FI102177B1 - Menetelmä uusien terapeuttisesti aktiivisten kromaani- ja tiokromaanijohdannaisten valmistamiseksi ja välituotteet - Google Patents

Menetelmä uusien terapeuttisesti aktiivisten kromaani- ja tiokromaanijohdannaisten valmistamiseksi ja välituotteet

Info

Publication number
FI102177B1
FI102177B1 FI913943A FI913943A FI102177B1 FI 102177 B1 FI102177 B1 FI 102177B1 FI 913943 A FI913943 A FI 913943A FI 913943 A FI913943 A FI 913943A FI 102177 B1 FI102177 B1 FI 102177B1
Authority
FI
Finland
Prior art keywords
preparation
chromane
intermediates
therapeutically active
novel therapeutically
Prior art date
Application number
FI913943A
Other languages
English (en)
Swedish (sv)
Other versions
FI102177B (fi
FI913943A0 (fi
Inventor
Lars-Gunnar Larsson
Rolf Noreen
Lucy Anna Renyi
Svante Bertil Ross
Daniel Dungan Sohn
Bjoern Eric Svensson
Seth Olov Thorberg
Original Assignee
Astra Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astra Ab filed Critical Astra Ab
Publication of FI913943A0 publication Critical patent/FI913943A0/fi
Application granted granted Critical
Publication of FI102177B publication Critical patent/FI102177B/fi
Publication of FI102177B1 publication Critical patent/FI102177B1/fi

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Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D335/00Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom
    • C07D335/04Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D335/06Benzothiopyrans; Hydrogenated benzothiopyrans
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/20Hypnotics; Sedatives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/24Antidepressants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/26Psychostimulants, e.g. nicotine, cocaine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D311/00Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D407/00Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/04Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D409/00Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D409/00Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/06Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D409/00Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D417/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Pain & Pain Management (AREA)
  • Anesthesiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Pyrane Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Cosmetics (AREA)
  • Threshing Machine Elements (AREA)
  • Liquid Crystal Substances (AREA)
  • Bakery Products And Manufacturing Methods Therefor (AREA)
  • Apparatuses For Bulk Treatment Of Fruits And Vegetables And Apparatuses For Preparing Feeds (AREA)
  • Medicinal Preparation (AREA)
  • Harvester Elements (AREA)
  • Curing Cements, Concrete, And Artificial Stone (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Emulsifying, Dispersing, Foam-Producing Or Wetting Agents (AREA)
FI913943A 1989-12-22 1991-08-21 Menetelmä uusien terapeuttisesti aktiivisten kromaani- ja tiokromaanijohdannaisten valmistamiseksi ja välituotteet FI102177B1 (fi)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
SE8904361 1989-12-22
SE8904361A SE8904361D0 (sv) 1989-12-22 1989-12-22 New chroman and thiochroman derivatives
SE9000863 1990-03-12
PCT/SE1990/000863 WO1991009853A1 (en) 1989-12-22 1990-12-19 New chroman and thiochroman derivatives

Publications (3)

Publication Number Publication Date
FI913943A0 FI913943A0 (fi) 1991-08-21
FI102177B FI102177B (fi) 1998-10-30
FI102177B1 true FI102177B1 (fi) 1998-10-30

Family

ID=20377869

Family Applications (1)

Application Number Title Priority Date Filing Date
FI913943A FI102177B1 (fi) 1989-12-22 1991-08-21 Menetelmä uusien terapeuttisesti aktiivisten kromaani- ja tiokromaanijohdannaisten valmistamiseksi ja välituotteet

Country Status (42)

Country Link
EP (1) EP0460169B1 (fi)
JP (1) JP2879972B2 (fi)
KR (1) KR0178991B1 (fi)
CN (1) CN1037438C (fi)
AT (1) ATE138918T1 (fi)
AU (1) AU641204B2 (fi)
CA (1) CA2047237C (fi)
CY (1) CY1991A (fi)
CZ (1) CZ283630B6 (fi)
DE (1) DE69027311T2 (fi)
DK (1) DK0460169T3 (fi)
DZ (1) DZ1469A1 (fi)
EG (1) EG19749A (fi)
ES (1) ES2087993T3 (fi)
FI (1) FI102177B1 (fi)
GR (1) GR3020497T3 (fi)
HK (1) HK55897A (fi)
HR (1) HRP920851B1 (fi)
HU (1) HU211860A9 (fi)
ID (1) ID945B (fi)
IE (1) IE80753B1 (fi)
IL (1) IL96712A (fi)
IS (1) IS1665B (fi)
LT (1) LT3967B (fi)
LV (2) LV10449B (fi)
MX (1) MX23889A (fi)
NO (1) NO180336C (fi)
NZ (1) NZ236407A (fi)
PH (1) PH30797A (fi)
PL (3) PL164592B1 (fi)
PT (1) PT96304B (fi)
RU (1) RU2092483C1 (fi)
SA (1) SA90110186B1 (fi)
SE (1) SE8904361D0 (fi)
SG (1) SG48043A1 (fi)
SI (1) SI9012429B (fi)
SK (1) SK657890A3 (fi)
TW (1) TW221056B (fi)
UA (1) UA34416C2 (fi)
WO (1) WO1991009853A1 (fi)
YU (2) YU47936B (fi)
ZA (1) ZA909708B (fi)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5420151A (en) * 1989-12-22 1995-05-30 Aktiebolaget Astra Chroman derivatives
ATE149480T1 (de) * 1990-08-15 1997-03-15 Lilly Co Eli Ring-substituierte 2-amino-1,2,3,4-tetra- hydronaphthaline, 3-aminochromane und 3- aminothiochromane
NZ241495A (en) * 1991-02-08 1994-10-26 Lilly Co Eli 2-amino-1,2,3,4-tetrahydronaphthalene and 3-aminochromane derivative, preparation and pharmaceutical compositions thereof
HRP920935A2 (en) * 1991-10-08 1995-08-31 Astra Ab New therapeutically active compound
SE9103745D0 (sv) * 1991-12-18 1991-12-18 Wikstroem Haakan Aryl-triflates and related compounds
FR2691149B1 (fr) * 1992-05-18 1994-07-08 Adir Nouveaux composes thiochromaniques, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent.
US5434174A (en) * 1992-07-17 1995-07-18 Eli Lilly And Company Isoxazole derivatives for the treatment of irritable bowel syndrome
SE9301732D0 (sv) * 1993-05-18 1993-05-18 Haakan Wilhelm Wikstroem New centrally acting 5-,6-,7-, and 8-substituted sulphone esters of n-monosubstituted 2-aminotetralins
SE9703378D0 (sv) * 1997-09-18 1997-09-18 Astra Ab New compounds
SE9703377D0 (sv) 1997-09-18 1997-09-18 Astra Ab New compounds
US6184226B1 (en) 1998-08-28 2001-02-06 Scios Inc. Quinazoline derivatives as inhibitors of P-38 α
AU2002217742B2 (en) 2001-01-16 2008-02-21 Astrazeneca Ab Therapeutic heterocyclic compounds
EP1353915A2 (en) * 2001-01-16 2003-10-22 AstraZeneca AB Therapeutic chroman compounds
BR0206513A (pt) 2001-01-16 2004-01-06 Astrazeneca Ab Composição, métodos de tratamento de um ser humano ou animal que sofre de depressão, ansiedade generalizada, distúrbios da alimentação, demência, distúrbio do p nico, distúrbios do sono, distúrbios gastrointestinais, distúrbios motores, distúrbios endócrinos, vasoespasmo e disfunção sexual, uso de qualquer um dos compostos, composição farmacêutica, e, processo para preparar compostos
US7504395B2 (en) 2001-07-20 2009-03-17 Psychogenics, Inc. Treatment for attention-deficit hyperactivity disorder
US7125904B2 (en) 2002-10-11 2006-10-24 Portela & C.A., S.A. Peripherally-selective inhibitors of dopamine-β-hydroxylase and method of their preparation
SE0301795D0 (sv) * 2003-06-19 2003-06-19 Astrazeneca Ab New use I
SE0301796D0 (sv) * 2003-06-19 2003-06-19 Astrazeneca Ab New use II
US20080221193A1 (en) * 2006-12-22 2008-09-11 Wyeth 3-amino chromane derivatives
SA08290245B1 (ar) * 2007-04-23 2012-02-12 استرازينيكا ايه بي مشتقات كربو كساميد جديدة من -n (8-اريل رباعي هيدرو نفثالين غير متجانس- 2- يل) أو -n (5-اريل كرومان غير متجانس -3-يل) لعلاج الألم
CN101712672B (zh) * 2008-10-06 2013-02-06 中国中医科学院中药研究所 一种治疗心脑血管系统疾病新化合物及其制备方法、用途
DE102010041948A1 (de) 2010-10-04 2012-04-05 Mahle International Gmbh Filtereinrichtung
GB201316410D0 (en) 2013-09-13 2013-10-30 Bial Portela & Ca Sa Processes for preparing peripherally-selective inhibitors of dopamine-?-hydroxylase and intermediates for use therein

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PH22522A (en) * 1985-09-03 1988-10-17 Ciba Geigy Ag 3-amino-dihydro-1-benzopyrans and benzothiopyrans, their pharmaceutical compositions and method of using said compounds
US4801605A (en) * 1986-08-29 1989-01-31 Ciba-Geigy Corporation 3-amino-dihydro-[1]-benzopyrans and benzothiopyrans
SE8605504D0 (sv) * 1986-12-19 1986-12-19 Astra Laekemedel Ab Novel chroman derivatives
US5258287A (en) * 1988-03-22 1993-11-02 Genentech, Inc. DNA encoding and methods of production of insulin-like growth factor binding protein BP53

Also Published As

Publication number Publication date
WO1991009853A1 (en) 1991-07-11
PL293065A1 (en) 1992-08-10
PH30797A (en) 1997-10-17
JP2879972B2 (ja) 1999-04-05
HK55897A (en) 1997-05-09
SG48043A1 (en) 1998-04-17
PL164608B1 (pl) 1994-08-31
NZ236407A (en) 1993-08-26
DE69027311D1 (en) 1996-07-11
CZ283630B6 (cs) 1998-05-13
MX23889A (es) 1993-10-01
TW221056B (fi) 1994-02-11
YU72191A (sh) 1995-01-31
CY1991A (en) 1997-09-05
GR3020497T3 (en) 1996-10-31
NO913273L (no) 1991-10-08
SE8904361D0 (sv) 1989-12-22
IL96712A (en) 1995-08-31
PL164592B1 (pl) 1994-08-31
AU641204B2 (en) 1993-09-16
YU47923B (sh) 1996-05-20
JPH04503682A (ja) 1992-07-02
KR920701193A (ko) 1992-08-11
YU47936B (sh) 1996-05-20
LT3967B (en) 1996-05-27
YU242990A (sh) 1993-10-20
CZ657890A3 (cs) 1998-02-18
LV11894A (lv) 1997-12-20
IE80753B1 (en) 1999-01-13
KR0178991B1 (ko) 1999-03-20
DK0460169T3 (da) 1996-09-23
IS1665B (is) 1997-07-04
SK280261B6 (sk) 1999-10-08
FI102177B (fi) 1998-10-30
UA34416C2 (uk) 2001-03-15
DE69027311T2 (de) 1996-10-24
RU2092483C1 (ru) 1997-10-10
NO180336B (no) 1996-12-23
AU6977091A (en) 1991-07-24
DZ1469A1 (fr) 2004-09-13
PT96304A (pt) 1991-09-30
CN1037438C (zh) 1998-02-18
LV11894B (en) 1998-05-20
PT96304B (pt) 1998-09-30
HRP920851A2 (en) 1995-10-31
NO180336C (no) 1997-04-02
IL96712A0 (en) 1991-09-16
EP0460169A1 (en) 1991-12-11
NO913273D0 (no) 1991-08-21
ES2087993T3 (es) 1996-08-01
HRP920851B1 (en) 2000-02-29
CA2047237C (en) 2003-02-11
IE904535A1 (en) 1991-07-03
ID945B (id) 1996-09-20
SI9012429A (en) 1997-12-31
PL293066A1 (en) 1992-08-10
IS3662A7 (is) 1991-06-23
LV10449B (en) 1995-10-20
EG19749A (en) 1996-01-31
ZA909708B (en) 1991-08-28
CA2047237A1 (en) 1991-06-23
FI913943A0 (fi) 1991-08-21
SK657890A3 (en) 1999-10-08
LV10449A (lv) 1995-02-20
CN1052669A (zh) 1991-07-03
SI9012429B (sl) 1998-10-31
PL164609B1 (en) 1994-08-31
LTIP1730A (en) 1995-08-25
SA90110186B1 (ar) 2001-11-11
EP0460169B1 (en) 1996-06-05
HU211860A9 (en) 1995-12-28
ATE138918T1 (de) 1996-06-15

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