IT1274038B - Chelanti macrociclici loro chelati e relativi usi in campo diagnostico - Google Patents

Chelanti macrociclici loro chelati e relativi usi in campo diagnostico

Info

Publication number
IT1274038B
IT1274038B ITMI941646A ITMI941646A IT1274038B IT 1274038 B IT1274038 B IT 1274038B IT MI941646 A ITMI941646 A IT MI941646A IT MI941646 A ITMI941646 A IT MI941646A IT 1274038 B IT1274038 B IT 1274038B
Authority
IT
Italy
Prior art keywords
chelates
diagnostic field
related uses
macrocyclic chelants
chelants
Prior art date
Application number
ITMI941646A
Other languages
English (en)
Inventor
Fulvio Uggeri
Pier Lucio Anelli
Giuseppe Manfredi
Marino Brocchetta
Franco Fedeli
Original Assignee
Bracco Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bracco Spa filed Critical Bracco Spa
Publication of ITMI941646A0 publication Critical patent/ITMI941646A0/it
Priority to ITMI941646A priority Critical patent/IT1274038B/it
Priority to US08/448,742 priority patent/US5622688A/en
Priority to AU32211/95A priority patent/AU691024B2/en
Priority to AT95928457T priority patent/ATE167477T1/de
Priority to ES95928457T priority patent/ES2100827T3/es
Priority to HU9700250A priority patent/HUT76805A/hu
Priority to KR1019970700527A priority patent/KR100376950B1/ko
Priority to PCT/EP1995/002931 priority patent/WO1996004259A1/en
Priority to JP8506155A priority patent/JP2941062B2/ja
Priority to DE0773936T priority patent/DE773936T1/de
Priority to CN95194377A priority patent/CN1064355C/zh
Priority to MX9700674A priority patent/MX9700674A/es
Priority to CA002196041A priority patent/CA2196041A1/en
Priority to BR9508435A priority patent/BR9508435A/pt
Priority to EP95928457A priority patent/EP0773936B1/en
Priority to DK95928457T priority patent/DK0773936T3/da
Priority to DE69503055T priority patent/DE69503055T2/de
Priority to IL11473295A priority patent/IL114732A0/xx
Priority to ZA956174A priority patent/ZA956174B/xx
Publication of ITMI941646A1 publication Critical patent/ITMI941646A1/it
Priority to US08/783,609 priority patent/US5708166A/en
Priority to NO970342A priority patent/NO307214B1/no
Priority to FI970327A priority patent/FI970327A/fi
Application granted granted Critical
Publication of IT1274038B publication Critical patent/IT1274038B/it
Priority to GR970300019T priority patent/GR970300019T1/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Si descrivono composti di formula generale (I), (FORMULA I) dove i gruppi A, B1, B2, e B3 sono definiti di seguito, utili come agenti di contrasto in risonanza magnetica nucleare a scopo diagnostico.
ITMI941646A 1994-07-29 1994-07-29 Chelanti macrociclici loro chelati e relativi usi in campo diagnostico IT1274038B (it)

Priority Applications (23)

