DE68920896D1 - N2-(1-Carboxy-3-phenylpropyl)-L-lysinderivate und Verfahren für die Herstellung von Lysinopril mit Hilfe dieser Verbindung. - Google Patents
N2-(1-Carboxy-3-phenylpropyl)-L-lysinderivate und Verfahren für die Herstellung von Lysinopril mit Hilfe dieser Verbindung.Info
- Publication number
- DE68920896D1 DE68920896D1 DE68920896T DE68920896T DE68920896D1 DE 68920896 D1 DE68920896 D1 DE 68920896D1 DE 68920896 T DE68920896 T DE 68920896T DE 68920896 T DE68920896 T DE 68920896T DE 68920896 D1 DE68920896 D1 DE 68920896D1
- Authority
- DE
- Germany
- Prior art keywords
- lysinopril
- phenylpropyl
- carboxy
- compound
- preparation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06086—Dipeptides with the first amino acid being basic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
- C07C237/20—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton containing six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
- C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
- C07C255/32—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring
- C07C255/42—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring the carbon skeleton being further substituted by singly-bound nitrogen atoms, not being further bound to other hetero atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/30—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D263/34—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D263/44—Two oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/02—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length in solution
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Analytical Chemistry (AREA)
- Peptides Or Proteins (AREA)
- Pyrrole Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP63083632A JPH01254651A (ja) | 1988-04-04 | 1988-04-04 | N↑2−(1−カルボキシ−3−フエニルプロピル)−l−リジン誘導体及び該化合物を用いるリジノプリルの製造法 |
Publications (2)
Publication Number | Publication Date |
---|---|
DE68920896D1 true DE68920896D1 (de) | 1995-03-16 |
DE68920896T2 DE68920896T2 (de) | 1995-05-24 |
Family
ID=13807843
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE68920896T Expired - Lifetime DE68920896T2 (de) | 1988-04-04 | 1989-04-04 | N2-(1-Carboxy-3-phenylpropyl)-L-lysinderivate und Verfahren für die Herstellung von Lysinopril mit Hilfe dieser Verbindung. |
Country Status (7)
Country | Link |
---|---|
EP (1) | EP0336368B1 (de) |
JP (1) | JPH01254651A (de) |
KR (1) | KR0143418B1 (de) |
CA (1) | CA1329681C (de) |
DE (1) | DE68920896T2 (de) |
ES (1) | ES2068214T3 (de) |
IE (1) | IE66388B1 (de) |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU7781991A (en) * | 1990-04-26 | 1991-11-27 | Schering Corporation | Diastereoselective process for preparing n-substituted amino acids and derivatives |
DE69332738T2 (de) * | 1993-01-08 | 2003-10-02 | Kanegafuchi Chemical Ind | Verfahren zur kristallisation von n2-((s)-1-ethoxycarbonyl-3-phenylpropyl)-n6-trifluoracetyl-l-lysyl-l-prolin |
DE4331540A1 (de) * | 1993-09-17 | 1995-03-23 | Degussa | Verfahren zur Reinigung von 1-[N·2·-((S)-Ethoxycarbonyl)-3-phenylpropyl)-N·6·-trifluoracetyl]-L-lysyl-L-prolin (Lisinopril(Tfa)ethylester) |
HU214579B (hu) * | 1995-03-14 | 1998-04-28 | Richter Gedeon Vegyészeti Gyár Rt. | Új eljárás lizinopril előállítására |
CN1053437C (zh) * | 1995-07-19 | 2000-06-14 | 五洲药厂 | 赖诺普利合成方法 |
IT1299341B1 (it) * | 1998-02-09 | 2000-03-16 | Pfc Italiana Srl | Processo per la produzione di alcossicarbonildipeptidi intermedi nella sintesi del lisinopril. |
US6271393B1 (en) | 1998-09-22 | 2001-08-07 | Kaneka Corporation | Process for producing N2-(1(S)-carboxy-3-phenylpropyl)-L-lysyl-L-proline |
SE0000382D0 (sv) | 2000-02-07 | 2000-02-07 | Astrazeneca Ab | New process |
JP2003026644A (ja) | 2001-07-11 | 2003-01-29 | Kanegafuchi Chem Ind Co Ltd | N2−(1(s)−エトキシカルボニル−3−フェニルプロピル)−n6−トリフルオロアセチル−l−リジンの精製方法 |
CN109422702B (zh) * | 2017-08-30 | 2023-04-18 | 上海科胜药物研发有限公司 | 赖诺普利中间体及其纯化方法 |
CN109422797B (zh) * | 2017-08-30 | 2023-12-19 | 上海科胜药物研发有限公司 | 一种赖诺普利中间体的制备方法 |
CN111285919B (zh) * | 2018-12-06 | 2022-07-12 | 浙江昌明药业有限公司 | 一种赖诺普利二聚物的制备方法、其中间体及制备方法 |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU569789B2 (en) * | 1984-05-03 | 1988-02-18 | Brigham And Women's Hospital | A.c.e. inhibitors to treat renal diseases |
EP0168769A3 (de) * | 1984-07-16 | 1989-02-08 | Merck & Co. Inc. | Verfahren zur Herstellung von Carboxyalkyldipeptiden |
US4652668A (en) * | 1985-07-03 | 1987-03-24 | Biomeasure, Inc. | Aromatic amino acid derivatives |
-
1988
- 1988-04-04 JP JP63083632A patent/JPH01254651A/ja active Granted
-
1989
- 1989-04-04 DE DE68920896T patent/DE68920896T2/de not_active Expired - Lifetime
- 1989-04-04 ES ES89105882T patent/ES2068214T3/es not_active Expired - Lifetime
- 1989-04-04 EP EP89105882A patent/EP0336368B1/de not_active Expired - Lifetime
- 1989-04-04 KR KR1019890004409A patent/KR0143418B1/ko not_active IP Right Cessation
- 1989-04-04 CA CA000595676A patent/CA1329681C/en not_active Expired - Lifetime
- 1989-04-04 IE IE106289A patent/IE66388B1/en not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
EP0336368A3 (en) | 1990-12-05 |
IE66388B1 (en) | 1995-12-27 |
KR890016060A (ko) | 1989-11-28 |
IE891062L (en) | 1989-10-04 |
JPH0576943B2 (de) | 1993-10-25 |
CA1329681C (en) | 1994-05-17 |
KR0143418B1 (ko) | 1998-07-15 |
EP0336368B1 (de) | 1995-02-01 |
ES2068214T3 (es) | 1995-04-16 |
EP0336368A2 (de) | 1989-10-11 |
JPH01254651A (ja) | 1989-10-11 |
DE68920896T2 (de) | 1995-05-24 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition |