CU23873B1 - Nuevo procedimiento para la preparación de un intermediario útil en la preparación de imidazotriazinonas sustituidas con sulfonamida - Google Patents
Nuevo procedimiento para la preparación de un intermediario útil en la preparación de imidazotriazinonas sustituidas con sulfonamidaInfo
- Publication number
- CU23873B1 CU23873B1 CUP2008000213A CU20080213A CU23873B1 CU 23873 B1 CU23873 B1 CU 23873B1 CU P2008000213 A CUP2008000213 A CU P2008000213A CU 20080213 A CU20080213 A CU 20080213A CU 23873 B1 CU23873 B1 CU 23873B1
- Authority
- CU
- Cuba
- Prior art keywords
- preparation
- imidazotriazinones
- sulfonamide
- replaced
- new procedure
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 2
- 229940124530 sulfonamide Drugs 0.000 title abstract 2
- 150000003456 sulfonamides Chemical group 0.000 title 1
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 abstract 3
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 2
- WETWJCDKMRHUPV-UHFFFAOYSA-N acetyl chloride Chemical compound CC(Cl)=O WETWJCDKMRHUPV-UHFFFAOYSA-N 0.000 abstract 1
- 239000012346 acetyl chloride Substances 0.000 abstract 1
- IJYHVZICHKCLMQ-UHFFFAOYSA-N imidazo[4,5-d]triazin-4-one Chemical class O=C1N=NN=C2N=CN=C12 IJYHVZICHKCLMQ-UHFFFAOYSA-N 0.000 abstract 1
- 125000000565 sulfonamide group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Endocrinology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Reproductive Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Cosmetics (AREA)
Abstract
La presente invención se refiere a un intermediario para procedimiento para la preparación de imidazotriazinonas sustituídas con sulfonamida de fórmula general (I) caracterizado porque los compuestos de fórmula V se trasforman con compuestos de fórmula general VI en una reacción de dos etapas en el sistema metanol y cloruro de acetilo /ácido acético.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE10063108A DE10063108A1 (de) | 2000-12-18 | 2000-12-18 | Verfahren zur Herstellung von Sulfonamid-substituierten Imidazotriazinonen |
PCT/EP2001/014239 WO2002050076A2 (de) | 2000-12-18 | 2001-12-05 | Verfahren zur herstellung von sulfonamid-substituierten imidazotriazinonen |
Publications (2)
Publication Number | Publication Date |
---|---|
CU20080213A7 CU20080213A7 (es) | 2012-06-21 |
CU23873B1 true CU23873B1 (es) | 2013-04-19 |
Family
ID=7667666
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CU20030128A CU23341B7 (es) | 2000-12-18 | 2003-06-09 | Procedimiento para la preparación de imidazotriazínonas sustituidas con sulfonamida |
CUP2008000213A CU23873B1 (es) | 2000-12-18 | 2008-11-17 | Nuevo procedimiento para la preparación de un intermediario útil en la preparación de imidazotriazinonas sustituidas con sulfonamida |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CU20030128A CU23341B7 (es) | 2000-12-18 | 2003-06-09 | Procedimiento para la preparación de imidazotriazínonas sustituidas con sulfonamida |
Country Status (43)
Families Citing this family (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE10063108A1 (de) * | 2000-12-18 | 2002-06-20 | Bayer Ag | Verfahren zur Herstellung von Sulfonamid-substituierten Imidazotriazinonen |
DE10107639A1 (de) * | 2001-02-15 | 2002-08-22 | Bayer Ag | 2-Alkoxyphenyl-substituierte Imidazotriazinone |
