SE9801992D0 - New 3-aryl-2-hydroxypropionic acid derivative I - Google Patents

New 3-aryl-2-hydroxypropionic acid derivative I

Info

Publication number
SE9801992D0
SE9801992D0 SE9801992A SE9801992A SE9801992D0 SE 9801992 D0 SE9801992 D0 SE 9801992D0 SE 9801992 A SE9801992 A SE 9801992A SE 9801992 A SE9801992 A SE 9801992A SE 9801992 D0 SE9801992 D0 SE 9801992D0
Authority
SE
Sweden
Prior art keywords
aryl
acid derivative
hydroxypropionic acid
new
novel
Prior art date
Application number
SE9801992A
Other languages
English (en)
Inventor
Kjell Andersson
Original Assignee
Astra Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astra Ab filed Critical Astra Ab
Priority to SE9801992A priority Critical patent/SE9801992D0/sv
Publication of SE9801992D0 publication Critical patent/SE9801992D0/sv
Priority to MA25592A priority patent/MA26635A1/fr
Priority to MA25591A priority patent/MA26634A1/fr
Priority to DZ990099A priority patent/DZ2799A1/xx
Priority to DZ990100A priority patent/DZ2800A1/xx
Priority to TW088108576A priority patent/TW446696B/zh
Priority to TW088108577A priority patent/TW548263B/zh
Priority to US09/341,904 priority patent/US6258850B1/en
Priority to ES99930059T priority patent/ES2205844T3/es
Priority to AU46671/99A priority patent/AU752261B2/en
Priority to IL13963699A priority patent/IL139636A/xx
Priority to KR1020007013673A priority patent/KR20010052529A/ko
Priority to TR2000/03581T priority patent/TR200003581T2/xx
Priority to AT99930059T priority patent/ATE246674T1/de
Priority to UA2000116620A priority patent/UA66852C2/uk
Priority to HU0103376A priority patent/HUP0103376A3/hu
Priority to BR9910921-2A priority patent/BR9910921A/pt
Priority to SI9930452T priority patent/SI1084102T1/xx
Priority to CA002333938A priority patent/CA2333938C/en
Priority to CNB2005100687433A priority patent/CN1310881C/zh
Priority to IDW20002669A priority patent/ID29457A/id
Priority to TR2000/03583T priority patent/TR200003583T2/xx
Priority to PL99345205A priority patent/PL195189B1/pl
Priority to SI9930405T priority patent/SI1084103T1/xx
Priority to PL99344681A priority patent/PL344681A1/xx
Priority to ES99930060T priority patent/ES2209457T3/es
Priority to AT99930060T priority patent/ATE251130T1/de
Priority to HU0103226A priority patent/HUP0103226A3/hu
Priority to PCT/SE1999/000941 priority patent/WO1999062872A1/en
Priority to CA002334374A priority patent/CA2334374A1/en
Priority to CN99809354A priority patent/CN1312795A/zh
Priority to DE69911770T priority patent/DE69911770T2/de
Priority to JP2000552085A priority patent/JP3554539B2/ja
Priority to IDW20002652A priority patent/ID28833A/id
Priority to CZ20004484A priority patent/CZ297424B6/cs
Priority to KR1020007013662A priority patent/KR100625152B1/ko
Priority to PT99930060T priority patent/PT1084102E/pt
Priority to UA2000116621A priority patent/UA71912C2/uk
Priority to PT99930059T priority patent/PT1084103E/pt
Priority to EEP200000720A priority patent/EE04772B1/xx
Priority to IL13963599A priority patent/IL139635A0/xx
Priority to EP99930059A priority patent/EP1084103B1/en
Priority to NZ508453A priority patent/NZ508453A/xx
Priority to DE69910203T priority patent/DE69910203T2/de
Priority to BR9910928-0A priority patent/BR9910928A/pt
Priority to SK1768-2000A priority patent/SK284642B6/sk
Priority to PCT/SE1999/000942 priority patent/WO1999062871A1/en
Priority to RU2000130189/04A priority patent/RU2214999C2/ru
Priority to JP2000552084A priority patent/JP3723739B2/ja
Priority to NZ508452A priority patent/NZ508452A/en
Priority to EEP200000725A priority patent/EE04463B1/xx
Priority to YUP-745/00A priority patent/RS49688B/sr
Priority to DK99930059T priority patent/DK1084103T3/da
Priority to DK99930060T priority patent/DK1084102T3/da
Priority to EP99930060A priority patent/EP1084102B1/en
Priority to SK1769-2000A priority patent/SK284849B6/sk
Priority to CN99809340A priority patent/CN1311772A/zh
