DK0548794T3 - Polyaspartamidderivater som adsorptionsmidler for galdesyrer, polyaspartamidderivater ladet med galdesyrer, fremgangsmåder - Google Patents

Polyaspartamidderivater som adsorptionsmidler for galdesyrer, polyaspartamidderivater ladet med galdesyrer, fremgangsmåder

Info

Publication number
DK0548794T3
DK0548794T3 DK92121461T DK92121461T DK0548794T3 DK 0548794 T3 DK0548794 T3 DK 0548794T3 DK 92121461 T DK92121461 T DK 92121461T DK 92121461 T DK92121461 T DK 92121461T DK 0548794 T3 DK0548794 T3 DK 0548794T3
Authority
DK
Denmark
Prior art keywords
bile acids
polyaspartamide
derivatives
polyaspartamide derivatives
adsorbents
Prior art date
Application number
DK92121461T
Other languages
English (en)
Inventor
Volker Dr Krone
Axel Dr Walch
Stefan Dr Muellner
Ernold Dr Dr Granzer
Original Assignee
Aventis Res & Tech Gmbh & Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Res & Tech Gmbh & Co filed Critical Aventis Res & Tech Gmbh & Co
Application granted granted Critical
Publication of DK0548794T3 publication Critical patent/DK0548794T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G73/00—Macromolecular compounds obtained by reactions forming a linkage containing nitrogen with or without oxygen or carbon in the main chain of the macromolecule, not provided for in groups C08G12/00 - C08G71/00
    • C08G73/06—Polycondensates having nitrogen-containing heterocyclic rings in the main chain of the macromolecule
    • C08G73/10—Polyimides; Polyester-imides; Polyamide-imides; Polyamide acids or similar polyimide precursors
    • C08G73/14—Polyamide-imides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A61K47/645—Polycationic or polyanionic oligopeptides, polypeptides or polyamino acids, e.g. polylysine, polyarginine, polyglutamic acid or peptide TAT
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G69/00—Macromolecular compounds obtained by reactions forming a carboxylic amide link in the main chain of the macromolecule
    • C08G69/02—Polyamides derived from amino-carboxylic acids or from polyamines and polycarboxylic acids
    • C08G69/08—Polyamides derived from amino-carboxylic acids or from polyamines and polycarboxylic acids derived from amino-carboxylic acids
    • C08G69/10—Alpha-amino-carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G69/00—Macromolecular compounds obtained by reactions forming a carboxylic amide link in the main chain of the macromolecule
    • C08G69/02—Polyamides derived from amino-carboxylic acids or from polyamines and polycarboxylic acids
    • C08G69/36—Polyamides derived from amino-carboxylic acids or from polyamines and polycarboxylic acids derived from amino acids, polyamines and polycarboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G73/00—Macromolecular compounds obtained by reactions forming a linkage containing nitrogen with or without oxygen or carbon in the main chain of the macromolecule, not provided for in groups C08G12/00 - C08G71/00
    • C08G73/06—Polycondensates having nitrogen-containing heterocyclic rings in the main chain of the macromolecule
    • C08G73/10—Polyimides; Polyester-imides; Polyamide-imides; Polyamide acids or similar polyimide precursors
    • C08G73/1092—Polysuccinimides
DK92121461T 1991-12-20 1992-12-17 Polyaspartamidderivater som adsorptionsmidler for galdesyrer, polyaspartamidderivater ladet med galdesyrer, fremgangsmåder DK0548794T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE4142147 1991-12-20

Publications (1)

Publication Number Publication Date
DK0548794T3 true DK0548794T3 (da) 1999-12-06

Family

ID=6447596

Family Applications (1)

Application Number Title Priority Date Filing Date
DK92121461T DK0548794T3 (da) 1991-12-20 1992-12-17 Polyaspartamidderivater som adsorptionsmidler for galdesyrer, polyaspartamidderivater ladet med galdesyrer, fremgangsmåder

Country Status (11)

