IT1299341B1 - Processo per la produzione di alcossicarbonildipeptidi intermedi nella sintesi del lisinopril. - Google Patents

Processo per la produzione di alcossicarbonildipeptidi intermedi nella sintesi del lisinopril.

Info

Publication number
IT1299341B1
IT1299341B1 IT98BO000063A ITBO980063A IT1299341B1 IT 1299341 B1 IT1299341 B1 IT 1299341B1 IT 98BO000063 A IT98BO000063 A IT 98BO000063A IT BO980063 A ITBO980063 A IT BO980063A IT 1299341 B1 IT1299341 B1 IT 1299341B1
Authority
IT
Italy
Prior art keywords
lisinopril
synthesis
production
alkoxy carbonyl
dipeptides
Prior art date
Application number
IT98BO000063A
Other languages
English (en)
Inventor
Vincenzo Cannata
Valeriano Merli
Stefano Saguatti
Original Assignee
Pfc Italiana Srl
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfc Italiana Srl filed Critical Pfc Italiana Srl
Publication of ITBO980063A0 publication Critical patent/ITBO980063A0/it
Priority to IT98BO000063A priority Critical patent/IT1299341B1/it
Priority to EP99101015A priority patent/EP0943621A3/en
Priority to HU9900153A priority patent/HUP9900153A3/hu
Priority to US09/237,071 priority patent/US6031112A/en
Priority to ZA9900534A priority patent/ZA99534B/xx
Priority to CA002260450A priority patent/CA2260450A1/en
Priority to IL12826499A priority patent/IL128264A0/xx
Priority to TR1999/00247A priority patent/TR199900247A2/xx
Priority to JP11030618A priority patent/JPH11269196A/ja
Priority to BR9900439-9A priority patent/BR9900439A/pt
Priority to US09/335,811 priority patent/US6166217A/en
Publication of ITBO980063A1 publication Critical patent/ITBO980063A1/it
Application granted granted Critical
Publication of IT1299341B1 publication Critical patent/IT1299341B1/it

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/06—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents
    • C07K1/061—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents using protecting groups
    • C07K1/064—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents using protecting groups for omega-amino or -guanidino functions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/06—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents
    • C07K1/08—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents using activating agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06086—Dipeptides with the first amino acid being basic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Analytical Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cardiology (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Peptides Or Proteins (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
IT98BO000063A 1998-02-09 1998-02-09 Processo per la produzione di alcossicarbonildipeptidi intermedi nella sintesi del lisinopril. IT1299341B1 (it)

Priority Applications (11)

Application Number Priority Date Filing Date Title
IT98BO000063A IT1299341B1 (it) 1998-02-09 1998-02-09 Processo per la produzione di alcossicarbonildipeptidi intermedi nella sintesi del lisinopril.
EP99101015A EP0943621A3 (en) 1998-02-09 1999-01-19 Process for the production of alkoxycarbonylpeptides intermediates in the synthesis of the lisinopril
HU9900153A HUP9900153A3 (en) 1998-02-09 1999-01-20 Process for producing alkoxycarbonyldipeptides intermediates in the synthesis of the lisinopril
US09/237,071 US6031112A (en) 1998-02-09 1999-01-25 Process for the production of alkoxycarbonyl-dipeptides intermediates in the synthesis of the lisinopril
ZA9900534A ZA99534B (en) 1998-02-09 1999-01-25 Process for the production of alkoxycarbonyldipeptides intermediates in the synthesis of the lisinopril.
CA002260450A CA2260450A1 (en) 1998-02-09 1999-01-27 Process for the production of alkoxycarbonyldipeptides intermediates in the synthesis of the lisinopril
IL12826499A IL128264A0 (en) 1998-02-09 1999-01-28 Process for the production of alkoxycarbonyldipeptides intermediates in the synthesis of the lisinopril
TR1999/00247A TR199900247A2 (xx) 1998-02-09 1999-02-05 Lisinopril sentezinde alkoksikarbonildipeptid ara �r�nlerinin �retim prosesi.
JP11030618A JPH11269196A (ja) 1998-02-09 1999-02-08 リジノプリル合成におけるアルコキシカルボニルジペプチド中間体の製造方法
BR9900439-9A BR9900439A (pt) 1998-02-09 1999-02-08 Processo para a produção de intermediários alcoxicarbonil-dipeptìdeos na sìntese de lisinopril.
US09/335,811 US6166217A (en) 1998-02-09 1999-06-18 Process for the production of alkoxycarbonyldipeptides intermediates in the synthesis of the lisinopril

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT98BO000063A IT1299341B1 (it) 1998-02-09 1998-02-09 Processo per la produzione di alcossicarbonildipeptidi intermedi nella sintesi del lisinopril.

Publications (3)

Publication Number Publication Date
ITBO980063A0 ITBO980063A0 (it) 1998-02-09
ITBO980063A1 ITBO980063A1 (it) 1999-08-09
IT1299341B1 true IT1299341B1 (it) 2000-03-16

Family

ID=11342848

Family Applications (1)

Application Number Title Priority Date Filing Date
IT98BO000063A IT1299341B1 (it) 1998-02-09 1998-02-09 Processo per la produzione di alcossicarbonildipeptidi intermedi nella sintesi del lisinopril.

Country Status (10)

Country Link
US (2) US6031112A (it)
EP (1) EP0943621A3 (it)
JP (1) JPH11269196A (it)
BR (1) BR9900439A (it)
CA (1) CA2260450A1 (it)
HU (1) HUP9900153A3 (it)
IL (1) IL128264A0 (it)
IT (1) IT1299341B1 (it)
TR (1) TR199900247A2 (it)
ZA (1) ZA99534B (it)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1307265B1 (it) * 1999-08-09 2001-10-30 P F C Italiana Srl Speciality Procedimento per la preparazione di prodotti intermedi nella sintesidi lisinopril.
IT1318623B1 (it) * 2000-07-13 2003-08-27 Isagro Ricerca Srl Procedimento per la preparazione di derivati dipeptidici.
US6462174B1 (en) 2001-06-25 2002-10-08 Astrazeneca Ab Amorphous compound
US6458769B1 (en) 2001-06-25 2002-10-01 Astrazeneca Ab Amorphous compound
US6627760B1 (en) 2001-06-25 2003-09-30 Astrazeneca Ab Amorphous compound
FR2916444B1 (fr) * 2007-05-25 2011-02-11 Sanofi Aventis Procede de preparation de n-carboxyanhydride enantiomeriquement enrichi.

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1290141A (it) * 1968-05-31 1972-09-20
IL58849A (en) * 1978-12-11 1983-03-31 Merck & Co Inc Carboxyalkyl dipeptides and derivatives thereof,their preparation and pharmaceutical compositions containing them
EP0168769A3 (en) * 1984-07-16 1989-02-08 Merck & Co. Inc. Process for preparing carboxyalkyl dipeptides
JPH01254651A (ja) * 1988-04-04 1989-10-11 Kanegafuchi Chem Ind Co Ltd Ｎ↑２−（１−カルボキシ−３−フエニルプロピル）−ｌ−リジン誘導体及び該化合物を用いるリジノプリルの製造法
SI9200213A (en) * 1992-09-16 1994-03-31 Krka Process for preparing alkyl-l-alanil-l-proline derivates

Also Published As

Publication number Publication date
BR9900439A (pt) 2000-05-09
EP0943621A3 (en) 2001-12-12
TR199900247A3 (tr) 2001-02-21
US6166217A (en) 2000-12-26
US6031112A (en) 2000-02-29
JPH11269196A (ja) 1999-10-05
HUP9900153A2 (hu) 1999-11-29
CA2260450A1 (en) 1999-08-09
HU9900153D0 (en) 1999-03-29
HUP9900153A3 (en) 2002-02-28
ITBO980063A1 (it) 1999-08-09
ZA99534B (en) 1999-07-26
EP0943621A2 (en) 1999-09-22
TR199900247A2 (xx) 2001-02-21
ITBO980063A0 (it) 1998-02-09
IL128264A0 (en) 2000-02-17

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Legal Events

Date Code Title Description
0001 Granted