DE69414194T2 - Aminosäurederivate und ihre Verwendung als Enkephalinase-Inhibitoren - Google Patents

Aminosäurederivate und ihre Verwendung als Enkephalinase-Inhibitoren

Info

Publication number
DE69414194T2
DE69414194T2 DE69414194T DE69414194T DE69414194T2 DE 69414194 T2 DE69414194 T2 DE 69414194T2 DE 69414194 T DE69414194 T DE 69414194T DE 69414194 T DE69414194 T DE 69414194T DE 69414194 T2 DE69414194 T2 DE 69414194T2
Authority
DE
Germany
Prior art keywords
amino acid
acid derivatives
enkephalinase inhibitors
enkephalinase
image
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69414194T
Other languages
English (en)
Other versions
DE69414194D1 (de
Inventor
Denis Danvy
Thierry Monteil
Christophe Lusson
Jean-Charles Schwartz
Claude Gros
Nadine Noel
Jeanne-Marie Lecomte
Pierre Duhamel
Lucette Duhamel
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bioprojet SC
Original Assignee
Bioprojet SC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bioprojet SC filed Critical Bioprojet SC
Publication of DE69414194D1 publication Critical patent/DE69414194D1/de
Application granted granted Critical
Publication of DE69414194T2 publication Critical patent/DE69414194T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
    • C07D317/50—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to atoms of the carbocyclic ring
    • C07D317/60—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
    • C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/60—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton with the carbon atom of at least one of the carboxyl groups bound to nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C327/00—Thiocarboxylic acids
    • C07C327/20—Esters of monothiocarboxylic acids
    • C07C327/32—Esters of monothiocarboxylic acids having sulfur atoms of esterified thiocarboxyl groups bound to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
DE69414194T 1993-07-16 1994-07-13 Aminosäurederivate und ihre Verwendung als Enkephalinase-Inhibitoren Expired - Fee Related DE69414194T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9308765A FR2707638B1 (fr) 1993-07-16 1993-07-16 Nouveaux dérivés d'amino-acides, leurs procédés de préparation et leur application thérapeutique.

Publications (2)

Publication Number Publication Date
DE69414194D1 DE69414194D1 (de) 1998-12-03
DE69414194T2 true DE69414194T2 (de) 1999-04-22

Family

ID=9449318

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69414194T Expired - Fee Related DE69414194T2 (de) 1993-07-16 1994-07-13 Aminosäurederivate und ihre Verwendung als Enkephalinase-Inhibitoren

Country Status (8)

Country Link
US (2) US5612371A (de)
EP (1) EP0634396B1 (de)
JP (1) JP3584496B2 (de)
AT (1) ATE172721T1 (de)
DE (1) DE69414194T2 (de)
DK (1) DK0634396T3 (de)
ES (1) ES2124861T3 (de)
FR (1) FR2707638B1 (de)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5760241A (en) * 1995-12-28 1998-06-02 Zambon Group S.P.A. Thiol derivatives with metallopeptidase inhibitory activity
FR2772027B1 (fr) * 1997-12-10 2000-02-04 Fournier Ind & Sante Procede de preparation asymetrique de derives de l'acide 2-mercaptomethyl-3-phenyl-propanoique, utilisation pour synthese de principes actifs chiraux
US6056363A (en) * 1997-12-29 2000-05-02 Maddox; Lee W. Reclining computer chair apparatus
EP0937710B1 (de) * 1998-02-16 2003-04-16 Ajinomoto Co., Inc. Verfahren zur Herstellung von optisch aktiven Phenylpropionsäure-Derivat
US6303799B1 (en) * 1998-11-10 2001-10-16 Naxcor Polynucleotide crosslinking agents
US6562995B1 (en) 2000-12-21 2003-05-13 Beacon Laboratories, Inc. Delta dicarbonyl compounds and methods for using the same
TW201809911A (zh) 2003-09-29 2018-03-16 尼康股份有限公司 曝光裝置及曝光方法、以及元件製造方法
US7022627B2 (en) 2003-10-31 2006-04-04 Asm International N.V. Method for the heat treatment of substrates
US6883250B1 (en) * 2003-11-04 2005-04-26 Asm America, Inc. Non-contact cool-down station for wafers
US6940047B2 (en) * 2003-11-14 2005-09-06 Asm International N.V. Heat treatment apparatus with temperature control system
KR100785270B1 (ko) 2006-09-08 2007-12-12 주식회사 대우일렉트로닉스 순간 가열 방식 스팀 청소기의 스팀 제어 장치
WO2021127642A1 (en) * 2019-12-19 2021-06-24 Massachusetts Institute Of Technology Selective valorization of biomass sugars

