ES2160093B1 - Derivados del acido p-hidroxifenil propionico como agentes antiproliferativos. - Google Patents
Derivados del acido p-hidroxifenil propionico como agentes antiproliferativos.Info
- Publication number
- ES2160093B1 ES2160093B1 ES200000660A ES200000660A ES2160093B1 ES 2160093 B1 ES2160093 B1 ES 2160093B1 ES 200000660 A ES200000660 A ES 200000660A ES 200000660 A ES200000660 A ES 200000660A ES 2160093 B1 ES2160093 B1 ES 2160093B1
- Authority
- ES
- Spain
- Prior art keywords
- derivatives
- antiproliferative agents
- acid
- hydroxifenil
- propionic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D307/58—One oxygen atom, e.g. butenolide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Immunology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Derivados del ácido p-hidroxifenil propiónico como agentes antiproliferativos. Derivados del compuesto ácido por p- hidroxifenil propiónico caracterizados por tener dichos derivados las formulas generales (I) y (Ia), donde n puede tomar los valores 1,2,3; R puede ser H ó CH{sub,3} y R{sub,1}, puede ser CH{sub,3} ó H con actividad farmacológica y su aplicación en medicina para el tratamiento de desórdenes del sistema inmunológico.
Priority Applications (7)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES200000660A ES2160093B1 (es) | 2000-03-20 | 2000-03-20 | Derivados del acido p-hidroxifenil propionico como agentes antiproliferativos. |
AU2001240702A AU2001240702A1 (en) | 2000-03-20 | 2001-03-16 | Derivatives of p- hydroxy phenyl propionic acid as antiproliferative agents |
PCT/ES2001/000102 WO2001072733A1 (es) | 2000-03-20 | 2001-03-16 | Derivados del acido p-hidroxifenil propionico como agentes antiproliferativos |
DE60101472T DE60101472T2 (de) | 2000-03-20 | 2001-03-16 | Derivate von p-hydroxyphenyl-propionsäure als antiproliferative mittel |
EP01911771A EP1284263B1 (en) | 2000-03-20 | 2001-03-16 | Derivatives of p- hydroxy phenyl propionic acid as antiproliferative agents |
ES01911771T ES2213106T3 (es) | 2000-03-20 | 2001-03-16 | Derivados del acido p-hidroxifenil propionico como agentes antiproliferativos. |
US10/251,914 US6818780B2 (en) | 2000-03-20 | 2002-09-20 | P-hydroxyphenyl propionic acid derivatives as antiproliferative agents |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES200000660A ES2160093B1 (es) | 2000-03-20 | 2000-03-20 | Derivados del acido p-hidroxifenil propionico como agentes antiproliferativos. |
Publications (2)
Publication Number | Publication Date |
---|---|
ES2160093A1 ES2160093A1 (es) | 2001-10-16 |
ES2160093B1 true ES2160093B1 (es) | 2002-06-16 |
Family
ID=8492770
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES200000660A Expired - Fee Related ES2160093B1 (es) | 2000-03-20 | 2000-03-20 | Derivados del acido p-hidroxifenil propionico como agentes antiproliferativos. |
ES01911771T Expired - Lifetime ES2213106T3 (es) | 2000-03-20 | 2001-03-16 | Derivados del acido p-hidroxifenil propionico como agentes antiproliferativos. |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES01911771T Expired - Lifetime ES2213106T3 (es) | 2000-03-20 | 2001-03-16 | Derivados del acido p-hidroxifenil propionico como agentes antiproliferativos. |
Country Status (6)
Country | Link |
---|---|
US (1) | US6818780B2 (es) |
EP (1) | EP1284263B1 (es) |
AU (1) | AU2001240702A1 (es) |
DE (1) | DE60101472T2 (es) |
ES (2) | ES2160093B1 (es) |
WO (1) | WO2001072733A1 (es) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2070533B1 (en) * | 2007-12-11 | 2014-05-07 | Apoteknos Para La Piel, s.l. | Use of a compound derived from P-hydroxyphenyl propionic acid for the treatment of psoriasis |
ES2379925B1 (es) * | 2010-10-06 | 2013-03-19 | Apoteknos Para La Piel, S.L. | PROCEDIMIENTO PARA LA SINTESIS DE LACTONAS DERIVADAS DEL ACIDO p-HIDROXIFENIL PROPIONICO |
ES2388965B1 (es) * | 2011-03-24 | 2013-09-05 | Apoteknos Para La Piel S L | PROCEDIMIENTO PARA LA SINTESIS DE LACTONAS DERIVADAS DEL ACIDO p-HIDROXIFENIL PROPIONICO MEJORADO. |
CN102212007A (zh) * | 2011-04-11 | 2011-10-12 | 启东东岳药业有限公司 | 高纯度2-羟甲基丙烯酸甲酯的制备方法 |
-
2000
- 2000-03-20 ES ES200000660A patent/ES2160093B1/es not_active Expired - Fee Related
-
2001
- 2001-03-16 EP EP01911771A patent/EP1284263B1/en not_active Expired - Lifetime
- 2001-03-16 ES ES01911771T patent/ES2213106T3/es not_active Expired - Lifetime
- 2001-03-16 DE DE60101472T patent/DE60101472T2/de not_active Expired - Lifetime
- 2001-03-16 AU AU2001240702A patent/AU2001240702A1/en not_active Abandoned
- 2001-03-16 WO PCT/ES2001/000102 patent/WO2001072733A1/es active IP Right Grant
-
2002
- 2002-09-20 US US10/251,914 patent/US6818780B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
DE60101472D1 (en) | 2004-01-22 |
ES2160093A1 (es) | 2001-10-16 |
WO2001072733A1 (es) | 2001-10-04 |
ES2213106T3 (es) | 2004-08-16 |
US20030199575A1 (en) | 2003-10-23 |
US6818780B2 (en) | 2004-11-16 |
AU2001240702A1 (en) | 2001-10-08 |
DE60101472T2 (de) | 2004-10-07 |
EP1284263A1 (en) | 2003-02-19 |
EP1284263B1 (en) | 2003-12-10 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
EC2A | Search report published |
Date of ref document: 20011016 Kind code of ref document: A1 Effective date: 20011016 |
|
FD1A | Patent lapsed |
Effective date: 20050321 |