EA200000711A1 - 11β-ГАЛОГЕН-7α-ЗАМЕЩЕННЫЕ ЭСТРАТРИЕНЫ, СПОСОБ ПОЛУЧЕНИЯ ФАРМАЦЕВТИЧЕСКИХ ПРЕПАРАТОВ, СОДЕРЖАЩИХ ЭТИ 11β-ГАЛОГЕН-7α-ЗАМЕЩЕННЫЕ ЭСТРАТРИЕНЫ, И ИХ ПРИМЕНЕНИЕ ДЛЯ ИЗГОТОВЛЕНИЯ ЛЕКАРСТВЕННЫХ СРЕДСТВ - Google Patents

11β-ГАЛОГЕН-7α-ЗАМЕЩЕННЫЕ ЭСТРАТРИЕНЫ, СПОСОБ ПОЛУЧЕНИЯ ФАРМАЦЕВТИЧЕСКИХ ПРЕПАРАТОВ, СОДЕРЖАЩИХ ЭТИ 11β-ГАЛОГЕН-7α-ЗАМЕЩЕННЫЕ ЭСТРАТРИЕНЫ, И ИХ ПРИМЕНЕНИЕ ДЛЯ ИЗГОТОВЛЕНИЯ ЛЕКАРСТВЕННЫХ СРЕДСТВ

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Publication number
EA200000711A1
EA200000711A1 EA200000711A EA200000711A EA200000711A1 EA 200000711 A1 EA200000711 A1 EA 200000711A1 EA 200000711 A EA200000711 A EA 200000711A EA 200000711 A EA200000711 A EA 200000711A EA 200000711 A1 EA200000711 A1 EA 200000711A1
Authority
EA
Eurasian Patent Office
Prior art keywords
halogen
application
estratriens
substitute
products
Prior art date
Application number
EA200000711A
Other languages
English (en)
Other versions
EA002623B1 (ru
Inventor
Рольф Больманн
Николаус Хайнрих
Хельмут Хофмайстер
Йорг Кролл
Херманн Кюнцер
Герхард Зауэр
Людвиг Цорн
Карл-Хайнрих Фритцемейер
Моника Лессль
Розмари Лихтнер
Юкишиге Нишино
Карстен Парчик
Мартин Шнайдер
Original Assignee
Шеринг Акциенгезельшафт
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE1997158390 external-priority patent/DE19758390A1/de
Priority claimed from DE1998106357 external-priority patent/DE19806357A1/de
Application filed by Шеринг Акциенгезельшафт filed Critical Шеринг Акциенгезельшафт
Publication of EA200000711A1 publication Critical patent/EA200000711A1/ru
Publication of EA002623B1 publication Critical patent/EA002623B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0094—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 containing nitrile radicals, including thiocyanide radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/30—Oestrogens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/32—Antioestrogens
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
    • C07J31/006—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring not covered by C07J31/003
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0072—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the A ring of the steroid being aromatic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J43/003—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed

Abstract

В заявке описываются новые 11β-галоген-7α- замещенные эстратриены общей формулы (I)в которой Rпредставляет собой атом фтора или хлора, а остальные заместители имеют значения, указанные более подробно в описании. Предлагаемые соединения обладают антиэстрогенными свойствами или эстрогенными свойствами с избирательным действием по отношению к тканям и могут применяться для изготовления соответствующих лекарственных средств.Международная заявка была опубликована вместе с отчетом о международном поиске.
EA200000711A 1997-12-23 1998-12-23 11β-ГАЛОГЕН-7α-ЗАМЕЩЕННЫЕ ЭСТРАТРИЕНЫ, СПОСОБ ПОЛУЧЕНИЯ ФАРМАЦЕВТИЧЕСКИХ ПРЕПАРАТОВ, СОДЕРЖАЩИХ ЭТИ 11β-ГАЛОГЕН-7α-ЗАМЕЩЕННЫЕ ЭСТРАТРИЕНЫ, И ИХ ПРИМЕНЕНИЕ ДЛЯ ИЗГОТОВЛЕНИЯ ЛЕКАРСТВЕННЫХ СРЕДСТВ EA002623B1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE1997158390 DE19758390A1 (de) 1997-12-23 1997-12-23 11ß-Halogen-7alpha-substituierte-Estratriene, Verfahren zur Herstellung pharmazeutischer Präparate, die diese 11ß-Halogen-7alpha-substituierte Estratriene enthalten, sowie deren Verwendung zur Herstellung von Arzneimitteln
DE1998106357 DE19806357A1 (de) 1998-02-10 1998-02-10 11beta-Halogen-7alpha-substituierte-Estratriene, Verfahren zur Herstellung pharmazeutischer Präparate, die diese 11beta-Halogen-7alpha-substituierte Estratriene enthalten, sowie deren Verwendung zur Herstellung von Arzneimitteln
PCT/EP1998/008470 WO1999033855A1 (de) 1997-12-23 1998-12-23 11β-HALOGEN-7α-SUBSTITUIERTE-ESTRATRIENE, VERFAHREN ZUR HERSTELLUNG PHARMAZEUTISCHER PRÄPARATE, DIE DIESE 11β-HALOGEN-7α-SUBSTITUIERTE-ESTRATRIENE ENTHALTEN, SOWIE DEREN VERWENDUNG ZUR HERSTELLUNG VON ARZNEIMITTELN