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2480747A1 (fr) * 1980-04-17 1981-10-23 Roques Bernard Derives d'acides amines et leur application therapeutique
US4401677A (en) * 1981-10-09 1983-08-30 E. R. Squibb & Sons, Inc. Enkephalinase inhibitors
US4722810A (en) * 1984-08-16 1988-02-02 E. R. Squibb & Sons, Inc. Enkephalinase inhibitors
DE3467754D1 (de) * 1983-10-03 1988-01-07 Squibb & Sons Inc Enkephalinase inhibitors
FR2556721B1 (fr) * 1983-12-14 1986-05-16 Roussel Uclaf Nouveaux derives de o-mercaptopropanamide d'o amino-acides, leur procede de preparation, leur application comme medicaments et les compositions les renfermant
FR2652087B1 (fr) * 1989-09-15 1993-10-15 Bioprojet Ste Civile Derives d'amino-acides, leur procede de preparation et leurs applications therapeutiques.

Also Published As

Publication number Publication date
EP0634396B1 (de) 1998-10-28
EP0634396A1 (de) 1995-01-18
DE69414194D1 (de) 1998-12-03
US5646313A (en) 1997-07-08
JP3584496B2 (ja) 2004-11-04
ATE172721T1 (de) 1998-11-15
FR2707638B1 (fr) 1995-08-18
ES2124861T3 (es) 1999-02-16
JPH07188158A (ja) 1995-07-25
FR2707638A1 (fr) 1995-01-20
US5612371A (en) 1997-03-18
DK0634396T3 (da) 1999-07-05

Similar Documents

Publication Publication Date Title
NO924433D0 (no) Isoksazol-4-karboksylsyreamider og hydroksyalkyliden-cyaneddiksyreamider, legemidler inneholdende disse forbindelsene og deres anvendelse
DK0624595T3 (da) Nor-galdesyrederivater, fremgangsmåde til deres fremstilling og anvendelse af disse forbindelser som lægemidler
DK0562512T3 (da) Sulfonamidocarbonylpyridin-2-carboxylsyreamider samt deres anvendelse som lægemidler
GR3018541T3 (en) Condensed heterocyclic compounds and their use in therapy.
DK0741694T3 (da) Phenyleddikesyrederivater, fremgangsmåder og mellemprodukter til deres fremstilling og midler indeholdende disse
EA200000759A1 (ru) Производные 2-(пурин-9-ил)-тетрагидрофуран-3,4-диола
IS1564B (is) Aðferð við framleiðslu á N1-súbstitúeruðum bensimidasólafleiðum til að nota við lækningar
DK0725779T3 (da) Hidtil ukendte (R)-5-Carbamoyl-8-fluor-3-N,N-disubstitueret-amino-3,4-dihydro-2H-1-benzopyraner
DK0530087T3 (da) Hidtil ukendte naphthylethylurinstof- og naphthylethylthiourinstofforbindelser, fremgangsmåde til fremstilling heraf og farmaceutiske midler, som indeholder dem
ATE229533T1 (de) Nitrat-salze als arzneimittel
DK0726899T3 (da) Nye pyrazincarboxamidderivater, deres fremstilling og deres anvendelse i lægemidler
DE3679920D1 (de) Spiro-3-heteroazolidinverbindungen und ihre salze, ihre herstellung und diese enthaltende pharmazeutische mittel.
DK0603649T3 (da) Substituerede 4-phenyl-pyridoner og 4-phenyl-2-alkoxypyridiner som HMG-CoA-reduktase-inhibitorer
FI903153A0 (fi) 11b-aryl-4-estrener, foerfarande foer deras framstaellning samt deras anvaendning som laekemedel.
DE68917485T2 (de) Pyridazinon-Derivate und diese enthaltende pharmazeutische Zubereitungen.
DE69414194T2 (de) Aminosäurederivate und ihre Verwendung als Enkephalinase-Inhibitoren
DK0952974T3 (da) Biphenylderivater substitueret med en aromatisk eller heteroaromatisk gruppe og farmaceutiske og kosmetiske præparater indeholdende disse derivater
DK0548794T3 (da) Polyaspartamidderivater som adsorptionsmidler for galdesyrer, polyaspartamidderivater ladet med galdesyrer, fremgangsmåder
ATE182586T1 (de) Pharmakologische verwendung von 5- aminophthaloylhydrazide; ihre zusammensetzung und anwendung
PT861250E (pt) Derivados de amidina e de isotioureia como inibidores de oxido nitrico sintase
DE59404557D1 (de) Hetero-tricyclisch-substituierte Phenyl-cyclohexan-carbonsäurederivate
ES2123728T3 (es) Derivados de pirrolo-pirazina de actividad 5-ht3.
DK0625520T3 (da) Thiazolotriazol- og thiazolodiazolderivater med fungicid aktivitet
DE3778642D1 (de) Therapeutikum zur behandlung von magengeschwueren.
ATE140922T1 (de) 3- oder 4-glykosyloxybenzopyranderivat und dieses enthaltende antiallergisches mittel

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee