DE69723111D1 - Nachweis biospezifischer fluoreszenz durch zwei-photonen-anregung - Google Patents

Nachweis biospezifischer fluoreszenz durch zwei-photonen-anregung

Info

Publication number
DE69723111D1
DE69723111D1 DE69723111T DE69723111T DE69723111D1 DE 69723111 D1 DE69723111 D1 DE 69723111D1 DE 69723111 T DE69723111 T DE 69723111T DE 69723111 T DE69723111 T DE 69723111T DE 69723111 D1 DE69723111 D1 DE 69723111D1
Authority
DE
Germany
Prior art keywords
photon excitation
specific fluorescence
bios
detect
detect bios
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69723111T
Other languages
English (en)
Other versions
DE69723111T2 (de
Inventor
Erkki Soini
Pekka Haenninen
Juhani Soini
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from FI964826A external-priority patent/FI104586B/fi
Priority claimed from FI971626A external-priority patent/FI104585B/fi
Application filed by Individual filed Critical Individual
Publication of DE69723111D1 publication Critical patent/DE69723111D1/de
Application granted granted Critical
Publication of DE69723111T2 publication Critical patent/DE69723111T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/557—Immunoassay; Biospecific binding assay; Materials therefor using kinetic measurement, i.e. time rate of progress of an antigen-antibody interaction
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
    • G01N33/54326—Magnetic particles

Landscapes

  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Cell Biology (AREA)
  • Pathology (AREA)
  • Food Science & Technology (AREA)
  • Biotechnology (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
DE69723111T 1996-12-03 1997-11-18 Nachweis biospezifischer fluoreszenz durch zwei-photonen-anregung Expired - Lifetime DE69723111T2 (de)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
FI964826A FI104586B (fi) 1996-12-03 1996-12-03 Menetelmä bioaffiniteettireaktion reaaliaikaista seuraamista varten
FI964826 1996-12-03
FI971626A FI104585B (fi) 1997-04-17 1997-04-17 Menetelmä bioaffiniteettimäärityksen dynamiikan laajentamiseksi
FI971626 1997-04-17
PCT/FI1997/000704 WO1998025143A1 (en) 1996-12-03 1997-11-18 Biospecific, two photon excitation, fluorescence detection and device

Publications (2)

Publication Number Publication Date
DE69723111D1 true DE69723111D1 (de) 2003-07-31
DE69723111T2 DE69723111T2 (de) 2004-02-19

Family

ID=26160267

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69723111T Expired - Lifetime DE69723111T2 (de) 1996-12-03 1997-11-18 Nachweis biospezifischer fluoreszenz durch zwei-photonen-anregung

Country Status (6)

Country Link
US (1) US6361956B1 (de)
EP (1) EP0968425B1 (de)
JP (1) JP3761898B2 (de)
AU (1) AU5054198A (de)
DE (1) DE69723111T2 (de)
WO (1) WO1998025143A1 (de)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69723111T2 (de) * 1996-12-03 2004-02-19 Erkki Soini Nachweis biospezifischer fluoreszenz durch zwei-photonen-anregung
US6376843B1 (en) * 1999-06-23 2002-04-23 Evotec Oai Ag Method of characterizing fluorescent molecules or other particles using generating functions
DE19935766A1 (de) * 1999-07-29 2001-02-01 Friedrich Schiller Uni Jena Bu Verfahren zur optischen Anregung von Fluorophor-markierter DNA und RNA
US7501092B2 (en) * 2001-06-06 2009-03-10 Nomadics, Inc. Manganese doped upconversion luminescence nanoparticles
US7008559B2 (en) * 2001-06-06 2006-03-07 Nomadics, Inc. Manganese doped upconversion luminescence nanoparticles
DE60234181D1 (de) 2001-07-02 2009-12-10 Arctic Diagnostics Oy Zwei photonen absorbierende bordipyrromethen-difluorid-farbstoffe und ihre anwendungen
US7067072B2 (en) * 2001-08-17 2006-06-27 Nomadics, Inc. Nanophase luminescence particulate material
EP1460414B1 (de) * 2001-12-27 2018-09-19 ARKRAY, Inc. Konzentrationsmessverfahren
US20070189359A1 (en) * 2002-06-12 2007-08-16 Wei Chen Nanoparticle thermometry and pressure sensors
GB2402475A (en) * 2003-06-04 2004-12-08 Inverness Medical Switzerland Analyte assay reading providing prompt result declaration
US7315378B2 (en) * 2003-06-04 2008-01-01 Inverness Medical Switzerland Gmbh Optical arrangement for assay reading device
US7239394B2 (en) 2003-06-04 2007-07-03 Inverness Medical Switzerland Gmbh Early determination of assay results
US7317532B2 (en) 2003-06-04 2008-01-08 Inverness Medical Switzerland Gmbh Flow sensing for determination of assay results
GB2450351B (en) 2007-06-20 2012-01-18 Cozart Bioscience Ltd Monitoring an Immunoassay
ITUD20080162A1 (it) * 2008-07-08 2010-01-09 Alifax Spa Procedimento e relativa apparecchiatura per l'esecuzione di analisi diagnostiche
GB2474224A (en) * 2009-07-07 2011-04-13 Toximet Ltd Devices and methods using fluorescent polymers in solid phase extraction
CN103025859A (zh) 2010-05-25 2013-04-03 阿尔利克斯公司 用于检测生物学和化学分析中的颗粒的位置自由度的方法和装置以及在免疫诊断学中的应用
US8828329B2 (en) 2010-10-01 2014-09-09 Church & Dwight, Co., Inc. Electronic analyte assaying device
FI20115285A0 (fi) * 2011-03-24 2011-03-24 Reagena Ltd Oy Menetelmä pikatestin suorittamiseksi
US9588113B2 (en) * 2012-02-22 2017-03-07 Church & Dwight Co., Inc. Methods for electronic analyte assaying
WO2016106286A1 (en) 2014-12-23 2016-06-30 Biodesy, Inc. Attachment of proteins to interfaces for use in nonlinear optical detection
FI20165148A (fi) 2016-02-25 2017-08-26 Arcdia Int Oy Ltd Kaksoisfotoniviritteistä fluoresenssia hyödyntävä bioaffiniteettimääritysmenetelmä
EP3546937A4 (de) * 2016-11-22 2020-07-01 Chemclin Diagnostics Co., Ltd. Verfahren, system, reagenzienkit und system zur überprüfung einer hd-hook-effekt-probe und zur durchführung von immunoassays
CN109470857B (zh) * 2016-11-22 2021-12-17 科美博阳诊断技术(上海)有限公司 免疫测定方法、用于鉴定免疫测定的系统和试剂盒
CN110832322A (zh) * 2017-05-03 2020-02-21 比奥德赛公司 利用双光子荧光测定法确定蛋白质结构的方法
TWI614502B (zh) * 2017-07-26 2018-02-11 國立成功大學 分析物濃度的檢測方法
CN110514651A (zh) * 2018-05-21 2019-11-29 博阳生物科技（上海）有限公司 一种化学发光免疫分析测定方法及使用该方法的系统、试剂盒
CN111795956B (zh) * 2020-06-29 2021-11-02 中国科学院苏州生物医学工程技术研究所 一种判断均相时间分辨荧光免疫分析钩状效应的方法

