RU93055882A - Производные n-сульфонил-2-оксоиндола, способ их получения, исходные для их получения, фармацевтическая композиция на их основе - Google Patents
Производные n-сульфонил-2-оксоиндола, способ их получения, исходные для их получения, фармацевтическая композиция на их основеInfo
- Publication number
- RU93055882A RU93055882A RU93055882/04A RU93055882A RU93055882A RU 93055882 A RU93055882 A RU 93055882A RU 93055882/04 A RU93055882/04 A RU 93055882/04A RU 93055882 A RU93055882 A RU 93055882A RU 93055882 A RU93055882 A RU 93055882A
- Authority
- RU
- Russia
- Prior art keywords
- derivatives
- oxoindol
- sulfonil
- original
- basis
- Prior art date
Links
- 239000008194 pharmaceutical composition Substances 0.000 title claims 2
- 238000004519 manufacturing process Methods 0.000 title 2
- KBZOIRJILGZLEJ-LGYYRGKSSA-N argipressin Chemical compound C([C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CSSC[C@@H](C(N[C@@H](CC=2C=CC(O)=CC=2)C(=O)N1)=O)N)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)NCC(N)=O)C1=CC=CC=C1 KBZOIRJILGZLEJ-LGYYRGKSSA-N 0.000 claims 1
- 229960003726 vasopressin Drugs 0.000 claims 1
Claims (1)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR9201034A FR2686878B1 (fr) | 1992-01-30 | 1992-01-30 | Derives du n-sulfonyl oxo-2 indole, leur preparation, les compositions pharmaceutiques en contenant. |
FR92/01034 | 1992-01-30 | ||
PCT/FR1993/000093 WO1993015051A1 (fr) | 1992-01-30 | 1993-01-28 | Derives du n-sulfonyl-2-oxoindole ayant une affinite pour les recepteurs de la vasopressine et/ou de l'ocytocine |
Publications (2)
Publication Number | Publication Date |
---|---|
RU93055882A true RU93055882A (ru) | 1996-12-10 |
RU2135469C1 RU2135469C1 (ru) | 1999-08-27 |
Family
ID=9426168
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
RU93055882A RU2135469C1 (ru) | 1992-01-30 | 1993-01-28 | Производные n-сульфонил-2-оксо-индола, способ их получения, промежуточные продукты и фармацевтическая композиция, имеющая агент, активный в отношении рецепторов вазопрессина и/или оцитоцина |
Country Status (20)
Country | Link |
---|---|
EP (1) | EP0581939B1 (ru) |
JP (1) | JPH06507182A (ru) |
AT (1) | ATE180773T1 (ru) |
AU (1) | AU662960B2 (ru) |
BR (1) | BR9303993A (ru) |
CA (1) | CA2107348A1 (ru) |
CZ (1) | CZ203793A3 (ru) |
DE (1) | DE69325130D1 (ru) |
FI (2) | FI934274A0 (ru) |
FR (1) | FR2686878B1 (ru) |
HU (1) | HUT68642A (ru) |
IL (1) | IL104559A0 (ru) |
MX (1) | MX9300498A (ru) |
NO (1) | NO180538C (ru) |
NZ (1) | NZ249158A (ru) |
RU (1) | RU2135469C1 (ru) |
SK (1) | SK105393A3 (ru) |
TW (1) | TW239126B (ru) |
WO (1) | WO1993015051A1 (ru) |
ZA (1) | ZA93649B (ru) |
Families Citing this family (53)
Publication number | Priority date | Publication date | Assignee | Title |
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FR2708605A1 (fr) * | 1993-07-30 | 1995-02-10 | Sanofi Sa | Dérivés du N-sulfonylindol-2-one, leur préparation, les compositions pharmaceutiques en contenant. |
US5849780A (en) * | 1992-01-30 | 1998-12-15 | Sanofi | 1-benzenesulfonyl-1-1,3-dihydroindol-2-one derivatives, their preparation and pharmaceutical compositions in which they are present |