Priority to US09/341,931 priority patent/US6630600B1/en
Priority to AU46672/99A priority patent/AU752262B2/en
Priority to MYPI99002209A priority patent/MY117785A/en
Priority to MYPI99002185A priority patent/MY129581A/en
Priority to TNTNSN99103A priority patent/TNSN99103A1/fr
Priority to TNTNSN99108A priority patent/TNSN99108A1/fr
Priority to ARP990102634A priority patent/AR035305A1/es
Priority to ARP990102635A priority patent/AR020875A1/es
Priority to EG65699A priority patent/EG24140A/xx
Priority to SA99200304A priority patent/SA99200304B1/ar
Priority to ARP000102487A priority patent/AR024061A2/es
Priority to HR20000782A priority patent/HRP20000782B1/xx
Priority to IS5714A priority patent/IS2071B/is
Priority to ZA200006774A priority patent/ZA200006774B/en
Priority to IS5744A priority patent/IS5744A/is
Priority to NO20006115A priority patent/NO323426B1/no
Priority to NO20006116A priority patent/NO20006116L/no
Priority to US09/861,163 priority patent/US20010034371A1/en
Priority to HK01105768A priority patent/HK1034957A1/xx
Priority to HK01105811A priority patent/HK1035711A1/xx
Priority to US10/039,868 priority patent/US6660879B2/en
Priority to JP2003273428A priority patent/JP2004043480A/ja
Priority to US10/669,131 priority patent/US20040229946A1/en
Priority to US10/678,739 priority patent/US20040229949A1/en
Priority to JP2004183263A priority patent/JP2004346079A/ja
Priority to US11/078,201 priority patent/US20060040979A1/en
Priority to US11/388,942 priority patent/US20060173204A1/en

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    • C07C303/30—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of esters of sulfonic acids by reactions not involving the formation of esterified sulfo groups
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    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/23—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
    • C07C323/39—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton at least one of the nitrogen atoms being part of any of the groups, X being a hetero atom, Y being any atom
    • C07C323/43—Y being a hetero atom
    • C07C323/44—X or Y being nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
    • C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/56—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C335/00—Thioureas, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C335/04—Derivatives of thiourea
    • C07C335/16—Derivatives of thiourea having nitrogen atoms of thiourea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C335/18—Derivatives of thiourea having nitrogen atoms of thiourea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by singly-bound oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated
SE9801992A 1998-06-04 1998-06-04 New 3-aryl-2-hydroxypropionic acid derivative I SE9801992D0 (sv)

Priority Applications (84)

Application Number Priority Date Filing Date Title
SE9801992A SE9801992D0 (sv) 1998-06-04 1998-06-04 New 3-aryl-2-hydroxypropionic acid derivative I
MA25592A MA26635A1 (fr) 1998-06-04 1999-05-20 Nouveau derive i de l'acide 3-aryl-2-hydroxypropionique
MA25591A MA26634A1 (fr) 1998-06-04 1999-05-20 Nouveaux derives de l'acide 3-aryl propionique et analogues
DZ990099A DZ2799A1 (fr) 1998-06-04 1999-05-23 Nouveaux dérivés de l'acide 3-aryl propionique et analogues.
DZ990100A DZ2800A1 (fr) 1998-06-04 1999-05-23 Nouveau dérivé de l'acide 3-aryl-2-hydroxypropionique.
TW088108576A TW446696B (en) 1998-06-04 1999-05-25 New 3-aryl-2-hydroxypropionic acid derivative I
TW088108577A TW548263B (en) 1998-06-04 1999-05-25 New 3-aryl propionic acid derivatives and analogs
US09/341,904 US6258850B1 (en) 1998-06-04 1999-05-31 3-aryl-2-hydroxypropionic acid derivative (I)
ES99930059T ES2205844T3 (es) 1998-06-04 1999-05-31 Nuevo derivado (i) de acido 3-aril-2-hidroxipropionico.
