HUP9900153A2 - Eljárás a lizinopril szintézisében intermedierekként alkalmazható (alkoxi-karbonil)-dipeptidek előállítására - Google Patents
Eljárás a lizinopril szintézisében intermedierekként alkalmazható (alkoxi-karbonil)-dipeptidek előállításáraInfo
- Publication number
- HUP9900153A2 HUP9900153A2 HU9900153A HUP9900153A HUP9900153A2 HU P9900153 A2 HUP9900153 A2 HU P9900153A2 HU 9900153 A HU9900153 A HU 9900153A HU P9900153 A HUP9900153 A HU P9900153A HU P9900153 A2 HUP9900153 A2 HU P9900153A2
- Authority
- HU
- Hungary
- Prior art keywords
- alkoxycarbonyldipeptides
- lisinopril
- intermediates
- synthesis
- producing
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 2
- 108010007859 Lisinopril Proteins 0.000 title 1
- 230000015572 biosynthetic process Effects 0.000 title 1
- 239000000543 intermediate Substances 0.000 title 1
- RLAWWYSOJDYHDC-BZSNNMDCSA-N lisinopril Chemical compound C([C@H](N[C@@H](CCCCN)C(=O)N1[C@@H](CCC1)C(O)=O)C(O)=O)CC1=CC=CC=C1 RLAWWYSOJDYHDC-BZSNNMDCSA-N 0.000 title 1
- 229960002394 lisinopril Drugs 0.000 title 1
- 238000003786 synthesis reaction Methods 0.000 title 1
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 abstract 3
- ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical compound CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 abstract 3
- 108010016626 Dipeptides Proteins 0.000 abstract 1
- ONIBWKKTOPOVIA-BYPYZUCNSA-N L-Proline Chemical compound OC(=O)[C@@H]1CCCN1 ONIBWKKTOPOVIA-BYPYZUCNSA-N 0.000 abstract 1
- 229930182821 L-proline Natural products 0.000 abstract 1
- 239000004472 Lysine Substances 0.000 abstract 1
- 125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000000843 powder Substances 0.000 abstract 1
- 229960002429 proline Drugs 0.000 abstract 1
- 229920006395 saturated elastomer Polymers 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
- FYSNRJHAOHDILO-UHFFFAOYSA-N thionyl chloride Chemical compound ClS(Cl)=O FYSNRJHAOHDILO-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/06—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents
- C07K1/061—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents using protecting groups
- C07K1/064—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents using protecting groups for omega-amino or -guanidino functions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/06—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents
- C07K1/08—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents using activating agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06086—Dipeptides with the first amino acid being basic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Analytical Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Peptides Or Proteins (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
A találmány tárgya eljárás (I) általánős képletű (alkőxi-karbőnil)-dipeptidek -, amelyek képletében R jelentése telített vagy telítetlen,adőtt esetben szűbsztitűált 1-6 szénatőmős alkilcsőpőrt -előállítására, őly módőn, hőgy egy (III) általánős képletű vegyületetinert őldószerben, N,N-dimetil-főrmamid jelenlétében szűlfinil-klőriddal reagáltatják; és az N6-(alkőxi-karbőnil)-L-lizinnek a b)lépésben nyert (IV) általánős képletű N-(karbőxi-anhidrid)-jét vizesacetőnős lúgős közegben L-prőlinnal reagáltatják. ŕ
