ME01395B - Postupak za izradu (1s)-4,5-dimetoksi-1-(metilaminometil)benzociklobutanai njegovih aditivnih soli kiselina kao i njegov a primena za sintezu ivabradina i njegovih farmaceutski prihvatljivih aditivnih soli kiselina - Google Patents

Postupak za izradu (1s)-4,5-dimetoksi-1-(metilaminometil)benzociklobutanai njegovih aditivnih soli kiselina kao i njegov a primena za sintezu ivabradina i njegovih farmaceutski prihvatljivih aditivnih soli kiselina

Info

Publication number
ME01395B
ME01395B MEP-2006-654A MEP2006654A ME01395B ME 01395 B ME01395 B ME 01395B ME P2006654 A MEP2006654 A ME P2006654A ME 01395 B ME01395 B ME 01395B
Authority
ME
Montenegro
Prior art keywords
acid addition
addition salts
synthesis
ivabradine
pharmaceutically acceptable
Prior art date
Application number
MEP-2006-654A
Other languages
German (de)
English (en)
French (fr)
Inventor
Jean Michel Lerestif
Blanco Isaac Gonzalez
Jean Pierre Lecouve
Daniel Brigot
Original Assignee
Servier Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Servier Lab filed Critical Servier Lab
Publication of ME01395B publication Critical patent/ME01395B/me

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/54—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C07C217/56—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by singly-bound oxygen atoms
    • C07C217/58—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by singly-bound oxygen atoms with amino groups and the six-membered aromatic ring, or the condensed ring system containing that ring, bound to the same carbon atom of the carbon chain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
    • C07C213/10—Separation; Purification; Stabilisation; Use of additives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
    • C07C213/08—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton by reactions not involving the formation of amino groups, hydroxy groups or etherified or esterified hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Hospice & Palliative Care (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

Postupak za sintezu jedinjenja formule (I): Postupak za sintezu jedinjenja formule (I): koje se primenjuje za sintezu  ivabradina,  njegovih farmaceutski prihvatljivih aditivnih  soli kiselinai njihovih  hidrata<!--[if !vml]--><!--[endif]--> koje se primenjuje za sintezu   ivabradina,   njegovih farmaceutski prihvatljivih aditivnih   soli kiselina i njihovih   hidrata
MEP-2006-654A 2004-05-19 2005-02-21 Postupak za izradu (1s)-4,5-dimetoksi-1-(metilaminometil)benzociklobutanai njegovih aditivnih soli kiselina kao i njegov a primena za sintezu ivabradina i njegovih farmaceutski prihvatljivih aditivnih soli kiselina ME01395B (me)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0405453A FR2870537A1 (fr) 2004-05-19 2004-05-19 Nouveau procede de synthese du (1s)-4,5-dimethoxy-1-(methyl aminomethyl-)-benzocyclobutane et de ses sels d'addition, et application a la synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable
EP05290384A EP1598333B1 (fr) 2004-05-19 2005-02-21 Procédé de synthèse du (1S)-4,5-diméthoxy-1-(méthylaminométhyl)-benzocyclobutane et de ses sels d'addition, et application à la synthèse de l'ivabradine et de ses sels d'addition à un acide pharmaceutiquement acceptable

Publications (1)

Publication Number Publication Date
ME01395B true ME01395B (me) 2010-03-02

Family

ID=34941962

Family Applications (1)

Application Number Title Priority Date Filing Date
MEP-2006-654A ME01395B (me) 2004-05-19 2005-02-21 Postupak za izradu (1s)-4,5-dimetoksi-1-(metilaminometil)benzociklobutanai njegovih aditivnih soli kiselina kao i njegov a primena za sintezu ivabradina i njegovih farmaceutski prihvatljivih aditivnih soli kiselina

Country Status (33)