AU46671/99A AU752261B2 (en) 1998-06-04 1999-05-31 New 3-aryl-2-hydroxypropionic acid derivative (I)
IL13963699A IL139636A (en) 1998-06-04 1999-05-31 (s)-2-ethoxy-3-[4-(2{4-methanesulfonyloxyphenyl} ethoxy) phenyl] propanoic acid, process for its preparation, pharmaceutical composition containing it and use thereof in the manufacture of medicament for the prophylaxis or treatment of clinical conditions associated with insulin resistance
KR1020007013673A KR20010052529A (ko) 1998-06-04 1999-05-31 신규한 3-아릴 프로피온산 유도체 및 동족체
TR2000/03581T TR200003581T2 (tr) 1998-06-04 1999-05-31 Yeni 3-aril-2-hidroksipropiyonik asit türevi (I)
AT99930059T ATE246674T1 (de) 1998-06-04 1999-05-31 Neue 3-aryl-2-hydroxypropionsäure-derivate
UA2000116620A UA66852C2 (uk) 1998-06-04 1999-05-31 Похідні та аналоги 3-арилпропіонової кислоти, спосіб їх отримання, фармацевтична композиція (варіанти) та спосіб профілактики та/або лікування асоційованих з резистентністю до інсуліну клінічних станів
HU0103376A HUP0103376A3 (en) 1998-06-04 1999-05-31 New 3-aryl-2-hydroxypropionic acid derivative, pharmaceutical compositions containing it, process for their preparation and their use
BR9910921-2A BR9910921A (pt) 1998-06-04 1999-05-31 Composto, processo para preparar o mesmo, formulação farmacêutica, uso de um composto, e, processo para a profilaxia e/ou tratamento de condições clìnicas associadas com a resistência à insulina
SI9930452T SI1084102T1 (en) 1998-06-04 1999-05-31 New 3-aryl propionic acid derivatives and analogs
CA002333938A CA2333938C (en) 1998-06-04 1999-05-31 New 3-aryl-2-hydroxypropionic acid derivative (i)
CNB2005100687433A CN1310881C (zh) 1998-06-04 1999-05-31 新的3－芳基－2－羟基丙酸衍生物i
IDW20002669A ID29457A (id) 1998-06-04 1999-05-31 Turunan dan analog asam 3-aril propionat
TR2000/03583T TR200003583T2 (tr) 1998-06-04 1999-05-31 Yeni 3-aril propiyonik asit türevleri ve benzerleri.
PL99345205A PL195189B1 (pl) 1998-06-04 1999-05-31 Kwas (S)-2-etoksy-3-[4-(2-{4-metanosulfonyloksyfenylo}-etoksy)fenylo]propanowy, sposób jego wytwarzania, związki pośrednie, środek farmaceutyczny i zastosowanie kwasu (S)-2-etoksy-3-[4-(2-{4-metanosulfonyloksyfenylo}etoksy)fenylo]propanowego
SI9930405T SI1084103T1 (en) 1998-06-04 1999-05-31 New 3-aryl-2-hydroxypropionic acid derivative (i)
PL99344681A PL344681A1 (en) 1998-06-04 1999-05-31 New 3-aryl propionic acid derivatives and analogs
ES99930060T ES2209457T3 (es) 1998-06-04 1999-05-31 Nuevos derivados del acido 3-aril-propionico, y analogos.
