LT3967B - New chroman and thiochroman derivatives - Google Patents

New chroman and thiochroman derivatives Download PDF

Info

Publication number
LT3967B
LT3967B LTIP1730A LTIP1730A LT3967B LT 3967 B LT3967 B LT 3967B LT IP1730 A LTIP1730 A LT IP1730A LT IP1730 A LTIP1730 A LT IP1730A LT 3967 B LT3967 B LT 3967B
Authority
LT
Lithuania
Prior art keywords
alkyl
formula
alkenyl
compound
hydrogen
Prior art date
Application number
LTIP1730A
Other languages
English (en)
Lithuanian (lt)
Inventor
Lars-Gunnar Larsson
Rolf Noreen
Lucy Anna Renyi
Svante Bertil Ross
Daniel Dungan Sohn
Bjoern Eric Svensson
Seth Olov Thorberg
Original Assignee
Astra Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astra Ab filed Critical Astra Ab
Publication of LTIP1730A publication Critical patent/LTIP1730A/xx
Publication of LT3967B publication Critical patent/LT3967B/lt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D335/00—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom
    • C07D335/04—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D335/06—Benzothiopyrans; Hydrogenated benzothiopyrans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Pain & Pain Management (AREA)
  • Anesthesiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pyrane Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Cosmetics (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Threshing Machine Elements (AREA)
  • Bakery Products And Manufacturing Methods Therefor (AREA)
  • Liquid Crystal Substances (AREA)
  • Apparatuses For Bulk Treatment Of Fruits And Vegetables And Apparatuses For Preparing Feeds (AREA)
  • Medicinal Preparation (AREA)
  • Harvester Elements (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Curing Cements, Concrete, And Artificial Stone (AREA)
  • Emulsifying, Dispersing, Foam-Producing Or Wetting Agents (AREA)
LTIP1730A 1989-12-22 1993-12-30 New chroman and thiochroman derivatives LT3967B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SE8904361A SE8904361D0 (sv) 1989-12-22 1989-12-22 New chroman and thiochroman derivatives

Publications (2)

Publication Number Publication Date
LTIP1730A LTIP1730A (en) 1995-08-25
LT3967B true LT3967B (en) 1996-05-27

Family

ID=20377869

Family Applications (1)

Application Number Title Priority Date Filing Date
LTIP1730A LT3967B (en) 1989-12-22 1993-12-30 New chroman and thiochroman derivatives

Country Status (42)

Country Link
EP (1) EP0460169B1 (fi)
JP (1) JP2879972B2 (fi)
KR (1) KR0178991B1 (fi)
CN (1) CN1037438C (fi)
AT (1) ATE138918T1 (fi)
AU (1) AU641204B2 (fi)
CA (1) CA2047237C (fi)
CY (1) CY1991A (fi)
CZ (1) CZ283630B6 (fi)
DE (1) DE69027311T2 (fi)
DK (1) DK0460169T3 (fi)
DZ (1) DZ1469A1 (fi)
EG (1) EG19749A (fi)
ES (1) ES2087993T3 (fi)
FI (1) FI102177B (fi)
GR (1) GR3020497T3 (fi)
HK (1) HK55897A (fi)
HR (1) HRP920851B1 (fi)
HU (1) HU211860A9 (fi)
ID (1) ID945B (fi)
IE (1) IE80753B1 (fi)
IL (1) IL96712A (fi)
IS (1) IS1665B (fi)
LT (1) LT3967B (fi)
LV (2) LV10449B (fi)
MX (1) MX23889A (fi)
NO (1) NO180336C (fi)
NZ (1) NZ236407A (fi)
PH (1) PH30797A (fi)
PL (3) PL164592B1 (fi)
PT (1) PT96304B (fi)
RU (1) RU2092483C1 (fi)
SA (1) SA90110186B1 (fi)
SE (1) SE8904361D0 (fi)
SG (1) SG48043A1 (fi)
SI (1) SI9012429B (fi)
SK (1) SK280261B6 (fi)
TW (1) TW221056B (fi)
UA (1) UA34416C2 (fi)
WO (1) WO1991009853A1 (fi)
YU (2) YU47936B (fi)
ZA (1) ZA909708B (fi)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5420151A (en) * 1989-12-22 1995-05-30 Aktiebolaget Astra Chroman derivatives
DK0471515T3 (da) * 1990-08-15 1997-07-21 Lilly Co Eli Ringsubstituerede 2-amino-1,2,3,4-tetrahydronphtalener, 3-aminochromaner og 3-aminothiochromaner
NZ241495A (en) * 1991-02-08 1994-10-26 Lilly Co Eli 2-amino-1,2,3,4-tetrahydronaphthalene and 3-aminochromane derivative, preparation and pharmaceutical compositions thereof
HRP920935A2 (en) * 1991-10-08 1995-08-31 Astra Ab New therapeutically active compound
SE9103745D0 (sv) * 1991-12-18 1991-12-18 Wikstroem Haakan Aryl-triflates and related compounds
FR2691149B1 (fr) * 1992-05-18 1994-07-08 Adir Nouveaux composes thiochromaniques, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent.
US5434174A (en) * 1992-07-17 1995-07-18 Eli Lilly And Company Isoxazole derivatives for the treatment of irritable bowel syndrome
SE9301732D0 (sv) * 1993-05-18 1993-05-18 Haakan Wilhelm Wikstroem New centrally acting 5-,6-,7-, and 8-substituted sulphone esters of n-monosubstituted 2-aminotetralins
SE9703377D0 (sv) * 1997-09-18 1997-09-18 Astra Ab New compounds
SE9703378D0 (sv) * 1997-09-18 1997-09-18 Astra Ab New compounds
US6184226B1 (en) 1998-08-28 2001-02-06 Scios Inc. Quinazoline derivatives as inhibitors of P-38 α
BR0206512A (pt) 2001-01-16 2004-01-06 Astrazeneca Ab Composto, método de tratamento de um ser humano ou animal que sofre de depressão, ansiedade generalizada, distúrbios da alimentação, demência, distúrbio do p nico, distúrbios do sono, distúrbios gastrointestinais, distúrbios motores, distúrbios endócrinos, vasoespasmo e disfunção sexual, uso de um composto, e, processo para preparar um composto.
IL156601A0 (en) * 2001-01-16 2004-01-04 Astrazeneca Ab Therapeutic chroman compounds
IL156602A0 (en) 2001-01-16 2004-01-04 Astrazeneca Ab Therapeutic chromone compounds
US7504395B2 (en) 2001-07-20 2009-03-17 Psychogenics, Inc. Treatment for attention-deficit hyperactivity disorder
US7125904B2 (en) 2002-10-11 2006-10-24 Portela & C.A., S.A. Peripherally-selective inhibitors of dopamine-β-hydroxylase and method of their preparation
SE0301796D0 (sv) * 2003-06-19 2003-06-19 Astrazeneca Ab New use II
SE0301795D0 (sv) * 2003-06-19 2003-06-19 Astrazeneca Ab New use I
WO2008080120A2 (en) * 2006-12-22 2008-07-03 Wyeth 3-amino chromane derivatives
SA08290245B1 (ar) * 2007-04-23 2012-02-12 استرازينيكا ايه بي مشتقات كربو كساميد جديدة من -n (8-اريل رباعي هيدرو نفثالين غير متجانس- 2- يل) أو -n (5-اريل كرومان غير متجانس -3-يل) لعلاج الألم
CN101712672B (zh) * 2008-10-06 2013-02-06 中国中医科学院中药研究所 一种治疗心脑血管系统疾病新化合物及其制备方法、用途
DE102010041948A1 (de) 2010-10-04 2012-04-05 Mahle International Gmbh Filtereinrichtung
GB201316410D0 (en) 2013-09-13 2013-10-30 Bial Portela & Ca Sa Processes for preparing peripherally-selective inhibitors of dopamine-?-hydroxylase and intermediates for use therein

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0222996A2 (de) 1985-09-03 1987-05-27 Ciba-Geigy Ag 3-Amino-dihydro-[1]-benzopyrane und Benzothiopyrane

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4801605A (en) * 1986-08-29 1989-01-31 Ciba-Geigy Corporation 3-amino-dihydro-[1]-benzopyrans and benzothiopyrans
SE8605504D0 (sv) * 1986-12-19 1986-12-19 Astra Laekemedel Ab Novel chroman derivatives
US5258287A (en) * 1988-03-22 1993-11-02 Genentech, Inc. DNA encoding and methods of production of insulin-like growth factor binding protein BP53

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0222996A2 (de) 1985-09-03 1987-05-27 Ciba-Geigy Ag 3-Amino-dihydro-[1]-benzopyrane und Benzothiopyrane

