PT99445A - Processo para preparacao de derivados do 1,4,7,10-tetraazaciclododecano mono-n--substituidos e de composicoes farmaceuticas que os contem - Google Patents

Processo para preparacao de derivados do 1,4,7,10-tetraazaciclododecano mono-n--substituidos e de composicoes farmaceuticas que os contem

Info

Publication number
PT99445A
PT99445A PT99445A PT9944591A PT99445A PT 99445 A PT99445 A PT 99445A PT 99445 A PT99445 A PT 99445A PT 9944591 A PT9944591 A PT 9944591A PT 99445 A PT99445 A PT 99445A
Authority
PT
Portugal
Prior art keywords
tetraazacyclododean
mono
derivatives
substituted
preparation
Prior art date
Application number
PT99445A
Other languages
English (en)
Other versions
PT99445B (pt
Inventor
Heinz Gries
Hubert Vogler
Johannes Platzek
Hans-Joachim Weinmann
Wolf-Rudiger Press
Original Assignee
Schering Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Ag filed Critical Schering Ag
Publication of PT99445A publication Critical patent/PT99445A/pt
Publication of PT99445B publication Critical patent/PT99445B/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/24—Nuclear magnetic resonance, electron spin resonance or other spin effects or mass spectrometry

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Plural Heterocyclic Compounds (AREA)
PT99445A 1990-11-08 1991-11-07 Processo para preparacao de derivados do 1,4,7,10-tetraazaciclododecano mono-n--substituidos e de composicoes farmaceuticas que os contem PT99445B (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE4035760A DE4035760A1 (de) 1990-11-08 1990-11-08 Mono-n-substituierte 1,4,7,10-tetraazacyclododecan-derivate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische mittel

Publications (2)

Publication Number Publication Date
PT99445A true PT99445A (pt) 1992-09-30
PT99445B PT99445B (pt) 1999-04-30

Family

ID=6417983

Family Applications (1)

Application Number Title Priority Date Filing Date
PT99445A PT99445B (pt) 1990-11-08 1991-11-07 Processo para preparacao de derivados do 1,4,7,10-tetraazaciclododecano mono-n--substituidos e de composicoes farmaceuticas que os contem

Country Status (16)

Country Link
US (2) US5277895A (pt)
EP (1) EP0485045B1 (pt)
JP (1) JP3137700B2 (pt)
AT (1) ATE175201T1 (pt)
AU (1) AU8772691A (pt)
CA (1) CA2055093A1 (pt)
DE (2) DE4035760A1 (pt)
DK (1) DK0485045T3 (pt)
ES (1) ES2128307T3 (pt)
FI (1) FI915282A (pt)
GR (1) GR3029775T3 (pt)
IE (1) IE913899A1 (pt)
IL (1) IL100015A0 (pt)
NO (1) NO914356L (pt)
PT (1) PT99445B (pt)
ZA (1) ZA918893B (pt)

