DK0726899T3 - Nye pyrazincarboxamidderivater, deres fremstilling og deres anvendelse i lægemidler - Google Patents

Nye pyrazincarboxamidderivater, deres fremstilling og deres anvendelse i lægemidler

Info

Publication number
DK0726899T3
DK0726899T3 DK94931018T DK94931018T DK0726899T3 DK 0726899 T3 DK0726899 T3 DK 0726899T3 DK 94931018 T DK94931018 T DK 94931018T DK 94931018 T DK94931018 T DK 94931018T DK 0726899 T3 DK0726899 T3 DK 0726899T3
Authority
DK
Denmark
Prior art keywords
pharmaceuticals
preparation
new
pyrazinecarboxamide derivatives
pyrazinecarboxamide
Prior art date
Application number
DK94931018T
Other languages
English (en)
Inventor
Dietrich Arndts
Otto Roos
Georg Speck
Walter Lisel
Wolf-Dietrich Bechtel
Original Assignee
Boehringer Ingelheim Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Pharma filed Critical Boehringer Ingelheim Pharma
Application granted granted Critical
Publication of DK0726899T3 publication Critical patent/DK0726899T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/10—Expectorants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/10—Antioedematous agents; Diuretics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
DK94931018T 1993-11-04 1994-10-31 Nye pyrazincarboxamidderivater, deres fremstilling og deres anvendelse i lægemidler DK0726899T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE4337609A DE4337609A1 (de) 1993-11-04 1993-11-04 Neue Pyrazincarboxamidderivate, ihre Herstellung und ihre Verwendung in Arzneimitteln
PCT/EP1994/003580 WO1995012592A1 (de) 1993-11-04 1994-10-31 Neue pyrazincarboxamidderivate, ihre herstellung und ihre verwendung in arzneimitteln

Publications (1)

Publication Number Publication Date
DK0726899T3 true DK0726899T3 (da) 2000-06-26

Family

ID=6501757

Family Applications (1)

Application Number Title Priority Date Filing Date
DK94931018T DK0726899T3 (da) 1993-11-04 1994-10-31 Nye pyrazincarboxamidderivater, deres fremstilling og deres anvendelse i lægemidler

Country Status (17)

Country Link
EP (1) EP0726899B1 (da)
JP (1) JPH09505035A (da)
KR (1) KR960705815A (da)
CN (1) CN1134151A (da)
AT (1) ATE188965T1 (da)
AU (1) AU690588B2 (da)
CA (1) CA2175837A1 (da)
CO (1) CO4290432A1 (da)
DE (2) DE4337609A1 (da)
DK (1) DK0726899T3 (da)
ES (1) ES2140565T3 (da)
GR (1) GR3033034T3 (da)
NZ (1) NZ274848A (da)
PL (1) PL314187A1 (da)
PT (1) PT726899E (da)
WO (1) WO1995012592A1 (da)
ZA (1) ZA948669B (da)