Also Published As

Publication number Publication date
PT96304B (pt) 1998-09-30
PL164609B1 (en) 1994-08-31
EP0460169A1 (en) 1991-12-11
DK0460169T3 (da) 1996-09-23
PT96304A (pt) 1991-09-30
JP2879972B2 (ja) 1999-04-05
ID945B (id) 1996-09-20
GR3020497T3 (en) 1996-10-31
IL96712A0 (en) 1991-09-16
HU211860A9 (en) 1995-12-28
NO913273L (no) 1991-10-08
CA2047237C (en) 2003-02-11
MX23889A (es) 1993-10-01
ES2087993T3 (es) 1996-08-01
CN1037438C (zh) 1998-02-18
SE8904361D0 (sv) 1989-12-22
DE69027311T2 (de) 1996-10-24
LV10449A (lv) 1995-02-20
LV10449B (en) 1995-10-20
PL164592B1 (pl) 1994-08-31
UA34416C2 (uk) 2001-03-15
YU72191A (sh) 1995-01-31
SG48043A1 (en) 1998-04-17
EP0460169B1 (en) 1996-06-05
FI913943A0 (fi) 1991-08-21
SK657890A3 (en) 1999-10-08
RU2092483C1 (ru) 1997-10-10
NO913273D0 (no) 1991-08-21
NO180336C (no) 1997-04-02
IL96712A (en) 1995-08-31
HK55897A (en) 1997-05-09
HRP920851B1 (en) 2000-02-29
YU47923B (sh) 1996-05-20
SA90110186B1 (ar) 2001-11-11
CZ657890A3 (cs) 1998-02-18
YU242990A (sh) 1993-10-20
LV11894A (lv) 1997-12-20
LTIP1730A (en) 1995-08-25
DE69027311D1 (en) 1996-07-11
FI102177B1 (fi) 1998-10-30
SK280261B6 (sk) 1999-10-08
CA2047237A1 (en) 1991-06-23
DZ1469A1 (fr) 2004-09-13
HRP920851A2 (en) 1995-10-31
SI9012429B (sl) 1998-10-31
EG19749A (en) 1996-01-31
NO180336B (no) 1996-12-23
JPH04503682A (ja) 1992-07-02
PH30797A (en) 1997-10-17
AU641204B2 (en) 1993-09-16
SI9012429A (en) 1997-12-31
FI102177B (fi) 1998-10-30
ATE138918T1 (de) 1996-06-15
LV11894B (en) 1998-05-20
CZ283630B6 (cs) 1998-05-13
AU6977091A (en) 1991-07-24
PL164608B1 (pl) 1994-08-31
ZA909708B (en) 1991-08-28
WO1991009853A1 (en) 1991-07-11
IS3662A7 (is) 1991-06-23
CY1991A (en) 1997-09-05
IE904535A1 (en) 1991-07-03
NZ236407A (en) 1993-08-26
KR0178991B1 (ko) 1999-03-20
PL293065A1 (en) 1992-08-10
YU47936B (sh) 1996-05-20
IE80753B1 (en) 1999-01-13
PL293066A1 (en) 1992-08-10
TW221056B (fi) 1994-02-11
KR920701193A (ko) 1992-08-11
CN1052669A (zh) 1991-07-03
IS1665B (is) 1997-07-04

Similar Documents

Publication Publication Date Title
LT3967B (en) New chroman and thiochroman derivatives
DE60312998T2 (de) 1-amido-4-phenyl-4-benzyloxymethyl-piperidin derivative und verwandte verbindungen als neurokinin-1 (nk-1) antagonsisten zur behandlung von erbrechen, depressionen, angstzustände und husten
US5650524A (en) Process for preparing (R)-3-amino-5-methoxychroman
JP4964380B2 (ja) ピラゾールカルボン酸の三環式誘導体、その製造法およびそれを含む医薬組成物
HU198014B (en) Process for producing antiarithmic sulfonamides and pharmaceutical compositions containing them
SK280731B6 (sk) 8-substituované 2-aminotetralíny, spôsob ich výrob
JPH07107047B2 (ja) 新規ヘテロ環式化合物及びその製法
WO2004113325A1 (de) Indol-derivate als serotonin-wiederaufnahme-inhibitoren
KR940011151B1 (ko) 시클로알킬 우레아 화합물
RU2237668C2 (ru) Новые соли морфолинобензамида, способ их получения, фармацевтическая композиция на их основе и способ лечения
JP3786983B2 (ja) ピロリジノン誘導体
US4792559A (en) 1,2,3,4-tetrahydroquinoline substituted 5-aminopentanenitrile compounds and their use as calcium modulators
JP3786984B2 (ja) ピペラジン誘導体
US6110943A (en) N-substituted (thiophen-2-yl)-piperidines and tetrahydropyridines as serotonergic agents

Legal Events

Date Code Title Description
MM9A Lapsed patents

Effective date: 20061230