ES2180799T3 - Tetrahidroquinolinas como antagonistas de nmda (n-metil-d-aspartato). - Google Patents

Tetrahidroquinolinas como antagonistas de nmda (n-metil-d-aspartato).

Info

Publication number
ES2180799T3
ES2180799T3 ES96933399T ES96933399T ES2180799T3 ES 2180799 T3 ES2180799 T3 ES 2180799T3 ES 96933399 T ES96933399 T ES 96933399T ES 96933399 T ES96933399 T ES 96933399T ES 2180799 T3 ES2180799 T3 ES 2180799T3
Authority
ES
Spain
Prior art keywords
antagonists
tetrahydrochinolines
nmda
aspartate
methyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES96933399T
Other languages
English (en)
Inventor
Fabio Romano Di
Simone Giacobbe
Barbara Bertani
Fabrizio Micheli
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
GlaxoSmithKline SpA
Original Assignee
GlaxoSmithKline SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9519893.3A external-priority patent/GB9519893D0/en
Priority claimed from GBGB9617306.7A external-priority patent/GB9617306D0/en
Application filed by GlaxoSmithKline SpA filed Critical GlaxoSmithKline SpA
Application granted granted Critical
Publication of ES2180799T3 publication Critical patent/ES2180799T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Addiction (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Molecular Biology (AREA)
  • Cardiology (AREA)
  • Pain & Pain Management (AREA)
  • Heart & Thoracic Surgery (AREA)
  • AIDS & HIV (AREA)
  • Communicable Diseases (AREA)
  • Otolaryngology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

SE DESCRIBEN COMPUESTOS DE FORMULA (I) O UNA SAL, O UN ESTER METABOLICAMENTE LABIL DE ESTOS, PROCEDIMIENTOS PARA SU PREPARACION Y SU USO COMO ANTAGONISTAS DE AMINOACIDOS DE EXCITACION.
ES96933399T 1995-09-29 1996-09-26 Tetrahidroquinolinas como antagonistas de nmda (n-metil-d-aspartato). Expired - Lifetime ES2180799T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9519893.3A GB9519893D0 (en) 1995-09-29 1995-09-29 Heterocyclic compounds
GBGB9617306.7A GB9617306D0 (en) 1996-08-17 1996-08-17 Heterocyclic compounds

Publications (1)

Publication Number Publication Date
ES2180799T3 true ES2180799T3 (es) 2003-02-16

Family

ID=26307841

Family Applications (1)

Application Number Title Priority Date Filing Date
ES96933399T Expired - Lifetime ES2180799T3 (es) 1995-09-29 1996-09-26 Tetrahidroquinolinas como antagonistas de nmda (n-metil-d-aspartato).

Country Status (29)

Country Link
US (1) US5977136A (es)
EP (1) EP0854867B1 (es)
JP (1) JP4108123B2 (es)
KR (1) KR100464895B1 (es)
CN (1) CN1130346C (es)
AP (1) AP876A (es)
AR (1) AR005233A1 (es)
AT (1) ATE221520T1 (es)
AU (1) AU708148B2 (es)
BR (1) BR9610733A (es)
CA (1) CA2232509A1 (es)
CZ (1) CZ292379B6 (es)
DE (1) DE69622731T2 (es)
DK (1) DK0854867T3 (es)
EA (1) EA000875B1 (es)
ES (1) ES2180799T3 (es)
HK (1) HK1009133A1 (es)
HU (1) HUP9900040A3 (es)
IL (1) IL123322A0 (es)
IS (1) IS4677A (es)
MX (1) MX9801967A (es)
NO (1) NO310355B1 (es)
NZ (1) NZ319596A (es)
PL (1) PL186781B1 (es)
PT (1) PT854867E (es)
SI (1) SI0854867T1 (es)
TR (1) TR199800531T1 (es)
TW (1) TW460465B (es)
WO (1) WO1997012870A1 (es)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9617305D0 (en) * 1996-08-17 1996-09-25 Glaxo Wellcome Spa Heterocyclic compounds
GB9706294D0 (en) * 1997-03-26 1997-05-14 Glaxo Wellcome Spa Heterocyclic compound
MY125037A (en) 1998-06-10 2006-07-31 Glaxo Wellcome Spa 1,2,3,4 tetrahydroquinoline derivatives
TW555757B (en) * 1998-07-31 2003-10-01 Akzo Nobel Nv Aminomethylcarboxylic acid derivatives
EP1103552A4 (en) * 1998-08-07 2003-01-15 Takeda Chemical Industries Ltd BENZOTHIEPINE DERIVATIVES, METHOD FOR THEIR PRODUCTION AND THEIR USE
GB9929037D0 (en) * 1999-12-08 2000-02-02 Glaxo Wellcome Spa Heterocyclic derivatives
MXPA04006281A (es) * 2001-12-28 2004-09-27 Acadia Pharm Inc Analogos de tetrahidroquinolina como agonistas muscarinicos.
DE10236910A1 (de) * 2002-08-12 2004-03-11 Grünenthal GmbH Substituierte 1,2,3,4-Tetrahydrochinolinderivate
RU2451014C2 (ru) * 2005-07-22 2012-05-20 Мотида Фармасьютикал Ко., Лтд. Новое производное гетероциклиден ацетамида
KR101136183B1 (ko) * 2005-07-22 2012-04-17 모찌다 세이야쿠 가부시끼가이샤 신규 헤테로시클리덴 아세트아미드 유도체
JP5291126B2 (ja) 2008-03-05 2013-09-18 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 三環式ピリジン誘導体、そのような化合物を含有する医薬、それらの使用及びそれらの調製方法
EP2286808A1 (en) * 2009-08-18 2011-02-23 Rheinische Friedrich-Wilhelms Universität Cytohesin inhibitors
KR20120123089A (ko) 2010-02-16 2012-11-07 화이자 인코포레이티드 5-ＨＴ₄ 수용체의 부분 효능제인 (Ｒ)-4-((4-((4-(테트라히드로푸란-3-일옥시)벤조［ｄ］이속사졸-3-일옥시)메틸)피페리딘-1-일)메틸)테트라히드로-2Ｈ-피란-4-올
BR112012020591A2 (pt) 2010-02-19 2017-10-10 Boehringer Ingelheim Int derivados de piridina tricíclica, medicamentos contendo tais compostos, seu uso e processo para sua preparação.
AR087577A1 (es) 2011-08-17 2014-04-03 Boehringer Ingelheim Int Derivados de furo[3,4-c]quinolina, medicamentos que contienen dichos compuestos, su uso y proceso para su preparacion
WO2016114655A1 (en) * 2015-01-12 2016-07-21 Ry Pharma B.V. Treating neuromuscular or neurologic disease through reducing gabaergic and/or glycinergic inhibitory neurotransmitter overstimulation
WO2017065602A1 (en) * 2015-10-13 2017-04-20 Ry Pharma B.V. Treating neuromuscular or neurologic disease through reducing gabaergic and/or glycinergic inhibitory neurotransmitter overstimulation

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL93610A0 (en) * 1989-03-08 1990-12-23 Merck Sharp & Dohme Tetrahydroquinoline derivatives,their preparation and pharmaceutical compositions containing them

Also Published As

Publication number Publication date
ATE221520T1 (de) 2002-08-15
NO310355B1 (no) 2001-06-25
IL123322A0 (en) 1998-09-24
NO981396L (no) 1998-05-27
HUP9900040A2 (hu) 1999-04-28
AU7214896A (en) 1997-04-28
JP4108123B2 (ja) 2008-06-25
KR19990063850A (ko) 1999-07-26
CZ292379B6 (cs) 2003-09-17
EA199800230A1 (ru) 1998-10-29
EP0854867B1 (en) 2002-07-31
CN1130346C (zh) 2003-12-10
CA2232509A1 (en) 1997-04-10
KR100464895B1 (ko) 2005-05-16
AR005233A1 (es) 1999-04-28
BR9610733A (pt) 1999-07-13
SI0854867T1 (en) 2003-02-28
AP9801212A0 (en) 1998-03-31
JPH11512728A (ja) 1999-11-02
PL186781B1 (pl) 2004-02-27
DE69622731D1 (de) 2002-09-05
DK0854867T3 (da) 2002-12-02
IS4677A (is) 1998-02-27
AU708148B2 (en) 1999-07-29
US5977136A (en) 1999-11-02
AP876A (en) 2000-09-27
WO1997012870A1 (en) 1997-04-10
TR199800531T1 (xx) 1998-06-22
EA000875B1 (ru) 2000-06-26
NZ319596A (en) 1999-09-29
PT854867E (pt) 2002-12-31
MX9801967A (es) 1998-08-30
HUP9900040A3 (en) 2001-01-29
EP0854867A1 (en) 1998-07-29
CN1202887A (zh) 1998-12-23
NO981396D0 (no) 1998-03-27
TW460465B (en) 2001-10-21
HK1009133A1 (en) 1999-05-28
DE69622731T2 (de) 2003-02-20
CZ94098A3 (cs) 1998-07-15
PL325966A1 (en) 1998-08-17

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