AR035305A1 - Derivados y analogos del acido 3-arilpropionico, proceso para su preparacion, formulaciones farmaceuticas, uso de los mismos en la elaboracion de medicamentos, y formulacion farmaceutica para usar en la profilaxis y/o tratamiento de trastornos clinicos asociados con la resistencia a la insulina - Google Patents

Derivados y analogos del acido 3-arilpropionico, proceso para su preparacion, formulaciones farmaceuticas, uso de los mismos en la elaboracion de medicamentos, y formulacion farmaceutica para usar en la profilaxis y/o tratamiento de trastornos clinicos asociados con la resistencia a la insulina

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Publication number
AR035305A1
AR035305A1 ARP990102634A ARP990102634A AR035305A1 AR 035305 A1 AR035305 A1 AR 035305A1 AR P990102634 A ARP990102634 A AR P990102634A AR P990102634 A ARP990102634 A AR P990102634A AR 035305 A1 AR035305 A1 AR 035305A1
Authority
AR
Argentina
Prior art keywords
defined above
aryl
alkyl
alkylaryl
represents hydrogen
Prior art date
Application number
ARP990102634A
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English (en)
Original Assignee
Astra Zeneca
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from SE9801990A external-priority patent/SE9801990D0/xx
Priority claimed from SE9801991A external-priority patent/SE9801991D0/xx
Priority claimed from SE9801992A external-priority patent/SE9801992D0/xx
Application filed by Astra Zeneca filed Critical Astra Zeneca
Publication of AR035305A1 publication Critical patent/AR035305A1/es

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    • C07C233/24—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring
    • C07C233/25—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of an acyclic saturated carbon skeleton
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
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    • C07C233/75—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring
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    • C07C271/28—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atom of at least one of the carbamate groups bound to a carbon atom of a six-membered aromatic ring to a carbon atom of a non-condensed six-membered aromatic ring
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    • C07C271/44—Esters of carbamic acids having oxygen atoms of carbamate groups bound to carbon atoms of six-membered aromatic rings with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
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    • C07C275/32—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by singly-bound oxygen atoms
    • C07C275/34—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by singly-bound oxygen atoms having nitrogen atoms of urea groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring
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    • C07C309/64—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to acyclic carbon atoms
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    • C07C311/02—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
    • C07C311/08—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton having the nitrogen atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
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    • C07C323/19—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton with singly-bound oxygen atoms bound to acyclic carbon atoms of the carbon skeleton
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    • C07C323/39—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton at least one of the nitrogen atoms being part of any of the groups, X being a hetero atom, Y being any atom
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Abstract

