YU47936B - Derivati hromana i tiohromana i postupak za njihovo dobijanje - Google Patents

Derivati hromana i tiohromana i postupak za njihovo dobijanje

Info

Publication number
YU47936B
YU47936B YU242990A YU242990A YU47936B YU 47936 B YU47936 B YU 47936B YU 242990 A YU242990 A YU 242990A YU 242990 A YU242990 A YU 242990A YU 47936 B YU47936 B YU 47936B
Authority
YU
Yugoslavia
Prior art keywords
chromane
procedure
production
thiochromane
derivatives
Prior art date
Application number
YU242990A
Other languages
English (en)
Other versions
YU242990A (sh
Inventor
L.G. Larsson
R. Noreen
L.A. Renyi
S.B. Ross
D.D. Sohn
B.E. Svensson
S.O. Thorberg
Original Assignee
Aktiebolaget Astra
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aktiebolaget Astra filed Critical Aktiebolaget Astra
Priority to SI9012429A priority Critical patent/SI9012429B/sl
Priority to HRP-2429/90A priority patent/HRP920851B1/xx
Publication of YU242990A publication Critical patent/YU242990A/sh
Publication of YU47936B publication Critical patent/YU47936B/sh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D335/00—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom
    • C07D335/04—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D335/06—Benzothiopyrans; Hydrogenated benzothiopyrans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Pain & Pain Management (AREA)
  • Anesthesiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pyrane Compounds (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Cosmetics (AREA)
  • Liquid Crystal Substances (AREA)
  • Threshing Machine Elements (AREA)
  • Bakery Products And Manufacturing Methods Therefor (AREA)
  • Harvester Elements (AREA)
  • Apparatuses For Bulk Treatment Of Fruits And Vegetables And Apparatuses For Preparing Feeds (AREA)
  • Curing Cements, Concrete, And Artificial Stone (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Emulsifying, Dispersing, Foam-Producing Or Wetting Agents (AREA)
  • Medicinal Preparation (AREA)

Abstract

Derivati hromana i tiohromana formule: u kojoj (O)p X je O ili S; p je ceo broj 0,1 ili 2; R je vodonik, fluor ili C1-6 alkil; R1 je vodonik, C1-6 alkil ili C2-6 alkenil; R2 je vodonik C1-6 alkil, C2-6 alkenil, C1-4 alkilaril, gde aril može sadržati 1 ili 2 heteroatoma birana od N, O ili S, a pri čemu je ili (i) eventualno supstituisan sa jednim ili više supstituenata nezavisno biranih od halogena, CN, CF3, C1-6 alkila, C2-6 alkenila ili C1-4 alkoksi, ili je (ii) vezan za dva susedna atoma ugljenika za rilni prsten, pri čemu je taj arilni prsten eventualno supstituisan sa jednim ili više supstituenata nezavino biranih od halogena, CN, CF3, C1-6 alkila, C2-6 alkenila ili C1-4 alkoksi; R4 je vodonik ili halogen; R5 je vodonik, C1-6 alkil ili C2-6 alkenil; R6 je C1-6 alkil ili C2-6 alenil; R5 i R6 mogu zajednički obrazovati 5- ili 6-člani prsten koji može sadržati 1 ili 2 heteroatoma birana od N, O ili S; R7 je vodonik, hidroksi, hlor, brom, C1-6 alkil, C2-6 alkenil, C1-4 alkoksi, NR8R9 ili 5- ili 6-člani aril koji može sadržati 1 ili 2 heteroatoma birana od N, O ili S, i koji je eventualno supstituisan sa jednim ili više halogena, CN, CF3, C1-6 alkilom, C2-6 alkenilom ili C1-4 alkoksi; R8 i R9 su oba nezavisno vodonik, C1-6 alkil, C2-6 alkenil, 5- ili 6-člani aril koji može sadržati 1 ili dva heteroatoma birana od N, O ili S, eventualno supstituisana halogenom, CN, CF3, C1-6 alkilom, C2-6 alkenilom, C1-4 alkoksi, ili mogu zajedno obrazovati jedan 5- ili 6-člani prsten koji sadrži 1 ili 2 heteroatoma birana od N, O ili S; njegov enantiomer ili so. Prijava sadrži još 1 nezavisan i 16 zavisnih zahteva.
YU242990A 1989-12-22 1990-12-21 Derivati hromana i tiohromana i postupak za njihovo dobijanje YU47936B (sh)

Priority Applications (2)

Application Number Priority Date Filing Date Title
SI9012429A SI9012429B (sl) 1989-12-22 1990-12-21 Novi derivati kromana in tiokromana
HRP-2429/90A HRP920851B1 (en) 1989-12-22 1992-10-02 New chroman and thiochroman derivatives

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SE8904361A SE8904361D0 (sv) 1989-12-22 1989-12-22 New chroman and thiochroman derivatives

Publications (2)

Publication Number Publication Date
YU242990A YU242990A (sh) 1993-10-20
YU47936B true YU47936B (sh) 1996-05-20

