AR002711A1 - Un compuesto de 2-carboxindol-3-substituido,un proceso para su preparacion, un nuevo compuesto intermediario para dicho proceso, el uso del compuesto parala fabricacion de un agente terapeutico y una composicion farmaceutica que comprende dicho compuesto. - Google Patents

Un compuesto de 2-carboxindol-3-substituido,un proceso para su preparacion, un nuevo compuesto intermediario para dicho proceso, el uso del compuesto parala fabricacion de un agente terapeutico y una composicion farmaceutica que comprende dicho compuesto.

Info

Publication number
AR002711A1
AR002711A1 ARP960101610A AR10161096A AR002711A1 AR 002711 A1 AR002711 A1 AR 002711A1 AR P960101610 A ARP960101610 A AR P960101610A AR 10161096 A AR10161096 A AR 10161096A AR 002711 A1 AR002711 A1 AR 002711A1
Authority
AR
Argentina
Prior art keywords
compound
substituted
alkyl
manufacture
pharmaceutical composition
Prior art date
Application number
ARP960101610A
Other languages
English (en)
Original Assignee
Glaxo Wellcome Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Wellcome Spa filed Critical Glaxo Wellcome Spa
Publication of AR002711A1 publication Critical patent/AR002711A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

La invención también se refiere a un proceso para la preparación del compuesto, a un nuevo compuesto intermediario para dicho proceso, al uso delcompuesto para la fabricación de un agente terapéutico y a una composición farmacéutica que comprende dicho compuesto. Un compuesto de 2-carboxindol-3-sustituido, de fórmula (I) o, una sal o éster metabólicamente lábil del mismo, en donde R es halógeno, alquilo, alcoxi, amino, alquilamino, dialquilamino,hidroxilo, trifluormetil, trifluormetoxi, nitro, ciano, SO2R4 o COR4, en donde R4 representa hidroxilo, metoxi, amino, alquilamino o dialquilamino; m es 0, 1,2; A es etinilo o etenilo substituido o nó; R1 es hidrógeno o alquilo, cicloalquilo, arilo o heterocíclico, substituidos o nó; R2 es hidrógeno oalquilo; o R1 y R2 juntos pueden formar un anillo heterocíclico de 5 a 7 miembros, el cual puede contener un heteroátomo adicional como O, S o N; R3 eshidrógeno o alquilo; n es cero o un número entero de 1 a 4; X = O óS.
ARP960101610A 1995-03-04 1996-03-01 Un compuesto de 2-carboxindol-3-substituido,un proceso para su preparacion, un nuevo compuesto intermediario para dicho proceso, el uso del compuesto parala fabricacion de un agente terapeutico y una composicion farmaceutica que comprende dicho compuesto. AR002711A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB9504361.8A GB9504361D0 (en) 1995-03-04 1995-03-04 Heterocyclic compounds

Publications (1)

Publication Number Publication Date
AR002711A1 true AR002711A1 (es) 1998-04-29

Family

ID=10770638

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP960101610A AR002711A1 (es) 1995-03-04 1996-03-01 Un compuesto de 2-carboxindol-3-substituido,un proceso para su preparacion, un nuevo compuesto intermediario para dicho proceso, el uso del compuesto parala fabricacion de un agente terapeutico y una composicion farmaceutica que comprende dicho compuesto.

Country Status (23)