DE10232113A1 (de) | 2002-07-16 | 2004-01-29 | Bayer Ag | Vardenafil Hydrochlorid Trihydrat enthaltende Arzneimittel |
DE202004006552U1 (de) * | 2004-04-26 | 2004-07-08 | Knürr AG | Kühlungssystem für Geräte- und Netzwerkschränke |
DE102004023069A1 (de) | 2004-05-11 | 2005-12-08 | Bayer Healthcare Ag | Neue Darreichungsformen des PDE 5-Inhibitors Vardenafil |
US7977478B2 (en) * | 2006-03-13 | 2011-07-12 | Dr. Reddy's Laboratories Limited | Polymorphic forms of vardenafil |
WO2009030095A1 (en) * | 2007-09-06 | 2009-03-12 | Topharman Shanghai Co., Ltd. | Process for preparing vardenafil and its intermediates |
ES2388371T3 (es) | 2007-12-28 | 2012-10-15 | Topharman Shanghai Co., Ltd. | N-{1-[3-(2-etoxi-5-(4-etilpiperazinil)bencenosulfonil)-4,5-dihidro-5-oxo-1,2,4-triazin-6-il]etil}-butiramida, método de preparación y uso |
EP2462127A1 (en) | 2009-08-07 | 2012-06-13 | Ranbaxy Laboratories Limited | Processes for the preparation of vardenafil |
PL390079A1 (pl) * | 2009-12-30 | 2011-07-04 | Zakłady Farmaceutyczne POLPHARMA Spółka Akcyjna | Sposób otrzymywania wardenafilu i jego izolacji jako soli z kwasem cytrynowym oraz krystaliczna postać tej soli |
CN102134242B (zh) | 2011-01-21 | 2013-08-28 | 浙江大德药业集团有限公司 | 一种用于治疗阳痿的快速长效的化合物 |
CZ303877B6 (cs) * | 2011-11-24 | 2013-06-05 | Zentiva, K.S. | Zpusob prípravy a izolace solí vardenafilu s kyselinami |
US20160317542A1 (en) | 2013-12-09 | 2016-11-03 | Respira Therapeutics, Inc. | Pde5 inhibitor powder formulations and methods relating thereto |
PL223869B1 (pl) | 2013-12-16 | 2016-11-30 | Starogardzkie Zakłady Farm Polpharma Spółka Akcyjna | Sposób otrzymywania wardenafilu i jego soli |
CN107383020A (zh) * | 2017-07-29 | 2017-11-24 | 合肥创新医药技术有限公司 | 一种伐地那非杂质的制备方法 |
JP2021506986A (ja) | 2017-12-20 | 2021-02-22 | クラリア・ファルマ・ホールディング・アクチボラグ | バルデナフィルを含むフィルム配合物、その調製法、およびその使用 |
CN115043757B (zh) * | 2022-07-27 | 2023-08-08 | 南京桦冠生物技术有限公司 | 一种连续化制备苄脒盐酸盐的方法 |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB9311920D0 (en) * | 1993-06-09 | 1993-07-28 | Pfizer Ltd | Therapeutic agents |
UA46166C2 (uk) | 1997-11-12 | 2002-05-15 | Баєр Акцієнгезельшафт | 2-фенілзаміщені імідазотриазинони як інгібітори фосфодіестерази, спосіб їх одержання та лікарський засіб на їх основі |
DE10063108A1 (de) * | 2000-12-18 | 2002-06-20 | Bayer Ag | Verfahren zur Herstellung von Sulfonamid-substituierten Imidazotriazinonen |
DE10107639A1 (de) * | 2001-02-15 | 2002-08-22 | Bayer Ag | 2-Alkoxyphenyl-substituierte Imidazotriazinone |
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2000
- 2000-12-18 DE DE10063108A patent/DE10063108A1/de not_active Withdrawn
-
2001
- 2001-05-12 UA UA2003076744A patent/UA75109C2/uk unknown
- 2001-11-28 AR ARP010105546A patent/AR032775A1/es active IP Right Grant
- 2001-11-28 DO DO2001000295A patent/DOP2001000295A/es unknown
- 2001-12-05 JP JP2002551969A patent/JP4441175B2/ja not_active Expired - Lifetime
- 2001-12-05 ES ES01271374T patent/ES2266098T3/es not_active Expired - Lifetime
- 2001-12-05 EP EP01271374A patent/EP1345939B1/de not_active Expired - Lifetime
- 2001-12-05 NZ NZ526477A patent/NZ526477A/xx not_active IP Right Cessation
- 2001-12-05 DK DK01271374T patent/DK1345939T3/da active
