendrocytes
ES2691033T3 (es) 2007-02-11 2018-11-23 Map Pharmaceuticals Inc. Método de administración terapéutica de DHE para activar el alivio rápido de la migraña a la vez que se reduce al mínimo el perfil de los efectos secundarios

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3256277A (en) * 1966-06-14 Azaspiro alkanes
GB823338A (en) * 1956-11-07 1959-11-11 Thomae Gmbh Dr K Diquaternary salts of aminoalkyl piperidines
US3106552A (en) * 1960-07-19 1963-10-08 Geschickter Fund Med Res Nu-substituted azaspiranes and azaspirane-diones and processes for their preparation
US3418324A (en) * 1961-03-13 1968-12-24 Geschickter Fund Med Res Heterocyclic secondary amines
US3282947A (en) * 1962-05-17 1966-11-01 Geschickter Fund Med Res Unsymmetrically substituted 3, 9-diazaspiro(5, 5)undecane compounds
BE648317A (da) * 1963-05-27
US3424755A (en) * 1964-03-09 1969-01-28 Rolf Denss 4-piperidine-p-fluorobutyrophenones and related compounds
US3432499A (en) * 1965-04-02 1969-03-11 Geschickter Fund Med Res Trifluoromethylazaspiranes and azaspirane diones
DE1770697C3 (de) * 1967-07-06 1981-04-23 Dupher International Research B.V., Weesp 2,2-(N-Methyl-2-azatetramethylen)- -adamantan, dessen Salze, Verfahren zu deren Herstellung und Arzneimittel
BE759371A (fr) * 1969-11-24 1971-05-24 Bristol Myers Co Azaspirodecanediones heterocycliques et procedes pour leur preparation
BE788490A (fr) * 1971-09-08 1973-01-02 Geschickter Fund Med Res Azaspiranes substitues par du silicium ou du germanium, leur preparation et compositions pharmaceutiques les contenant
US4468393A (en) * 1982-12-06 1984-08-28 Unimed, Inc. Treatment of arthritis
WO1985005031A1 (en) * 1984-05-09 1985-11-21 The Australian National University A method for the modulation of the immune response
JPH0662407B2 (ja) * 1984-12-25 1994-08-17 株式会社三和化学研究所 安定化された３―オキシゲルミルプロピオン酸ポリマーを有効成分とする免疫調整剤
US4654333A (en) * 1986-02-18 1987-03-31 Unimed, Inc. Treatment of multiple sclerosis

Also Published As

Publication number Publication date
FI901530A0 (fi) 1990-03-27
US4963557A (en) 1990-10-16
HU885889D0 (en) 1991-11-28
NO901392L (no) 1990-03-27
CY1955A (en) 1997-05-16
NZ226354A (en) 1991-02-26
FI93006B (fi) 1994-10-31
NO901392D0 (no) 1990-03-27
CN1032437A (zh) 1989-04-19
DK77090D0 (da) 1990-03-23
FI93006C (fi) 1995-02-10
NO173824B (no) 1993-11-01
HU208809B (en) 1995-06-28
DE3852266D1 (de) 1995-01-12
AU2533388A (en) 1989-04-18
EP0310321A3 (en) 1991-02-06
EP0310321B1 (en) 1994-11-30
JPH03500290A (ja) 1991-01-24
IL87908A0 (en) 1989-03-31
DK77090A (da) 1990-03-23
ATE114463T1 (de) 1994-12-15
PT88603B (pt) 1992-12-31
MX9203765A (es) 1992-07-01
IE882929L (en) 1989-03-28
ES2064356T3 (es) 1995-02-01
IL87908A (en) 1993-02-21
DE3852266T2 (de) 1995-05-18
CA1313189C (en) 1993-01-26
IE67891B1 (en) 1996-05-01
ZW12388A1 (en) 1989-01-04
AU619780B2 (en) 1992-02-06
DK170042B1 (da) 1995-05-08
WO1989002889A1 (en) 1989-04-06
HK1006274A1 (en) 1999-02-19
KR0166336B1 (ko) 1999-01-15
GR3014931T3 (en) 1995-05-31
KR890701562A (ko) 1989-12-20
PT88603A (pt) 1988-10-01
JP2582888B2 (ja) 1997-02-19
HUT57722A (en) 1991-12-30
CN1031618C (zh) 1996-04-24
EP0310321A2 (en) 1989-04-05

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