Country Link
US (2) US5714138A (da)
EP (1) EP0548794B1 (da)
JP (1) JPH0665372A (da)
AT (1) ATE180968T1 (da)
CA (1) CA2085782A1 (da)
DE (1) DE59209709D1 (da)
DK (1) DK0548794T3 (da)
ES (1) ES2134787T3 (da)
FI (1) FI925734A (da)
GR (1) GR3030882T3 (da)
NO (1) NO302482B1 (da)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FI925734A (fi) * 1991-12-20 1993-06-21 Hoechst Ag Polyaspartamidderivat som adsorptionsmedel foer gallsyra, polyaspartamidderivat innehaollande gallsyror och foerfarande foer framstaellning av dessa samt anvaendning av dessa som laekemedel
DE69413590D1 (de) * 1993-04-23 1998-11-05 Rhone Poulenc Chimie Polyanhydroasparaginsäure und seine bioabbaubaren Hydrolyseprodukte
US5994391A (en) * 1994-09-13 1999-11-30 G.D. Searle And Company Benzothiepines having activity as inhibitors of ileal bile acid transport and taurocholate uptake
US6262277B1 (en) 1994-09-13 2001-07-17 G.D. Searle And Company Intermediates and processes for the preparation of benzothiepines having activity as inhibitors of ileal bile acid transport and taurocholate uptake
US6107494A (en) * 1994-09-13 2000-08-22 G.D. Searle And Company Substituted 5-aryl-benzothiepines having activity as inhibitors of ileal bile acid transport and taurocholate uptake
US6268392B1 (en) 1994-09-13 2001-07-31 G. D. Searle & Co. Combination therapy employing ileal bile acid transport inhibiting benzothiepines and HMG Co-A reductase inhibitors
US6642268B2 (en) 1994-09-13 2003-11-04 G.D. Searle & Co. Combination therapy employing ileal bile acid transport inhibiting benzothipines and HMG Co-A reductase inhibitors
JP2002533410A (ja) 1998-12-23 2002-10-08 ジー．ディー．サール エルエルシー 心臓血管に適用するためのコレステリルエステル転送タンパク質阻害剤およびフィブリン酸誘導体の組み合わせ
US6489366B1 (en) 1998-12-23 2002-12-03 G. D. Searle, Llc Combinations of cholesteryl ester transfer protein inhibitors and nicotinic acid derivatives for cardiovascular indications
AU776953B2 (en) 1998-12-23 2004-09-30 G.D. Searle Llc Combinations of ileal bile acid transport inhibitors and bile acid sequestring agents for cardiovascular indications
AU2157400A (en) 1998-12-23 2000-07-31 G.D. Searle & Co. Combinations of cholesteryl ester transfer protein inhibitors and hmg coa reductase inhibitors for cardiovascular indications
BR9916565A (pt) 1998-12-23 2002-01-29 Searle Llc Combinações de inibidores do transporte ácido da bile ileal e derivados do ácido fìbrico para indicações cardiovasculares
EP1340510A1 (en) 1998-12-23 2003-09-03 G.D. Searle LLC. Combinations of cholesteryl ester transfer protein inhibitors and bile acid sequestering agents for cardiovascular indications
NZ512536A (en) 1998-12-23 2003-11-28 G Combinations of ileal bile acid transport inhibitors and cholesteryl ester transfer protein inhibitors for cardiovascular indications
JP2003528830A (ja) 2000-03-10 2003-09-30 ファルマシア・コーポレーション テトラヒドロベンゾチエピン類の製造方法
US6933269B2 (en) * 2001-08-03 2005-08-23 The Procter & Gamble Company Polyaspartate derivatives for use in detergent compositions
EP1448546A4 (en) 2001-11-02 2005-02-02 Searle Llc MONO- AND DI-FLUORINATED BENZOTHIEPINE COMPOUNDS AS INHIBITORS OF TRANSPORT OF ACIDICALLY DEPENDENT SODIUM ACILIC (ASBT) BILIARY ACIDS AND TAUROCHOLATE RECOVERY
EP1465885A4 (en) 2002-01-17 2005-04-27 Pharmacia Corp NOVEL ALKYL / ARYL HYDROXY OR CETOTHIEPINE COMPOUNDS AS INHIBITORS OF BILIARY ACID TRANSPORT OF THE ILEAL TYPE AND ABSORPTION OF TAUROCHOLATE
FR2837710B1 (fr) * 2002-03-26 2005-07-08 Innovations Pharma Ag Composition topique a base de resines echangeuses d'ions, notamment pour le traitement des erythemes
CN108264639B (zh) * 2017-12-20 2020-08-07 湖北工业大学 一种温度pH双重响应性肉桂酸-聚天冬酰胺扼合物及其水相交联方法

