GB1018450A - New guanidine derivatives and process for preparing the same - Google Patents

New guanidine derivatives and process for preparing the same

Info

Publication number
GB1018450A
GB1018450A GB39059/65A GB3905965A GB1018450A GB 1018450 A GB1018450 A GB 1018450A GB 39059/65 A GB39059/65 A GB 39059/65A GB 3905965 A GB3905965 A GB 3905965A GB 1018450 A GB1018450 A GB 1018450A
Authority
GB
United Kingdom
Prior art keywords
acid addition
formula
free base
pharmaceutical preparations
amine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB39059/65A
Inventor
Patrick Michail Guy Bavin
Graham John Durant
Robert Geoffrey Willi Spickett
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Smith Kline and French Laboratories Ltd
Original Assignee
Smith Kline and French Laboratories Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smith Kline and French Laboratories Ltd filed Critical Smith Kline and French Laboratories Ltd
Priority to GB39059/65A priority Critical patent/GB1018450A/en
Publication of GB1018450A publication Critical patent/GB1018450A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C281/00—Derivatives of carbonic acid containing functional groups covered by groups C07C269/00 - C07C279/00 in which at least one nitrogen atom of these functional groups is further bound to another nitrogen atom not being part of a nitro or nitroso group
    • C07C281/16—Compounds containing any of the groups, e.g. aminoguanidine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C277/00—Preparation of guanidine or its derivatives, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
    • C07C277/08—Preparation of guanidine or its derivatives, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups of substituted guanidines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
    • C07C279/04—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

The invention comprises compounds of the general formula <FORM:1018450/C2/1> (wherein Ar is a phenyl group optionally substituted by one or more halogen atoms or C1-3 alkyl groups and B is an alkylene group containing 2, 3 or 4 chain carbon atoms) and acid addition salts thereof, pharmaceutical preparations containing them, and their preparation by reacting an amine of the formula Ar-S-B-NH2 with an isothiouronium salt having in its free base form the formula <FORM:1018450/C2/2> (wherein Alk is a C1-3 alkyl group), optionally followed by conversion of the resulting acid addition salt to the corresponding free base or a different acid addition salt. The amine starting materials are prepared by standard methods. The compounds of the invention block the peripheral sympathetic nervous system and may be administered orally or parenterally in the form of pharmaceutical preparations (e.g. tablets, lozenges, capsules or suspensions) containing them in association with a carrier.
GB39059/65A 1961-02-15 1961-02-15 New guanidine derivatives and process for preparing the same Expired GB1018450A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
GB39059/65A GB1018450A (en) 1961-02-15 1961-02-15 New guanidine derivatives and process for preparing the same

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB39059/65A GB1018450A (en) 1961-02-15 1961-02-15 New guanidine derivatives and process for preparing the same

Publications (1)

Publication Number Publication Date
GB1018450A true GB1018450A (en) 1966-01-26

Family

ID=10407388

Family Applications (1)

Application Number Title Priority Date Filing Date
GB39059/65A Expired GB1018450A (en) 1961-02-15 1961-02-15 New guanidine derivatives and process for preparing the same

Country Status (1)

Country Link
GB (1) GB1018450A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2068420A1 (en) * 1969-10-28 1971-08-27 Roussel Uclaf Benzothienyl methyl guanidine antihypertensive

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2068420A1 (en) * 1969-10-28 1971-08-27 Roussel Uclaf Benzothienyl methyl guanidine antihypertensive

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