MX9706605A - Derivados de indol como antagonistas de los aminoacidos exitadores. - Google Patents

Derivados de indol como antagonistas de los aminoacidos exitadores.

Info

Publication number
MX9706605A
MX9706605A MX9706605A MX9706605A MX9706605A MX 9706605 A MX9706605 A MX 9706605A MX 9706605 A MX9706605 A MX 9706605A MX 9706605 A MX9706605 A MX 9706605A MX 9706605 A MX9706605 A MX 9706605A
Authority
MX
Mexico
Prior art keywords
indole derivatives
eaa antagonists
eaa
antagonists
preparation
Prior art date
Application number
MX9706605A
Other languages
English (en)
Other versions
MXPA97006605A (es
Inventor
Nadia Conti
Romano Di Fabio
Elisabetta De Magistris
Aldo Feriani
Original Assignee
Glaxo Wellcome Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Wellcome Spa filed Critical Glaxo Wellcome Spa
Publication of MXPA97006605A publication Critical patent/MXPA97006605A/es
Publication of MX9706605A publication Critical patent/MX9706605A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Se describen los compuestos de la formula (I): o una sal, o un éster metabolicamente lábil del mismo, y los procesos para su preparacion, su uso en medicina y los intermediarios para usarse en su preparacion.
MX9706605A 1995-03-04 1996-03-01 Derivados de indol como antagonistas de los aminoacidos exitadores. MX9706605A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB9504361.8A GB9504361D0 (en) 1995-03-04 1995-03-04 Heterocyclic compounds
GB9504361.8 1995-03-04
PCT/EP1996/000840 WO1996027588A1 (en) 1995-03-04 1996-03-01 Indole derivatives as eaa antagonists

Publications (2)

Publication Number Publication Date
MXPA97006605A MXPA97006605A (es) 1998-02-01
MX9706605A true MX9706605A (es) 1998-02-28

Family

ID=10770638

Family Applications (1)

Application Number Title Priority Date Filing Date
MX9706605A MX9706605A (es) 1995-03-04 1996-03-01 Derivados de indol como antagonistas de los aminoacidos exitadores.

Country Status (23)

