CU20080213A7 - Nuevo procedimiento para la preparación de un intermediario útil en la preparación de imidazotriazinonas sustituidas con sulfonamida - Google Patents

Nuevo procedimiento para la preparación de un intermediario útil en la preparación de imidazotriazinonas sustituidas con sulfonamida

Info

Publication number
CU20080213A7
CU20080213A7 CU20080213A CU20080213A CU20080213A7 CU 20080213 A7 CU20080213 A7 CU 20080213A7 CU 20080213 A CU20080213 A CU 20080213A CU 20080213 A CU20080213 A CU 20080213A CU 20080213 A7 CU20080213 A7 CU 20080213A7
Authority
CU
Cuba
Prior art keywords
preparation
imidazotriazinones
sulfonamide
replaced
new procedure
Prior art date
Application number
CU20080213A
Other languages
English (en)
Other versions
CU23873B1 (es
Inventor
Karl-Heinz Wahl
Werner Heilmann
Reinhold Gehring
Marc Nowakowski
Original Assignee
Bayer Schering Pharma Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Schering Pharma Ag filed Critical Bayer Schering Pharma Ag
Publication of CU20080213A7 publication Critical patent/CU20080213A7/es
Publication of CU23873B1 publication Critical patent/CU23873B1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Endocrinology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Reproductive Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Cosmetics (AREA)

Abstract

La presente invención se refiere a un intermediario para procedimiento para la preparación de imidazotriazinonas sustituídas con sulfonamida de fórmula general (I) caracterizado porque los compuestos de fórmula V se trasforman con compuestos de fórmula general VI en una reacción de dos etapas en el sistema metanol y cloruro de acetilo /ácido acético.
CUP2008000213A 2000-12-18 2008-11-17 Nuevo procedimiento para la preparación de un intermediario útil en la preparación de imidazotriazinonas sustituidas con sulfonamida CU23873B1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10063108A DE10063108A1 (de) 2000-12-18 2000-12-18 Verfahren zur Herstellung von Sulfonamid-substituierten Imidazotriazinonen
PCT/EP2001/014239 WO2002050076A2 (de) 2000-12-18 2001-12-05 Verfahren zur herstellung von sulfonamid-substituierten imidazotriazinonen

Publications (2)

Publication Number Publication Date
CU20080213A7 true CU20080213A7 (es) 2012-06-21
CU23873B1 CU23873B1 (es) 2013-04-19

Family

ID=7667666

Family Applications (2)

Application Number Title Priority Date Filing Date
CU20030128A CU23341B7 (es) 2000-12-18 2003-06-09 Procedimiento para la preparación de imidazotriazínonas sustituidas con sulfonamida
CUP2008000213A CU23873B1 (es) 2000-12-18 2008-11-17 Nuevo procedimiento para la preparación de un intermediario útil en la preparación de imidazotriazinonas sustituidas con sulfonamida

Family Applications Before (1)

Application Number Title Priority Date Filing Date
CU20030128A CU23341B7 (es) 2000-12-18 2003-06-09 Procedimiento para la preparación de imidazotriazínonas sustituidas con sulfonamida

Country Status (43)

