KR960705815A - 신규한 피라진 카복스아미드 유도체, 이의 제조방법 및 약제에 있어서의 이의 용도(Novel pyrazine carboxamide derivatives, their production and their use in medicaments) - Google Patents
신규한 피라진 카복스아미드 유도체, 이의 제조방법 및 약제에 있어서의 이의 용도(Novel pyrazine carboxamide derivatives, their production and their use in medicaments)Info
- Publication number
- KR960705815A KR960705815A KR1019960702301A KR19960702301A KR960705815A KR 960705815 A KR960705815 A KR 960705815A KR 1019960702301 A KR1019960702301 A KR 1019960702301A KR 19960702301 A KR19960702301 A KR 19960702301A KR 960705815 A KR960705815 A KR 960705815A
- Authority
- KR
- South Korea
- Prior art keywords
- medicaments
- production
- carboxamide derivatives
- pyrazine carboxamide
- novel pyrazine
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/10—Expectorants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/10—Antioedematous agents; Diuretics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Pulmonology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE4337609A DE4337609A1 (de) | 1993-11-04 | 1993-11-04 | Neue Pyrazincarboxamidderivate, ihre Herstellung und ihre Verwendung in Arzneimitteln |
| PCT/EP1994/003580 WO1995012592A1 (de) | 1993-11-04 | 1994-10-31 | Neue pyrazincarboxamidderivate, ihre herstellung und ihre verwendung in arzneimitteln |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| KR960705815A true KR960705815A (ko) | 1996-11-08 |
Family
ID=6501757
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1019960702301A KR960705815A (ko) | 1993-11-04 | 1996-05-03 | 신규한 피라진 카복스아미드 유도체, 이의 제조방법 및 약제에 있어서의 이의 용도(Novel pyrazine carboxamide derivatives, their production and their use in medicaments) |
Country Status (17)
| Country | Link |
|---|---|
| EP (1) | EP0726899B1 (ko) |
| JP (1) | JPH09505035A (ko) |
| KR (1) | KR960705815A (ko) |
| CN (1) | CN1134151A (ko) |
| AT (1) | ATE188965T1 (ko) |
| AU (1) | AU690588B2 (ko) |
| CA (1) | CA2175837A1 (ko) |
| CO (1) | CO4290432A1 (ko) |
| DE (2) | DE4337609A1 (ko) |
| DK (1) | DK0726899T3 (ko) |
| ES (1) | ES2140565T3 (ko) |
| GR (1) | GR3033034T3 (ko) |
| NZ (1) | NZ274848A (ko) |
| PL (1) | PL314187A1 (ko) |
| PT (1) | PT726899E (ko) |
| WO (1) | WO1995012592A1 (ko) |
| ZA (1) | ZA948669B (ko) |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19548812A1 (de) * | 1995-12-27 | 1997-07-03 | Hoechst Ag | Verwendung von Inhibitoren des zellulären Na·+·/H·+·-Exchangers (NHE) zur Herstellung eines Medikaments zur Atemstimulation |
| DE19738604A1 (de) * | 1997-09-04 | 1999-03-11 | Hoechst Marion Roussel De Gmbh | Die Verwendung von Hemmern des Natrium-Wasserstoff-Austauschers zur Herstellung eines Medikaments zur Verminderung der Giftigkeit cardiotoxischer Stoffe |
| WO2000075115A1 (fr) | 1999-06-03 | 2000-12-14 | Takeda Chemical Industries, Ltd. | Preparations s'administrant par voie nasale |
| US6156758A (en) * | 1999-09-08 | 2000-12-05 | Isis Pharmaceuticals, Inc. | Antibacterial quinazoline compounds |
| MXPA04010288A (es) | 2002-04-19 | 2005-05-17 | Cellular Genomics Inc | Imidazo[1,2-a]pirazin-8-ilaminas, y metodos para su fabricacion y usos. |
| AU2003270489A1 (en) | 2002-09-09 | 2004-03-29 | Cellular Genomics, Inc. | 6-ARYL-IMIDAZO(1,2-a)PYRAZIN-8-YLAMINES, METHOD OF MAKING, AND METHOD OF USE THEREOF |
| WO2004072081A1 (en) | 2003-02-10 | 2004-08-26 | Cellular Genomics, Inc. | Certain 8-heteroaryl-6-phenyl-imidazo[1,2-a]pyrazines as modulators of kinase activity |
| WO2005014599A1 (en) | 2003-06-04 | 2005-02-17 | Cellular Genomics, Inc. | Imidazo[1,2-a]pyrazin-8-ylamines and method of inhibition of bruton’s tyrosine kinase by such compounds |
| US7393848B2 (en) | 2003-06-30 | 2008-07-01 | Cgi Pharmaceuticals, Inc. | Certain heterocyclic substituted imidazo[1,2-A]pyrazin-8-ylamines and methods of inhibition of Bruton's tyrosine kinase by such compounds |
| BRPI0412285A (pt) | 2003-07-02 | 2006-09-19 | Hoffmann La Roche | os compostos de quinazolinona substituìda por arilamina |
| US7259164B2 (en) | 2003-08-11 | 2007-08-21 | Cgi Pharmaceuticals, Inc. | Certain substituted imidazo[1,2-a]pyrazines, as modulators of kinase activity |
| WO2005030776A1 (en) | 2003-09-23 | 2005-04-07 | Vertex Pharmaceuticals Incorporated | Pyrazolopyrrole derivatives as protein kinase inhibitors |
| US7777040B2 (en) | 2005-05-03 | 2010-08-17 | Cgi Pharmaceuticals, Inc. | Certain substituted ureas, as modulators of kinase activity |
| US20090221612A1 (en) | 2008-02-13 | 2009-09-03 | Mitchell Scott A | Certain substituted amides, method of making, and method of use thereof |
| ES2744541T3 (es) | 2008-12-08 | 2020-02-25 | Gilead Connecticut Inc | Inhibidores de imidazopirazina Syk |
| US8450321B2 (en) | 2008-12-08 | 2013-05-28 | Gilead Connecticut, Inc. | 6-(1H-indazol-6-yl)-N-[4-(morpholin-4-yl)phenyl]imidazo-[1,2-A]pyrazin-8-amine, or a pharmaceutically acceptable salt thereof, as a SYK inhibitor |
| PE20140975A1 (es) | 2008-12-08 | 2014-08-25 | Gilead Connecticut Inc | Derivados de imidazopirazina como inhibidores de syk |
| US9562056B2 (en) | 2010-03-11 | 2017-02-07 | Gilead Connecticut, Inc. | Imidazopyridines Syk inhibitors |
| BR112013005823B8 (pt) * | 2010-09-13 | 2022-11-22 | Otsuka Pharma Co Ltd | Compostos heterocíclicos para o tratamento ou prevenção de distúrbios causados pela neurotransmissão reduzida de serotonina, norefnefrina ou dopamina |
| MY176803A (en) | 2013-07-30 | 2020-08-21 | Gilead Connecticut Inc | Polymorph of syk inhibitors |
| EA201690127A1 (ru) | 2013-07-30 | 2016-07-29 | Джилид Коннектикут, Инк. | Состав на основе ингибиторов syk |
| CN103467392B (zh) * | 2013-10-09 | 2016-08-17 | 重庆工商大学 | 一种多卤代吡嗪甲酰胺衍生物及其盐类、制备方法和用途 |
| CN105764516A (zh) | 2013-12-04 | 2016-07-13 | 吉利德科学公司 | 治疗癌症的方法 |
