DK77090A - Immunmodulerende azaspiraner - Google Patents

Immunmodulerende azaspiraner Download PDF

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Publication number
DK77090A
DK77090A DK077090A DK77090A DK77090A DK 77090 A DK77090 A DK 77090A DK 077090 A DK077090 A DK 077090A DK 77090 A DK77090 A DK 77090A DK 77090 A DK77090 A DK 77090A
Authority
DK
Denmark
Prior art keywords
azaspiran
azaspirans
immunomodulatory
animal
derivative
Prior art date
Application number
DK077090A
Other languages
English (en)
Other versions
DK170042B1 (da
DK77090D0 (da
Inventor
Alison Mary Badger
David Aaron Schwartz
Elaine Nicholas Cheeseman
Michael John Dimartino
James Woodrow Dorman
Christopher Kevin Mirabelli
Donald Harold Picker
Original Assignee
Smithkline Beckman Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smithkline Beckman Corp filed Critical Smithkline Beckman Corp
Publication of DK77090A publication Critical patent/DK77090A/da
Publication of DK77090D0 publication Critical patent/DK77090D0/da
Application granted granted Critical
Publication of DK170042B1 publication Critical patent/DK170042B1/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/20—Spiro-condensed ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • C—CHEMISTRY; METALLURGY
    • C04—CEMENTS; CONCRETE; ARTIFICIAL STONE; CERAMICS; REFRACTORIES
    • C04B—LIME, MAGNESIA; SLAG; CEMENTS; COMPOSITIONS THEREOF, e.g. MORTARS, CONCRETE OR LIKE BUILDING MATERIALS; ARTIFICIAL STONE; CERAMICS; REFRACTORIES; TREATMENT OF NATURAL STONE
    • C04B35/00—Shaped ceramic products characterised by their composition; Ceramics compositions; Processing powders of inorganic compounds preparatory to the manufacturing of ceramic products
    • C04B35/01—Shaped ceramic products characterised by their composition; Ceramics compositions; Processing powders of inorganic compounds preparatory to the manufacturing of ceramic products based on oxide ceramics
    • C04B35/45—Shaped ceramic products characterised by their composition; Ceramics compositions; Processing powders of inorganic compounds preparatory to the manufacturing of ceramic products based on oxide ceramics based on copper oxide or solid solutions thereof with other oxides
    • C04B35/4504—Shaped ceramic products characterised by their composition; Ceramics compositions; Processing powders of inorganic compounds preparatory to the manufacturing of ceramic products based on oxide ceramics based on copper oxide or solid solutions thereof with other oxides containing rare earth oxides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/54—Spiro-condensed
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/96—Spiro-condensed ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/22—Bridged ring systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Ceramic Engineering (AREA)
  • Manufacturing & Machinery (AREA)
  • Materials Engineering (AREA)
  • Structural Engineering (AREA)
  • Rheumatology (AREA)
  • Biomedical Technology (AREA)
  • Transplantation (AREA)
  • Pain & Pain Management (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Saccharide Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DK077090A 1987-09-28 1990-03-23 Immunmodulerende azaspiraner, farmaceutiske midler, der indeholder dem, samt anvendelse af azaspiranerne til fremstilling af et immunmodulerende middel DK170042B1 (da)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US10170487A 1987-09-28 1987-09-28
US10170487 1987-09-28
US07/244,229 US4963557A (en) 1987-09-28 1988-09-13 Immunomodulatory azaspiranes
US24422988 1988-09-13
PCT/US1988/003323 WO1989002889A1 (en) 1987-09-28 1988-09-27 Immunomodulatory azaspiranes
US8803323 1988-09-27

Publications (3)

Publication Number Publication Date
DK77090A true DK77090A (da) 1990-03-23
DK77090D0 DK77090D0 (da) 1990-03-23
DK170042B1 DK170042B1 (da) 1995-05-08

Family

ID=26798539

Family Applications (1)

Application Number Title Priority Date Filing Date
DK077090A DK170042B1 (da) 1987-09-28 1990-03-23 Immunmodulerende azaspiraner, farmaceutiske midler, der indeholder dem, samt anvendelse af azaspiranerne til fremstilling af et immunmodulerende middel

Country Status (24)