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT98BO000063A IT1299341B1 (it) | 1998-02-09 | 1998-02-09 | Processo per la produzione di alcossicarbonildipeptidi intermedi nella sintesi del lisinopril. |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| HU9900153D0 HU9900153D0 (en) | 1999-03-29 |
| HUP9900153A2 true HUP9900153A2 (hu) | 1999-11-29 |
| HUP9900153A3 HUP9900153A3 (en) | 2002-02-28 |
Family
ID=11342848
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU9900153A HUP9900153A3 (en) | 1998-02-09 | 1999-01-20 | Process for producing alkoxycarbonyldipeptides intermediates in the synthesis of the lisinopril |
Country Status (10)
| Country | Link |
|---|---|
| US (2) | US6031112A (hu) |
| EP (1) | EP0943621A3 (hu) |
| JP (1) | JPH11269196A (hu) |
| BR (1) | BR9900439A (hu) |
| CA (1) | CA2260450A1 (hu) |
| HU (1) | HUP9900153A3 (hu) |
| IL (1) | IL128264A0 (hu) |
| IT (1) | IT1299341B1 (hu) |
| TR (1) | TR199900247A3 (hu) |
| ZA (1) | ZA99534B (hu) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1307265B1 (it) * | 1999-08-09 | 2001-10-30 | P F C Italiana Srl Speciality | Procedimento per la preparazione di prodotti intermedi nella sintesidi lisinopril. |
| IT1318623B1 (it) * | 2000-07-13 | 2003-08-27 | Isagro Ricerca Srl | Procedimento per la preparazione di derivati dipeptidici. |
| US6462174B1 (en) | 2001-06-25 | 2002-10-08 | Astrazeneca Ab | Amorphous compound |
| US6627760B1 (en) | 2001-06-25 | 2003-09-30 | Astrazeneca Ab | Amorphous compound |
| US6458769B1 (en) | 2001-06-25 | 2002-10-01 | Astrazeneca Ab | Amorphous compound |
| FR2916444B1 (fr) * | 2007-05-25 | 2011-02-11 | Sanofi Aventis | Procede de preparation de n-carboxyanhydride enantiomeriquement enrichi. |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1290141A (hu) * | 1968-05-31 | 1972-09-20 | ||
| IL58849A (en) * | 1978-12-11 | 1983-03-31 | Merck & Co Inc | Carboxyalkyl dipeptides and derivatives thereof,their preparation and pharmaceutical compositions containing them |
| EP0168769A3 (en) * | 1984-07-16 | 1989-02-08 | Merck & Co. Inc. | Process for preparing carboxyalkyl dipeptides |
| JPH01254651A (ja) * | 1988-04-04 | 1989-10-11 | Kanegafuchi Chem Ind Co Ltd | Ｎ↑２−（１−カルボキシ−３−フエニルプロピル）−ｌ−リジン誘導体及び該化合物を用いるリジノプリルの製造法 |
| SI9200213A (en) * | 1992-09-16 | 1994-03-31 | Krka | Process for preparing alkyl-l-alanil-l-proline derivates |
-
1998
- 1998-02-09 IT IT98BO000063A patent/IT1299341B1/it active IP Right Grant
-
1999
- 1999-01-19 EP EP99101015A patent/EP0943621A3/en not_active Withdrawn
- 1999-01-20 HU HU9900153A patent/HUP9900153A3/hu unknown
- 1999-01-25 ZA ZA9900534A patent/ZA99534B/xx unknown
- 1999-01-25 US US09/237,071 patent/US6031112A/en not_active Expired - Fee Related
- 1999-01-27 CA CA002260450A patent/CA2260450A1/en not_active Abandoned
- 1999-01-28 IL IL12826499A patent/IL128264A0/xx unknown
- 1999-02-05 TR TR1999/00247A patent/TR199900247A3/tr unknown
- 1999-02-08 JP JP11030618A patent/JPH11269196A/ja active Pending
- 1999-02-08 BR BR9900439-9A patent/BR9900439A/pt not_active Application Discontinuation
- 1999-06-18 US US09/335,811 patent/US6166217A/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| EP0943621A3 (en) | 2001-12-12 |
| HUP9900153A3 (en) | 2002-02-28 |
| ZA99534B (en) | 1999-07-26 |
| IT1299341B1 (it) | 2000-03-16 |
| US6031112A (en) | 2000-02-29 |
| JPH11269196A (ja) | 1999-10-05 |
| ITBO980063A0 (it) | 1998-02-09 |
| CA2260450A1 (en) | 1999-08-09 |
| ITBO980063A1 (it) | 1999-08-09 |
| US6166217A (en) | 2000-12-26 |
| BR9900439A (pt) | 2000-05-09 |
| TR199900247A2 (xx) | 2001-02-21 |
| TR199900247A3 (tr) | 2001-02-21 |
| EP0943621A2 (en) | 1999-09-22 |
| HU9900153D0 (en) | 1999-03-29 |
| IL128264A0 (en) | 2000-02-17 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DE502007005927D1 (de) | Verfahren zur Stabilisierung von Thiophenderivaten | |
| FI941766A0 (fi) | sPLA2:n 1H-indoli-3-etikkahappohydratsidi-inhibiittoreita | |
| EA200200481A1 (ru) | Способ получения производных 4-трифторметилсульфинилпиразола | |
| PT1315694E (pt) | Inibidores da adesao celular mediada por alfa 4 | |
| DE60306547D1 (de) | Substituierte 3-alkyl- und 3-arylalkyl-1h-indol-1-yl-essigsäure-derivate als plasminogen aktivator inhibitor-1 (pai-1) inhibitoren | |
| CU23873B1 (es) | Nuevo procedimiento para la preparación de un intermediario útil en la preparación de imidazotriazinonas sustituidas con sulfonamida | |
| CY1108553T1 (el) | Μεθοδος οξειδωσης για παρασκευη του ενδιαμεσου 6.αλφα., 9.αλφα,-διφθορο-11.βητα., 17.αλφα.-διϋδροξυ-16.αλφα.-μεθυλ.-ανδροστ-1,4-διεν-3-ονης 17.βητα καρβοξυλικου οξεος | |
| Noguchi et al. | Convenient preparation of primary amides via activation of carboxylic acids with ethyl chloroformate and triethylamine under mild conditions | |
| HUP9900153A2 (hu) | Eljárás a lizinopril szintézisében intermedierekként alkalmazható (alkoxi-karbonil)-dipeptidek előállítására | |
| ES2251292B1 (es) | Procedimiento para la obtencion de un compuesto farmaceuticamente activo y de sus intermedios de sintesis. | |
| DK1931630T3 (da) | N-substituerede 3,4-alkylendioxypyrroler, ester-substituerede dihydroxypyrroler og fremgangsmåder til syntese af disse pyrroler | |
| NO20075829L (no) | Syntese | |
| ATE423764T1 (de) | Verfahren zur herstellung von hydrazon-derivaten | |
| Spetzler et al. | Masked side-chain aldehyde amino acids for solid-phase synthesis and ligation | |
| DK0708762T3 (da) | Fremgangsmåde til fremstilling af HIV protease-inhibitorer | |
| DK1489080T3 (da) | Fremgangsmåde til frembringelse af cilostazol | |
| ATE353896T1 (de) | Verfahren zur herstellung von zolpidem | |
| ATE312082T1 (de) | Verfahren zur herstellung von dicyanomethyliden und heterozyklische verbindungen | |
| ATE349545T1 (de) | Enzymatisches verfahren zur herstellung von substituierter 2-amino-3-(2-amino-phenylsulfanyl)-propionsäure | |
| ATE528358T1 (de) | Verfahren zur herstellung einer azoverbindung | |
| KR100424341B1 (ko) | 1-메틸인다졸-3-카르복실산의 제조방법 | |
| JPWO2004099136A1 (ja) | ピロリジン誘導体の製造方法 | |
| JP4059949B2 (ja) | １ｈ−１，２，４−トリアゾール−５−イル酢酸エステル化合物の製造方法 | |
| JPH083132A (ja) | プロリルプロリン誘導体及びその新規な製造法 | |
| DE59908860D1 (de) | Verfahren zur Synthese alpha-substituierter Ringsysteme |