Family

ID=20377869

Family Applications (2)

Application Number Title Priority Date Filing Date
YU242990A YU47936B (sh) 1989-12-22 1990-12-21 Derivati hromana i tiohromana i postupak za njihovo dobijanje
YU72191A YU47923B (sh) 1989-12-22 1991-04-22 Uredjaj za sečenje biljne mase sa dva rezna diska i sa više od jednim kontra nožem

Family Applications After (1)

Application Number Title Priority Date Filing Date
YU72191A YU47923B (sh) 1989-12-22 1991-04-22 Uredjaj za sečenje biljne mase sa dva rezna diska i sa više od jednim kontra nožem

Country Status (42)

Country Link
EP (1) EP0460169B1 (sh)
JP (1) JP2879972B2 (sh)
KR (1) KR0178991B1 (sh)
CN (1) CN1037438C (sh)
AT (1) ATE138918T1 (sh)
AU (1) AU641204B2 (sh)
CA (1) CA2047237C (sh)
CY (1) CY1991A (sh)
CZ (1) CZ283630B6 (sh)
DE (1) DE69027311T2 (sh)
DK (1) DK0460169T3 (sh)
DZ (1) DZ1469A1 (sh)
EG (1) EG19749A (sh)
ES (1) ES2087993T3 (sh)
FI (1) FI102177B (sh)
GR (1) GR3020497T3 (sh)
HK (1) HK55897A (sh)
HR (1) HRP920851B1 (sh)
HU (1) HU211860A9 (sh)
ID (1) ID945B (sh)
IE (1) IE80753B1 (sh)
IL (1) IL96712A (sh)
IS (1) IS1665B (sh)
LT (1) LT3967B (sh)
LV (2) LV10449B (sh)
MX (1) MX23889A (sh)
NO (1) NO180336C (sh)
NZ (1) NZ236407A (sh)
PH (1) PH30797A (sh)
PL (3) PL164609B1 (sh)
PT (1) PT96304B (sh)
RU (1) RU2092483C1 (sh)
SA (1) SA90110186B1 (sh)
SE (1) SE8904361D0 (sh)
SG (1) SG48043A1 (sh)
SI (1) SI9012429B (sh)
SK (1) SK657890A3 (sh)
TW (1) TW221056B (sh)
UA (1) UA34416C2 (sh)
WO (1) WO1991009853A1 (sh)
YU (2) YU47936B (sh)
ZA (1) ZA909708B (sh)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5420151A (en) * 1989-12-22 1995-05-30 Aktiebolaget Astra Chroman derivatives
ES2100211T3 (es) * 1990-08-15 1997-06-16 Lilly Co Eli 2-amino-1,2,3,4-tetrahidronaftalenos, 3-aminocromanos y 3-aminotiocromanos sustituidos en el anillo.
ES2102456T3 (es) * 1991-02-08 1997-08-01 Lilly Co Eli 3-amino-1,2,3,4-tetrahidronaftalenos sustituidos en el anillo.
HRP920935A2 (en) * 1991-10-08 1995-08-31 Astra Ab New therapeutically active compound
SE9103745D0 (sv) * 1991-12-18 1991-12-18 Wikstroem Haakan Aryl-triflates and related compounds
FR2691149B1 (fr) * 1992-05-18 1994-07-08 Adir Nouveaux composes thiochromaniques, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent.
US5434174A (en) * 1992-07-17 1995-07-18 Eli Lilly And Company Isoxazole derivatives for the treatment of irritable bowel syndrome
SE9301732D0 (sv) * 1993-05-18 1993-05-18 Haakan Wilhelm Wikstroem New centrally acting 5-,6-,7-, and 8-substituted sulphone esters of n-monosubstituted 2-aminotetralins
SE9703378D0 (sv) * 1997-09-18 1997-09-18 Astra Ab New compounds
SE9703377D0 (sv) 1997-09-18 1997-09-18 Astra Ab New compounds
US6184226B1 (en) 1998-08-28 2001-02-06 Scios Inc. Quinazoline derivatives as inhibitors of P-38 α
MXPA03006268A (es) 2001-01-16 2003-09-22 Astrazeneca Ab Compuestos terapeuticos de cromano.
AU2002217742B2 (en) 2001-01-16 2008-02-21 Astrazeneca Ab Therapeutic heterocyclic compounds
CA2434015A1 (en) * 2001-01-16 2002-07-18 Astrazeneca Ab Therapeutic chroman compounds
WO2003007956A1 (en) 2001-07-20 2003-01-30 Psychogenics, Inc. Treatment for attention-deficit hyperactivity disorder
US7125904B2 (en) 2002-10-11 2006-10-24 Portela & C.A., S.A. Peripherally-selective inhibitors of dopamine-β-hydroxylase and method of their preparation
SE0301796D0 (sv) * 2003-06-19 2003-06-19 Astrazeneca Ab New use II
SE0301795D0 (sv) * 2003-06-19 2003-06-19 Astrazeneca Ab New use I
WO2008080120A2 (en) * 2006-12-22 2008-07-03 Wyeth 3-amino chromane derivatives
SA08290245B1 (ar) * 2007-04-23 2012-02-12 استرازينيكا ايه بي مشتقات كربو كساميد جديدة من -n (8-اريل رباعي هيدرو نفثالين غير متجانس- 2- يل) أو -n (5-اريل كرومان غير متجانس -3-يل) لعلاج الألم
CN101712672B (zh) * 2008-10-06 2013-02-06 中国中医科学院中药研究所 一种治疗心脑血管系统疾病新化合物及其制备方法、用途
DE102010041948A1 (de) 2010-10-04 2012-04-05 Mahle International Gmbh Filtereinrichtung
GB201316410D0 (en) 2013-09-13 2013-10-30 Bial Portela & Ca Sa Processes for preparing peripherally-selective inhibitors of dopamine-?-hydroxylase and intermediates for use therein