Country Link
US (1) US5919811A (es)
EP (1) EP0813524A1 (es)
JP (1) JPH11501041A (es)
KR (1) KR19980702735A (es)
CN (1) CN1182417A (es)
AR (1) AR002711A1 (es)
AU (1) AU708291B2 (es)
BR (1) BR9607346A (es)
CA (1) CA2214583A1 (es)
CO (1) CO4700452A1 (es)
CZ (1) CZ277997A3 (es)
EA (1) EA000308B1 (es)
GB (1) GB9504361D0 (es)
HU (1) HUP9801838A3 (es)
IL (1) IL117331A (es)
MX (1) MX9706605A (es)
NO (1) NO309323B1 (es)
NZ (1) NZ303200A (es)
PE (1) PE62396A1 (es)
PL (1) PL322084A1 (es)
TW (1) TW438773B (es)
WO (1) WO1996027588A1 (es)
ZA (1) ZA961697B (es)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5886191A (en) * 1997-08-18 1999-03-23 Dupont Pharmaceuticals Company Amidinoindoles, amidinoazoles, and analogs thereof
GB9902455D0 (en) * 1999-02-05 1999-03-24 Zeneca Ltd Chemical compounds
JP2005518371A (ja) * 2001-12-10 2005-06-23 アムジエン・インコーポレーテツド バニロイド受容体リガンド及び治療に於けるこれらの使用
GB0205176D0 (en) * 2002-03-06 2002-04-17 Astrazeneca Ab Chemical compounds
EP1615878B1 (en) * 2003-01-14 2012-04-04 Cytokinetics, Inc. Compounds, compositions and methods of treatment for heart failure
JP5080970B2 (ja) * 2004-06-17 2012-11-21 サイトキネティクス・インコーポレーテッド 心疾患を治療するための置換尿素誘導体
US7176222B2 (en) 2004-07-27 2007-02-13 Cytokinetics, Inc. Syntheses of ureas
US7538223B2 (en) * 2005-08-04 2009-05-26 Cytokinetics, Inc. Compounds, compositions and methods
WO2007075377A2 (en) * 2005-12-15 2007-07-05 Cytokinetics, Inc. Certain chemical entities, compositions and methods
US20070208000A1 (en) * 2005-12-15 2007-09-06 Morgan Bradley P Certain chemical entities, compositions and methods
EP1959960B1 (en) * 2005-12-15 2013-04-10 Cytokinetics, Inc. Certain chemical entities, compositions and methods
US7825120B2 (en) * 2005-12-15 2010-11-02 Cytokinetics, Inc. Certain substituted ((piperazin-1-ylmethyl)benzyl)ureas
US7718657B2 (en) * 2005-12-16 2010-05-18 Cytokinetics, Inc. Certain indanyl urea modulators of the cardiac sarcomere
JP5178526B2 (ja) * 2005-12-19 2013-04-10 サイトキネティクス・インコーポレーテッド 化合物、組成物および方法
WO2009035927A2 (en) * 2007-09-13 2009-03-19 Arete Therapeutics, Inc. Bis-cyclyl substitued ureas or amides as soluble epoxide hydrolase inhibitors
PE20091101A1 (es) 2007-12-18 2009-07-26 Pharminox Ltd AMIDAS DE ACIDO 3-SUBSTITUIDO-4-OXO-3,4-DIHIDRO-IMIDAZO[5,1-d] [1,2,3,5-TETRACINA-8-CARBOXILICO Y SU EMPLEO
JP2012530775A (ja) 2009-06-23 2012-12-06 ファーミノックス リミテッド ３−置換−８−置換−３Ｈ−イミダゾ［５，１−ｄ］［１，２，３，５−テトラジン−４−オン化合物及びその使用
US20130012706A1 (en) 2010-03-01 2013-01-10 Pharminox Limited Methods and Intermediates for the Synthesis of 4-oxo-3,4-dihydro-imidazo[5,1-d][1,2,3,5]tetrazines
WO2012085501A1 (en) 2010-12-20 2012-06-28 Pharminox Limited 8 - sulfo - imidazotetrazin- 4 - one compounds and their use as anticancer drug
TW202128630A (zh) 2019-11-11 2021-08-01 荷蘭商卡普三世責任有限公司 工業規模上用於生產ε-己內醯胺及硫酸銨之方法及設備

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5145845A (en) * 1991-05-14 1992-09-08 Warner-Lambert Co. Substituted 2-carboxylindoles having pharmaceutical activity
GB9208492D0 (en) * 1992-04-16 1992-06-03 Glaxo Spa Heterocyclic compounds
GB9304500D0 (en) * 1993-03-05 1993-04-21 Glaxo Spa Heterocyclic compounds
US5519048A (en) * 1993-05-27 1996-05-21 Merrell Pharmaceuticals Inc. 3-(indol-3-yl)-propenoic acid derivatives and pharmaceutical compositions thereof

Also Published As

Publication number Publication date
AR002711A1 (es) 1998-04-29
IL117331A0 (en) 1996-07-23
AU4943896A (en) 1996-09-23
PE62396A1 (es) 1997-01-11
EA000308B1 (ru) 1999-04-29
GB9504361D0 (en) 1995-04-26
EA199700160A1 (ru) 1998-02-26
CN1182417A (zh) 1998-05-20
HUP9801838A3 (en) 2000-04-28
JPH11501041A (ja) 1999-01-26
CA2214583A1 (en) 1996-09-12
US5919811A (en) 1999-07-06
CO4700452A1 (es) 1998-12-29
AU708291B2 (en) 1999-07-29
BR9607346A (pt) 1997-12-30
EP0813524A1 (en) 1997-12-29
TW438773B (en) 2001-06-07
HUP9801838A2 (hu) 1998-12-28
ZA961697B (en) 1997-10-01
PL322084A1 (en) 1998-01-05
NO974043L (no) 1997-11-03
NZ303200A (en) 1999-01-28
IL117331A (en) 2000-06-29
WO1996027588A1 (en) 1996-09-12
NO974043D0 (no) 1997-09-03
KR19980702735A (ko) 1998-08-05
NO309323B1 (no) 2001-01-15
CZ277997A3 (cs) 1998-06-17

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