EA200200491A1 - Замещенные 1,2,3,4,5,6-гексагидро-2,6-метано-3-бензазоцины и их применение в качестве лекарственных средств - Google Patents

Замещенные 1,2,3,4,5,6-гексагидро-2,6-метано-3-бензазоцины и их применение в качестве лекарственных средств

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Publication number
EA200200491A1
EA200200491A1 EA200200491A EA200200491A EA200200491A1 EA 200200491 A1 EA200200491 A1 EA 200200491A1 EA 200200491 A EA200200491 A EA 200200491A EA 200200491 A EA200200491 A EA 200200491A EA 200200491 A1 EA200200491 A1 EA 200200491A1
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EA
Eurasian Patent Office
Prior art keywords
methano
application
substituted
hexagidro
benzozins
Prior art date
Application number
EA200200491A
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English (en)
Other versions
EA005681B1 (ru
Inventor
Маттиас Грауэрт
Адриан Картер
Томас Вайзер
Хельмут Энзингер
Вольфрам Гаида
Йоахим Мирау
Original Assignee
Бёрингер Ингельхайм Фарма Кг
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Бёрингер Ингельхайм Фарма Кг filed Critical Бёрингер Ингельхайм Фарма Кг
Publication of EA200200491A1 publication Critical patent/EA200200491A1/ru
Publication of EA005681B1 publication Critical patent/EA005681B1/ru

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    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • AHUMAN NECESSITIES
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    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/04Centrally acting analgesics, e.g. opioids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/08Antiepileptics; Anticonvulsants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16Anti-Parkinson drugs
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/18Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
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    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/04Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D221/00Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/22Bridged ring systems
    • C07D221/26Benzomorphans
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    • C07ORGANIC CHEMISTRY
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    • C07D307/02Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/04Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D307/06Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to ring carbon atoms

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  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
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  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Cardiology (AREA)
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  • Hospice & Palliative Care (AREA)
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  • Vascular Medicine (AREA)
  • Pulmonology (AREA)
  • Reproductive Health (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

В заявке описываются замещенные 1,2,3,4,5,6-гексагидро-2,6-метано-3-бензазоцины общей формулы (1)в которой радикалы R, R, R, R, R, R, R, X и А имеют значения, указанные в описании и в пунктах формулы изобретения, а также способ их получения и их применение в качестве лекарственных средств.Международная заявка была опубликована вместе с отчетом о международном поиске.
EA200200491A 1999-11-27 2000-11-21 Замещенные 1,2,3,4,5,6-гексагидро-2,6-метано-3-бензазоцины и их применение в качестве лекарственных средств EA005681B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19957156A DE19957156A1 (de) 1999-11-27 1999-11-27 Substituierte 1,2,3,4,5,6-Hexahydro-2,6-methano-3-benzazocine und ihre Verwendung als Arzneimittel
PCT/EP2000/011585 WO2001051471A1 (de) 1999-11-27 2000-11-21 Substituierte 1,2,3,4,5,6-hexahydro-2,6-methano-3-benzazocine und ihre verwendung als arzneimittel

Publications (2)

Publication Number Publication Date
EA200200491A1 true EA200200491A1 (ru) 2002-12-26
EA005681B1 EA005681B1 (ru) 2005-04-28

Family

ID=7930562

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200200491A EA005681B1 (ru) 1999-11-27 2000-11-21 Замещенные 1,2,3,4,5,6-гексагидро-2,6-метано-3-бензазоцины и их применение в качестве лекарственных средств

Country Status (33)