- 2001-12-05 KR KR1020037008063A patent/KR100787288B1/ko active IP Right Grant
- 2001-12-05 SI SI200130606T patent/SI1345939T1/sl unknown
- 2001-12-05 RU RU2003122192/04A patent/RU2299211C2/ru active
- 2001-12-05 MX MXPA03005429A patent/MXPA03005429A/es active IP Right Grant
- 2001-12-05 HU HU0302467A patent/HU229296B1/hu unknown
- 2001-12-05 SK SK750-2003A patent/SK286894B6/sk not_active IP Right Cessation
- 2001-12-05 AU AU1708902A patent/AU1708902A/xx active Pending
- 2001-12-05 CZ CZ20031692A patent/CZ297005B6/cs not_active IP Right Cessation
- 2001-12-05 PL PL365310A patent/PL207294B1/pl unknown
- 2001-12-05 AT AT01271374T patent/ATE328885T1/de active
- 2001-12-05 AU AU2002217089A patent/AU2002217089B2/en not_active Expired
- 2001-12-05 EE EEP200300294A patent/EE05308B1/xx unknown
- 2001-12-05 PT PT01271374T patent/PT1345939E/pt unknown
- 2001-12-05 BR BRPI0116227A patent/BRPI0116227B8/pt not_active IP Right Cessation
- 2001-12-05 CA CA002431933A patent/CA2431933C/en not_active Expired - Lifetime
- 2001-12-05 WO PCT/EP2001/014239 patent/WO2002050076A2/de active IP Right Grant
- 2001-12-05 DE DE50110080T patent/DE50110080D1/de not_active Expired - Lifetime
- 2001-12-05 CN CNB018208177A patent/CN1227253C/zh not_active Expired - Lifetime
- 2001-12-13 MY MYPI20015689A patent/MY126689A/en unknown
- 2001-12-14 HN HN2001000278A patent/HN2001000278A/es unknown
- 2001-12-14 UY UY27070A patent/UY27070A1/es not_active IP Right Cessation
- 2001-12-14 GT GT200100251A patent/GT200100251A/es unknown
- 2001-12-15 IL IL15627801A patent/IL156278A0/xx unknown
- 2001-12-17 US US10/022,954 patent/US6777551B2/en not_active Expired - Lifetime
- 2001-12-17 TW TW090131175A patent/TWI289562B/zh not_active IP Right Cessation
- 2001-12-17 PE PE2001001258A patent/PE20020590A1/es active IP Right Grant
- 2001-12-17 SV SV2001000766A patent/SV2003000766A/es active IP Right Grant
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2003
- 2003-06-03 IL IL156278A patent/IL156278A/en active IP Right Grant
- 2003-06-09 CU CU20030128A patent/CU23341B7/es unknown
- 2003-06-09 BG BG107892A patent/BG66142B1/bg unknown
- 2003-06-16 NO NO20032731A patent/NO325398B1/no not_active IP Right Cessation
- 2003-06-17 EC EC2003004657A patent/ECSP034657A/es unknown
- 2003-06-18 ZA ZA200304705A patent/ZA200304705B/en unknown
- 2003-06-18 MA MA27202A patent/MA25927A1/fr unknown
- 2003-07-17 HR HR20030583A patent/HRP20030583B1/xx not_active IP Right Cessation
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2004
- 2004-07-02 US US10/884,686 patent/US20050014756A1/en not_active Abandoned
- 2004-09-03 HK HK04106667A patent/HK1063799A1/xx not_active IP Right Cessation
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2005
- 2005-05-05 US US11/124,452 patent/US6998483B2/en not_active Expired - Lifetime
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2006
- 2006-09-05 CY CY20061101263T patent/CY1105197T1/el unknown
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2008
- 2008-11-17 CU CUP2008000213A patent/CU23873B1/es active IP Right Grant
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2017
- 2017-03-28 UY UY0001037172A patent/UY37172A/es not_active Application Discontinuation
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