GB936268A - 4-phenyl-4-carbalkoxy-piperidinium compounds, their manufacture and compositions containing them - Google Patents

4-phenyl-4-carbalkoxy-piperidinium compounds, their manufacture and compositions containing them

Info

Publication number
GB936268A
GB936268A GB528162A GB528162A GB936268A GB 936268 A GB936268 A GB 936268A GB 528162 A GB528162 A GB 528162A GB 528162 A GB528162 A GB 528162A GB 936268 A GB936268 A GB 936268A
Authority
GB
United Kingdom
Prior art keywords
compounds
general formula
alkyl
group
compositions containing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB528162A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Boehringer Ingelheim Pharma GmbH and Co KG
Original Assignee
Dr Karl Thomae GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dr Karl Thomae GmbH filed Critical Dr Karl Thomae GmbH
Publication of GB936268A publication Critical patent/GB936268A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D211/62—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals attached in position 4
    • C07D211/64—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals attached in position 4 having an aryl radical as the second substituent in position 4

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The invention comprises piperidinium compounds of the general formula: <FORM:0936268/IV(a)/1> (in which R1 is a C1-4 alkyl group, R2 and R3 are C3-7-alkyl or -alkenyl groups which may be the same or different, straight or branched chained, provided at least one of R2 and R3 is an alkenyl group, and X- is an anion); the preparation thereof by reacting a piperidine of the general formula: <FORM:0936268/IV(a)/2> with a compound R3Hal (Hal representing a halogen atom); and pharmaceutical compositions containing them (see Group VI). Specifications 935,318 and 935,410 are referred to.ALSO:Analgesic compositions comprise the compounds of the general formula <FORM:0936268/VI/1> (in which R1 is a C1-4-alkyl group, and R2 and R3 are the same or different, straight or branched chained C3-7-alkyl or -alkenyl groups, at least one of R2 and R3 being an alkenyl group, and X is an anion) together with a pharmaceutical diluent or excipient and optionally containing a morphinic analgesic such as morphine, meperidine or methadene. The piperidinium compounds, in addition, suppress the undesirable side effects of the morphinic analgesics. Compositions may be in forms suitable for oral or rectal administration but preferably in the form of solutions for parenteral administration. Examples of such solutions are given. Specifications 935,318 and 935,410 are referred to.
GB528162A 1961-02-11 1962-02-12 4-phenyl-4-carbalkoxy-piperidinium compounds, their manufacture and compositions containing them Expired GB936268A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DEB0061245 1961-02-11

Publications (1)

Publication Number Publication Date
GB936268A true GB936268A (en) 1963-09-11

Family

ID=6973129

Family Applications (1)

Application Number Title Priority Date Filing Date
GB528162A Expired GB936268A (en) 1961-02-11 1962-02-12 4-phenyl-4-carbalkoxy-piperidinium compounds, their manufacture and compositions containing them

Country Status (2)

Country Link
CH (1) CH408003A (en)
GB (1) GB936268A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3627772A (en) * 1969-11-13 1971-12-14 Boehringer Sohn Ingelheim 1-lower alkenyl-4-phenyl-4-carbonyl-piperidine derivatives and salts

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3627772A (en) * 1969-11-13 1971-12-14 Boehringer Sohn Ingelheim 1-lower alkenyl-4-phenyl-4-carbonyl-piperidine derivatives and salts

Also Published As

Publication number Publication date
CH408003A (en) 1966-02-28

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