Country Link
EP (1) EP1235809B1 (ru)
JP (1) JP2003519687A (ru)
KR (1) KR20020058042A (ru)
CN (1) CN1177825C (ru)
AR (1) AR026586A1 (ru)
AT (1) ATE254108T1 (ru)
AU (1) AU5789701A (ru)
BG (1) BG106682A (ru)
BR (1) BR0015786A (ru)
CA (1) CA2383114C (ru)
CO (1) CO5251469A1 (ru)
CZ (1) CZ20022120A3 (ru)
DE (2) DE19957156A1 (ru)
DK (1) DK1235809T3 (ru)
EA (1) EA005681B1 (ru)
EE (1) EE200200267A (ru)
ES (1) ES2210036T3 (ru)
HK (1) HK1052176A1 (ru)
HR (1) HRP20020460A2 (ru)
HU (1) HUP0204169A3 (ru)
IL (1) IL149607A0 (ru)
MX (1) MXPA02003822A (ru)
NO (1) NO20022457L (ru)
NZ (1) NZ519758A (ru)
PL (1) PL355493A1 (ru)
PT (1) PT1235809E (ru)
SK (1) SK9302002A3 (ru)
TR (1) TR200302031T4 (ru)
UA (1) UA72566C2 (ru)
UY (1) UY26448A1 (ru)
WO (1) WO2001051471A1 (ru)
YU (1) YU37902A (ru)
ZA (1) ZA200204056B (ru)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6683089B2 (en) 2002-02-02 2004-01-27 Boehringer Ingelheim Pharma Gmbh & Co. Kg N-allyoxyethyl-1,2,3,4,5,6-hexahydro-2,6-methano-3-benzazocine-10-ols
DE10204276A1 (de) * 2002-02-02 2003-08-07 Boehringer Ingelheim Pharma N-Allyloxyethyl-1,2,3,4,5,6-Hexahydro-2,6-methano-3-benzazocine und ihre Verwendung als Arzneimittel
WO2014072809A2 (en) * 2012-11-09 2014-05-15 Purdue Pharma L.P. Benzomorphan analogs and the use thereof

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4121821A1 (de) * 1991-07-02 1993-01-14 Boehringer Ingelheim Kg Neue benzomorphane und ihre verwendung als arzneimittel
US5354758A (en) * 1992-12-16 1994-10-11 Japan Tobacco Inc. Benzomorphans useful as NMDA receptor antagonists
DE19740110A1 (de) * 1997-09-12 1999-03-18 Boehringer Ingelheim Pharma Substituierte 1,2,3,4,5,6-Hexahydro-2,6-methano-3-benzazocin-10-ole, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
DE19907874A1 (de) * 1999-02-23 2000-08-24 Boehringer Ingelheim Pharma N-(5-Phenyl-tetrahydrofuranyl)methyl- und N-(6-Phenyl-tetrahydropyranyl)methyl substituierte 1,2,3,4,5,6-Hexahydro-2,6-methano-3-benzazocin-10-ole, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel

Also Published As

Publication number Publication date
YU37902A (sh) 2005-07-19
HRP20020460A2 (en) 2003-10-31
CA2383114C (en) 2008-06-17
IL149607A0 (en) 2002-11-10
CA2383114A1 (en) 2001-07-19
TR200302031T4 (tr) 2004-01-21
EE200200267A (et) 2003-06-16
DE19957156A1 (de) 2001-05-31
BR0015786A (pt) 2002-08-13
JP2003519687A (ja) 2003-06-24
CN1177825C (zh) 2004-12-01
EP1235809A1 (de) 2002-09-04
CN1399630A (zh) 2003-02-26
UY26448A1 (es) 2001-06-29
ZA200204056B (en) 2003-07-30
AR026586A1 (es) 2003-02-19
WO2001051471A1 (de) 2001-07-19
CZ20022120A3 (cs) 2002-09-11
NZ519758A (en) 2004-05-28
DK1235809T3 (da) 2004-03-15
ES2210036T3 (es) 2004-07-01
KR20020058042A (ko) 2002-07-12
AU5789701A (en) 2001-07-24
MXPA02003822A (es) 2002-12-13
HK1052176A1 (en) 2003-09-05
CO5251469A1 (es) 2003-02-28
PT1235809E (pt) 2004-04-30
NO20022457D0 (no) 2002-05-24
UA72566C2 (ru) 2005-03-15
NO20022457L (no) 2002-05-24
BG106682A (bg) 2003-01-31
DE50004455D1 (de) 2003-12-18
HUP0204169A3 (en) 2005-03-29
ATE254108T1 (de) 2003-11-15
EP1235809B1 (de) 2003-11-12
SK9302002A3 (en) 2002-11-06
PL355493A1 (en) 2004-05-04
HUP0204169A2 (hu) 2003-03-28
EA005681B1 (ru) 2005-04-28

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MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG MD TJ TM RU