Country Link
US (1) US6982350B2 (me)
EP (1) EP1598333B1 (me)
JP (1) JP4148952B2 (me)
KR (1) KR100649289B1 (me)
CN (1) CN1332933C (me)
AR (1) AR047746A1 (me)
AT (1) ATE342885T1 (me)
AU (1) AU2005200883B2 (me)
BR (1) BRPI0500480B8 (me)
CA (1) CA2496708C (me)
CY (1) CY1105826T1 (me)
DE (1) DE602005000187T2 (me)
DK (1) DK1598333T3 (me)
EA (1) EA007746B1 (me)
EG (1) EG23719A (me)
ES (1) ES2275258T3 (me)
FR (1) FR2870537A1 (me)
GE (1) GEP20074135B (me)
HK (1) HK1081945A1 (me)
HR (1) HRP20060449T3 (me)
MA (1) MA27640A1 (me)
ME (1) ME01395B (me)
MX (1) MXPA05005139A (me)
MY (1) MY139475A (me)
NO (1) NO330968B1 (me)
NZ (1) NZ538329A (me)
PL (1) PL1598333T3 (me)
PT (1) PT1598333E (me)
RS (1) RS50512B (me)
SI (1) SI1598333T1 (me)
UA (1) UA79482C2 (me)
WO (1) WO2005123659A1 (me)
ZA (1) ZA200501469B (me)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
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ES2381771T3 (es) * 2006-11-30 2012-05-31 Cadila Healthcare Limited Procedimiento para la preparación de hidrocloruro de ivabradina
KR101478855B1 (ko) 2007-05-30 2015-01-02 인드-스위프트 래버러토리즈 리미티드 이바브라딘 히드로클로라이드 및 그의 다형태의 제조방법
CN101434552B (zh) * 2007-11-16 2012-05-23 江苏恒瑞医药股份有限公司 4,5-二甲氧基-1-(甲基氨基甲基)-苯并环丁烷的拆分
FR2927900B1 (fr) * 2008-02-27 2010-09-17 Clariant Specialty Fine Chem Procede de preparation d'alpha-aminoacetals optiquement actifs.
FR2933975B1 (fr) * 2008-07-17 2011-02-18 Servier Lab Nouveau procede de preparation de benzocyclobutenes fonctionnalises,et application a la synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable.
FR2935381B1 (fr) * 2008-08-29 2010-12-17 Servier Lab Nouveau procede de resolution des enantiomerees du (3,4-dimethoxy-bicyclo°4.2.0!octa-1,3,5-trien-7-yl)nitrile et application a la synthese de l'ivabradine
CN101671265B (zh) * 2008-09-12 2012-08-15 中国科学院上海药物研究所 一种苯并环丁烷类化合物及其制备方法与用途
CN102264689B (zh) * 2008-12-22 2014-12-31 新梅斯托克尔卡公司 制备伊伐布雷定的方法
FR2940287B1 (fr) * 2008-12-24 2010-12-24 Servier Lab Nouveau procede de synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable.
ME00986B (me) 2009-03-31 2012-06-20 Servier Lab Novi postupak sinteze ivabradina i njegovih adicionih soli sa farmaceutski prihvatljivom kiselinom
ME00987B (me) * 2009-03-31 2012-06-20 Servier Lab Novi postupak sinteze ivabradina i njegovih soli sa farmaceutski prihvatljivom kiselinom
SI23290A (sl) 2010-02-12 2011-08-31 Krka D.D., Novo Mesto Nove oblike ivabradin hidroklorida
HUP1000245A2 (en) 2010-05-07 2011-11-28 Richter Gedeon Nyrt Industrial process for the production ivabradin salts
CN102249937A (zh) * 2010-05-18 2011-11-23 上海京新生物医药有限公司 1-(s)-4,5-二甲氧基-1-甲胺基甲基-苯并环丁烷的制备方法
CN102372642B (zh) * 2011-07-04 2014-01-08 江苏宇田生物医药科技有限公司 (1s)-4,5-二甲氧基-1-[(甲基氨基)甲基]苯并环丁烷的制备方法
ITMI20111467A1 (it) * 2011-08-01 2013-02-02 Laboratorio Chimico Int Spa Procedimento per la preparazione di ivabradina e di suoi intermedi di sintesi
CN102408346B (zh) * 2011-10-31 2014-07-02 江苏阿尔法药业有限公司 一种4,5-二甲氧基-1-（甲基氨基甲基）-苯并环丁烷的制备方法
FR2984320B1 (fr) * 2011-12-20 2013-11-29 Servier Lab Nouveau procede de synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable
FR2986804A1 (fr) * 2012-02-09 2013-08-16 Servier Lab Procede de synthese enzymatique de l'acide (7s) 3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-triene 7-carboxylique ou de ses esters, et application a la synthese de l'ivabradine et de ses sels
FR2988720B1 (fr) * 2012-03-27 2014-03-14 Servier Lab Nouveau procede de synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable
FR2993561B1 (fr) 2012-07-17 2014-10-31 Servier Lab Procede de synthese enzymatique de la (7s)-1-(3,4-dimethoxy bicyclo[4.2.0]octa-1,3,5-triene 7-yl) n-methyl methanamine, et application a la synthese de l'ivabradine et de ses sels
CN103848789B (zh) * 2012-11-29 2016-05-18 江苏恒瑞医药股份有限公司 一种伊伐布雷定的制备方法
FR3003859B1 (fr) * 2013-03-26 2015-03-13 Servier Lab "procede de synthese de derives de la 7,8-dimethoxy-1,3-dihydro-2h-3-benzazepin-2-one et application a la synthese de l'ivabradine"
FR3005658B1 (fr) * 2013-05-17 2015-04-24 Servier Lab "procede de synthese du 3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-triene-7-carbonitrile, et application a la synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable"
WO2015022702A2 (en) * 2013-08-10 2015-02-19 Ind-Swift Laboratories Limited Process for preparation of 4,5-dimethoxybenzene derivatives and use in the synthesis of ivabradine and salts thereof
CN103524360B (zh) * 2013-10-17 2015-09-30 安徽安腾药业有限责任公司 一种伊伐布雷定关键中间体的合成方法
CN105960394B (zh) * 2014-02-06 2019-03-15 宇部兴产株式会社 二氢吲哚化合物的制造方法
EP3101010A1 (en) 2015-06-03 2016-12-07 Urquima S.A. New method for the preparation of highly pure ivabradine base and salts thereof
CN110483312A (zh) * 2019-08-27 2019-11-22 北京阳光诺和药物研究有限公司 一种高纯度盐酸伊伐布雷定及其中间体的制备方法
CN115286577B (zh) * 2022-08-25 2023-10-20 江苏永安制药有限公司 一种盐酸伊伐布雷定及其中间体的制备方法