Application Number Priority Date Filing Date Title
ITMI941646A IT1274038B (it) 1994-07-29 1994-07-29 Chelanti macrociclici loro chelati e relativi usi in campo diagnostico
US08/448,742 US5622688A (en) 1994-07-29 1995-05-24 Macrocyclic chelants, their chelates and uses thereof in the diagnostic field
CA002196041A CA2196041A1 (en) 1994-07-29 1995-07-24 Macrocyclic chelants, their chelates and uses thereof in the diagnostic field
BR9508435A BR9508435A (pt) 1994-07-29 1995-07-24 Quelentes macrocíclicos seus quelatos e usos dos mesmos no campo diagnóstico
ES95928457T ES2100827T3 (es) 1994-07-29 1995-07-24 Quelatantes macrociclicos, sus quelatos y usos de los mismos en el campo diagnostico.
HU9700250A HUT76805A (en) 1994-07-29 1995-07-24 Macrocyclic chelants, their chelates and uses thereof in the diagnostic field
KR1019970700527A KR100376950B1 (ko) 1994-07-29 1995-07-24 대환식킬레이트제,이들의킬레이트및진단분야에서의이의용도
PCT/EP1995/002931 WO1996004259A1 (en) 1994-07-29 1995-07-24 Macrocyclic chelants, their chelates and uses thereof in the diagnostic field
JP8506155A JP2941062B2 (ja) 1994-07-29 1995-07-24 大環状キレート化剤、それらのキレート化合物および診断分野におけるそれらの用途
DE0773936T DE773936T1 (de) 1994-07-29 1995-07-24 Makrozyclische chelante, ihre chelate und verwendungen in diagnostik
CN95194377A CN1064355C (zh) 1994-07-29 1995-07-24 大环螯合剂及其螯合物及其在诊断领域的应用
MX9700674A MX9700674A (es) 1994-07-29 1995-07-24 Agentes quelantes macrociclicos, sus quelatos y los usos de los mismos en el campo del diagnostico.
AU32211/95A AU691024B2 (en) 1994-07-29 1995-07-24 Macrocyclic chelants, their chelates and uses thereof in the diagnostic field
AT95928457T ATE167477T1 (de) 1994-07-29 1995-07-24 Makrozyclische chelante, ihre chelate und verwendungen in diagnostik
EP95928457A EP0773936B1 (en) 1994-07-29 1995-07-24 Macrocyclic chelants, their chelates and uses thereof in the diagnostic field
DK95928457T DK0773936T3 (da) 1994-07-29 1995-07-24 Makrocykliske chelatdannende stoffer, deres chelater og anvendelse inden for det diagnostiske område
DE69503055T DE69503055T2 (de) 1994-07-29 1995-07-24 Makrozyclische chelante, ihre chelate und verwendungen in diagnostik
IL11473295A IL114732A0 (en) 1994-07-29 1995-07-25 Macrocyclic chelants their chelates and uses thereof in the diagnostic field
ZA956174A ZA956174B (en) 1994-07-29 1995-07-25 Macrocyclic chelants their chelates and uses thereof in the diagnostic field
US08/783,609 US5708166A (en) 1994-07-29 1997-01-14 Macrocyclic chelants, their chelates and uses thereof in the diagnostic field
NO970342A NO307214B1 (no) 1994-07-29 1997-01-27 Makrosykliske chelanter, deres chelater og anvendelse derav innen det diagnostiske felt
FI970327A FI970327A (fi) 1994-07-29 1997-01-27 Makrosykliset kelantit, niiden kelaatit ja käytöt diagnostiikan alalla
GR970300019T GR970300019T1 (en) 1994-07-29 1997-07-30 Macrocyclic chelants, their chelates and uses thereof in the diagnostic field

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ITMI941646A IT1274038B (it) 1994-07-29 1994-07-29 Chelanti macrociclici loro chelati e relativi usi in campo diagnostico

Publications (3)

Publication Number Publication Date
ITMI941646A0 ITMI941646A0 (it) 1994-07-29
ITMI941646A1 ITMI941646A1 (it) 1996-01-29
IT1274038B true IT1274038B (it) 1997-07-14

Family

ID=11369406

Family Applications (1)

Application Number Title Priority Date Filing Date
ITMI941646A IT1274038B (it) 1994-07-29 1994-07-29 Chelanti macrociclici loro chelati e relativi usi in campo diagnostico

Country Status (21)