Derivados y análogos del ácido 3-arilpropiónico que tienen la formula general (1) así como los estereoisómeros e isómeros ópticos y racematos de los mismos, así como las sales farmacéuticamente aceptables, solvatos y formas cristalinas de los mismos, en los cuales la fórmula A está situada en la posición orto, meta o para y representa (2) y (3), donde R es hidrógeno, ORa, donde Ra representa hidrógeno, alquilo, arilo o alquilarilo, -NRaRb, donde Ra y Rb son iguales o diferentes y Ra es como se definiera anteriormente y Rb representa hidrógeno, alquilo, arilo, alquilarilo, ciano, -OH, -O alquilo, -O arilo, -O alquilarilo, -CORc o -SO2Rd, donde Rc representa hidrógeno, alquilo, arilo o alquilarilo y Rd representa alquilo, arilo o alquilarilo; R1 es alquilo, arilo, alquenilo, alquinilo, ciano, -ORe, donde Re es alquilo, acilo, arilo o alquilarilo, -O[CH2]m-ORf, donde Rf representa hidrógeno, alquilo, acilo, arilo o alquilarilo y m representa un entero de 1-8; -OCONRaRc, donde Ra y Rc son como se definieran anteriormente; -SRd, donde Rd es como se definiera anteriormente; -SO2NRaRf, donde Rf y Ra son como se definieran anteriormente; -SO2ORa, donde Ra es como se definiera anteriormente; -COORd, donde Rd es como se definiera anteriormente; R2 es hidrógeno, halógeno, alquilo, arilo o alquilarilo; R3 y R4 son iguales o diferentes y cada uno de ellos representa hidrógeno, alquilo, arilo o alquilarilo, n es un entero de 1 - 6, D está situado en la posición orto, meta o para y representa -OSO2Rd, donde Rd es como se definiera anteriormente; -OCONRfRa, donde Rf y Ra son como se definieran anteriormente; -NRcCOORd, donde Rc y Rd son como se definieran anteriormente; -NRcCORa, donde Rc y Ra son como se definieran anteriormente; -NRcRd, donde Rc y Rd son como se definieran anteriormente; -NRcSO2Rd, donde Rc y Rd son como se definieran anteriormente; -NRcCONRaRk, donde Ra, Rc y Rk son iguales o diferentes y cada uno de ellos representa hidrógeno, alquilo, arilo o alquilarilo; -NRcCSNRaRk, donde Ra, Rc y Rk son iguales o diferentes y cada uno de ellos representa hidrógeno, alquilo, arilo o alquilarilo; -SO2Rd, donde Rd es como se definiera anteriormente; -SORd, donde Rd es como se definiera anteriormente; .-SRc, donde Rc es como se definiera anteriormente; -SO2NRaRf, donde Rf y Ra es como se definiera anteriormente; donde SO2ORa, donde Ra es como se definiera anteriormente; -CN, -CONRcRa, donde Rc y Ra son como se definieran anteriormente; D' está situado en la posición orto, meta o para y representa hidrógeno, alquilo, acilo, arilo, alquilarilo, halógeno, -CN, -NO2, -NRfRb, donde Rf y Rb son como se definieran anteriormente; -ORf, donde Rf es como se definiera anteriormente; -OSO2Rd, donde Rd es como se definiera anteriormente; D'' está situado en la posición orto, meta o para y representa hidrógeno, alquilo, acilo, arilo, alquilarilo, halógeno, -CN, -NO2, -NRfRb, donde Rf y Rb son como se definieran anteriormente, -ORf, donde Rf es como se definiera anteriormente; -OSO2Rd, donde Rd es como se definiera anteriormente. Proceso para su preparación, formulaciones farmacéuticas que los contienen, el uso de los mismos en la elaboración de un medicamento para la profilaxis y/o tratamiento de trastornos clínicos asociados con la resistencia a la insulina y formulación farmacéutica para usar en la profilaxis y/o tratamiento de trastornos clínicos asociados con la resistencia a la insulina.
ARP990102634A 1998-06-04 1999-06-03 Derivados y analogos del acido 3-arilpropionico, proceso para su preparacion, formulaciones farmaceuticas, uso de los mismos en la elaboracion de medicamentos, y formulacion farmaceutica para usar en la profilaxis y/o tratamiento de trastornos clinicos asociados con la resistencia a la insulina AR035305A1 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
SE9801990A SE9801990D0 (sv) 1998-06-04 1998-06-04 New 3-aryl propionic acid derivatives and analogs
SE9801991A SE9801991D0 (sv) 1998-06-04 1998-06-04 New 3-aryl-2-hydroxypropionic acid derivative II
SE9801992A SE9801992D0 (sv) 1998-06-04 1998-06-04 New 3-aryl-2-hydroxypropionic acid derivative I

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AR035305A1 true AR035305A1 (es) 2004-05-12

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ARP990102634A AR035305A1 (es) 1998-06-04 1999-06-03 Derivados y analogos del acido 3-arilpropionico, proceso para su preparacion, formulaciones farmaceuticas, uso de los mismos en la elaboracion de medicamentos, y formulacion farmaceutica para usar en la profilaxis y/o tratamiento de trastornos clinicos asociados con la resistencia a la insulina

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CA2334374A1 (en) 1999-12-09
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US6630600B1 (en) 2003-10-07
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HK1034957A1 (en) 2001-11-09
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MY129581A (en) 2007-04-30
JP3723739B2 (ja) 2005-12-07
WO1999062871A1 (en) 1999-12-09
TR200003583T2 (tr) 2001-05-21
KR20010052529A (ko) 2001-06-25
ID29457A (id) 2001-08-30
TW548263B (en) 2003-08-21
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EE04463B1 (et) 2005-04-15
DE69911770D1 (de) 2003-11-06
AU4667299A (en) 1999-12-20
PL344681A1 (en) 2001-11-19
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US20060173204A1 (en) 2006-08-03
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