EA199800230A1 - Тетрагидрохинолины в качестве антагонистов nmda (n-метил-d-аспарагиновой кислоты) - Google Patents

Тетрагидрохинолины в качестве антагонистов nmda (n-метил-d-аспарагиновой кислоты)

Info

Publication number
EA199800230A1
EA199800230A1 EA199800230A EA199800230A EA199800230A1 EA 199800230 A1 EA199800230 A1 EA 199800230A1 EA 199800230 A EA199800230 A EA 199800230A EA 199800230 A EA199800230 A EA 199800230A EA 199800230 A1 EA199800230 A1 EA 199800230A1
Authority
EA
Eurasian Patent Office
Prior art keywords
tetrahydrochinoline
methyl
nmda antagonists
asparagic acid
asparagic
Prior art date
Application number
EA199800230A
Other languages
English (en)
Other versions
EA000875B1 (ru
Inventor
Романо Ди Фабио
Симоне Джаккобе
Барбара Бертани
Фабрицио Микели
Original Assignee
ГЛАКСО ВЕЛЛКАМ СпА
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9519893.3A external-priority patent/GB9519893D0/en
Priority claimed from GBGB9617306.7A external-priority patent/GB9617306D0/en
Application filed by ГЛАКСО ВЕЛЛКАМ СпА filed Critical ГЛАКСО ВЕЛЛКАМ СпА
Publication of EA199800230A1 publication Critical patent/EA199800230A1/ru
Publication of EA000875B1 publication Critical patent/EA000875B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Addiction (AREA)
  • Pain & Pain Management (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Molecular Biology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Cardiology (AREA)
  • Oncology (AREA)
  • AIDS & HIV (AREA)
  • Otolaryngology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Соединения формулы (I), или их соль, или метаболически лабильный эфир, способы их получения и их применение в качестве антагонистов возбуждающих аминокислот.Международная заявка была опубликована вместе с отчетом о международном поиске.
EA199800230A 1995-09-29 1996-09-26 Тетрагидрохинолины в качестве антагонистов nmda (n-метил-d-аспарагиновой кислоты) EA000875B1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB9519893.3A GB9519893D0 (en) 1995-09-29 1995-09-29 Heterocyclic compounds
GBGB9617306.7A GB9617306D0 (en) 1996-08-17 1996-08-17 Heterocyclic compounds
PCT/EP1996/004206 WO1997012870A1 (en) 1995-09-29 1996-09-26 Tetrahydroquinolines as nmda antagonists

Publications (2)

Publication Number Publication Date
EA199800230A1 true EA199800230A1 (ru) 1998-10-29
EA000875B1 EA000875B1 (ru) 2000-06-26

Family

ID=26307841

Family Applications (1)

Application Number Title Priority Date Filing Date
EA199800230A EA000875B1 (ru) 1995-09-29 1996-09-26 Тетрагидрохинолины в качестве антагонистов nmda (n-метил-d-аспарагиновой кислоты)

Country Status (29)

Country Link
US (1) US5977136A (ru)
EP (1) EP0854867B1 (ru)
JP (1) JP4108123B2 (ru)
KR (1) KR100464895B1 (ru)
CN (1) CN1130346C (ru)
AP (1) AP876A (ru)
AR (1) AR005233A1 (ru)
AT (1) ATE221520T1 (ru)
AU (1) AU708148B2 (ru)
BR (1) BR9610733A (ru)
CA (1) CA2232509A1 (ru)
CZ (1) CZ292379B6 (ru)
DE (1) DE69622731T2 (ru)
DK (1) DK0854867T3 (ru)
EA (1) EA000875B1 (ru)
ES (1) ES2180799T3 (ru)
HK (1) HK1009133A1 (ru)
HU (1) HUP9900040A3 (ru)
IL (1) IL123322A0 (ru)
IS (1) IS4677A (ru)
MX (1) MX9801967A (ru)
NO (1) NO310355B1 (ru)
NZ (1) NZ319596A (ru)
PL (1) PL186781B1 (ru)
PT (1) PT854867E (ru)
SI (1) SI0854867T1 (ru)
TR (1) TR199800531T1 (ru)
TW (1) TW460465B (ru)
WO (1) WO1997012870A1 (ru)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9617305D0 (en) * 1996-08-17 1996-09-25 Glaxo Wellcome Spa Heterocyclic compounds
GB9706294D0 (en) * 1997-03-26 1997-05-14 Glaxo Wellcome Spa Heterocyclic compound
MY125037A (en) 1998-06-10 2006-07-31 Glaxo Wellcome Spa 1,2,3,4 tetrahydroquinoline derivatives
TW555757B (en) * 1998-07-31 2003-10-01 Akzo Nobel Nv Aminomethylcarboxylic acid derivatives
EP1103552A4 (en) * 1998-08-07 2003-01-15 Takeda Chemical Industries Ltd BENZOTHIEPINE DERIVATIVES, METHOD FOR THEIR PRODUCTION AND THEIR USE
GB9929037D0 (en) * 1999-12-08 2000-02-02 Glaxo Wellcome Spa Heterocyclic derivatives
MXPA04006281A (es) * 2001-12-28 2004-09-27 Acadia Pharm Inc Analogos de tetrahidroquinolina como agonistas muscarinicos.
DE10236910A1 (de) * 2002-08-12 2004-03-11 Grünenthal GmbH Substituierte 1,2,3,4-Tetrahydrochinolinderivate
RU2451014C2 (ru) * 2005-07-22 2012-05-20 Мотида Фармасьютикал Ко., Лтд. Новое производное гетероциклиден ацетамида
KR101136183B1 (ko) * 2005-07-22 2012-04-17 모찌다 세이야쿠 가부시끼가이샤 신규 헤테로시클리덴 아세트아미드 유도체
JP5291126B2 (ja) 2008-03-05 2013-09-18 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 三環式ピリジン誘導体、そのような化合物を含有する医薬、それらの使用及びそれらの調製方法
EP2286808A1 (en) * 2009-08-18 2011-02-23 Rheinische Friedrich-Wilhelms Universität Cytohesin inhibitors
KR20120123089A (ko) 2010-02-16 2012-11-07 화이자 인코포레이티드 5-ＨＴ₄ 수용체의 부분 효능제인 (Ｒ)-4-((4-((4-(테트라히드로푸란-3-일옥시)벤조［ｄ］이속사졸-3-일옥시)메틸)피페리딘-1-일)메틸)테트라히드로-2Ｈ-피란-4-올
BR112012020591A2 (pt) 2010-02-19 2017-10-10 Boehringer Ingelheim Int derivados de piridina tricíclica, medicamentos contendo tais compostos, seu uso e processo para sua preparação.
AR087577A1 (es) 2011-08-17 2014-04-03 Boehringer Ingelheim Int Derivados de furo[3,4-c]quinolina, medicamentos que contienen dichos compuestos, su uso y proceso para su preparacion
WO2016114655A1 (en) * 2015-01-12 2016-07-21 Ry Pharma B.V. Treating neuromuscular or neurologic disease through reducing gabaergic and/or glycinergic inhibitory neurotransmitter overstimulation
WO2017065602A1 (en) * 2015-10-13 2017-04-20 Ry Pharma B.V. Treating neuromuscular or neurologic disease through reducing gabaergic and/or glycinergic inhibitory neurotransmitter overstimulation

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL93610A0 (en) * 1989-03-08 1990-12-23 Merck Sharp & Dohme Tetrahydroquinoline derivatives,their preparation and pharmaceutical compositions containing them

Also Published As

Publication number Publication date
ATE221520T1 (de) 2002-08-15
NO310355B1 (no) 2001-06-25
IL123322A0 (en) 1998-09-24
NO981396L (no) 1998-05-27
HUP9900040A2 (hu) 1999-04-28
AU7214896A (en) 1997-04-28
JP4108123B2 (ja) 2008-06-25
KR19990063850A (ko) 1999-07-26
CZ292379B6 (cs) 2003-09-17
EP0854867B1 (en) 2002-07-31
CN1130346C (zh) 2003-12-10
CA2232509A1 (en) 1997-04-10
KR100464895B1 (ko) 2005-05-16
AR005233A1 (es) 1999-04-28
BR9610733A (pt) 1999-07-13
SI0854867T1 (en) 2003-02-28
AP9801212A0 (en) 1998-03-31
JPH11512728A (ja) 1999-11-02
PL186781B1 (pl) 2004-02-27
DE69622731D1 (de) 2002-09-05
DK0854867T3 (da) 2002-12-02
ES2180799T3 (es) 2003-02-16
IS4677A (is) 1998-02-27
AU708148B2 (en) 1999-07-29
US5977136A (en) 1999-11-02
AP876A (en) 2000-09-27
WO1997012870A1 (en) 1997-04-10
TR199800531T1 (xx) 1998-06-22
EA000875B1 (ru) 2000-06-26
NZ319596A (en) 1999-09-29
PT854867E (pt) 2002-12-31
MX9801967A (es) 1998-08-30
HUP9900040A3 (en) 2001-01-29
EP0854867A1 (en) 1998-07-29
CN1202887A (zh) 1998-12-23
NO981396D0 (no) 1998-03-27
TW460465B (en) 2001-10-21
HK1009133A1 (en) 1999-05-28
DE69622731T2 (de) 2003-02-20
CZ94098A3 (cs) 1998-07-15
PL325966A1 (en) 1998-08-17

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Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG MD TJ TM

MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): RU