GB936268A - 4-phenyl-4-carbalkoxy-piperidinium compounds, their manufacture and compositions containing them - Google Patents
4-phenyl-4-carbalkoxy-piperidinium compounds, their manufacture and compositions containing themInfo
- Publication number
- GB936268A GB936268A GB528162A GB528162A GB936268A GB 936268 A GB936268 A GB 936268A GB 528162 A GB528162 A GB 528162A GB 528162 A GB528162 A GB 528162A GB 936268 A GB936268 A GB 936268A
- Authority
- GB
- United Kingdom
- Prior art keywords
- compounds
- general formula
- alkyl
- group
- compositions containing
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D211/62—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals attached in position 4
- C07D211/64—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals attached in position 4 having an aryl radical as the second substituent in position 4
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The invention comprises piperidinium compounds of the general formula: <FORM:0936268/IV(a)/1> (in which R1 is a C1-4 alkyl group, R2 and R3 are C3-7-alkyl or -alkenyl groups which may be the same or different, straight or branched chained, provided at least one of R2 and R3 is an alkenyl group, and X- is an anion); the preparation thereof by reacting a piperidine of the general formula: <FORM:0936268/IV(a)/2> with a compound R3Hal (Hal representing a halogen atom); and pharmaceutical compositions containing them (see Group VI). Specifications 935,318 and 935,410 are referred to.ALSO:Analgesic compositions comprise the compounds of the general formula <FORM:0936268/VI/1> (in which R1 is a C1-4-alkyl group, and R2 and R3 are the same or different, straight or branched chained C3-7-alkyl or -alkenyl groups, at least one of R2 and R3 being an alkenyl group, and X is an anion) together with a pharmaceutical diluent or excipient and optionally containing a morphinic analgesic such as morphine, meperidine or methadene. The piperidinium compounds, in addition, suppress the undesirable side effects of the morphinic analgesics. Compositions may be in forms suitable for oral or rectal administration but preferably in the form of solutions for parenteral administration. Examples of such solutions are given. Specifications 935,318 and 935,410 are referred to.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DEB0061245 | 1961-02-11 |
Publications (1)
Publication Number | Publication Date |
---|---|
GB936268A true GB936268A (en) | 1963-09-11 |
Family
ID=6973129
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB528162A Expired GB936268A (en) | 1961-02-11 | 1962-02-12 | 4-phenyl-4-carbalkoxy-piperidinium compounds, their manufacture and compositions containing them |
Country Status (2)
Country | Link |
---|---|
CH (1) | CH408003A (en) |
GB (1) | GB936268A (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3627772A (en) * | 1969-11-13 | 1971-12-14 | Boehringer Sohn Ingelheim | 1-lower alkenyl-4-phenyl-4-carbonyl-piperidine derivatives and salts |
-
1962
- 1962-02-02 CH CH126462A patent/CH408003A/en unknown
- 1962-02-12 GB GB528162A patent/GB936268A/en not_active Expired
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3627772A (en) * | 1969-11-13 | 1971-12-14 | Boehringer Sohn Ingelheim | 1-lower alkenyl-4-phenyl-4-carbonyl-piperidine derivatives and salts |
Also Published As
Publication number | Publication date |
---|---|
CH408003A (en) | 1966-02-28 |
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