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3679378D1 (de) * 1985-09-03 1991-06-27 Ciba Geigy Ag 3-amino-dihydro-(1)-benzopyrane und benzothiopyrane.
US4801605A (en) * 1986-08-29 1989-01-31 Ciba-Geigy Corporation 3-amino-dihydro-[1]-benzopyrans and benzothiopyrans
SE8605504D0 (sv) * 1986-12-19 1986-12-19 Astra Laekemedel Ab Novel chroman derivatives
US5258287A (en) * 1988-03-22 1993-11-02 Genentech, Inc. DNA encoding and methods of production of insulin-like growth factor binding protein BP53

Also Published As

Publication number Publication date
KR0178991B1 (ko) 1999-03-20
NO913273D0 (no) 1991-08-21
PL293066A1 (en) 1992-08-10
ES2087993T3 (es) 1996-08-01
PL164609B1 (en) 1994-08-31
YU47923B (sh) 1996-05-20
EP0460169A1 (en) 1991-12-11
IS1665B (is) 1997-07-04
FI102177B1 (fi) 1998-10-30
CZ283630B6 (cs) 1998-05-13
IE904535A1 (en) 1991-07-03
LV11894A (lv) 1997-12-20
IL96712A0 (en) 1991-09-16
FI913943A0 (fi) 1991-08-21
AU641204B2 (en) 1993-09-16
PL164592B1 (pl) 1994-08-31
ZA909708B (en) 1991-08-28
NZ236407A (en) 1993-08-26
LV10449B (en) 1995-10-20
HU211860A9 (en) 1995-12-28
IS3662A7 (is) 1991-06-23
KR920701193A (ko) 1992-08-11
SI9012429A (en) 1997-12-31
LV11894B (en) 1998-05-20
IE80753B1 (en) 1999-01-13
ID945B (id) 1996-09-20
LT3967B (en) 1996-05-27
PT96304B (pt) 1998-09-30
SE8904361D0 (sv) 1989-12-22
NO180336B (no) 1996-12-23
CA2047237A1 (en) 1991-06-23
YU72191A (sh) 1995-01-31
NO913273L (no) 1991-10-08
JP2879972B2 (ja) 1999-04-05
HK55897A (en) 1997-05-09
MX23889A (es) 1993-10-01
NO180336C (no) 1997-04-02
SK280261B6 (sk) 1999-10-08
PH30797A (en) 1997-10-17
UA34416C2 (uk) 2001-03-15
EP0460169B1 (en) 1996-06-05
FI102177B (fi) 1998-10-30
GR3020497T3 (en) 1996-10-31
JPH04503682A (ja) 1992-07-02
DE69027311D1 (en) 1996-07-11
AU6977091A (en) 1991-07-24
SI9012429B (sl) 1998-10-31
CA2047237C (en) 2003-02-11
SK657890A3 (en) 1999-10-08
YU242990A (sh) 1993-10-20
LTIP1730A (en) 1995-08-25
HRP920851B1 (en) 2000-02-29
DE69027311T2 (de) 1996-10-24
PL164608B1 (pl) 1994-08-31
TW221056B (sh) 1994-02-11
DZ1469A1 (fr) 2004-09-13
ATE138918T1 (de) 1996-06-15
CZ657890A3 (cs) 1998-02-18
RU2092483C1 (ru) 1997-10-10
HRP920851A2 (en) 1995-10-31
PT96304A (pt) 1991-09-30
EG19749A (en) 1996-01-31
CN1052669A (zh) 1991-07-03
WO1991009853A1 (en) 1991-07-11
SG48043A1 (en) 1998-04-17
LV10449A (lv) 1995-02-20
PL293065A1 (en) 1992-08-10
CN1037438C (zh) 1998-02-18
SA90110186B1 (ar) 2001-11-11
CY1991A (en) 1997-09-05
DK0460169T3 (da) 1996-09-23
IL96712A (en) 1995-08-31

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