US5686624A (en) * | 1992-01-30 | 1997-11-11 | Sanofi | 1-benzenesulfonyl-1,3-dihydro-indol-2-one derivatives, their preparation and pharmaceutical compositions in which they are present |
FR2708606B1 (fr) * | 1993-07-30 | 1995-10-27 | Sanofi Sa | Dérivés du N-phénylalkylindol-2-one, leur préparation, les compositions pharmaceutiques en contenant. |
FR2708608B1 (fr) * | 1993-07-30 | 1995-10-27 | Sanofi Sa | Dérivés de N-sulfonylbenzimidazolone, leur préparation, les compositions pharmaceutiques en contenant. |
FR2714378B1 (fr) * | 1993-12-24 | 1996-03-15 | Sanofi Sa | Dérivés de l'indol-2-one substitués en 3 par un groupe azoté, leur préparation, les compositions pharmaceutiques en contenant. |
FR2722190B1 (fr) * | 1994-07-05 | 1996-10-04 | Sanofi Sa | Derives de 1-benzyl-1,3-dihydro-2h-benzimidazol-2-one, leur preparation, les compositions pharmaceutique en contenant |
WO1996036611A1 (en) * | 1995-05-19 | 1996-11-21 | Chiroscience Limited | 3,4-disubstituted-phenylsulphonamides and their therapeutic use |
FR2740136B1 (fr) * | 1995-10-24 | 1998-01-09 | Sanofi Sa | Derives d'indolin-2-one, procede pour leur preparation et les compositions pharmaceutiques les contenant |
US5756497A (en) * | 1996-03-01 | 1998-05-26 | Merck & Co., Inc. | Tocolytic oxytocin receptor antagonists |
ES2218191T3 (es) | 1999-07-21 | 2004-11-16 | Astrazeneca Ab | Nuevos compuestos. |
GB9918684D0 (en) * | 1999-08-09 | 1999-10-13 | Novartis Ag | Organic compounds |
US7186745B2 (en) | 2001-03-06 | 2007-03-06 | Astrazeneca Ab | Indolone derivatives having vascular damaging activity |
DE10222034A1 (de) * | 2002-05-17 | 2003-11-27 | Bayer Ag | Tetrahydroisochinolin-Derivate |
US8580842B2 (en) | 2003-09-30 | 2013-11-12 | Abbott Gmbh & Co. Kg | Heteroaryl-substituted 1,3-dihydroindol-2-one derivatives and medicaments containing them |
US20050070718A1 (en) | 2003-09-30 | 2005-03-31 | Abbott Gmbh & Co. Kg | Heteroaryl-substituted 1,3-dihydroindol-2-one derivatives and medicaments containing them |
US7414052B2 (en) | 2004-03-30 | 2008-08-19 | Wyeth | Phenylaminopropanol derivatives and methods of their use |
US7517899B2 (en) | 2004-03-30 | 2009-04-14 | Wyeth | Phenylaminopropanol derivatives and methods of their use |
EP1831197A2 (de) * | 2004-12-31 | 2007-09-12 | Abbott GmbH & Co. KG | Substituierte oxindol-derivate, diese enthaltende arzneimittel und deren verwendung |
US8030499B2 (en) | 2005-01-28 | 2011-10-04 | Taisho Pharmaceutical Co., Ltd. | 1,3-dihydro-2H-indole-2-one compound and pyrrolidine-2-one compound fused with aromatic heterocycle |
DE102005015957A1 (de) * | 2005-03-31 | 2006-10-05 | Abbott Gmbh & Co. Kg | Substituierte Oxindol-Derivate, diese enthaltende Arzneimittel und deren Verwendung |
WO2006100082A2 (de) | 2005-03-24 | 2006-09-28 | Abbott Gmbh & Co. Kg | Substituierte oxindol-derivate, diese enthaltende arzneimittel und deren verwendung |
DE102005014904A1 (de) * | 2005-03-26 | 2007-02-01 | Abbott Gmbh & Co. Kg | Substituierte Oxindol-Derivate, diese enthaltende Arzneimittel und deren Verwendung |
DE102005014936A1 (de) | 2005-03-24 | 2006-12-14 | Abbott Gmbh & Co. Kg | Substituierte Oxindol-Derivate, diese enthaltende Arzneimittel und deren Verwendung |
AR056968A1 (es) | 2005-04-11 | 2007-11-07 | Xenon Pharmaceuticals Inc | Compuestos espiro-oxindol y composiciones farmacéuticas |