Families Citing this family (60)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5316757A (en) * 1984-10-18 1994-05-31 Board Of Regents, The University Of Texas System Synthesis of polyazamacrocycles with more than one type of side-chain chelating groups
US5362476A (en) * 1984-10-18 1994-11-08 Board Of Regents, The University Of Texas System Alkyl phosphonate polyazamacrocyclic cheates for MRI
GB9320277D0 (en) * 1993-10-01 1993-11-17 Nycomed Salutar Inc Chelants
US5650133A (en) * 1990-01-19 1997-07-22 Nycomed Salutar Macrocyclic polyaza dichelates linked through ring nitrogens via an amide or ester functionality
US5972307A (en) * 1989-10-23 1999-10-26 Nycomed Salutar, Inc. Dichelants
US5021409A (en) * 1989-12-21 1991-06-04 Johnson Matthey Plc Antiviral cyclic polyamines
DE4115789A1 (de) * 1991-05-10 1992-11-12 Schering Ag Makrocyclische polymer-komplexbildner, deren komplexe, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische mittel
TW213864B (pt) * 1991-08-01 1993-10-01 Squibb & Sons Inc
DE4237943C2 (de) * 1992-11-06 1997-10-23 Schering Ag Verfahren zur Herstellung von Metallkomplexen der N-beta-Hydroxyalkyl-tri-N-carboxyalkyl-1,4,7,10-tetraazacyclododecan- und N-beta-Hydroxyalkyl-tri-N-carboxyalkyl-1,4,8,11-tetraazacyclotetradecan-Derivate
US5410043A (en) * 1991-12-06 1995-04-25 Schering Aktiengesellschaft Process for the production of mono-N-substituted tetraaza macrocycles
DE4140779A1 (de) * 1991-12-06 1993-06-09 Schering Ag Berlin Und Bergkamen, 1000 Berlin, De Verfahren zur herstellung von mono-n-substituierten tetraazamakrocyclen
DE4218744C2 (de) * 1992-06-04 1997-11-06 Schering Ag Verfahren zur Herstellung von N-ß-Hxdroxyalkyl-tri-N-carboxylalkyl-1,4,7,10-tetraazacyclododecan- und N-ß-Hydroxyalkyl-tri-N-carboxyalkyl-1,4,8,11-tetraazacyclotetradecan-Derivaten und deren Metallkomplexe
DE69331319T2 (de) * 1992-06-09 2002-08-08 Neorx Corp., Seattle Biotin-DOTA Konjugate und deren Verwendung in "Pretargeting" Verfahren
DE4317588C2 (de) * 1993-05-24 1998-04-16 Schering Ag Fluorhaltige makrocyclische Metallkomplexe, Verfahren zu ihrer Herstellung, sowie ihre Verwendung
DE4318369C1 (de) * 1993-05-28 1995-02-09 Schering Ag Verwendung von makrocyclischen Metallkomplexen als Temperatursonden
GB9318550D0 (en) * 1993-09-07 1993-10-20 Nycomed Salutar Inc Chelants
EP0661279B1 (fr) * 1993-12-30 2001-03-07 Guerbet Ligands polyaminés, complexes métalliques, procédé de préparation, applications diagnostiques et thérapeutiques
GB9407435D0 (en) * 1994-04-14 1994-06-08 Nycomed Salutar Inc Compounds
US6693190B1 (en) 1994-05-11 2004-02-17 Bracco International B.V. Enhanced relaxivity monomeric and multimeric compounds
IT1274038B (it) * 1994-07-29 1997-07-14 Bracco Spa Chelanti macrociclici loro chelati e relativi usi in campo diagnostico
TW319763B (pt) 1995-02-01 1997-11-11 Epix Medical Inc
US5955605A (en) * 1995-02-21 1999-09-21 Neorx Corporation Biotinidase resistant biotin-DOTA conjugates
US5801228A (en) * 1995-06-07 1998-09-01 Nycomed Imaging As Polymeric contrast agents for medical imaging
DE19546234C1 (de) * 1995-12-04 1997-08-28 Schering Ag Neue makrobicyclische Verbindungen, Verfahren zu ihrer Herstellung und diese makrobicyclischen Verbindungen enthaltende pharmazeutische Mittel
US6045776A (en) * 1996-12-04 2000-04-04 Schering Aktiengesellschaft Process for the production of metal-complex carboxylic acid amides
US5919433A (en) * 1996-12-04 1999-07-06 Schering Aktiengesellschaft Macrocyclic metal complex carboxylic acids, their use as well as process for their production
DE19719033C1 (de) * 1997-04-29 1999-01-28 Schering Ag Ionenpaare, Verfahren zu ihrer Herstellung und ihre Verwendung als Kontrastmittel
DE19724186C2 (de) * 1997-06-02 2002-07-18 Schering Ag Verfahren zur Mono- und 1,7-Bis-N-ß-Hydroxyalkylierung von Cyclen und die entsprechenden N-ß-Hydroxyalkyl-1,4,7,10-tetraazacyclododecan-Li-Salz-Komplexe