Country Link
US (2) US5622688A (it)
EP (1) EP0773936B1 (it)
JP (1) JP2941062B2 (it)
KR (1) KR100376950B1 (it)
CN (1) CN1064355C (it)
AT (1) ATE167477T1 (it)
AU (1) AU691024B2 (it)
BR (1) BR9508435A (it)
CA (1) CA2196041A1 (it)
DE (2) DE69503055T2 (it)
DK (1) DK0773936T3 (it)
ES (1) ES2100827T3 (it)
FI (1) FI970327A (it)
GR (1) GR970300019T1 (it)
HU (1) HUT76805A (it)
IL (1) IL114732A0 (it)
IT (1) IT1274038B (it)
MX (1) MX9700674A (it)
NO (1) NO307214B1 (it)
WO (1) WO1996004259A1 (it)
ZA (1) ZA956174B (it)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1274038B (it) * 1994-07-29 1997-07-14 Bracco Spa Chelanti macrociclici loro chelati e relativi usi in campo diagnostico
US6060040A (en) * 1996-12-23 2000-05-09 Bracco Research S.A. Cross-linked polymeric compositions for increasing the MRI contrast in visualising the digestive tract of patients
IT1291624B1 (it) * 1997-04-18 1999-01-11 Bracco Spa Chelati complessi di metalli paramagnetici a bassa tossicita'
FR2772025B1 (fr) * 1997-12-10 2000-03-03 Guerbet Sa Chelates metalliques de macrocycles polyaminocarboxyliques et leur application a l'imagerie par resonance magnetique
AU3225900A (en) * 1999-02-09 2000-08-29 Board Of Regents, The University Of Texas System Ph sensitive mri contrast agents
WO2002032292A2 (en) * 2000-10-18 2002-04-25 The Board Of Trustess Of The Leland Stanford Junior University Methods for development and use of diagnostic and therapeutic agents
CA2425873A1 (en) * 2000-10-19 2002-04-25 The General Hospital Corporation Imaging of enzymatic activity
US20030100829A1 (en) * 2001-11-27 2003-05-29 Sheng-Ping Zhong Medical devices with magnetic resonance visibility enhancing material
US20040215240A1 (en) * 2003-04-11 2004-10-28 Lovett Eric G. Reconfigurable subcutaneous cardiac device
FR2857967B1 (fr) * 2003-07-25 2015-04-24 Centre Nat Rech Scient Complexes de lanthanide, leur preparation et leurs utilisations
US20050107838A1 (en) * 2003-09-18 2005-05-19 Lovett Eric G. Subcutaneous cardiac rhythm management with disordered breathing detection and treatment
EP1765812B1 (en) * 2004-07-02 2009-04-29 Bracco Imaging S.p.A Contrast agents endowed with high relaxivity for use in magnetic resonance imaging (mri) which contain a chelating moiety with polyhydroxylated substituents
CN109384737A (zh) * 2017-08-04 2019-02-26 天津科伦药物研究有限公司 一种四氮杂环钇络合物及其制备方法和应用

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4885363A (en) * 1987-04-24 1989-12-05 E. R. Squibb & Sons, Inc. 1-substituted-1,4,7-triscarboxymethyl-1,4,7,10-tetraazacyclododecane and analogs
IT1224416B (it) * 1987-12-24 1990-10-04 Bracco Ind Chimica Spa Chelanti macrociclici e loro chelati
US5053503A (en) * 1989-02-17 1991-10-01 Centocor Chelating agents
DE4035760A1 (de) * 1990-11-08 1992-05-14 Schering Ag Mono-n-substituierte 1,4,7,10-tetraazacyclododecan-derivate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische mittel
IT1274038B (it) * 1994-07-29 1997-07-14 Bracco Spa Chelanti macrociclici loro chelati e relativi usi in campo diagnostico
GB9504910D0 (en) * 1995-03-10 1995-04-26 Nycomed Imaging As Compounds

Also Published As

Publication number Publication date
CA2196041A1 (en) 1996-02-15
ITMI941646A0 (it) 1994-07-29
ES2100827T3 (es) 1998-09-16
NO307214B1 (no) 2000-02-28
AU691024B2 (en) 1998-05-07
DE69503055D1 (de) 1998-07-23
HUT76805A (en) 1997-11-28
JPH10503505A (ja) 1998-03-31
KR970704713A (ko) 1997-09-06
ATE167477T1 (de) 1998-07-15
NO970342D0 (no) 1997-01-27
KR100376950B1 (ko) 2003-07-16
MX9700674A (es) 1997-04-30
WO1996004259A1 (en) 1996-02-15
ES2100827T1 (es) 1997-07-01
CN1154108A (zh) 1997-07-09
FI970327A (fi) 1997-03-25
DK0773936T3 (da) 1999-04-06
BR9508435A (pt) 1997-12-23
US5622688A (en) 1997-04-22
US5708166A (en) 1998-01-13
CN1064355C (zh) 2001-04-11
AU3221195A (en) 1996-03-04
EP0773936A1 (en) 1997-05-21
NO970342L (no) 1997-04-01
GR970300019T1 (en) 1997-07-30
FI970327A0 (fi) 1997-01-27
EP0773936B1 (en) 1998-06-17
DE773936T1 (de) 1997-09-25
ITMI941646A1 (it) 1996-01-29
JP2941062B2 (ja) 1999-08-25
IL114732A0 (en) 1995-11-27
ZA956174B (en) 1996-03-07
DE69503055T2 (de) 1998-10-15

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Legal Events

Date Code Title Description
0001 Granted
TA Fee payment date (situation as of event date), data collected since 19931001

Effective date: 19970729