ES2160093A1 - Derivados del acido p-hidroxifenil propionico como agentes antiproliferativos. - Google Patents

Derivados del acido p-hidroxifenil propionico como agentes antiproliferativos.

Info

Publication number
ES2160093A1
ES2160093A1 ES200000660A ES200000660A ES2160093A1 ES 2160093 A1 ES2160093 A1 ES 2160093A1 ES 200000660 A ES200000660 A ES 200000660A ES 200000660 A ES200000660 A ES 200000660A ES 2160093 A1 ES2160093 A1 ES 2160093A1
Authority
ES
Spain
Prior art keywords
derivatives
propionic acid
hydroxy phenyl
antiproliferative agents
phenyl propionic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
ES200000660A
Other languages
English (en)
Other versions
ES2160093B1 (es
Inventor
Barrera Jaime Bermejo
Silva Margarita Hernandez
De Mon Melchor Alvarez
Ranierir Juan Pablo Pivel
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
INVESTIG Y MEDICINA SL
SAETABIS BIO CONSULTING
Consejo Superior de Investigaciones Cientificas CSIC
Original Assignee
INVESTIG Y MEDICINA SL
SAETABIS BIO CONSULTING
Consejo Superior de Investigaciones Cientificas CSIC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to ES200000660A priority Critical patent/ES2160093B1/es
Application filed by INVESTIG Y MEDICINA SL, SAETABIS BIO CONSULTING, Consejo Superior de Investigaciones Cientificas CSIC filed Critical INVESTIG Y MEDICINA SL
Priority to DE60101472T priority patent/DE60101472T2/de
Priority to EP01911771A priority patent/EP1284263B1/en
Priority to PCT/ES2001/000102 priority patent/WO2001072733A1/es
Priority to ES01911771T priority patent/ES2213106T3/es
Priority to AU2001240702A priority patent/AU2001240702A1/en
Publication of ES2160093A1 publication Critical patent/ES2160093A1/es
Application granted granted Critical
Publication of ES2160093B1 publication Critical patent/ES2160093B1/es
Priority to US10/251,914 priority patent/US6818780B2/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/58—One oxygen atom, e.g. butenolide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Derivados del ácido p-hidroxifenil propiónico como agentes antiproliferativos. Derivados del compuesto ácido por p- hidroxifenil propiónico caracterizados por tener dichos derivados las formulas generales (I) y (Ia), donde n puede tomar los valores 1,2,3; R puede ser H ó CH{sub,3} y R{sub,1}, puede ser CH{sub,3} ó H con actividad farmacológica y su aplicación en medicina para el tratamiento de desórdenes del sistema inmunológico.
ES200000660A 2000-03-20 2000-03-20 Derivados del acido p-hidroxifenil propionico como agentes antiproliferativos. Expired - Fee Related ES2160093B1 (es)

Priority Applications (7)

Application Number Priority Date Filing Date Title
ES200000660A ES2160093B1 (es) 2000-03-20 2000-03-20 Derivados del acido p-hidroxifenil propionico como agentes antiproliferativos.
EP01911771A EP1284263B1 (en) 2000-03-20 2001-03-16 Derivatives of p- hydroxy phenyl propionic acid as antiproliferative agents
PCT/ES2001/000102 WO2001072733A1 (es) 2000-03-20 2001-03-16 Derivados del acido p-hidroxifenil propionico como agentes antiproliferativos
ES01911771T ES2213106T3 (es) 2000-03-20 2001-03-16 Derivados del acido p-hidroxifenil propionico como agentes antiproliferativos.
DE60101472T DE60101472T2 (de) 2000-03-20 2001-03-16 Derivate von p-hydroxyphenyl-propionsäure als antiproliferative mittel
AU2001240702A AU2001240702A1 (en) 2000-03-20 2001-03-16 Derivatives of p- hydroxy phenyl propionic acid as antiproliferative agents
US10/251,914 US6818780B2 (en) 2000-03-20 2002-09-20 P-hydroxyphenyl propionic acid derivatives as antiproliferative agents

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES200000660A ES2160093B1 (es) 2000-03-20 2000-03-20 Derivados del acido p-hidroxifenil propionico como agentes antiproliferativos.

Publications (2)

Publication Number Publication Date
ES2160093A1 true ES2160093A1 (es) 2001-10-16
ES2160093B1 ES2160093B1 (es) 2002-06-16

Family

ID=8492770

Family Applications (2)

Application Number Title Priority Date Filing Date
ES200000660A Expired - Fee Related ES2160093B1 (es) 2000-03-20 2000-03-20 Derivados del acido p-hidroxifenil propionico como agentes antiproliferativos.
ES01911771T Expired - Lifetime ES2213106T3 (es) 2000-03-20 2001-03-16 Derivados del acido p-hidroxifenil propionico como agentes antiproliferativos.

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES01911771T Expired - Lifetime ES2213106T3 (es) 2000-03-20 2001-03-16 Derivados del acido p-hidroxifenil propionico como agentes antiproliferativos.