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4760548A (en) * 1986-06-13 1988-07-26 International Business Machines Corporation Method and apparatus for producing a curve image
US5171688A (en) * 1988-08-30 1992-12-15 Cholestech Corporation Self-corrected assay device
US5100627A (en) * 1989-11-30 1992-03-31 The Regents Of The University Of California Chamber for the optical manipulation of microscopic particles
US5198369A (en) * 1990-04-25 1993-03-30 Canon Kabushiki Kaisha Sample measuring method using agglomeration reaction of microcarriers
EP0723146B1 (de) 1992-09-14 2004-05-06 Sri International Up-converting reporter Molekül für biologische und andere Testverfahren unter Verwendung von Laseranregungstechniken
WO1994016313A2 (de) * 1993-01-18 1994-07-21 Evotec Biosystems Gmbh Verfahren und vorrichtung zur bewertung der fitness von biopolymeren
US5469255A (en) * 1993-01-28 1995-11-21 Kamada; Kenji Method and apparatus for spectrometric measurement of particulate surfaces
EP0682671A4 (de) 1993-02-01 1998-01-14 Seq Ltd Verfahren und geräte zur sequenzierung von dns.
FI96452C (fi) 1994-01-26 1996-06-25 Pekka Haenninen Menetelmä väriaineiden virittämiseksi
US5512745A (en) * 1994-03-09 1996-04-30 Board Of Trustees Of The Leland Stanford Jr. University Optical trap system and method
FI101829B1 (fi) 1995-03-07 1998-08-31 Erkki Juhani Soini Biospesifinen määritysmenetelmä
FI98765C (fi) 1995-01-16 1997-08-11 Erkki Soini Virtaussytometrinen menetelmä ja laite
WO1996022531A1 (en) * 1995-01-16 1996-07-25 Erkki Soini A biospecific multiparameter assay method
US5631141A (en) * 1995-05-05 1997-05-20 The Regents Of The University Of California High resolution biosensor for in-situ microthermometry
US5620857A (en) * 1995-06-07 1997-04-15 United States Of America, As Represented By The Secretary Of Commerce Optical trap for detection and quantitation of subzeptomolar quantities of analytes
DE69723111T2 (de) * 1996-12-03 2004-02-19 Erkki Soini Nachweis biospezifischer fluoreszenz durch zwei-photonen-anregung

Also Published As

Publication number Publication date
US6361956B1 (en) 2002-03-26
JP3761898B2 (ja) 2006-03-29
EP0968425A1 (de) 2000-01-05
DE69723111T2 (de) 2004-02-19
AU5054198A (en) 1998-06-29
WO1998025143A1 (en) 1998-06-11
JP2001506750A (ja) 2001-05-22
EP0968425B1 (de) 2003-06-25

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