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Also Published As

Publication number Publication date
NZ538329A (en) 2005-10-28
MXPA05005139A (es) 2005-11-24
MA27640A1 (fr) 2005-12-01
US20050261376A1 (en) 2005-11-24
NO330968B1 (no) 2011-08-29
ATE342885T1 (de) 2006-11-15
ES2275258T3 (es) 2007-06-01
EP1598333B1 (fr) 2006-10-18
EA007746B1 (ru) 2006-12-29
JP2005330263A (ja) 2005-12-02
KR20060042118A (ko) 2006-05-12
BRPI0500480A (pt) 2006-06-06
AU2005200883A1 (en) 2005-12-08
CA2496708A1 (fr) 2005-11-19
HRP20060449T3 (en) 2007-03-31
CY1105826T1 (el) 2011-02-02
AR047746A1 (es) 2006-02-15
EP1598333A1 (fr) 2005-11-23
KR100649289B1 (ko) 2006-11-24
RS50512B (sr) 2010-03-02
CN1699331A (zh) 2005-11-23
GEP20074135B (en) 2007-06-25
NO20050883D0 (no) 2005-02-18
PL1598333T3 (pl) 2006-12-29
EG23719A (en) 2007-06-17
HK1081945A1 (en) 2006-05-26
AU2005200883B2 (en) 2010-07-15
DK1598333T3 (da) 2007-02-12
PT1598333E (pt) 2007-01-31
DE602005000187D1 (de) 2006-11-30
ZA200501469B (en) 2005-11-30
DE602005000187T2 (de) 2007-09-06
SI1598333T1 (sl) 2007-02-28
EA200500239A1 (ru) 2005-12-29
BRPI0500480B8 (pt) 2021-05-25
UA79482C2 (en) 2007-06-25
MY139475A (en) 2009-10-30
FR2870537A1 (fr) 2005-11-25
BRPI0500480B1 (pt) 2020-08-11
NO20050883L (no) 2005-11-21
JP4148952B2 (ja) 2008-09-10
CN1332933C (zh) 2007-08-22
US6982350B2 (en) 2006-01-03
CA2496708C (fr) 2011-03-15
WO2005123659A1 (fr) 2005-12-29

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