Country Link
US (1) US5919811A (es)
EP (1) EP0813524A1 (es)
JP (1) JPH11501041A (es)
KR (1) KR19980702735A (es)
CN (1) CN1182417A (es)
AR (1) AR002711A1 (es)
AU (1) AU708291B2 (es)
BR (1) BR9607346A (es)
CA (1) CA2214583A1 (es)
CO (1) CO4700452A1 (es)
CZ (1) CZ277997A3 (es)
EA (1) EA000308B1 (es)
GB (1) GB9504361D0 (es)
HU (1) HUP9801838A3 (es)
IL (1) IL117331A (es)
MX (1) MX9706605A (es)
NO (1) NO309323B1 (es)
NZ (1) NZ303200A (es)
PE (1) PE62396A1 (es)
PL (1) PL322084A1 (es)
TW (1) TW438773B (es)
WO (1) WO1996027588A1 (es)
ZA (1) ZA961697B (es)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5886191A (en) * 1997-08-18 1999-03-23 Dupont Pharmaceuticals Company Amidinoindoles, amidinoazoles, and analogs thereof
GB9902455D0 (en) * 1999-02-05 1999-03-24 Zeneca Ltd Chemical compounds
PL373484A1 (en) * 2001-12-10 2005-09-05 Amgen Inc. Vanilloid receptor ligands and their use in treatments
GB0205176D0 (en) * 2002-03-06 2002-04-17 Astrazeneca Ab Chemical compounds
WO2004064730A2 (en) * 2003-01-14 2004-08-05 Cytokinetics, Inc. Compounds, compositions and methods
MXPA06014495A (es) * 2004-06-17 2007-03-01 Cytokinetics Inc Compuestos, composiciones y metodos.
US7176222B2 (en) 2004-07-27 2007-02-13 Cytokinetics, Inc. Syntheses of ureas
US7538223B2 (en) * 2005-08-04 2009-05-26 Cytokinetics, Inc. Compounds, compositions and methods
US7825120B2 (en) * 2005-12-15 2010-11-02 Cytokinetics, Inc. Certain substituted ((piperazin-1-ylmethyl)benzyl)ureas
ES2419007T3 (es) 2005-12-15 2013-08-19 Cytokinetics, Inc. Ciertas entidades químicas, composiciones y procedimientos
US20070208000A1 (en) * 2005-12-15 2007-09-06 Morgan Bradley P Certain chemical entities, compositions and methods
WO2007075377A2 (en) * 2005-12-15 2007-07-05 Cytokinetics, Inc. Certain chemical entities, compositions and methods
EP1959962A2 (en) * 2005-12-16 2008-08-27 Cytokinetics, Inc. Certain chemical entities, compositions, and methods
JP5178526B2 (ja) * 2005-12-19 2013-04-10 サイトキネティクス・インコーポレーテッド 化合物、組成物および方法
WO2009035927A2 (en) * 2007-09-13 2009-03-19 Arete Therapeutics, Inc. Bis-cyclyl substitued ureas or amides as soluble epoxide hydrolase inhibitors
PE20091101A1 (es) 2007-12-18 2009-07-26 Pharminox Ltd AMIDAS DE ACIDO 3-SUBSTITUIDO-4-OXO-3,4-DIHIDRO-IMIDAZO[5,1-d] [1,2,3,5-TETRACINA-8-CARBOXILICO Y SU EMPLEO
ES2583006T3 (es) 2009-06-23 2016-09-16 Pharminox Limited Compuestos de 3-sustituido-8-sustituido-3H-imidazo[5,1-d][1,2,3,5-tetrazin-4-ona y su uso
WO2011107726A1 (en) 2010-03-01 2011-09-09 Pharminox Ltd Methods and intermediates for the synthesis of 4-oxo-3,4-dihydro-imidazo[5,1-d][1,2,3,5]tetrazines
WO2012085501A1 (en) 2010-12-20 2012-06-28 Pharminox Limited 8 - sulfo - imidazotetrazin- 4 - one compounds and their use as anticancer drug
TW202128630A (zh) 2019-11-11 2021-08-01 荷蘭商卡普三世責任有限公司 工業規模上用於生產ε-己內醯胺及硫酸銨之方法及設備

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5145845A (en) * 1991-05-14 1992-09-08 Warner-Lambert Co. Substituted 2-carboxylindoles having pharmaceutical activity
GB9208492D0 (en) * 1992-04-16 1992-06-03 Glaxo Spa Heterocyclic compounds
GB9304500D0 (en) * 1993-03-05 1993-04-21 Glaxo Spa Heterocyclic compounds
US5519048A (en) * 1993-05-27 1996-05-21 Merrell Pharmaceuticals Inc. 3-(indol-3-yl)-propenoic acid derivatives and pharmaceutical compositions thereof