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DE19548812A1 (de) * 1995-12-27 1997-07-03 Hoechst Ag Verwendung von Inhibitoren des zellulären Na·+·/H·+·-Exchangers (NHE) zur Herstellung eines Medikaments zur Atemstimulation
DE19738604A1 (de) * 1997-09-04 1999-03-11 Hoechst Marion Roussel De Gmbh Die Verwendung von Hemmern des Natrium-Wasserstoff-Austauschers zur Herstellung eines Medikaments zur Verminderung der Giftigkeit cardiotoxischer Stoffe
WO2000075115A1 (fr) 1999-06-03 2000-12-14 Takeda Chemical Industries, Ltd. Preparations s'administrant par voie nasale
US6156758A (en) * 1999-09-08 2000-12-05 Isis Pharmaceuticals, Inc. Antibacterial quinazoline compounds
CA2482991A1 (en) 2002-04-19 2003-10-30 Cellular Genomics, Inc. Imidazo[1,2-a]pyrazin-8-ylamines method of making and method of use thereof
WO2004022562A1 (en) 2002-09-09 2004-03-18 Cellular Genomics, Inc. 6-ARYL-IMIDAZO[1,2-a]PYRAZIN-8-YLAMINES, METHOD OF MAKING, AND METHOD OF USE THEREOF
WO2004072081A1 (en) 2003-02-10 2004-08-26 Cellular Genomics, Inc. Certain 8-heteroaryl-6-phenyl-imidazo[1,2-a]pyrazines as modulators of kinase activity
US7405295B2 (en) 2003-06-04 2008-07-29 Cgi Pharmaceuticals, Inc. Certain imidazo[1,2-a]pyrazin-8-ylamines and method of inhibition of Bruton's tyrosine kinase by such compounds
US7393848B2 (en) 2003-06-30 2008-07-01 Cgi Pharmaceuticals, Inc. Certain heterocyclic substituted imidazo[1,2-A]pyrazin-8-ylamines and methods of inhibition of Bruton's tyrosine kinase by such compounds
JP2009513502A (ja) 2003-07-02 2009-04-02 エフ．ホフマン−ラ ロシュ アーゲー アリールアミン置換キナゾリノン化合物
WO2005019220A2 (en) 2003-08-11 2005-03-03 Cellular Genomics Inc. Substituted imidazo[1,2-a]pyrazines as modulators of kinase activity
ATE546452T1 (de) 2003-09-23 2012-03-15 Vertex Pharma Pyrazolopyrrolderivate als proteinkinaseinhibitoren
US7777040B2 (en) 2005-05-03 2010-08-17 Cgi Pharmaceuticals, Inc. Certain substituted ureas, as modulators of kinase activity
AU2009215191A1 (en) 2008-02-13 2009-08-20 Gilead Connecticut, Inc. 6-aryl-imidaz0[l, 2-a] pyrazine derivatives, method of making, and method of use thereof
US8450321B2 (en) 2008-12-08 2013-05-28 Gilead Connecticut, Inc. 6-(1H-indazol-6-yl)-N-[4-(morpholin-4-yl)phenyl]imidazo-[1,2-A]pyrazin-8-amine, or a pharmaceutically acceptable salt thereof, as a SYK inhibitor
JP5696052B2 (ja) 2008-12-08 2015-04-08 ギリアード コネチカット， インコーポレイテッド イミダゾピラジンｓｙｋ阻害剤
PT2716157T (pt) 2008-12-08 2016-08-23 Gilead Connecticut Inc Imidazopirazinas ¿ inibidores de syc
US9562056B2 (en) 2010-03-11 2017-02-07 Gilead Connecticut, Inc. Imidazopyridines Syk inhibitors
CN103180312B (zh) * 2010-09-13 2016-01-20 大塚制药株式会社 用于治疗或预防因血清素、去甲肾上腺素或多巴胺的神经传导的降低所导致的紊乱的杂环化合物
JP6153667B2 (ja) 2013-07-30 2017-06-28 ギリアード コネチカット， インコーポレイテッド Ｓｋｙ阻害剤の製剤
PL3027618T3 (pl) 2013-07-30 2021-04-19 Kronos Bio, Inc. Polimorf inhibitorów syk
CN103467392B (zh) * 2013-10-09 2016-08-17 重庆工商大学 一种多卤代吡嗪甲酰胺衍生物及其盐类、制备方法和用途
SG11201603050TA (en) 2013-12-04 2016-05-30 Gilead Sciences Inc Methods for treating cancers
TWI735853B (zh) 2013-12-23 2021-08-11 美商克洛諾斯生技有限公司 脾酪胺酸激酶抑制劑
US9290505B2 (en) 2013-12-23 2016-03-22 Gilead Sciences, Inc. Substituted imidazo[1,2-a]pyrazines as Syk inhibitors
MA40075A (fr) 2014-07-14 2016-01-21 Gilead Sciences Inc Combinaisons pour traiter des cancers
US11384082B2 (en) 2017-08-25 2022-07-12 Kronos Bio, Inc. Hydrates of polymorphs of 6-(1H-indazol-6-YL)-N-(4-morpholinophenyl)-2,3-dihydroimidazo[1,2-A]pyrazin-8-amine bisemsylate as Syk inhibitors
CN113950479A (zh) 2019-02-22 2022-01-18 克洛诺斯生物股份有限公司 作为syk抑制剂的缩合吡嗪的固体形式

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL299931A (da) * 1962-10-30
TW213903B (da) * 1991-08-16 1993-10-01 Boehringer Ingelheim Kg

Also Published As

Publication number Publication date
ES2140565T3 (es) 2000-03-01
CO4290432A1 (es) 1996-04-17
PL314187A1 (en) 1996-09-02
CN1134151A (zh) 1996-10-23
ATE188965T1 (de) 2000-02-15
NZ274848A (en) 1998-03-25
CA2175837A1 (en) 1995-05-11
EP0726899B1 (de) 2000-01-19
WO1995012592A1 (de) 1995-05-11
PT726899E (pt) 2000-04-28
GR3033034T3 (en) 2000-08-31
DE4337609A1 (de) 1995-05-11
DE59409094D1 (de) 2000-02-24
KR960705815A (ko) 1996-11-08
AU7993694A (en) 1995-05-23
ZA948669B (en) 1995-07-04
EP0726899A1 (de) 1996-08-21
JPH09505035A (ja) 1997-05-20
AU690588B2 (en) 1998-04-30

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