AT99930060T ATE251130T1 (de) 1998-06-04 1999-05-31 Neue 3-aryl-propionsäurederivate und analoge
HU0103226A HUP0103226A3 (en) 1998-06-04 1999-05-31 New 3-aryl propionic acid derivatives and analogs
PCT/SE1999/000941 WO1999062872A1 (en) 1998-06-04 1999-05-31 New 3-aryl-2-hydroxypropionic acid derivative (i)
CA002334374A CA2334374A1 (en) 1998-06-04 1999-05-31 New 3-aryl propionic acid derivatives and analogs
CN99809354A CN1312795A (zh) 1998-06-04 1999-05-31 新的3－芳基丙酸衍生物和其类似物
DE69911770T DE69911770T2 (de) 1998-06-04 1999-05-31 Neue 3-aryl-propionsäurederivate und analoge
JP2000552085A JP3554539B2 (ja) 1998-06-04 1999-05-31 新規な３−アリール−２−ヒドロキシプロピオン酸誘導体ｉ
IDW20002652A ID28833A (id) 1998-06-04 1999-05-31 Turunan asam 3-aril-2-hidroksipropionat
CZ20004484A CZ297424B6 (cs) 1998-06-04 1999-05-31 Kyselina (S)-2-ethoxy-3-{4-[2-(4-methansulfonyloxyfenyl)-ethoxy]fenyl}propanová, zpusob její prípravy, farmaceutický prostredek s jejím obsahem a její pouzití
KR1020007013662A KR100625152B1 (ko) 1998-06-04 1999-05-31 신규한 3-아릴-2-히드록시프로피온산 유도체 (ｉ)
PT99930060T PT1084102E (pt) 1998-06-04 1999-05-31 Novos derivados do acido 3-aril-propionico e analogos
UA2000116621A UA71912C2 (en) 1998-06-04 1999-05-31 3-aryl-2-hydroxypropionic acid derivative, a process for its manufacture (variants), intermediate compound, a pharmaceutical composition (variants) and a method for prevention and/or treatment of clinical conditions associated with insulin resistance
PT99930059T PT1084103E (pt) 1998-06-04 1999-05-31 Novo derivado do acido 3-aril-2-hidroxipropionico (i)
EEP200000720A EE04772B1 (et) 1998-06-04 1999-05-31 3-arüül-2-hüdroksüpropaanhappe derivaat (I)
IL13963599A IL139635A0 (en) 1998-06-04 1999-05-31 New 3-aryl propionic acid derivatives and analogs
EP99930059A EP1084103B1 (en) 1998-06-04 1999-05-31 New 3-aryl-2-hydroxypropionic acid derivative (i)
NZ508453A NZ508453A (en) 1998-06-04 1999-05-31 New 3-aryl propionic acid derivatives and analogs and their use in the treatment of insulin resistance
DE69910203T DE69910203T2 (de) 1998-06-04 1999-05-31 Neue 3-aryl-2-hydroxypropionsäure-derivate
BR9910928-0A BR9910928A (pt) 1998-06-04 1999-05-31 Composto, processo para a prepará-lo, uso do mesmo, formulação, e, processo para a profilaxia e/ou tratamento de condições clinicas associadas com resistência a insulina
SK1768-2000A SK284642B6 (sk) 1998-06-04 1999-05-31 Deriváty kyseliny 3-aryl-2-hydroxypropiónovej, farmaceutický prípravok s ich obsahom a ich použitie
PCT/SE1999/000942 WO1999062871A1 (en) 1998-06-04 1999-05-31 New 3-aryl propionic acid derivatives and analogs
RU2000130189/04A RU2214999C2 (ru) 1998-06-04 1999-05-31 Производное 3-арил-2-гидроксипропионовой кислоты, способ его получения(варианты), фармацевтический препарат, способ лечения и промежуточный продукт
JP2000552084A JP3723739B2 (ja) 1998-06-04 1999-05-31 新規３−アリールプロピオン酸誘導体および類似体
NZ508452A NZ508452A (en) 1998-06-04 1999-05-31 New 3-aryl-2-hydroxypropionic acid derivative (I)
EEP200000725A EE04463B1 (et) 1998-06-04 1999-05-31 3-arüülpropaanhappe derivaadid ja nende analoogid, nende valmistamise meetod, neid sisaldavad ravimkoostised ja ühendid kasutamiseks ravis
YUP-745/00A RS49688B (sr) 1998-06-04 1999-05-31 Novi derivat 3-aril-2- hidroksipropionske kiseline (i)
DK99930059T DK1084103T3 (da) 1998-06-04 1999-05-31 Nyt 3-aryl-2-hydroxpropionsyrederivat (I)
DK99930060T DK1084102T3 (da) 1998-06-04 1999-05-31 Nye 3-arylpropionsyrederivater og analoge
EP99930060A EP1084102B1 (en) 1998-06-04 1999-05-31 New 3-aryl propionic acid derivatives and analogs