Country Status (6)

Country Link
US (1) US6818780B2 (es)
EP (1) EP1284263B1 (es)
AU (1) AU2001240702A1 (es)
DE (1) DE60101472T2 (es)
ES (2) ES2160093B1 (es)
WO (1) WO2001072733A1 (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2070533B1 (en) * 2007-12-11 2014-05-07 Apoteknos Para La Piel, s.l. Use of a compound derived from P-hydroxyphenyl propionic acid for the treatment of psoriasis
ES2379925B1 (es) * 2010-10-06 2013-03-19 Apoteknos Para La Piel, S.L. PROCEDIMIENTO PARA LA SINTESIS DE LACTONAS DERIVADAS DEL ACIDO p-HIDROXIFENIL PROPIONICO
ES2388965B1 (es) * 2011-03-24 2013-09-05 Apoteknos Para La Piel S L PROCEDIMIENTO PARA LA SINTESIS DE LACTONAS DERIVADAS DEL ACIDO p-HIDROXIFENIL PROPIONICO MEJORADO.
CN102212007A (zh) * 2011-04-11 2011-10-12 启东东岳药业有限公司 高纯度2-羟甲基丙烯酸甲酯的制备方法

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
HOWIE, G.A. et al. Potential antitumor agents. Synthesis of bifunctional alpha-methylene gamma-butyrolactones. J. Med. Chem., 1976, Vol. 19, no 2, paginas 309-313. *
KUPCHAN, S.M. et al. Tumor inhibitors. 69. Structure cytotoxicity relationships among the sesquiterpenes lactones. J. Med. Chem., 1971, Vol. 14, no 12, paginas 1147-1152. *
NAKAGAWA, M. et al. Terrecyclic acid A, a new antibiotic from Aspergillus Terreus. I. Taxonomy, production, and chemical and biological properties. J. Antibiotic, 1982, Vol. 35, paginas 778-782. *
OGMUNDSDOTTIR, H.M. et al. Antiproliferative effects of lichen-derived inhibitors of 5-Lipoxygenase on malignant cell-lines and mitogen-stimulated lymphocytes. J. Pharm. Pharmacol., 1998, Vol. 50, no 1, paginas 107-115, ISSN 0022-3573 *

Also Published As

Publication number Publication date
ES2213106T3 (es) 2004-08-16
EP1284263B1 (en) 2003-12-10
US20030199575A1 (en) 2003-10-23
DE60101472D1 (en) 2004-01-22
DE60101472T2 (de) 2004-10-07
ES2160093B1 (es) 2002-06-16
EP1284263A1 (en) 2003-02-19
AU2001240702A1 (en) 2001-10-08
WO2001072733A1 (es) 2001-10-04
US6818780B2 (en) 2004-11-16

Similar Documents

Publication Publication Date Title
SE9801992D0 (sv) New 3-aryl-2-hydroxypropionic acid derivative I
YU69902A (sh) Novi derivati piperazina
SE9900100D0 (sv) New compounds
ATE175671T1 (de) Heterocyclylcarbonylsubstituierte benzofuranyl- und -thiophenylalkancarbonsäurederivate
TR200000129T2 (tr) Yepyeni spiroazabisiklik heterosiklik bileşikler.
BR9916798A (pt) 4-arilamino, 4-arilóxi e 4-ariltio diarilaminas e seus derivados como inibidores seletivos de mek
TR200200579T2 (tr) Amino-tirazolpiridin türevleri.
NZ516349A (en) Conjugates of phytosterol or phytostanol with ascorbic acid and use thereof in treating or preventing cardiovascular disease
TR199802060T2 (xx) Aminoisokinolinler ve aminopiridin t�revlerinin iltihap �nleyiciler olarak kullan�m�.
IT1285770B1 (it) Composti corticoidei
DE69229339D1 (de) Kristallines tiagabinehydrochlorid-monohydrat, seine herstellung und verwendung
TR200002248T2 (tr) Yeni dihidroksiheksanoik asit türevleri
DK1066291T3 (da) Svampedræbende 6-(2-halogen-4-alkoxyphenyl)-triazolopyrimidiner
NO984950D0 (no) Forbindelser med veksthormonfrigj°rende egenskaper
FI970469A0 (fi) Bentsimidatsolijohdannaisia, joilla on dopaminerginen aktiivisuus
ATE259813T1 (de) Triazolopyrimidinderivate
ES2160093A1 (es) Derivados del acido p-hidroxifenil propionico como agentes antiproliferativos.
ATE250610T1 (de) Kaliumkanal-blockierende mittel
DK1100824T3 (da) Forbindelser med væksthormonfrigivende egenskaber
NO941084L (no) Neuroleptiske 2-substituerte perhydro-1-H-pyrido[1,2-aÅpyraziner
DK0625520T3 (da) Thiazolotriazol- og thiazolodiazolderivater med fungicid aktivitet
NO20003629L (no) Forbindelser med veksthormonfrigjørende egenskaper
AU2001292698A1 (en) Hexahydropyrazino `1'2' : 1, 6!- pyrido `3, 4-b! indole-1, 4-dione derivatives for the treatment of cardiovascular disorders and erectile disfunction
AU7935887A (en) Therapeutic agent for the treatment of peptic ulcer disease
EA200400877A1 (ru) 2'-гало-3',5'-диалкоксифен-1'-илимино-2-имидазолидиновые производные и их применение для лечения недержания мочи

Legal Events

Date Code Title Description
EC2A Search report published

Date of ref document: 20011016

Kind code of ref document: A1

Effective date: 20011016

FD1A Patent lapsed

Effective date: 20050321