| TWI662037B (zh) | 2013-12-23 | 2019-06-11 | 美商基利科學股份有限公司 | 脾酪胺酸激酶抑制劑 |
| US9290505B2 (en) | 2013-12-23 | 2016-03-22 | Gilead Sciences, Inc. | Substituted imidazo[1,2-a]pyrazines as Syk inhibitors |
| SG11201610551TA (en) | 2014-07-14 | 2017-01-27 | Gilead Sciences Inc | Combinations for treating cancers |
| CN111051311A (zh) | 2017-08-25 | 2020-04-21 | 吉利德科学公司 | Syk抑制剂的多晶型物 |
| US11339168B2 (en) | 2019-02-22 | 2022-05-24 | Kronos Bio, Inc. | Crystalline forms of 6-(6-aminopyrazin-2-yl)-N-(4-(4-(oxetan-3-yl)piperazin-1-yl)phenyl)imidazo[1,2-a]pyrazin-8-amine as Syk inhibitors |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL299931A (ko) * | 1962-10-30 | |||
| TW213903B (ko) * | 1991-08-16 | 1993-10-01 | Boehringer Ingelheim Kg |
-
1993
- 1993-11-04 DE DE4337609A patent/DE4337609A1/de not_active Withdrawn
-
1994
- 1994-10-31 DE DE59409094T patent/DE59409094D1/de not_active Expired - Fee Related
- 1994-10-31 CN CN94194016A patent/CN1134151A/zh active Pending
- 1994-10-31 PT PT94931018T patent/PT726899E/pt unknown
- 1994-10-31 EP EP94931018A patent/EP0726899B1/de not_active Expired - Lifetime
- 1994-10-31 ES ES94931018T patent/ES2140565T3/es not_active Expired - Lifetime
- 1994-10-31 CA CA002175837A patent/CA2175837A1/en not_active Abandoned
- 1994-10-31 NZ NZ274848A patent/NZ274848A/en unknown
- 1994-10-31 WO PCT/EP1994/003580 patent/WO1995012592A1/de active IP Right Grant
- 1994-10-31 DK DK94931018T patent/DK0726899T3/da active
- 1994-10-31 AU AU79936/94A patent/AU690588B2/en not_active Ceased
- 1994-10-31 AT AT94931018T patent/ATE188965T1/de not_active IP Right Cessation
- 1994-10-31 PL PL94314187A patent/PL314187A1/xx unknown
- 1994-10-31 JP JP7513010A patent/JPH09505035A/ja active Pending
- 1994-11-02 CO CO94050173A patent/CO4290432A1/es unknown
- 1994-11-03 ZA ZA948669A patent/ZA948669B/xx unknown
-
1996
- 1996-05-03 KR KR1019960702301A patent/KR960705815A/ko not_active Application Discontinuation
-
2000
- 2000-03-22 GR GR20000400720T patent/GR3033034T3/el not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| ZA948669B (en) | 1995-07-04 |
| ATE188965T1 (de) | 2000-02-15 |
| DE4337609A1 (de) | 1995-05-11 |
| PL314187A1 (en) | 1996-09-02 |
| AU690588B2 (en) | 1998-04-30 |
| DE59409094D1 (de) | 2000-02-24 |
| NZ274848A (en) | 1998-03-25 |
| EP0726899B1 (de) | 2000-01-19 |
| EP0726899A1 (de) | 1996-08-21 |
| JPH09505035A (ja) | 1997-05-20 |
| WO1995012592A1 (de) | 1995-05-11 |
| AU7993694A (en) | 1995-05-23 |
| PT726899E (pt) | 2000-04-28 |
| CA2175837A1 (en) | 1995-05-11 |
| CN1134151A (zh) | 1996-10-23 |
| DK0726899T3 (da) | 2000-06-26 |
| CO4290432A1 (es) | 1996-04-17 |
| GR3033034T3 (en) | 2000-08-31 |
| ES2140565T3 (es) | 2000-03-01 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| WITN | Application deemed withdrawn, e.g. because no request for examination was filed or no examination fee was paid |