SK1769-2000A SK284849B6 (sk) 1998-06-04 1999-05-31 Deriváty a analógy kyseliny 3-arylpropiónovej, spôsob ich prípravy, farmaceutické formulácie s ich obsahom a ich použitie
CN99809340A CN1311772A (zh) 1998-06-04 1999-05-31 新的3－芳基－2－羟基丙酸衍生物i
US09/341,931 US6630600B1 (en) 1998-06-04 1999-05-31 3-aryl propionic acid derivatives and analogs
AU46672/99A AU752262B2 (en) 1998-06-04 1999-05-31 New 3-aryl propionic acid derivatives and analogs
MYPI99002209A MY117785A (en) 1998-06-04 1999-06-02 New 3-aryl-2-hydroxypropionic acid derivatives i
MYPI99002185A MY129581A (en) 1998-06-04 1999-06-02 New 3-aryl propionic acid derivatives and analogs
TNTNSN99103A TNSN99103A1 (fr) 1998-06-04 1999-06-02 Nouveaux derives de l'acide 3-aryl propionique et analogues
TNTNSN99108A TNSN99108A1 (fr) 1998-06-04 1999-06-02 Nouveau derive i de l'acide 3-aryl-2-hydroxypropionique
ARP990102634A AR035305A1 (es) 1998-06-04 1999-06-03 Derivados y analogos del acido 3-arilpropionico, proceso para su preparacion, formulaciones farmaceuticas, uso de los mismos en la elaboracion de medicamentos, y formulacion farmaceutica para usar en la profilaxis y/o tratamiento de trastornos clinicos asociados con la resistencia a la insulina
ARP990102635A AR020875A1 (es) 1998-06-04 1999-06-03 Compuesto acido (s)-2-etoxi-3-[4-(2-(4-metansulfoniloxi fenil)etoxi)fenil]-propanoico, proceso para su preparacion formulaicon farmaceutica, uso de dicho compuesto en la elaboracion de medicamentos, y formulacion farmaceutica
EG65699A EG24140A (en) 1998-06-04 1999-06-03 New 3-aryl-2-hydroxypropionic acid derivative
SA99200304A SA99200304B1 (ar) 1998-06-04 1999-06-28 مشتق جديد رقم 1 لـــ -2-aryl-3 hydroxypropionic acid
ARP000102487A AR024061A2 (es) 1998-06-04 2000-05-22 Intermediario acido 2-etoxi-3(-(2[4-metansulfoniloxifenil*etoxi*fenil*propanoico
HR20000782A HRP20000782B1 (en) 1998-06-04 2000-11-16 New 3-aryl-2-hydroxypropionic acid derivative (i)
IS5714A IS2071B (is) 1998-06-04 2000-11-17 Ný 3-arýl-2-hýdroxýprópíonsýruafleiða (I)
ZA200006774A ZA200006774B (en) 1998-06-04 2000-11-20 New 3-aryl-2-hydroxypropionic acid derivative (I).
IS5744A IS5744A (is) 1998-06-04 2000-11-29 Nýjar 3-arýl-própíónsýruafleiður og -hliðstæður
NO20006115A NO323426B1 (no) 1998-06-04 2000-12-01 Nytt 3-aryl-2-hydroksypropionsyrederivat, fremgangsmate for fremstilling derav samt anvendelse derav i terapi
NO20006116A NO20006116L (no) 1998-06-04 2000-12-01 Nye 3-arylpropionsyrederivater og -analoger
US09/861,163 US20010034371A1 (en) 1998-06-04 2001-05-18 New 3-aryl-2-hydroxypropionic acid derivative I
HK01105768A HK1034957A1 (en) 1998-06-04 2001-08-16 New 3-aryl propionic acid derivatives and analogs
HK01105811A HK1035711A1 (en) 1998-06-04 2001-08-17 New 3-aryl-2-hydroxypropionic acid derivative (i)
US10/039,868 US6660879B2 (en) 1998-06-04 2002-01-04 3-aryl-2-hydroxypropionic acid derivative I
JP2003273428A JP2004043480A (ja) 1998-06-04 2003-07-11 新規な３−アリール−２−ヒドロキシプロピオン酸誘導体ｉの中間体
US10/669,131 US20040229946A1 (en) 1998-06-04 2003-09-22 New 3-aryl-2-hydroxypropionic acid derivative I
US10/678,739 US20040229949A1 (en) 1998-06-04 2003-10-02 New 3-aryl propionic acid derivatives and analogs
JP2004183263A JP2004346079A (ja) 1998-06-04 2004-06-22 新規３−アリールプロピオン酸誘導体および類似体
US11/078,201 US20060040979A1 (en) 1998-06-04 2005-03-11 3-Aryl-2-hydroxypropionic acid derivative I
US11/388,942 US20060173204A1 (en) 1998-06-04 2006-03-24 New 3-aryl propionic acid derivatives and analogs

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AT (1) ATE246674T1 (sv)
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TW (1) TW446696B (sv)
UA (1) UA71912C2 (sv)
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