Publications (2)

Publication Number Publication Date
EA200000711A1 true EA200000711A1 (ru) 2001-02-26
EA002623B1 EA002623B1 (ru) 2002-06-27

Family

ID=26042916

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200000711A EA002623B1 (ru) 1997-12-23 1998-12-23 11β-ГАЛОГЕН-7α-ЗАМЕЩЕННЫЕ ЭСТРАТРИЕНЫ, СПОСОБ ПОЛУЧЕНИЯ ФАРМАЦЕВТИЧЕСКИХ ПРЕПАРАТОВ, СОДЕРЖАЩИХ ЭТИ 11β-ГАЛОГЕН-7α-ЗАМЕЩЕННЫЕ ЭСТРАТРИЕНЫ, И ИХ ПРИМЕНЕНИЕ ДЛЯ ИЗГОТОВЛЕНИЯ ЛЕКАРСТВЕННЫХ СРЕДСТВ

Country Status (27)

Country Link
US (1) US6780855B2 (ru)
EP (1) EP1042355B1 (ru)
JP (1) JP2001527088A (ru)
KR (1) KR20010024806A (ru)
CN (1) CN1131235C (ru)
AR (1) AR015500A1 (ru)
AT (1) ATE232543T1 (ru)
AU (1) AU750801B2 (ru)
BG (1) BG104553A (ru)
BR (1) BR9814416A (ru)
CA (1) CA2316444A1 (ru)
DE (1) DE59807213D1 (ru)
DK (1) DK1042355T3 (ru)
EA (1) EA002623B1 (ru)
EE (1) EE200000380A (ru)
ES (1) ES2191371T3 (ru)
HU (1) HUP0100568A3 (ru)
ID (1) ID26207A (ru)
IL (1) IL136938A0 (ru)
IS (1) IS5526A (ru)
NO (1) NO20003286L (ru)
NZ (1) NZ505348A (ru)
PE (1) PE20000129A1 (ru)
PL (1) PL341299A1 (ru)
SK (1) SK9442000A3 (ru)
TR (1) TR200001973T2 (ru)
WO (1) WO1999033855A1 (ru)

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JP5298631B2 (ja) 2007-05-18 2013-09-25 住友化学株式会社 有機硫黄化合物及びその有害節足動物防除用途
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TW200904329A (en) 2007-05-18 2009-02-01 Sumitomo Chemical Co Organic sulfur compound and its use for controlling harmful arthropod
DE102007032800A1 (de) 2007-07-10 2009-01-15 Bayer Schering Pharma Aktiengesellschaft Nichtsteroidale Progesteronrezeptor-Modulatoren
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DE102009034366A1 (de) 2009-07-20 2011-01-27 Bayer Schering Pharma Aktiengesellschaft 17-Hydroxy-17-pentafluorethyl-estra-4,9(10)-dien-11-methylenoxyalkylenaryl-Derivate, Verfahren zu ihrer Herstellung und ihre Verwendung zur Behandlung von Krankheiten
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Also Published As

Publication number Publication date
JP2001527088A (ja) 2001-12-25
NO20003286D0 (no) 2000-06-22
SK9442000A3 (en) 2001-04-09
NZ505348A (en) 2002-10-25
US6780855B2 (en) 2004-08-24
EP1042355A1 (de) 2000-10-11
BG104553A (bg) 2001-02-28
EE200000380A (et) 2001-12-17
ATE232543T1 (de) 2003-02-15
ES2191371T3 (es) 2003-09-01
EA002623B1 (ru) 2002-06-27
PE20000129A1 (es) 2000-03-11
HUP0100568A2 (hu) 2001-08-28
EP1042355B1 (de) 2003-02-12
AR015500A1 (es) 2001-05-02
PL341299A1 (en) 2001-04-09
AU750801B2 (en) 2002-07-25
US20030069434A1 (en) 2003-04-10
BR9814416A (pt) 2000-10-10
AU2276399A (en) 1999-07-19
IS5526A (is) 2000-06-09
HUP0100568A3 (en) 2002-01-28
CN1286693A (zh) 2001-03-07
DK1042355T3 (da) 2003-04-22
CN1131235C (zh) 2003-12-17
IL136938A0 (en) 2001-06-14
NO20003286L (no) 2000-08-23
TR200001973T2 (tr) 2001-01-22
DE59807213D1 (de) 2003-03-20
CA2316444A1 (en) 1999-07-08
ID26207A (id) 2000-12-07
WO1999033855A1 (de) 1999-07-08
KR20010024806A (ko) 2001-03-26

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