Country Link
US (3) US6777551B2 (es)
EP (1) EP1345939B1 (es)
JP (1) JP4441175B2 (es)
KR (1) KR100787288B1 (es)
CN (1) CN1227253C (es)
AR (1) AR032775A1 (es)
AT (1) ATE328885T1 (es)
AU (2) AU2002217089B2 (es)
BG (1) BG66142B1 (es)
BR (1) BRPI0116227B8 (es)
CA (1) CA2431933C (es)
CU (2) CU23341B7 (es)
CY (1) CY1105197T1 (es)
CZ (1) CZ297005B6 (es)
DE (2) DE10063108A1 (es)
DK (1) DK1345939T3 (es)
DO (1) DOP2001000295A (es)
EC (1) ECSP034657A (es)
EE (1) EE05308B1 (es)
ES (1) ES2266098T3 (es)
GT (1) GT200100251A (es)
HK (1) HK1063799A1 (es)
HN (1) HN2001000278A (es)
HR (1) HRP20030583B1 (es)
HU (1) HU229296B1 (es)
IL (2) IL156278A0 (es)
MA (1) MA25927A1 (es)
MX (1) MXPA03005429A (es)
MY (1) MY126689A (es)
NO (1) NO325398B1 (es)
NZ (1) NZ526477A (es)
PE (1) PE20020590A1 (es)
PL (1) PL207294B1 (es)
PT (1) PT1345939E (es)
RU (1) RU2299211C2 (es)
SI (1) SI1345939T1 (es)
SK (1) SK286894B6 (es)
SV (1) SV2003000766A (es)
TW (1) TWI289562B (es)
UA (1) UA75109C2 (es)
UY (2) UY27070A1 (es)
WO (1) WO2002050076A2 (es)
ZA (1) ZA200304705B (es)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10063108A1 (de) * 2000-12-18 2002-06-20 Bayer Ag Verfahren zur Herstellung von Sulfonamid-substituierten Imidazotriazinonen
DE10107639A1 (de) * 2001-02-15 2002-08-22 Bayer Ag 2-Alkoxyphenyl-substituierte Imidazotriazinone
DE10232113A1 (de) 2002-07-16 2004-01-29 Bayer Ag Vardenafil Hydrochlorid Trihydrat enthaltende Arzneimittel
DE202004006552U1 (de) * 2004-04-26 2004-07-08 Knürr AG Kühlungssystem für Geräte- und Netzwerkschränke
DE102004023069A1 (de) 2004-05-11 2005-12-08 Bayer Healthcare Ag Neue Darreichungsformen des PDE 5-Inhibitors Vardenafil
US7977478B2 (en) * 2006-03-13 2011-07-12 Dr. Reddy's Laboratories Limited Polymorphic forms of vardenafil
CN101965348B (zh) * 2007-09-06 2013-11-13 上海特化医药科技有限公司 伐地那非的制备方法及其中间体
JP5411161B2 (ja) 2007-12-28 2014-02-12 上海特化医薬科技有限公司 Ｎ−｛１−［３−（２−エトキシ−５−（４−エチルピペラジニル）スルホニルフェニル）−４，５−ジヒドロ−５−オキソ−１，２，４−トリアジン−６−イル］エチル｝ブチルアミド、その調製方法及び用途
WO2011016016A1 (en) 2009-08-07 2011-02-10 Ranbaxy Laboratories Limited Processes for the preparation of vardenafil
PL390079A1 (pl) * 2009-12-30 2011-07-04 Zakłady Farmaceutyczne POLPHARMA Spółka Akcyjna Sposób otrzymywania wardenafilu i jego izolacji jako soli z kwasem cytrynowym oraz krystaliczna postać tej soli
CN102134242B (zh) 2011-01-21 2013-08-28 浙江大德药业集团有限公司 一种用于治疗阳痿的快速长效的化合物
CZ2011767A3 (cs) 2011-11-24 2013-06-05 Zentiva, K.S. Zpusob prípravy a izolace solí vardenafilu s kyselinami
WO2015089105A1 (en) 2013-12-09 2015-06-18 Respira Therapeutics, Inc. Pde5 inhibitor powder formulations and methods relating thereto
PL223869B1 (pl) 2013-12-16 2016-11-30 Starogardzkie Zakłady Farm Polpharma Spółka Akcyjna Sposób otrzymywania wardenafilu i jego soli
CN107383020A (zh) * 2017-07-29 2017-11-24 合肥创新医药技术有限公司 一种伐地那非杂质的制备方法
AU2018386444A1 (en) 2017-12-20 2020-07-23 Klaria Pharma Holding Ab Film formulation comprising vardenafil, method for its preparation, and use thereof
CN115043757B (zh) * 2022-07-27 2023-08-08 南京桦冠生物技术有限公司 一种连续化制备苄脒盐酸盐的方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9301192D0 (en) * 1993-06-09 1993-06-09 Trott Francis W Flower shaped mechanised table
AU738675B2 (en) * 1997-11-12 2001-09-20 Bayer Intellectual Property Gmbh 2-phenyl-substituted imidazotriazinones as phosphodiesterase inhibitors
DE10063108A1 (de) * 2000-12-18 2002-06-20 Bayer Ag Verfahren zur Herstellung von Sulfonamid-substituierten Imidazotriazinonen
DE10107639A1 (de) * 2001-02-15 2002-08-22 Bayer Ag 2-Alkoxyphenyl-substituierte Imidazotriazinone