Also Published As

Publication number Publication date
MX9706605A (es) 1998-02-28
IL117331A0 (en) 1996-07-23
NO309323B1 (no) 2001-01-15
NO974043L (no) 1997-11-03
HUP9801838A3 (en) 2000-04-28
EA000308B1 (ru) 1999-04-29
CO4700452A1 (es) 1998-12-29
NO974043D0 (no) 1997-09-03
HUP9801838A2 (hu) 1998-12-28
BR9607346A (pt) 1997-12-30
JPH11501041A (ja) 1999-01-26
CZ277997A3 (cs) 1998-06-17
AU708291B2 (en) 1999-07-29
PE62396A1 (es) 1997-01-11
EP0813524A1 (en) 1997-12-29
NZ303200A (en) 1999-01-28
AU4943896A (en) 1996-09-23
ZA961697B (en) 1997-10-01
PL322084A1 (en) 1998-01-05
US5919811A (en) 1999-07-06
WO1996027588A1 (en) 1996-09-12
CA2214583A1 (en) 1996-09-12
GB9504361D0 (en) 1995-04-26
CN1182417A (zh) 1998-05-20
KR19980702735A (ko) 1998-08-05
IL117331A (en) 2000-06-29
TW438773B (en) 2001-06-07
EA199700160A1 (ru) 1998-02-26

Similar Documents

Publication Publication Date Title
AR002711A1 (es) Un compuesto de 2-carboxindol-3-substituido,un proceso para su preparacion, un nuevo compuesto intermediario para dicho proceso, el uso del compuesto parala fabricacion de un agente terapeutico y una composicion farmaceutica que comprende dicho compuesto.
ES2185338T3 (es) Derivados de fumagilol y procedimientos para su fabricacion.
HUP9700779A1 (hu) Ösztrogén vegyületek, eljárás előállításukra, ezeket tartalmazó gyógyszerkészítmények és alkalmazásuk
DE69836422D1 (de) N-heterocyclische derivate als nos inhibitoren
AR035455A1 (es) Derivados triciclicos de alquilhidroxamato , procesos para su elaboracion, composiciones farmaceuticas que los contienen, y el uso de dichos compuestos en la preparacion de medicamentos
ES2188194T3 (es) 1,8-naftiridin-4(1h)-onas sustituidas como inhibidores de la fosfodiesterasa 4.
AR013078A1 (es) Derivados de tetrahidroisoquinoleina, una sal de los mismos, procedimiento para su preparacion, composicion farmaceutica que los comprende y el uso de losmismos en la preparacion de un medicamento.
JPS5665869A (en) Novel 22hydroxyalkyll3*4*55trihydroxyypiperidine compound* its manufacture and drug
EA200100090A2 (ru) Новые пиперидин-4-сульфонамидные производные, способ их получения и содержащие их фармацевтические композиции
ES2073258T3 (es) Nuevos derivados de la urea, su preparacion y su aplicacion en terapeutica.
ES2106936T3 (es) Derivados de carbazolona y procedimientos para su preparacion.
MX9306529A (es) Derivados de pirazol condensado, metodo para fabricarlos y composicion farmaceutica que los contiene
DK542582A (da) Phenolestere
DE69720966D1 (de) Benzo[c]chinolizin derivate,deren herstellung und verwendung als 5-alfa-reduktase inhibitoren
AU539177B2 (en) Amino alkoxy pyrazoles
DE69808922T2 (de) Thiazolobenzoheterocyclen, ihre herstellung und diese enthaltende phatrmazeutische zubereitungen
IL111404A (en) Pharmaceutical compositions for the enhancement ofmemory and cognition comprising 3-aryl-4-alkyl and 4,5-dialkyl-4H-1,2,4-triazoles and some such novel compounds
BR0201312A (pt) Compostos de pirimidin-4-ona, processo para sua preparação e composições farmacêuticas contendo os referidos
AR007291A1 (es) Nuevos derivados de 10,11-dihidro-10-oxo-5h-dibenz/b, f/azepina-5-carboxamida, metodo de preparacion y su uso en la preparacion de una composicion farmaceutica
AU547599B2 (en) Tricyclic compounds
AR009274A1 (es) Un composicion farmaeutica que incluye tropnilpiperazinas como ligandos del receptor d4 de dopamina, compuestos, usos para la preparacion demedicamentos y procedimiento de preparacion de los compuestos.
MX4658E (es) Procedimiento para preparar compuestos de acidos 3-cefem-4-carboxilicos 3,7 disubstituidos
EA199901049A2 (ru) Спироимидазолиновые соединения, способ их получения и фармацевтическая композиция, содержащая их
SE9902147D0 (sv) Nya föreningar och farmaceutiska kompositioner innehållande desamma
ATE20749T1 (de) Dithiino (1,4) (2,3-c) pyrrolderivate, ihre herstellung und solche enthaltende arzneimittel.