TR200001973T2 - 11 ß-halojen-7alfa-ile ikame edilmiş-estratrienler, bu 11ß-halojen-7alfa-ile ikame edilmiş-estratrienleri içeren farmasötik terkiplerin üretimi için yöntem ve ilaç üretiminde kullanımları. - Google Patents
11 ß-halojen-7alfa-ile ikame edilmiş-estratrienler, bu 11ß-halojen-7alfa-ile ikame edilmiş-estratrienleri içeren farmasötik terkiplerin üretimi için yöntem ve ilaç üretiminde kullanımları.Info
- Publication number
- TR200001973T2 TR200001973T2 TR2000/01973T TR200001973T TR200001973T2 TR 200001973 T2 TR200001973 T2 TR 200001973T2 TR 2000/01973 T TR2000/01973 T TR 2000/01973T TR 200001973 T TR200001973 T TR 200001973T TR 200001973 T2 TR200001973 T2 TR 200001973T2
- Authority
- TR
- Turkey
- Prior art keywords
- estratrienes
- halogen
- substituted
- 7alpha
- manufacture
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
- C07J41/0094—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 containing nitrile radicals, including thiocyanide radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/30—Oestrogens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/32—Antioestrogens
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
- C07J31/006—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring not covered by C07J31/003
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
- C07J41/0072—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the A ring of the steroid being aromatic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
- C07J43/003—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed
Abstract
Bulus asagidaki genel formül I' in 11 -halojen-7alfa-ile-ikame edilmis-estratrienleriyle alakalidir: (Formül (I)) Burada R11 bir flor veya klor atomudur ve diger sübstitüanlar tarfnamede ayrintili olarak açiklanmis anlamlara sahiptir. Bilesimler antiöstrojen veya doku seçici östrojen özelliklere sahiptir ve ilaç üretimi uygundur.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE1997158390 DE19758390A1 (de) | 1997-12-23 | 1997-12-23 | 11ß-Halogen-7alpha-substituierte-Estratriene, Verfahren zur Herstellung pharmazeutischer Präparate, die diese 11ß-Halogen-7alpha-substituierte Estratriene enthalten, sowie deren Verwendung zur Herstellung von Arzneimitteln |
DE1998106357 DE19806357A1 (de) | 1998-02-10 | 1998-02-10 | 11beta-Halogen-7alpha-substituierte-Estratriene, Verfahren zur Herstellung pharmazeutischer Präparate, die diese 11beta-Halogen-7alpha-substituierte Estratriene enthalten, sowie deren Verwendung zur Herstellung von Arzneimitteln |
Publications (1)
Publication Number | Publication Date |
---|---|
TR200001973T2 true TR200001973T2 (tr) | 2001-01-22 |
Family
ID=26042916
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
TR2000/01973T TR200001973T2 (tr) | 1997-12-23 | 1998-12-23 | 11 ß-halojen-7alfa-ile ikame edilmiş-estratrienler, bu 11ß-halojen-7alfa-ile ikame edilmiş-estratrienleri içeren farmasötik terkiplerin üretimi için yöntem ve ilaç üretiminde kullanımları. |
Country Status (27)
Country | Link |
---|---|
US (1) | US6780855B2 (tr) |
EP (1) | EP1042355B1 (tr) |
JP (1) | JP2001527088A (tr) |
KR (1) | KR20010024806A (tr) |
CN (1) | CN1131235C (tr) |
AR (1) | AR015500A1 (tr) |
AT (1) | ATE232543T1 (tr) |
AU (1) | AU750801B2 (tr) |
BG (1) | BG104553A (tr) |
BR (1) | BR9814416A (tr) |
CA (1) | CA2316444A1 (tr) |
DE (1) | DE59807213D1 (tr) |
DK (1) | DK1042355T3 (tr) |
EA (1) | EA002623B1 (tr) |
EE (1) | EE200000380A (tr) |
ES (1) | ES2191371T3 (tr) |
HU (1) | HUP0100568A3 (tr) |
ID (1) | ID26207A (tr) |
IL (1) | IL136938A0 (tr) |
IS (1) | IS5526A (tr) |
NO (1) | NO20003286L (tr) |
NZ (1) | NZ505348A (tr) |
PE (1) | PE20000129A1 (tr) |
PL (1) | PL341299A1 (tr) |
SK (1) | SK9442000A3 (tr) |
TR (1) | TR200001973T2 (tr) |
WO (1) | WO1999033855A1 (tr) |
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CZ299945B6 (cs) * | 2000-10-18 | 2008-12-29 | Schering Aktiengesellschaft | Lécivo obsahující 17alfa-fluoralkylsteroid pro lécení karcinomu prsu rezistentního vuci steroidum |
DE10159217A1 (de) * | 2001-11-27 | 2003-06-05 | Schering Ag | 17alpha-Alkyl-17ß-oxy-estratriene und Zwischenprodukte zu deren Herstellung, Verwendung der 17alpha-Alkyl-17ß-oxy-estratriene zur Herstellung von Arzneimitteln sowie pharmazeutische Präparate |
AU2006202187B2 (en) * | 2001-11-27 | 2008-11-06 | Bayer Schering Pharma Aktiengesellschaft | 17alpah-alkyl-17beta-oxy-estratrienes and intermediate products for their production, uses thereof and pharmaceutical preparations |
US20040242551A1 (en) * | 2003-05-28 | 2004-12-02 | Schering Ag | Composition comprising antiprogestins and pure antiestrogens for prophylaxis and treatment of hormone-dependent diseases |
WO2005035517A1 (en) * | 2003-10-14 | 2005-04-21 | Council Of Scientific And Industrial Research | (3r, 4r)-trans-3,4-diarylchroman derivatives with estrogenic activity |
EP1771462B1 (en) * | 2004-07-27 | 2010-09-29 | Sicor Inc. | A process for the preparation of 7-alpha-alkylated 19-norsteroids |
WO2007060839A1 (en) | 2005-11-22 | 2007-05-31 | Sumitomo Chemical Company, Limited | Organic sulfur compounds and use thereof as arthropodicides |
DE102007023614A1 (de) | 2007-05-21 | 2008-11-27 | Bayer Schering Pharma Aktiengesellschaft | Nichtsteroidale Progesteronrezeptor-Modulatoren |
DE102007049630A1 (de) | 2007-10-11 | 2009-10-29 | Bayer Schering Pharma Aktiengesellschaft | Nichtsteroidale Progesteronrezeptor-Modulatoren |
JP5298631B2 (ja) | 2007-05-18 | 2013-09-25 | 住友化学株式会社 | 有機硫黄化合物及びその有害節足動物防除用途 |
JP2009001551A (ja) | 2007-05-18 | 2009-01-08 | Sumitomo Chemical Co Ltd | 有機硫黄化合物及びその有害節足動物防除用途 |
TW200904329A (en) | 2007-05-18 | 2009-02-01 | Sumitomo Chemical Co | Organic sulfur compound and its use for controlling harmful arthropod |
DE102007032800A1 (de) | 2007-07-10 | 2009-01-15 | Bayer Schering Pharma Aktiengesellschaft | Nichtsteroidale Progesteronrezeptor-Modulatoren |
EP2033948A1 (en) * | 2007-08-30 | 2009-03-11 | Bayer Schering Pharma Aktiengesellschaft | Process for preparing Estrogen-antagonistic 11beta-Fluoro-17alpha-alkylestra-1,3,5 (10)-triene-3, 17-diols having a 7alpha-(xi-Alkylamino-omega-perfluoroalkyl)alkyl side chain and alpha-Alkyl(amino)-omega-perfluoro(alkyl)alkanes and processes for their preparation |
UA96076C2 (en) | 2007-10-16 | 2011-09-26 | Репрос Терапьютикс Инк. | Use of trans-clomiphene |
EP2053055A1 (de) * | 2007-10-24 | 2009-04-29 | Bayer Schering Pharma Aktiengesellschaft | 11.beta.-Fluoro-3-acetoxyestra-3,5-dien-17-on und Verfahren zu seiner Herstellung |
DE102007058747A1 (de) | 2007-12-05 | 2009-06-10 | Bayer Schering Pharma Aktiengesellschaft | Nichtsteroidale Progesteronrezeptor-Modulatoren |
EP2070942A1 (de) | 2007-12-13 | 2009-06-17 | Bayer Schering Pharma Aktiengesellschaft | Verfahren zur Aromatisierung von 19-Nor-androst-4-en-3-onen zu Estra-1,3,5(10)-trienen |
EP2070941A1 (en) | 2007-12-14 | 2009-06-17 | Bayer Schering Pharma Aktiengesellschaft | Stereoselective synthesis of selective estrogen receptor down-regulators |
EP2070909A1 (de) | 2007-12-15 | 2009-06-17 | Bayer Schering Pharma AG | Nichtsteroidale Progesteronrezeptor-Modulatoren |
EP2258375A1 (de) | 2009-06-04 | 2010-12-08 | Bayer Schering Pharma Aktiengesellschaft | 17B-alkyl-17alpha-oxy-estratriene |
DE102009034368A1 (de) | 2009-07-20 | 2011-01-27 | Bayer Schering Pharma Aktiengesellschaft | 17-Hydroxy-17-pentafluorethyl-estra-4,9(10)-dien-11-acyloxyalkylenphenyl-Derivate, Verfahren zu ihrer Herstellung und ihre Verwendung zur Behandlung von Krankheiten |
DE102009034367A1 (de) | 2009-07-20 | 2011-01-27 | Bayer Schering Pharma Aktiengesellschaft | 17-Hydroxy-17-pentafluorethyl-estra-4,9(10)-dien-11-benzyliden-Derivate, Verfahren zu deren Herstellung und deren Verwendung zur Behandlung von Krankheiten |
DE102009034362A1 (de) | 2009-07-20 | 2011-01-27 | Bayer Schering Pharma Aktiengesellschaft | 17-Hydroxy-17-pentafluorethyl-estra-4,9(10)-dien-11-aryl-Derivate, Verfahren zu ihrer Herstellung und ihre Verwendung zur Behandlung von Krankheiten |
DE102009034366A1 (de) | 2009-07-20 | 2011-01-27 | Bayer Schering Pharma Aktiengesellschaft | 17-Hydroxy-17-pentafluorethyl-estra-4,9(10)-dien-11-methylenoxyalkylenaryl-Derivate, Verfahren zu ihrer Herstellung und ihre Verwendung zur Behandlung von Krankheiten |
DE102009034526A1 (de) | 2009-07-21 | 2011-02-10 | Bayer Schering Pharma Aktiengesellschaft | 17-Hydroxy-17-pentafluorethyl-estra-4,9(10)-dien-11-ethinylphenyl-Derivate, Verfahren zu deren Herstellung und deren Verwendung zur Behandlung von Krankheiten |
DE102009034525A1 (de) | 2009-07-21 | 2011-01-27 | Bayer Schering Pharma Aktiengesellschaft | 17-Hydroxy-17-pentafluorethyl-estra-4,9(10)-dien-11-aryl-Derivate, Verfahren zu ihrer Herstellung und ihre Verwendung zur Behandlung von Krankheiten |
DE102010007722A1 (de) | 2010-02-10 | 2011-08-11 | Bayer Schering Pharma Aktiengesellschaft, 13353 | Progesteronrezeptorantagonisten |
DE102010007719A1 (de) | 2010-02-10 | 2011-08-11 | Bayer Schering Pharma Aktiengesellschaft, 13353 | Progesteronrezeptorantagonisten |
DE102010030538A1 (de) | 2010-06-25 | 2011-12-29 | Bayer Schering Pharma Aktiengesellschaft | 6,7-Dihydro-5H-benzo[7]annulen-Derivate, Verfahren zu ihrer Herstellung, pharmazeutische Präparate die diese enthalten, sowie deren Verwendung zur Herstellung von Arzneimitteln |
DE102011004899A1 (de) | 2011-03-01 | 2012-09-06 | Bayer Pharma Aktiengesellschaft | 17-Hydroxy-17-pentafluorethyl-estra-4,9(10)-dien-11-aryl-Derivate, Verfahren zu ihrer Herstellung und ihre Verwendung zur Behandlung von Krankheiten |
DE102011087987A1 (de) | 2011-12-08 | 2013-06-13 | Bayer Intellectual Property Gmbh | 6,7-Dihydro-5H-benzo[7]annulen-Derivate, Verfahren zu ihrer Herstellung, pharmazeutische Präparate die diese enthalten, sowie deren Verwendung zur Herstellung von Arzneimitteln |
JP2015508825A (ja) | 2012-02-29 | 2015-03-23 | レプロス セラピューティクス インコーポレイティド | アンドロゲン欠乏症を治療するための併用療法 |
EP2983671B1 (en) | 2013-04-11 | 2018-10-24 | Bayer Pharma Aktiengesellschaft | Progesterone receptor antagonist dosage form |
AU2013386732B2 (en) * | 2013-04-18 | 2018-10-18 | Xi'an Libang Pharmaceutical Technology Co., Ltd. | Ester derivative of 7-alpha-[9-(4,4,5,5,5-pentafluoropentylsulphinyl)nonyl]oestra-1,3,5(10)-triene-3,17beta-diol having antitumour activity and preparation method thereof |
CN104387435B (zh) * | 2014-12-10 | 2017-05-10 | 天津孚音生物科技发展有限公司 | 一种化合物及其制备方法与应用 |
CN106146599A (zh) * | 2015-04-07 | 2016-11-23 | 江苏希迪制药有限公司 | 一种回收因亚砜构型比例不合格的氟维司群或其衍生物的方法 |
US11633382B2 (en) | 2015-11-10 | 2023-04-25 | Paracrine Therapeutics Ab | Treatment of ER-negative breast cancer with an PDGF-CC inhibitor and anti-estrogen |
CN112778089B (zh) * | 2021-01-04 | 2023-09-05 | 万知科技股份有限公司 | 一种4,4,4-三氟-1-丁醇及其同系物的新合成方法 |
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US3076829A (en) * | 1961-09-15 | 1963-02-05 | Schering Corp | Novel 9, 11-disubstituted estratriene derivatives |
GB8327256D0 (en) * | 1983-10-12 | 1983-11-16 | Ici Plc | Steroid derivatives |
HU208150B (en) * | 1988-10-31 | 1993-08-30 | Endorecherche Inc | Process for producing new estrogen derivatives having steroid hormone inhibitor activity and pharmaceutical compositions comprising such derivatives |
DE19635525A1 (de) * | 1996-08-20 | 1998-02-26 | Schering Ag | 7alpha-(xi-Aminoalkyl)-estratriene, Verfahren zu deren Herstellung, pharmazeutische Präparate, die diese 7alpha(xi-Aminoalkyl-estratriene enthalten sowie deren Verwendung zur Herstellung von Arzneimitteln |
US5866560A (en) * | 1996-08-20 | 1999-02-02 | Schering Ag | 7α-(ξ-aminoalkyl)-estratrienes, process for their production, pharmaceutical preparations which contain these 7α-(ξ-aminoalkyl)-estratrienes as well as their use for the production of pharmaceutical agents |
-
1998
- 1998-12-18 AR ARP980106471A patent/AR015500A1/es not_active Application Discontinuation
- 1998-12-18 PE PE1998001246A patent/PE20000129A1/es not_active Application Discontinuation
- 1998-12-23 US US09/380,413 patent/US6780855B2/en not_active Expired - Fee Related
- 1998-12-23 EA EA200000711A patent/EA002623B1/ru not_active IP Right Cessation
- 1998-12-23 SK SK944-2000A patent/SK9442000A3/sk unknown
- 1998-12-23 HU HU0100568A patent/HUP0100568A3/hu unknown
- 1998-12-23 NZ NZ505348A patent/NZ505348A/xx unknown
- 1998-12-23 AU AU22763/99A patent/AU750801B2/en not_active Ceased
- 1998-12-23 IL IL13693898A patent/IL136938A0/xx unknown
- 1998-12-23 PL PL98341299A patent/PL341299A1/xx unknown
- 1998-12-23 DK DK98966410T patent/DK1042355T3/da active
- 1998-12-23 TR TR2000/01973T patent/TR200001973T2/tr unknown
- 1998-12-23 KR KR1020007006955A patent/KR20010024806A/ko not_active Application Discontinuation
- 1998-12-23 WO PCT/EP1998/008470 patent/WO1999033855A1/de not_active Application Discontinuation
- 1998-12-23 EP EP98966410A patent/EP1042355B1/de not_active Expired - Lifetime
- 1998-12-23 AT AT98966410T patent/ATE232543T1/de not_active IP Right Cessation
- 1998-12-23 CA CA002316444A patent/CA2316444A1/en not_active Abandoned
- 1998-12-23 JP JP2000526531A patent/JP2001527088A/ja active Pending
- 1998-12-23 ES ES98966410T patent/ES2191371T3/es not_active Expired - Lifetime
- 1998-12-23 CN CN98812631A patent/CN1131235C/zh not_active Expired - Fee Related
- 1998-12-23 DE DE59807213T patent/DE59807213D1/de not_active Expired - Fee Related
- 1998-12-23 EE EEP200000380A patent/EE200000380A/xx unknown
- 1998-12-23 BR BR9814416-2A patent/BR9814416A/pt not_active IP Right Cessation
- 1998-12-23 ID IDW20001234A patent/ID26207A/id unknown
-
2000
- 2000-06-09 IS IS5526A patent/IS5526A/is unknown
- 2000-06-22 NO NO20003286A patent/NO20003286L/no not_active Application Discontinuation
- 2000-06-23 BG BG104553A patent/BG104553A/bg unknown
Also Published As
Publication number | Publication date |
---|---|
JP2001527088A (ja) | 2001-12-25 |
NO20003286D0 (no) | 2000-06-22 |
SK9442000A3 (en) | 2001-04-09 |
NZ505348A (en) | 2002-10-25 |
US6780855B2 (en) | 2004-08-24 |
EP1042355A1 (de) | 2000-10-11 |
BG104553A (bg) | 2001-02-28 |
EE200000380A (et) | 2001-12-17 |
ATE232543T1 (de) | 2003-02-15 |
ES2191371T3 (es) | 2003-09-01 |
EA200000711A1 (ru) | 2001-02-26 |
EA002623B1 (ru) | 2002-06-27 |
PE20000129A1 (es) | 2000-03-11 |
HUP0100568A2 (hu) | 2001-08-28 |
EP1042355B1 (de) | 2003-02-12 |
AR015500A1 (es) | 2001-05-02 |
PL341299A1 (en) | 2001-04-09 |
AU750801B2 (en) | 2002-07-25 |
US20030069434A1 (en) | 2003-04-10 |
BR9814416A (pt) | 2000-10-10 |
AU2276399A (en) | 1999-07-19 |
IS5526A (is) | 2000-06-09 |
HUP0100568A3 (en) | 2002-01-28 |
CN1286693A (zh) | 2001-03-07 |
DK1042355T3 (da) | 2003-04-22 |
CN1131235C (zh) | 2003-12-17 |
IL136938A0 (en) | 2001-06-14 |
NO20003286L (no) | 2000-08-23 |
DE59807213D1 (de) | 2003-03-20 |
CA2316444A1 (en) | 1999-07-08 |
ID26207A (id) | 2000-12-07 |
WO1999033855A1 (de) | 1999-07-08 |
KR20010024806A (ko) | 2001-03-26 |
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