IT1292128B1 (it) * 1997-06-11 1999-01-25 Bracco Spa Processo per la preparazione di chelanti macrociclici e loro chelati con ioni metallici paramagnetici
DE19744003B4 (de) * 1997-09-26 2004-07-08 Schering Ag Kontrastmittel für das Infarkt- und Nekroseimaging
US5991513A (en) * 1997-09-30 1999-11-23 Levien; Raphael L Method and apparatus for suppressing moire patterns
FR2772025B1 (fr) * 1997-12-10 2000-03-03 Guerbet Sa Chelates metalliques de macrocycles polyaminocarboxyliques et leur application a l'imagerie par resonance magnetique
DE19849465A1 (de) * 1998-10-21 2000-04-27 Schering Ag Dimere Ionenpaare, Verfahren zu ihrer Herstellung und ihre Verwendung als Kontrastmittel
US6342598B1 (en) 1998-11-26 2002-01-29 Bracco International B.V. Amphipatic polycarboxylic chelates and complexes with paramagnetic metals as MRI contrast agents
WO2000047111A1 (en) * 1999-02-09 2000-08-17 Board Of Regents The University Of Texas System Ph sensitive mri contrast agents
EP1088559A3 (de) * 1999-09-29 2002-10-02 INSTITUT FÜR DIAGNOSTIKFORSCHUNG GmbH AN DER FREIEN UNIVERSITÄT BERLIN Galenische Formulierungen
US20030113267A1 (en) * 1999-12-29 2003-06-19 Knopp Michael V. Colon contrast enhanced imaging
PL359292A1 (en) 2000-09-29 2004-08-23 Anormed Inc. Process for preparation of n-1 protected n ring nitrogen containing cyclic polyamines and products thereof
US7048907B2 (en) * 2001-02-05 2006-05-23 Biophysics Assay Laboratory, Inc. Synthesis, compositions and methods for the measurement of the concentration of stable-isotope labeled compounds in life forms and life form excretory products
US6906050B2 (en) * 2001-05-31 2005-06-14 Miravant Pharmaceuticals, Inc. Substituted porphyrin and azaporphyrin derivatives and their use in photodynamic therapy, radioimaging and MRI diagnosis
US6911671B2 (en) * 2002-09-23 2005-06-28 Eastman Kodak Company Device for depositing patterned layers in OLED displays
US7067170B2 (en) * 2002-09-23 2006-06-27 Eastman Kodak Company Depositing layers in OLED devices using viscous flow
AU2004206956A1 (en) * 2003-01-22 2004-08-05 The General Hospital Corporation Amyloid-binding, metal-chelating agents
WO2008134289A2 (en) * 2007-04-26 2008-11-06 Mallinckrodt Inc. High relaxivity coordinatively unsaturated lanthanide complexes
US8074729B2 (en) 2007-11-28 2011-12-13 Cnh America Llc Vertical tillage system
EP2072060A1 (en) 2007-12-18 2009-06-24 Institut Curie Methods and compositions for the preparation and use of toxin conjugates.
EP3156078B1 (en) 2009-04-10 2020-03-04 INSERM (Institut National de la Santé et de la Recherche Médicale) Fucoidans as ligands for the diagnosis of degenerative pathologies
GB0922369D0 (en) * 2009-12-22 2010-02-03 Hammersmith Imanet Ltd Labelled biotin conjugates
US9233971B2 (en) * 2010-08-26 2016-01-12 Kunyuan Cui Lipomacrocycles and uses thereof
WO2012136813A2 (en) 2011-04-07 2012-10-11 Universitetet I Oslo Agents for medical radar diagnosis
NZ616637A (en) 2011-04-21 2016-01-29 Bayer Ip Gmbh Preparation of high-purity gadobutrol
EP2836597A1 (en) 2012-04-11 2015-02-18 Institut National de la Santé et de la Recherche Médicale (INSERM) Matrix metalloproteinase 9 (mmp-9) aptamer and uses thereof
JP6178198B2 (ja) 2013-09-30 2017-08-09 株式会社東芝 音声翻訳システム、方法およびプログラム
WO2015117626A1 (de) * 2014-02-07 2015-08-13 Rijksuniversiteit Groningen Oligo- und polyaminotetrazole und ihre verwendung als mri kontrastmittel
DK3386954T3 (da) 2015-12-10 2021-02-15 Bracco Imaging Spa Dimere kontrastmidler
SG11201804415QA (en) 2015-12-10 2018-06-28 Bracco Imaging Spa Contrast agents
CN108779082B (zh) * 2016-04-13 2022-08-02 伯拉考成像股份公司 造影剂
SG11201901460UA (en) 2016-09-27 2019-03-28 Bayer Pharma AG Method for producing the crystalline form of modification a of calcobutrol
US10793533B2 (en) 2016-12-12 2020-10-06 Bracco Imaging S.P.A. Dimeric contrast agents
CN110357828B (zh) * 2019-08-13 2021-03-19 牡丹江医学院 一种核磁共振造影剂及其制备方法和用途