AR053710A1 (es) | 2005-04-11 | 2007-05-16 | Xenon Pharmaceuticals Inc | Compuestos espiroheterociclicos y sus usos como agentes terapeuticos |
EP1943250A1 (en) | 2005-09-09 | 2008-07-16 | Euro-Celtique S.A. | Fused and spirocycle compounds and the use thereof |
WO2007063123A1 (de) | 2005-12-02 | 2007-06-07 | Abbott Gmbh & Co. Kg | Substituierte oxindol-derivate, diese enthaltende arzneimittel und deren verwendung |
WO2008025736A1 (en) | 2006-08-26 | 2008-03-06 | Abbott Gmbh & Co. Kg | Substituted benzimidazolone derivatives, medicaments comprising them and their use |
DE102006040915A1 (de) | 2006-08-26 | 2008-03-20 | Abbott Gmbh & Co. Kg | Substituierte Oxindol-Derivate, diese enthaltende Arzneimittel und deren Verwendung |
CA2665849A1 (en) * | 2006-09-22 | 2008-03-27 | Janssen Pharmaceutica N.V. | Spiro benzazepines used as vasopressin antagonists |
US7825111B2 (en) * | 2006-09-22 | 2010-11-02 | Janssen Pharmaceutica Nv | Substituted spiroheterocycles |
MX2009003876A (es) | 2006-10-12 | 2009-05-11 | Xenon Pharmaceuticals Inc | Uso de compuestos de espiro-oxindol como agentes terapeuticos. |
FR2909668B1 (fr) * | 2006-12-12 | 2009-01-23 | Sanofi Aventis Sa | Derives de 5-alkyloxy-indolin-2-one,leur preparation et leurs applications en therapeutique |
US8486979B2 (en) | 2006-12-12 | 2013-07-16 | Abbvie Inc. | 1,2,4 oxadiazole compounds and methods of use thereof |
US20080167286A1 (en) | 2006-12-12 | 2008-07-10 | Abbott Laboratories | Pharmaceutical compositions and their methods of use |
UY30846A1 (es) | 2006-12-30 | 2008-07-31 | Abbott Gmbh & Amp | Derivados de oxindol sustituidos, medicamentos que los comprenden y uso de los mismos |
MX2010006204A (es) | 2007-12-07 | 2011-03-16 | Abbott Gmbh & Co Kg | Derivados de oxindol 5,6-disubstituidos y el uso de los mismos para el tratamiento de enfermedades dependientes de la vasopresina. |
RU2484090C2 (ru) | 2007-12-07 | 2013-06-10 | Эбботт Гмбх Унд Ко.Кг | 5-галогензамещенные производные оксиндола и их применение для лечения вазопрессинзависимых заболеваний |
US8703774B2 (en) | 2007-12-07 | 2014-04-22 | AbbVie Deutschland GmbH & Co. KG | Carbamate-substituted oxindole derivatives and use thereof for the treatment of vasopressin-dependent diseases |
EP2231643B1 (de) | 2007-12-07 | 2012-10-31 | Abbott GmbH & Co. KG | Amidomethyl-substitutierte Oxindol-Derivate und ihre Verwendung zur Herstellung eines Medikaments zur Behandlung von Vasopressin-abhängigen Erkrankungen |
CN106146469A (zh) | 2007-12-27 | 2016-11-23 | Abbvie德国有限责任两合公司 | 取代的羟吲哚衍生物及其用于治疗加压素依赖性疾病的应用 |
FR2927625B1 (fr) | 2008-02-19 | 2010-03-12 | Sanofi Aventis | Nouveaux derives de 3-aminoalkyl-1,3-dihydro-2h-indol-2-one, leur preparation et leur application en therapeutique |
FR2930249B1 (fr) * | 2008-04-21 | 2010-05-14 | Sanofi Aventis | Nouveaux derives de 3-aminoalkyl-1,3-dihydro-2h-indol-2-one, leur preparation et leur application en therapeutique. |
KR101286323B1 (ko) | 2008-10-17 | 2013-07-15 | 제논 파마슈티칼스 인크. | 스피로-옥스인돌 화합물 및 치료제로서의 그의 용도 |
CA2741024A1 (en) | 2008-10-17 | 2010-04-22 | Xenon Pharmaceuticals Inc. | Spiro-oxindole compounds and their use as therapeutic agents |
EP2435080A2 (en) | 2009-05-29 | 2012-04-04 | Abbott Laboratories | Pharmaceutical compositions for the treatment of pain |
AR077252A1 (es) | 2009-06-29 | 2011-08-10 | Xenon Pharmaceuticals Inc | Enantiomeros de compuestos de espirooxindol y sus usos como agentes terapeuticos |
MY165579A (en) | 2009-10-14 | 2018-04-05 | Xenon Pharmaceuticals Inc | Synthetic methods for spiro-oxindole compounds |
CN105726531A (zh) | 2010-02-26 | 2016-07-06 | 泽农医药公司 | 用于局部给药的螺-羟吲哚化合物的药物组合物及其作为治疗剂的用途 |
EP2881391A1 (en) | 2013-12-05 | 2015-06-10 | Bayer Pharma Aktiengesellschaft | Spiroindoline carbocycle derivatives and pharmaceutical compositions thereof |
WO2016127068A1 (en) | 2015-02-05 | 2016-08-11 | Teva Pharmaceuticals International Gmbh | Methods of treating postherpetic neuralgia with a topical formulation of a spiro-oxindole compound |
US20170204087A1 (en) * | 2016-01-20 | 2017-07-20 | Chemocentryx, Inc. | 2-oxindole compounds |
Family Cites Families (7)
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US2540057A (en) | 1947-07-02 | 1951-01-30 | Gen Aniline & Film Corp | Aromatic and heterocyclic diazosulfones |
US3838167A (en) * | 1972-08-01 | 1974-09-24 | Lilly Co Eli | Process for preparing indoles |
DK167393B1 (da) | 1985-12-30 | 1993-10-25 | Roussel Uclaf | 1-sulfonyl-2-oxo-pyrrolidinderivater, deres fremstilling og farmaceutiske praeparater med indhold deraf |
US4863437A (en) * | 1986-03-20 | 1989-09-05 | Clarke Ellis W | Means for fluid administration |
US4803217A (en) * | 1986-12-24 | 1989-02-07 | Merck & Co., Inc. | Hapalindolinone compounds as vassopressin antagonists |
EP0303418A3 (en) * | 1987-08-11 | 1990-11-07 | Smithkline Beecham Laboratoires Pharmaceutiques | Substituted indolones, useful in the treatment of heart or asthmatic diseases |
US5206261A (en) * | 1989-07-25 | 1993-04-27 | Taiho Pharmaceutical Company, Limited | Oxindole derivative |
-
1992
- 1992-01-30 FR FR9201034A patent/FR2686878B1/fr not_active Expired - Fee Related
-
1993
- 1993-01-28 BR BR9303993A patent/BR9303993A/pt not_active Application Discontinuation
- 1993-01-28 WO PCT/FR1993/000093 patent/WO1993015051A1/fr not_active Application Discontinuation
- 1993-01-28 JP JP5512992A patent/JPH06507182A/ja active Pending
- 1993-01-28 NZ NZ249158A patent/NZ249158A/en unknown
- 1993-01-28 HU HU9302762A patent/HUT68642A/hu unknown
- 1993-01-28 RU RU93055882A patent/RU2135469C1/ru active
- 1993-01-28 DE DE69325130T patent/DE69325130D1/de not_active Expired - Lifetime
- 1993-01-28 EP EP93904135A patent/EP0581939B1/fr not_active Expired - Lifetime
- 1993-01-28 CZ CZ932037A patent/CZ203793A3/cs unknown
- 1993-01-28 AU AU35043/93A patent/AU662960B2/en not_active Ceased
- 1993-01-28 AT AT93904135T patent/ATE180773T1/de not_active IP Right Cessation
- 1993-01-28 CA CA002107348A patent/CA2107348A1/en not_active Abandoned
- 1993-01-28 SK SK1053-93A patent/SK105393A3/sk unknown
- 1993-01-29 MX MX9300498A patent/MX9300498A/es unknown
- 1993-01-29 IL IL104559A patent/IL104559A0/xx unknown
- 1993-01-29 ZA ZA93649A patent/ZA93649B/xx unknown
- 1993-01-30 TW TW082100691A patent/TW239126B/zh active
- 1993-09-29 NO NO933482A patent/NO180538C/no unknown
- 1993-09-29 FI FI934274A patent/FI934274A0/fi unknown
-
1998
- 1998-02-13 FI FI980341A patent/FI980341A/fi unknown
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