Also Published As

Publication number Publication date
BR0116227B1 (pt) 2014-08-26
HK1063799A1 (en) 2005-01-14
DOP2001000295A (es) 2002-12-15
CN1481386A (zh) 2004-03-10
CU23873B1 (es) 2013-04-19
AR032775A1 (es) 2003-11-26
JP4441175B2 (ja) 2010-03-31
BG66142B1 (bg) 2011-07-29
GT200100251A (es) 2002-10-01
US6777551B2 (en) 2004-08-17
HRP20030583A2 (en) 2005-06-30
UY37172A (es) 2017-06-30
IL156278A (en) 2009-06-15
SK286894B6 (sk) 2009-07-06
MY126689A (en) 2006-10-31
CU23341B7 (es) 2009-02-20
ECSP034657A (es) 2003-07-25
DK1345939T3 (da) 2006-09-25
JP2004517849A (ja) 2004-06-17
CN1227253C (zh) 2005-11-16
SI1345939T1 (sl) 2006-10-31
ZA200304705B (en) 2004-08-12
US20050014756A1 (en) 2005-01-20
HUP0302467A2 (hu) 2003-11-28
NO20032731D0 (no) 2003-06-16
CA2431933A1 (en) 2002-06-27
EE200300294A (et) 2003-10-15
HN2001000278A (es) 2002-01-30
US20050203298A1 (en) 2005-09-15
MXPA03005429A (es) 2004-05-04
EP1345939A2 (de) 2003-09-24
NO325398B1 (no) 2008-04-21
BG107892A (bg) 2004-08-31
NO20032731L (no) 2003-06-16
HU229296B1 (en) 2013-10-28
SK7502003A3 (en) 2003-10-07
PL207294B1 (pl) 2010-11-30
CZ20031692A3 (cs) 2003-10-15
HUP0302467A3 (en) 2004-11-29
PL365310A1 (en) 2004-12-27
RU2299211C2 (ru) 2007-05-20
DE50110080D1 (de) 2006-07-20
ES2266098T3 (es) 2007-03-01
UY27070A1 (es) 2002-07-31
KR100787288B1 (ko) 2007-12-20
AU2002217089B2 (en) 2006-01-12
EP1345939B1 (de) 2006-06-07
CA2431933C (en) 2009-12-01
IL156278A0 (en) 2004-01-04
BRPI0116227B8 (pt) 2021-05-25
US6998483B2 (en) 2006-02-14
DE10063108A1 (de) 2002-06-20
HRP20030583B1 (en) 2011-09-30
SV2003000766A (es) 2003-01-13
CZ297005B6 (cs) 2006-08-16
MA25927A1 (fr) 2003-10-01
US20020137930A1 (en) 2002-09-26
NZ526477A (en) 2004-12-24
AU1708902A (en) 2002-07-01
WO2002050076A3 (de) 2002-08-29
PE20020590A1 (es) 2002-07-13
EE05308B1 (et) 2010-06-15
PT1345939E (pt) 2006-08-31
TWI289562B (en) 2007-11-11
KR20030063430A (ko) 2003-07-28
ATE328885T1 (de) 2006-06-15
CY1105197T1 (el) 2010-03-03
BR0116227A (pt) 2003-12-30
UA75109C2 (en) 2006-03-15
WO2002050076A2 (de) 2002-06-27

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