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS53144592A (en) * 1977-05-19 1978-12-15 Tabuse Iwao 122alkyll1*4*7*100tetrazacyclotridecane
JPS53144593A (en) * 1977-05-19 1978-12-15 Iwao Tabuse Alklycyclum
US4190462A (en) * 1978-07-04 1980-02-26 Shell Oil Company Dissolving barium sulfate scale with aqueous solutions of salts of carboxymethyl monocyclic macrocyclic polyamines
US4647447A (en) * 1981-07-24 1987-03-03 Schering Aktiengesellschaft Diagnostic media
US5059412A (en) * 1984-06-04 1991-10-22 The Dow Chemical Company Macrocyclic aminophosphonic acid complexes for the treatment of calcific tumors
US4678667A (en) * 1985-07-02 1987-07-07 501 Regents of the University of California Macrocyclic bifunctional chelating agents
DE3772785D1 (de) * 1986-01-23 1991-10-17 Squibb & Sons Inc 1-substituiertes-4,7,10-triscarboxymethyl-1,4,7,10-tetraazacyclododecan und analoga.
US4885363A (en) * 1987-04-24 1989-12-05 E. R. Squibb & Sons, Inc. 1-substituted-1,4,7-triscarboxymethyl-1,4,7,10-tetraazacyclododecane and analogs
DE3625417C2 (de) * 1986-07-28 1998-10-08 Schering Ag Tetraazacyclododecan-Derivate
IT1224416B (it) * 1987-12-24 1990-10-04 Bracco Ind Chimica Spa Chelanti macrociclici e loro chelati
US5132409A (en) * 1987-01-12 1992-07-21 Bracco Industria Chimica S.P.A. Macrocyclic chelating agents and chelates thereof
FR2637895B1 (fr) * 1988-10-14 1992-11-06 Guerbet Sa Nouveaux ligands cycliques azotes, complexes metalliques formes par ces ligands, compositions de diagnostic contenant ces complexes et procede de preparation des ligands
FR2614020B1 (fr) * 1987-04-14 1989-07-28 Guerbet Sa Nouveaux ligands cycliques azotes, complexes metalliques formes par ces ligands, compositions de diagnostic contenant ces complexes et procede de preparation des ligands.
US5049667A (en) * 1987-04-14 1991-09-17 Guerbet S.A. Nitrogen-containing cyclic ligands
EP0299795B1 (en) * 1987-07-16 1992-03-18 Nycomed As Aminopolycarboxylic acids and derivatives thereof
DE3728525A1 (de) * 1987-08-24 1989-03-16 Schering Ag Mehrkernige substituierte komplexbildner, komplexe und komplexsalze, verfahren zu deren herstellung und diese enthaltende pharmazeutische mittel
US4889931A (en) * 1988-09-27 1989-12-26 Salutar, Inc. Manganese (II) chelate manufacture
AU6709390A (en) * 1989-12-22 1991-06-27 E.R. Squibb & Sons, Inc. 10-(2'-hydroxy-3'-polyoxaalkyl)-1,4,7-tris-carboxymethyl -1,4,7,10-tetraazacyclododecane
AU625529B2 (en) * 1989-12-22 1992-07-16 E.R. Squibb & Sons, Inc. 10-(2'-hydroxy-3'-alkoxy-1,4,7-triscarboxymethyl-1,4,7,10- tetraazacyclododecanes
DE4009119A1 (de) * 1990-03-19 1991-09-26 Schering Ag 1,4,7,10-tetraazacyclododecan-butyltriole, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische mittel
US5262532A (en) * 1991-07-22 1993-11-16 E.R. Squibb & Sons, Inc. Paramagnetic metalloporphyrins as contrast agents for magnetic resonance imaging