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB747901A (en) * 1953-07-01 1956-04-18 Courtaulds Ltd Improvements in and relating to the treatment of synthetic polypeptides
GB1024393A (en) * 1963-03-30 1966-03-30 Asahi Chemical Ind Process for polymerizing n-carboxy-ª‡-amino acid anhydrides
FR1603159A (da) * 1967-07-20 1971-03-22
US3846380A (en) * 1972-10-31 1974-11-05 M Teranishi Polyamino acid derivatives and compositions containing same
GB1506217A (en) * 1975-08-26 1978-04-05 Taiho Pharmaceutical Co Ltd Oral antilipemic composition
US4363797A (en) * 1977-09-14 1982-12-14 Societe Anonyme Dite: L'oreal Polyaspartic acid derivatives, their preparation and their use in cosmetic composition
FR2424293A1 (fr) * 1978-04-27 1979-11-23 Oreal Nouveau procede de preparation de l'acide polydehydroaspartique
JPS6086124A (ja) * 1983-10-17 1985-05-15 Nitto Boseki Co Ltd 規則性ポリアミノ酸樹脂の製造方法
DE3626672A1 (de) * 1986-08-07 1988-02-11 Bayer Ag Polyasparaginamidsaeure
DE3700128A1 (de) * 1987-01-03 1988-07-14 Hoechst Ag Biologisch abbaubare poly- (hydroxyalkyl)- aminodicarbonsaeure-derivate, verfahren zu ihrer herstellung und verwendung derselben fuer depotzubereitungen mit kontrollierter wirkstoffabgabe
JP2909500B2 (ja) * 1989-03-23 1999-06-23 ベルレックス、ラボラトリーズ、レンコーポレイテッド 水溶性抗高脂質血症剤として有用な官能化側鎖を有するポリアミド
US5516758A (en) * 1989-03-23 1996-05-14 Berlex Laboratories, Inc. Polyamides bearing functionalized side chains useful as water soluble hypolipidemic agents
DE4002736A1 (de) * 1990-01-31 1991-08-01 Hoechst Ag Biologisch abbaubare polymere, verfahren zu ihrer herstellung und verwendung derselben fuer depotzubereitungen mit kontrollierter wirkstoffabgabe
US5190982A (en) * 1990-04-26 1993-03-02 Hoechst Aktiengesellschaft Ultrasonic contrast agents, processes for their preparation and the use thereof as diagnostic and therapeutic agents
CA2040996A1 (en) * 1990-05-02 1991-11-03 Robert L. Albright Composition and method for controlling cholesterol
US5057597A (en) * 1990-07-03 1991-10-15 Koskan Larry P Process for the manufacture of anhydro polyamino acids and polyamino acids
FI925734A (fi) * 1991-12-20 1993-06-21 Hoechst Ag Polyaspartamidderivat som adsorptionsmedel foer gallsyra, polyaspartamidderivat innehaollande gallsyror och foerfarande foer framstaellning av dessa samt anvaendning av dessa som laekemedel

Also Published As

Publication number Publication date
EP0548794A2 (de) 1993-06-30
CA2085782A1 (en) 1993-06-21
US5714138A (en) 1998-02-03
NO924921D0 (no) 1992-12-18
NO924921L (no) 1993-06-21
EP0548794A3 (en) 1994-11-23
ES2134787T3 (es) 1999-10-16
EP0548794B1 (de) 1999-06-09
US6036948A (en) 2000-03-14
GR3030882T3 (en) 1999-11-30
ATE180968T1 (de) 1999-06-15
DE59209709D1 (de) 1999-07-15
FI925734A0 (fi) 1992-12-17
JPH0665372A (ja) 1994-03-08
NO302482B1 (no) 1998-03-09
FI925734A (fi) 1993-06-21

Similar Documents

Publication Publication Date Title
DK0548794T3 (da) Polyaspartamidderivater som adsorptionsmidler for galdesyrer, polyaspartamidderivater ladet med galdesyrer, fremgangsmåder
IE892272L (en) Novel fused heterocyclic compounds
JPS6429362A (en) 3-demethylmevalonic acid derivative
NZ247201A (en) Substituted sulphonylamido- or sulphonamidocarbonyl-pyridine-2-carboxamide derivatives and pharmaceutical compositions
AU1033292A (en) Indole piperazine derivatives and pharmaceutical preparations containing such derivatives
IE820856L (en) Omega-cyano-1,omega-diphenyl-azaalkane derivatives.
ATE157088T1 (de) Neue chinolon- und naphthyridoncarbonsäurederivate
AU7736191A (en) Oxazolidinones
DE69414194D1 (de) Aminosäurederivate und ihre Verwendung als Enkephalinase-Inhibitoren
ATE92469T1 (de) Neue alpha-aminocarbonsaeure-derivate, ihre herstellung und verwendung.
RU92004562A (ru) Новые цефалоспорины, имеющие в положении 7 замещенный оксииминный радикал, метод их получения и их использование в качестве медикаментов, фармацевтический состав на их основе
DE3461378D1 (en) Rifamycins derivatives and preparation and pharmaceutical compositions thereof
ES2165358T3 (es) Utilizaciones de la proteinquinasa de neurofilamento/tau pk40.
AU2240388A (en) Azachromane derivatives
DE3851979D1 (de) Substituierte Vinylcephalosporine, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel.
NZ223333A (en) 3-phenyl-7h-thiazole (3,2-b (1,2, triazin-7-one derivatives and pharmaceutical compositions
WO1995022544A3 (de) Substituierte 1,3,8-triaza-spiro(4,5)-decan-4-on-derivate als vorstufen zur herstellung von pharmazeutika
PL312966A1 (en) Derivatives of thiocarbamoil