GB823338A - Diquaternary salts of aminoalkyl piperidines - Google Patents

Diquaternary salts of aminoalkyl piperidines

Info

Publication number
GB823338A
GB823338A GB34624/57A GB3462457A GB823338A GB 823338 A GB823338 A GB 823338A GB 34624/57 A GB34624/57 A GB 34624/57A GB 3462457 A GB3462457 A GB 3462457A GB 823338 A GB823338 A GB 823338A
Authority
GB
United Kingdom
Prior art keywords
compound
formula
different
represent
alkyl groups
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB34624/57A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Boehringer Ingelheim Pharma GmbH and Co KG
Original Assignee
Dr Karl Thomae GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dr Karl Thomae GmbH filed Critical Dr Karl Thomae GmbH
Publication of GB823338A publication Critical patent/GB823338A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/20—Spiro-condensed ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/10—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms
    • C07D211/14—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The invention comprises compounds of the general formula <FORM:0823338/IV (a)/1> (wherein R1 and R2, which may be the same or different, represent alkyl or aralkyl groups or jointly form with C4 a 5-10 membered ring which is unsubstituted or substituted by one or more alkyl groups of 1-6 carbon atoms, R3 and R4 represent hydrogen atoms, R5 and R6, and X1 and X2, represent identical or different alkyl groups, n is an integer from 2 to 6, and Y1- and Y2- represent identical or different anions of inorganic or organic acids); the preparation thereof by quaternizing a compound of the formula <FORM:0823338/IV (a)/2> with a compound X1Y1 and/or a compound X2Y2, or by reacting a compound of the formula <FORM:0823338/IV (a)/3> with a compound of the formula <FORM:0823338/IV (a)/4> (wherein A1 represents an atom or group reactive with the N-substituted piperidine), and in either case, if desired, replacing Y1- and/or Y2- by another anion or anions, e.g. with the aid of an ion exchange resin; and pharmaceutical compositions containing the products (see Group VI). Bis-tertiary amines of the second general formula above are prepared by reducing cyclic amides of the formula <FORM:0823338/IV (a)/5> or by reacting a compound of the formula <FORM:0823338/IV (a)/6> with a compound of the formula <FORM:0823338/IV (a)/7>ALSO:Compositions for the treatment of hypertension, lung oedema or circulatory disorders comprise, in admixture with a compatible pharmaceutical carrier, one or more ganglion-blocking agents of the general formula <FORM:0823338/VI/1> wherein R1 and R2, which may be the same or different, represent alkyl or aralkyl groups or jointly form with C4 a 5-10 membered ring which is unsubstituted or substituted by one or more alkyl groups of 1-6 carbon atoms, R3 and R4 represent hydrogen atoms, R5 and R6, and X1 and X2 represent identical or different alkyl groups, n is an integer from 2 to 6, and Y1- and Y2- represent identical or different anions of inorganic or organic acids. The compositions may be in the form of ampoules, tablets, capsules or drops for oral administration, or an injectable form, e.g. in pyrogen-free water, for parenteral administration.
GB34624/57A 1956-11-07 1957-11-06 Diquaternary salts of aminoalkyl piperidines Expired GB823338A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE823338X 1956-11-07

Publications (1)

Publication Number Publication Date
GB823338A true GB823338A (en) 1959-11-11

Family

ID=6745993

Family Applications (1)

Application Number Title Priority Date Filing Date
GB34624/57A Expired GB823338A (en) 1956-11-07 1957-11-06 Diquaternary salts of aminoalkyl piperidines

Country Status (1)

Country Link
GB (1) GB823338A (en)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3106552A (en) * 1960-07-19 1963-10-08 Geschickter Fund Med Res Nu-substituted azaspiranes and azaspirane-diones and processes for their preparation
US4963557A (en) * 1987-09-28 1990-10-16 Smithkline Beecham Corporation Immunomodulatory azaspiranes
US5591748A (en) * 1991-06-07 1997-01-07 Smithkline Beecham Corporation Immunomodulatory azaspiranes

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3106552A (en) * 1960-07-19 1963-10-08 Geschickter Fund Med Res Nu-substituted azaspiranes and azaspirane-diones and processes for their preparation
US4963557A (en) * 1987-09-28 1990-10-16 Smithkline Beecham Corporation Immunomodulatory azaspiranes
US5591748A (en) * 1991-06-07 1997-01-07 Smithkline Beecham Corporation Immunomodulatory azaspiranes

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