Also Published As

Publication number Publication date
JP3137700B2 (ja) 2001-02-26
US5277895A (en) 1994-01-11
FI915282A (fi) 1992-05-09
EP0485045B1 (de) 1998-12-30
DE59109082D1 (de) 1999-02-11
IE913899A1 (en) 1992-05-20
PT99445B (pt) 1999-04-30
ZA918893B (en) 1992-08-26
ES2128307T3 (es) 1999-05-16
GR3029775T3 (en) 1999-06-30
JPH04288063A (ja) 1992-10-13
DE4035760A1 (de) 1992-05-14
DK0485045T3 (da) 1999-08-30
FI915282A0 (fi) 1991-11-08
ATE175201T1 (de) 1999-01-15
EP0485045A3 (en) 1992-10-28
CA2055093A1 (en) 1992-05-09
IL100015A0 (en) 1992-08-18
EP0485045A2 (de) 1992-05-13
NO914356L (no) 1992-05-11
NO914356D0 (no) 1991-11-07
AU8772691A (en) 1992-05-14
US5871709A (en) 1999-02-16

Similar Documents

Publication Publication Date Title
PT99445A (pt) Processo para preparacao de derivados do 1,4,7,10-tetraazaciclododecano mono-n--substituidos e de composicoes farmaceuticas que os contem
PT97065A (pt) Processo para a preparacao de 1,4,7,1o-tetraazaciclodecano-butiltrois e de composicoes farmaceuticas que os contem
PT93689A (pt) Processo para a preparacao de benzimidazois e de composicoes farmaceuticas que os contem
PT94925A (pt) Processo para a preparacao de derivados de tiazol e de composicoes farmaceuticas que os contem
DK0618898T3 (da) Amidinoderivater
PT93531A (pt) Processo para a preparacao de derivados de n-(3-hidroxi-4-piperidinil)(dihidrobenzofurano,dihidro-2h-benzopirano ou dihidrobenzodioxin)carboxamidas e de composicoes farmaceuticas que os contem
PT96145A (pt) Processo para a preparacao de novos derivados de aminoacidos e de composicoes farmaceuticas que os contem
EA199901015A1 (ru) 4"-замещенные производные 9-деоксо-9а-а3а-9а-гомоэритромицина а
ES2100907T3 (es) Bencimidazoles, medicamentos que contienen estos compuestos y proced imiento para su preparacion.
ES2083123T3 (es) Nuevos derivados de aril-etil-aminas, su procedimiento de preparacion y composiciones farmaceuticas que los contienen.
PT96394A (pt) Processo para a preparacao de novos derivados do acido a-nor-esteroide-3-carboxilico e de composicoes farmaceuticas que os contem
PT100041A (pt) Processo para a preparacao de derivados de indol e de composicoes farmaceuticas que os contem
PT101725A (pt) Processo para a preparacao de um composto de diarilo anti-aterosclerotico e de composicoes farmaceuticas que o contem
PT83535B (pt) Processo para a preparacao de composicoes farmaceuticas contendo derivados de aminoacidos
ES2098023T3 (es) Compuestos de estructura guanidinica y composiciones farmaceuticas que los contienen.
PT89729A (pt) Processo para a preparacao de derivados de cefalosporina e de composicoes farmaceuticas que os contem
ES2111871T3 (es) Nuevos derivados de aminoacidos, su procedimiento de preparacion y composiciones farmaceuticas que los contienen.
PE45195A1 (es) Derivado de aminoacido, procedimiento para su preparacion y composicion farmaceutica que lo contiene
PT97286A (pt) Processo para a preparacao de novos derivados do 3-aminocromano e de composicoes farmaceuticas que os contem
PT91203A (pt) Processo para a preparacao de novos derivados de antibioticos bu-3608 e de composicoes farmaceuticas que os contem
MX9400165A (es) Derivados de ter-butilergolina, proceso para su produccion y composiciones farmaceuticas que los contienen.
PT92952A (pt) Processo para a preparacao de acidos 3-fenil-5,6-di-hidrobenz { c }acridina-7- carboxilicos, de compostos relacionados e de composicoes farmaceuticas que os contem
PT84680B (pt) Processo para a preparacao de derivados de 1,5-benzotiazepina e de composicoes farmaceuticas que os contem
PT100216A (pt) N- 4,5-di-hidroxi- e 4,5,8-tri-hidroxi-9,10-di-hidro-9,10-dioxo-2-antracentil carbonil -aminoacidos uteis na terapia de afeccoes osteoarticulares, processo para a sua preparacao e composicoes farmaceuticas que os contem
PT91873A (pt) Processo para a preparacao de composicoes farmaceuticas contendo acidos oxapenem-3-carboxilicos estaveis uteis como inibidores de beta-lactamase

Legal Events

Date Code Title Description
BB1A Laying open of patent application

Effective date: 19920525

FG3A Patent granted, date of granting

Effective date: 19990119

MM4A Annulment/lapse due to non-payment of fees, searched and examined patent

Free format text: LAPSE DUE TO NON-PAYMENT OF FEES

Effective date: 20080721