ATE221520T1 - Tetrahydrochinoline als nmda antagonisten - Google Patents

Tetrahydrochinoline als nmda antagonisten

Info

Publication number
ATE221520T1
ATE221520T1 AT96933399T AT96933399T ATE221520T1 AT E221520 T1 ATE221520 T1 AT E221520T1 AT 96933399 T AT96933399 T AT 96933399T AT 96933399 T AT96933399 T AT 96933399T AT E221520 T1 ATE221520 T1 AT E221520T1
Authority
AT
Austria
Prior art keywords
tetrahydrocinolines
nmda antagonists
nmda
antagonists
Prior art date
Application number
AT96933399T
Other languages
English (en)
Inventor
Fabio Romano Di
Simone Giacobbe
Barbara Bertani
Fabrizio Micheli
Original Assignee
Glaxo Wellcome Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9519893.3A external-priority patent/GB9519893D0/en
Priority claimed from GBGB9617306.7A external-priority patent/GB9617306D0/en
Application filed by Glaxo Wellcome Spa filed Critical Glaxo Wellcome Spa
Application granted granted Critical
Publication of ATE221520T1 publication Critical patent/ATE221520T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Virology (AREA)
  • Cardiology (AREA)
  • Pain & Pain Management (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Communicable Diseases (AREA)
  • AIDS & HIV (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Molecular Biology (AREA)
  • Oncology (AREA)
  • Addiction (AREA)
  • Otolaryngology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
AT96933399T 1995-09-29 1996-09-26 Tetrahydrochinoline als nmda antagonisten ATE221520T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB9519893.3A GB9519893D0 (en) 1995-09-29 1995-09-29 Heterocyclic compounds
GBGB9617306.7A GB9617306D0 (en) 1996-08-17 1996-08-17 Heterocyclic compounds
PCT/EP1996/004206 WO1997012870A1 (en) 1995-09-29 1996-09-26 Tetrahydroquinolines as nmda antagonists

Publications (1)

Publication Number Publication Date
ATE221520T1 true ATE221520T1 (de) 2002-08-15

Family

ID=26307841

Family Applications (1)

Application Number Title Priority Date Filing Date
AT96933399T ATE221520T1 (de) 1995-09-29 1996-09-26 Tetrahydrochinoline als nmda antagonisten

Country Status (29)

Country Link
US (1) US5977136A (de)
EP (1) EP0854867B1 (de)
JP (1) JP4108123B2 (de)
KR (1) KR100464895B1 (de)
CN (1) CN1130346C (de)
AP (1) AP876A (de)
AR (1) AR005233A1 (de)
AT (1) ATE221520T1 (de)
AU (1) AU708148B2 (de)
BR (1) BR9610733A (de)
CA (1) CA2232509A1 (de)
CZ (1) CZ292379B6 (de)
DE (1) DE69622731T2 (de)
DK (1) DK0854867T3 (de)
EA (1) EA000875B1 (de)
ES (1) ES2180799T3 (de)
HK (1) HK1009133A1 (de)
HU (1) HUP9900040A3 (de)
IL (1) IL123322A0 (de)
IS (1) IS4677A (de)
MX (1) MX9801967A (de)
NO (1) NO310355B1 (de)
NZ (1) NZ319596A (de)
PL (1) PL186781B1 (de)
PT (1) PT854867E (de)
SI (1) SI0854867T1 (de)
TR (1) TR199800531T1 (de)
TW (1) TW460465B (de)
WO (1) WO1997012870A1 (de)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9617305D0 (en) * 1996-08-17 1996-09-25 Glaxo Wellcome Spa Heterocyclic compounds
GB9706294D0 (en) * 1997-03-26 1997-05-14 Glaxo Wellcome Spa Heterocyclic compound
MY125037A (en) * 1998-06-10 2006-07-31 Glaxo Wellcome Spa 1,2,3,4 tetrahydroquinoline derivatives
US6355672B1 (en) * 1998-08-07 2002-03-12 Takeda Chemical Industries, Ltd. Benzothiepin derivatives, process for the preparation of the same and uses thereof
TW555757B (en) * 1998-07-31 2003-10-01 Akzo Nobel Nv Aminomethylcarboxylic acid derivatives
GB9929037D0 (en) 1999-12-08 2000-02-02 Glaxo Wellcome Spa Heterocyclic derivatives
AU2002359875B2 (en) * 2001-12-28 2009-01-08 Acadia Pharmaceuticals Inc. Tetrahydroquinoline analogues as muscarinic agonists
DE10236910A1 (de) * 2002-08-12 2004-03-11 Grünenthal GmbH Substituierte 1,2,3,4-Tetrahydrochinolinderivate
KR101136183B1 (ko) 2005-07-22 2012-04-17 모찌다 세이야쿠 가부시끼가이샤 신규 헤테로시클리덴 아세트아미드 유도체
RU2451014C2 (ru) * 2005-07-22 2012-05-20 Мотида Фармасьютикал Ко., Лтд. Новое производное гетероциклиден ацетамида
RU2010140442A (ru) * 2008-03-05 2012-04-10 Бёрингер Ингельхайм Интернациональ Гмбх (De) Трициклические производные пиридина, лекарственные средства, содержащие такие соединения, их применение и способ их получения
EP2286808A1 (de) * 2009-08-18 2011-02-23 Rheinische Friedrich-Wilhelms Universität Cytohesininhibitoren
AU2011216950A1 (en) 2010-02-16 2012-08-23 Pfizer Inc. (R)-4-((4-((4-(tetrahydrofuran-3-yloxy) benzo[d]isoxazol-3-yloxy)methyl)piperidin-1-yl)methyl)tetrahydro-2H-pyran-4-ol, a partial agonist of 5-HT4 receptors
KR20130000379A (ko) 2010-02-19 2013-01-02 베링거 인겔하임 인터내셔날 게엠베하 트리사이클릭 피리딘 유도체, 이러한 화합물을 함유하는 약제, 이의 용도 및 이의 제조방법
AR087577A1 (es) 2011-08-17 2014-04-03 Boehringer Ingelheim Int Derivados de furo[3,4-c]quinolina, medicamentos que contienen dichos compuestos, su uso y proceso para su preparacion
WO2016114655A1 (en) * 2015-01-12 2016-07-21 Ry Pharma B.V. Treating neuromuscular or neurologic disease through reducing gabaergic and/or glycinergic inhibitory neurotransmitter overstimulation
WO2017065602A1 (en) * 2015-10-13 2017-04-20 Ry Pharma B.V. Treating neuromuscular or neurologic disease through reducing gabaergic and/or glycinergic inhibitory neurotransmitter overstimulation

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69029668T2 (de) * 1989-03-08 1997-08-07 Merck Sharp & Dohme Tetrahydroquinolin-Derivate, verwendbar bei neurodegenerativen Krankheiten

Also Published As

Publication number Publication date
AP876A (en) 2000-09-27
CA2232509A1 (en) 1997-04-10
KR19990063850A (ko) 1999-07-26
EA000875B1 (ru) 2000-06-26
HUP9900040A2 (hu) 1999-04-28
US5977136A (en) 1999-11-02
MX9801967A (es) 1998-08-30
PL186781B1 (pl) 2004-02-27
NO981396D0 (no) 1998-03-27
PT854867E (pt) 2002-12-31
JPH11512728A (ja) 1999-11-02
JP4108123B2 (ja) 2008-06-25
CN1130346C (zh) 2003-12-10
PL325966A1 (en) 1998-08-17
DE69622731D1 (de) 2002-09-05
BR9610733A (pt) 1999-07-13
CZ94098A3 (cs) 1998-07-15
IS4677A (is) 1998-02-27
NZ319596A (en) 1999-09-29
AP9801212A0 (en) 1998-03-31
EP0854867B1 (de) 2002-07-31
AU708148B2 (en) 1999-07-29
TW460465B (en) 2001-10-21
DE69622731T2 (de) 2003-02-20
EA199800230A1 (ru) 1998-10-29
CZ292379B6 (cs) 2003-09-17
AU7214896A (en) 1997-04-28
AR005233A1 (es) 1999-04-28
KR100464895B1 (ko) 2005-05-16
EP0854867A1 (de) 1998-07-29
DK0854867T3 (da) 2002-12-02
HK1009133A1 (en) 1999-05-28
SI0854867T1 (en) 2003-02-28
NO981396L (no) 1998-05-27
CN1202887A (zh) 1998-12-23
HUP9900040A3 (en) 2001-01-29
NO310355B1 (no) 2001-06-25
TR199800531T1 (xx) 1998-06-22
ES2180799T3 (es) 2003-02-16
WO1997012870A1 (en) 1997-04-10
IL123322A0 (en) 1998-09-24

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