Country Link
US (1) US4963557A (da)
EP (1) EP0310321B1 (da)
JP (1) JP2582888B2 (da)
KR (1) KR0166336B1 (da)
CN (1) CN1031618C (da)
AT (1) ATE114463T1 (da)
AU (1) AU619780B2 (da)
CA (1) CA1313189C (da)
CY (1) CY1955A (da)
DE (1) DE3852266T2 (da)
DK (1) DK170042B1 (da)
ES (1) ES2064356T3 (da)
FI (1) FI93006C (da)
GR (1) GR3014931T3 (da)
HK (1) HK1006274A1 (da)
HU (1) HU208809B (da)
IE (1) IE67891B1 (da)
IL (1) IL87908A (da)
MX (1) MX9203765A (da)
NO (1) NO173824C (da)
NZ (1) NZ226354A (da)
PT (1) PT88603B (da)
WO (1) WO1989002889A1 (da)
ZW (1) ZW12388A1 (da)

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US6051596A (en) * 1990-08-10 2000-04-18 Anormed, Inc. Immunosuppressive compositions
WO1992004899A1 (en) * 1990-09-24 1992-04-02 Smithkline Beecham Corporation Methods
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US5591748A (en) * 1991-06-07 1997-01-07 Smithkline Beecham Corporation Immunomodulatory azaspiranes
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GB9122735D0 (en) * 1991-10-25 1991-12-11 Smithkline Beecham Corp Methods
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GB9217121D0 (en) * 1992-08-13 1992-09-23 Smithkline Beecham Corp Methods
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GB9315351D0 (en) * 1993-07-23 1993-09-08 Smithkline Beecham Corp Methods
GB9315340D0 (en) * 1993-07-23 1993-09-08 Smithkline Beecham Corp Methods
GB9315306D0 (en) * 1993-07-23 1993-09-08 Smithkline Beecham Corp Methods
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US5786376A (en) * 1994-07-23 1998-07-28 Smithkline Beecham Corporation Methods of treating opportunistic infections with azaspiranes
GB9414901D0 (en) * 1994-07-23 1994-09-14 Smithkline Beecham Corp Methods
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US5734061A (en) * 1994-12-07 1998-03-31 Smithkline Beecham Corporation Process for preparing spirocyclic lactams
US5637314A (en) * 1995-06-07 1997-06-10 Beth Israel Deaconess Medical Center, Inc. Topical and systemic application of buspirone or derivatives thereof for treating atopic dermatitis
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KR101382733B1 (ko) 2005-03-23 2014-04-14 액테리온 파마슈티칼 리미티드 면역조절물질로서의 수첨 벤조(ｃ) 티오펜 유도체
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Also Published As

Publication number Publication date
JP2582888B2 (ja) 1997-02-19
US4963557A (en) 1990-10-16
CN1032437A (zh) 1989-04-19
NZ226354A (en) 1991-02-26
EP0310321A2 (en) 1989-04-05
JPH03500290A (ja) 1991-01-24
ES2064356T3 (es) 1995-02-01
KR890701562A (ko) 1989-12-20
HU208809B (en) 1995-06-28
IE882929L (en) 1989-03-28
WO1989002889A1 (en) 1989-04-06
NO173824C (no) 1994-02-09
AU619780B2 (en) 1992-02-06
CA1313189C (en) 1993-01-26
MX9203765A (es) 1992-07-01
CY1955A (en) 1997-05-16
AU2533388A (en) 1989-04-18
EP0310321A3 (en) 1991-02-06
ZW12388A1 (en) 1989-01-04
ATE114463T1 (de) 1994-12-15
DE3852266T2 (de) 1995-05-18
FI901530A0 (fi) 1990-03-27
NO901392L (no) 1990-03-27
DE3852266D1 (de) 1995-01-12
CN1031618C (zh) 1996-04-24
HU885889D0 (en) 1991-11-28
DK170042B1 (da) 1995-05-08
NO901392D0 (no) 1990-03-27
IL87908A (en) 1993-02-21
IL87908A0 (en) 1989-03-31
IE67891B1 (en) 1996-05-01
GR3014931T3 (en) 1995-05-31
DK77090D0 (da) 1990-03-23
HUT57722A (en) 1991-12-30
PT88603B (pt) 1992-12-31
FI93006C (fi) 1995-02-10
NO173824B (no) 1993-11-01
KR0166336B1 (ko) 1999-01-15
EP0310321B1 (en) 1994-11-30
FI93006B (fi) 1994-10-31
PT88603A (pt) 1988-10-01
HK1006274A1 (en) 1999-02-19

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B1 Patent granted (law 1993)
PUP Patent expired