BR9601909A - N,n-dietil-8,8-dipropil-2-azaspiro(4,5)decano-2-propan amina dimaleato - Google Patents

N,n-dietil-8,8-dipropil-2-azaspiro(4,5)decano-2-propan amina dimaleato

Info

Publication number
BR9601909A
BR9601909A BR9601909-3A BR9601909A BR9601909A BR 9601909 A BR9601909 A BR 9601909A BR 9601909 A BR9601909 A BR 9601909A BR 9601909 A BR9601909 A BR 9601909A
Authority
BR
Brazil
Prior art keywords
azaspiro
decane
dipropyl
diethyl
treatment
Prior art date
Application number
BR9601909-3A
Other languages
English (en)
Inventor
Raymond E Dagger
Carolyn W Grady
Original Assignee
Smithkline Beecham Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smithkline Beecham Corp filed Critical Smithkline Beecham Corp
Publication of BR9601909A publication Critical patent/BR9601909A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/54—Spiro-condensed

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Patente de Invenção:"N,N-DIETIL-8,8-DIPROPIL-2-AZASPIRO[4,5]DECANO- 2-PROPANAMINA DIMALEATO". A presente invenção refere-se a um agente imunomodulatório aperfeiçoado, o sal dimaleato de N, N-dietil-8,8-dipropil-2-azaspiro[4,5]decano-2-propanamina. O composto é representado pela Estrutura 1: (I) O composto desta invenção é útil como um agente imunomodulatório, particularmente no tratamento da artrite reumatóide. A N,N-dietil-8,8-dipropil-2-azaspiro[4,5]decano-2-propanamina é um composto divulgado e reivindicado juntamente com os sais, hidratos e solvatos farmaceuticamente aceitáveis do mesmo, como sendo útil como um agente imunomodulatório, particularmente no tratamento da artrite reumatóide. A N,N-dietil-8,8-dipropil-2-azaspiro[4,5]decano-2-propanamia compreende também uma composição farmacêutica e um veículo ou um diluente farmaceuticamente aceitável e, um método opara induzir a imunimodulação que compreende a administração de uma quantidade imunomodulatória eficaz a um paciente necessitando tal tratamento; e um método, no qual o paciente necessita tratamento para artrite reumatóide.
BR9601909-3A 1995-07-13 1996-07-03 N,n-dietil-8,8-dipropil-2-azaspiro(4,5)decano-2-propan amina dimaleato BR9601909A (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US113995P 1995-07-13 1995-07-13

Publications (1)

Publication Number Publication Date
BR9601909A true BR9601909A (pt) 1999-10-13

Family

ID=21694582

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9601909-3A BR9601909A (pt) 1995-07-13 1996-07-03 N,n-dietil-8,8-dipropil-2-azaspiro(4,5)decano-2-propan amina dimaleato

Country Status (3)

Country Link
US (1) US5744495A (pt)
BR (1) BR9601909A (pt)
ZA (1) ZA965882B (pt)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU6637096A (en) * 1995-07-13 1997-02-10 Smithkline Beecham Corporation N,n-dimethyl-8,8-dipropyl-2-azaspiro{4,5}decane-2-propanamin e dimaleate
JP2010503710A (ja) 2006-09-18 2010-02-04 ラプトール ファーマシューティカル インコーポレイテッド 受容体関連タンパク質（ｒａｐ）結合体の投与による肝障害の処置
US20100203146A1 (en) * 2009-02-09 2010-08-12 Callisto Pharmaceuticals, Inc. Intermittent dosing strategy for treating rheumatoid arthritis
US20120077778A1 (en) 2010-09-29 2012-03-29 Andrea Bourdelais Ladder-Frame Polyether Conjugates

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4963557A (en) * 1987-09-28 1990-10-16 Smithkline Beecham Corporation Immunomodulatory azaspiranes
KR100215167B1 (ko) * 1990-08-10 1999-08-16 위샤르트 아이 시 면역 억제 조성물
ZA921120B (en) * 1991-02-19 1993-01-27 Smithkline Beecham Corp Cytokine inhibitors
GB9122735D0 (en) * 1991-10-25 1991-12-11 Smithkline Beecham Corp Methods
US5482959A (en) * 1992-01-28 1996-01-09 Smithkline Beecham Corporation Method for delaying aids in an HIV infected individual by administration of substituted azaspirane compounds
GB9217116D0 (en) * 1992-08-13 1992-09-23 Smithkline Beecham Corp Methods
GB9315340D0 (en) * 1993-07-23 1993-09-08 Smithkline Beecham Corp Methods
GB9315351D0 (en) * 1993-07-23 1993-09-08 Smithkline Beecham Corp Methods
GB9315306D0 (en) * 1993-07-23 1993-09-08 Smithkline Beecham Corp Methods
GB9325854D0 (en) * 1993-12-17 1994-02-23 Smithkline Beecham Corp Porcess
GB9414902D0 (en) * 1994-07-23 1994-09-14 Smithkline Beecham Corp Methods
US5534522A (en) * 1995-06-07 1996-07-09 Warner-Lambert Company (R)-(Z)-1-azabicyclo [2.2.1] heptan-3-one,O-[3-(3-methoxyphenyl)-2-propynyl] oxime maleate as a pharmaceutical agent

Also Published As

Publication number Publication date
US5744495A (en) 1998-04-28
ZA965882B (en) 1997-01-29

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Legal Events

Date Code Title Description
PCP Transfer pending
HKT Transfer or change (deleted)
PC Transfer

Free format text: ANORMED INC. (CA)

FB34 Technical and formal requirements: requirement - article 34 of industrial property law
FB36 Technical and formal requirements: requirement - article 36 of industrial property law
FB36 Technical and formal requirements: requirement - article 36 of industrial property law
HJEG Technical examination (opinion): technical examination (opinion) related to article 229 of industrial property law
FM Others concerning applications: unknown petition
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 10A,11A E 12A ANUIDADES.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO PUBLICADO NA RPI 1971 DE 14/10/2008.